Gene Page:DOCK9

概括?
GeneID 23348
Symbol DOCK9
同义词 Ziz1 | Zizimin1
描述 dedicator of cytokinesis 9
参考 MIM:607325|HGNC:HGNC:14132|Ensembl：ENSG00000088387|HPRD：09542|Vega:OTTHUMG00000017260
Gene type protein-coding
Map location 13q32.3
Pascal p-value 0.915
Sherlock P值 0.112
DMG 2 (# studies)
eGene Anterior cingulate cortex BA24
迈尔斯的顺式和跨性别
Support COMPOSITESET
Darnell FMRP targets
Ascano FMRP targets

数据源中的基因
Gene set name Method of gene set 描述 Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Nishioka_2013 Genome-wide DNA methylation analysis The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 3
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 3

第一节遗传学和表观遗传学注释

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) beta（dis） FDR (dis) Study
CG21712331 13 99630489 DOCK9 4.84E-4 -0.722 0.046 DMG:Wockner_2014
cg10811485 13 99630583 DOCK9 4.921E-4 -0.673 0.047 DMG:Wockner_2014
cg04836038 13 99739382 DOCK9 -0.041 0.75 DMG:Nishioka_2013

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
RS16894557 chr6 28999825 DOCK9 23348 0.06 trans
RS3825428 13 99398883 DOCK9 ENSG00000088387.13 1.45694E-6 0.04 339996 gtex_brain_ba24
rs3782997 13 99398932 DOCK9 ENSG00000088387.13 1.45694E-6 0.04 339947 gtex_brain_ba24
rs3782994 13 99401848 DOCK9 ENSG00000088387.13 1.45694E-6 0.04 337031 gtex_brain_ba24

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
C11orf82 0.87 0.83
KNTC1 0.87 0.81
PCNA 0.86 0.76
fancd2 0.86 0.82
C21orf45 0.86 0.81
PLK4 0.85 0.83
NCAPG2 0.85 0.82
GINS2 0.85 0.60
永恒 0.85 0.74
stil 0.84 0.81
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.27 -0.63 -0.79
AF347015.33 -0.62 -0.78
MT-CO2 -0.62 -0.79
AF347015.31 -0.62 -0.77
MT-CYB -0.61 -0.78
AF347015.8 -0.61 -0.80
AF347015.15 -0.61 -0.79
HLA-F -0.59 -0.69
AIFM3 -0.59 -0.69
AF347015.2 -0.59 -0.77

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005085 guanyl-nucleotide交换因素活动 IEA -
GO:0005525 GTP binding IEA -
GO:0051020 GTPase结合 IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0008150 生物_Process ND -
细胞分量 去的术语 Evidence Neuro keywords PubMed ID
GO:0012505 内膜系统 IEA -
GO:0005575 cellular_component ND -
GO:0016020 膜 IEA -

V.途径注释

Pathway name Pathway size ＃szgr 2.0基因 Info
PID CDC42 REG途径 30 22 该途径中的所有SZGR 2.0基因
REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 132 101 该途径中的所有SZGR 2.0基因
REACTOME HEMOSTASIS 466 331 该途径中的所有SZGR 2.0基因
家长mtor信号向上 567 375 该途径中的所有SZGR 2.0基因
ONKEN UVEAL MELANOMA UP 783 507 该途径中的所有SZGR 2.0基因
DAVICIONI MOLECULAR ARMS VS ERMS UP 332 228 该途径中的所有SZGR 2.0基因
MULLIGHAN NPM1 MUTATED SIGNATURE 1 UP 276 165 该途径中的所有SZGR 2.0基因
MULLIGHAN NPM1 SIGNATURE 3 UP 341 197 该途径中的所有SZGR 2.0基因
TIEN INTESTINE PROBIOTICS 6HR DN 167 100 该途径中的所有SZGR 2.0基因
tien肠益生菌24小时 557 331 该途径中的所有SZGR 2.0基因
斋丁嫩造血干细胞DN 226 132 该途径中的所有SZGR 2.0基因
多德鼻咽癌 1821 933 该途径中的所有SZGR 2.0基因
DELYS THYROID CANCER UP 443 294 该途径中的所有SZGR 2.0基因
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781年 1082 该途径中的所有SZGR 2.0基因
HAMAI APOPTOSIS VIA TRAIL UP 584 356 该途径中的所有SZGR 2.0基因
PEREZ TP53 TARGETS 1174 695 该途径中的所有SZGR 2.0基因
DACOSTA UV RESPONSE VIA ERCC3 XPCS DN 88 71 该途径中的所有SZGR 2.0基因
DACOSTA UV RESPONSE VIA ERCC3 TTD DN 84 63 该途径中的所有SZGR 2.0基因
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 该途径中的所有SZGR 2.0基因
Goldrath免疫记忆 65 42 该途径中的所有SZGR 2.0基因
BURTON ADIPOGENESIS 10 30 17 该途径中的所有SZGR 2.0基因
IVANOVA HEMATOPOIESIS STEM CELL LONG TERM 302 191 该途径中的所有SZGR 2.0基因
YAMAZAKI TCEB3 TARGETS UP 175 116 该途径中的所有SZGR 2.0基因
Chen lvad支持失败的心 103 69 该途径中的所有SZGR 2.0基因
DAZARD RESPONSE TO UV NHEK DN 318 220 该途径中的所有SZGR 2.0基因
DAZARD UV RESPONSE CLUSTER G6 153 112 该途径中的所有SZGR 2.0基因
Creighton内分泌疗法抗性3 720 440 该途径中的所有SZGR 2.0基因
HELLER HDAC TARGETS UP 317 208 该途径中的所有SZGR 2.0基因
BOQUEST STEM CELL DN 216 143 该途径中的所有SZGR 2.0基因
Keshelava多种耐药性 88 56 该途径中的所有SZGR 2.0基因
ZHAN MULTIPLE MYELOMA MF DN 41 28 该途径中的所有SZGR 2.0基因
MIKKELSEN ES ICP WITH H3K4ME3 718 401 该途径中的所有SZGR 2.0基因
CHYLA CBFA2T3 TARGETS UP 387 225 该途径中的所有SZGR 2.0基因
JOHNSTONE PARVB TARGETS 2 DN 336 211 该途径中的所有SZGR 2.0基因
TORCHIA TARGETS OF EWSR1 FLI1 FUSION DN 321 200 该途径中的所有SZGR 2.0基因
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080 713 该途径中的所有SZGR 2.0基因
RATTENBACHER BOUND BY CELF1 467 251 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position mirna id miRNA seq
UTR start UTR end Match method
mir-136 977 983 1A hsa-miR-136 ACUCCAUUUGUUUUGAUGAUGGA
miR-148/152 472 479 1A,m8 hsa-miR-148a UCAGUGCACUACAGAACUUUGU
hsa-miR-152脑 UCAGUGCAUGACAGAACUUGGG
hsa-miR-148b UCAGUGCAUCACAGAACUUUGU
mir-153 929 935 1A hsa-miR-153 Uugcauagucacaaaaguga
mir-182 1039 1046 1A,m8 hsa-miR-182 UUUGGCAAUGGUAGAACUCACA
miR-203.1 854 860 m8 HSA-MIR-203 UGAAAUGUUUAGGACCACUAG
miR-208 347 353 1A HSA-MIR-208 AUAAGACGAGCAAAAAGCUUGU
miR-214 1204 1210 m8 HSA-MIR-214脑 ACAGCAGGCACAGACAGGCAG
miR-25/32/92/363/367 970 977 1A,m8 HSA-MIR-25脑 CAUUGCACUUGUCUCGGUCUGA
hsa-miR-32 UAUUGCACAUUACUAAGUUGC
hsa-miR-92 UAUUGCACUUGUCCCGGCCUG
hsa-miR-367 AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZ UAUUGCACUCGUCCCGGCCUC
miR-409-3p 554 560 1A hsa-miR-409-3p CGAAUGUUGCUCGGUGAACCCCU
miR-410 1118 1124 m8 hsa-miR-410 AAUAUAACACAGAUGGCCUGU
miR-448 928 935 1A,m8 HSA-MIR-448 uugcauauguaggauguccccau
miR-452 164 170 m8 HSA-MIR-452 UguuugcaggaaacugagaC
miR-455 551 557 m8 HSA-MIR-455 UAUGUGCCUUUGGACUACAUCG
HSA-MIR-455 UAUGUGCCUUUGGACUACAUCG
mir-493-5p 803 809 m8 hsa-miR-493-5p UUGUACAUGGUAGGCUUUCAUU
mir-499 347 353 1A hsa-miR-499 uuaagacuugcagugauguuaa
miR-9 739 745 m8 hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA
miR-96 1040 1046 1A hsa-miR-96脑 UUUGGCACUAGCACAUUUUUGC