Gene Page:PSD3

Summary？
基因 23362
象征 PSD3
Synonyms efa6d | efa6r | hca67
Description pleckstrin and Sec7 domain containing 3
Reference MIM：614440|HGNC：HGNC：19093|Ensembl:ENSG00000156011|HPRD：11462|Vega：Otthumg00000163711
基因类型 蛋白质编码
Map location 8p21.3
Pascal p-value 9.249e-5
Sherlock p-value 0.5
胎儿β 1.154
DMG 1 (# studies)
主持人 小脑
Myers' cis & trans
Support 细胞内信号转导
g2cdb.humanpsd
G2CDB.HUMANPSP
CompositeSet

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CV:GWASdb Genome-wide Association Studies 精神分裂症的GWASDB记录
CV:PGCnp 全基因组协会研究 GWAS
DMG：Wockner_2014 全基因组DNA甲基化分析 该数据集包括4641个差异甲基化探针，对应于精神分裂症患者（n = 24）和对照组（n = 24）之间的2929个独特基因。 2
GSMA_I Genome scan meta-analysis Psr: 0.031
GSMA_IIA Genome scan meta-analysis (All samples) PSR：0.03086
gsma_iie Genome scan meta-analysis (European-ancestry samples) Psr: 0.00057
go_annotation 将与神经相关的关键字映射到基因本体论注释 与神经相关的关键字的命中：1

Section I. Genetics and epigenetics annotation

@差异甲基化基因

Probe 染色体 位置 最近的基因 p（dis） Beta (dis) fdr（dis） 学习
CG05835241 8 18448662 PSD3 2.68E-4 0.368 0.038 DMG：Wockner_2014
cg08040428 8 18870913 PSD3 3.762E-4 -0.362 0.043 DMG：Wockner_2014

@EQTL注释

SNP ID 染色体 位置 主持人 Gene Entrez ID pvalue QVALUE TSS距离 EQTL类型
RS10994209 Chr10 61877705 PSD3 23362 0.16 反式

第二节。转录组注释

一般基因表达（GTEX）

不可用

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

前10个积极共表达的基因
Gene Pearson's Correlation 斯皮尔曼的相关性
DDX23 0.96 0.95
UBE2R2 0.95 0.95
polr3d 0.95 0.95
ZNF259 0.95 0.96
PJA1 0.95 0.96
SPATS2 0.95 0.94
PA2G4 0.94 0.93
GPN1 0.94 0.93
SF3B2 0.94 0.94
NOC2L 0.94 0.94
Top 10 negatively co-expressed genes
Gene Pearson's Correlation 斯皮尔曼的相关性
MT-CO2 -0.82 -0.90
AF347015.31 -0.82 -0.90
AF347015.33 -0.81 -0.90
FXYD1 -0.81 -0.91
AF347015.27 -0.80 -0.89
mt-cyb -0.79 -0.88
AF347015.8 -0.78 -0.89
S100B -0.77 -0.85
HIGD1B -0.77 -0.88
ifi27 -0.77 -0.86

第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
去：0005086 ARF guanyl-nucleotide exchange factor activity 国际能源机构 -
生物过程 去学期 证据 神经关键字 PubMed ID
GO:0032012 调节ARF蛋白信号转导 国际能源机构 -
Cellular component 去学期 证据 神经关键字 PubMed ID
GO:0045211 postsynaptic membrane 国际能源机构 突触，神经递质（GO期限：5） -
GO:0045202 突触 国际能源机构 neuron, Synap, Neurotransmitter, Glial (GO term level: 2) -
去：0005622 细胞内 国际能源机构 -
去：0005624 membrane fraction 国际能源机构 -
去：0005886 plasma membrane 国际能源机构 -
GO:0030054 cell junction 国际能源机构 -

Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
KEGG内吞作用 183 132 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN 526 357 All SZGR 2.0 genes in this pathway
DAVICIONI MOLECULAR ARMS VS ERMS DN 182 111 All SZGR 2.0 genes in this pathway
周的炎症反应生活 485 293 All SZGR 2.0 genes in this pathway
THUM收缩心力衰竭DN 244 147 All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP 276 187 All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS DN 384 230 All SZGR 2.0 genes in this pathway
Scibetta KDM5B靶向DN 81 55 All SZGR 2.0 genes in this pathway
Kim WT1靶向12小时 162 116 All SZGR 2.0 genes in this pathway
Gozgit ESR1靶向DN 781 465 All SZGR 2.0 genes in this pathway
甲状腺癌 443 294 All SZGR 2.0 genes in this pathway
Lindgren膀胱癌簇3 DN 229 142 All SZGR 2.0 genes in this pathway
VANHARANTA UTERINE FIBROID WITH 7Q DELETION UP 67 37 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712 443 All SZGR 2.0 genes in this pathway
Dacosta UV响应通过ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
Mohankumar TLX1靶向DN 193 112 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024 594 All SZGR 2.0 genes in this pathway
唱歌转移基质 110 70 All SZGR 2.0 genes in this pathway
ROSS ACUTE MYELOID LEUKEMIA CBF 82 57 All SZGR 2.0 genes in this pathway
ROSS AML WITH AML1 ETO FUSION 76 55 All SZGR 2.0 genes in this pathway
HADDAD B淋巴细胞祖细胞 293 193 All SZGR 2.0 genes in this pathway
阿尔茨海默氏病dn 1237 837 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830 547 All SZGR 2.0 genes in this pathway
Dazard对UV NHEK DN的反应 318 220 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 5 482 296 All SZGR 2.0 genes in this pathway
RIGGINS TAMOXIFEN RESISTANCE DN 220 147 All SZGR 2.0 genes in this pathway
riggi ewing肉瘤祖先DN 191 123 All SZGR 2.0 genes in this pathway
肝癌DN中的阿塞维多甲基化 940 425 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BRAIN DN 85 58 All SZGR 2.0 genes in this pathway
骨骼中的Smid乳腺癌复发 97 61 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL A UP 84 52 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701 446 All SZGR 2.0 genes in this pathway
Bonome卵巢癌的生存率不佳 31 22 All SZGR 2.0 genes in this pathway
Bonome卵巢癌的生存最佳逃亡 246 152 All SZGR 2.0 genes in this pathway
Bonome卵巢癌的生存次优秀 510 309 All SZGR 2.0 genes in this pathway
Rutella对CSF2RB和IL4的响应 338 225 All SZGR 2.0 genes in this pathway
Rutella对HGF的反应 418 282 All SZGR 2.0 genes in this pathway
Rutella对HGF与CSF2RB和IL4 DN的响应 245 150 All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER DN 238 145 All SZGR 2.0 genes in this pathway
Valk AML群集13 30 20 All SZGR 2.0 genes in this pathway
Boyault肝癌子类G123 DN 51 30 All SZGR 2.0 genes in this pathway
Yagi AML带8 21易位 368 247 All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA2 UP 87 50 All SZGR 2.0 genes in this pathway
钱德兰转移DN 306 191 All SZGR 2.0 genes in this pathway
Mikkelsen ES HCP与H3未甲基化 63 31 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN 505 328 All SZGR 2.0 genes in this pathway
BHAT ESR1不是通过AKT1 DN的目标 88 61 All SZGR 2.0 genes in this pathway
BHAT ESR1通过AKT1 DN目标 82 51 All SZGR 2.0 genes in this pathway
Bruins通过TP53组C的UVC响应 92 60 All SZGR 2.0 genes in this pathway
棕熊UVC响应迟到 1137 655 All SZGR 2.0 genes in this pathway
通过p38完成的phong TNF响应 227 151 All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM A 182 108 All SZGR 2.0 genes in this pathway
Zwang 3类由EGF瞬时诱导 222 159 All SZGR 2.0 genes in this pathway
Zwang仅通过第一egf脉冲瞬时向上 1839 928 All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族 Target position miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
Let-7/98 821 827 1a hsa-let-7abrain ugagguaguaguauauaguu
hsa-let-7bbrain ugagguaguagguuguguguguu
hsa-let-7cbrain UGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrain AGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrain ugagguaggagguuauauagu
hsa-let-7fbrain UGAGGUAGUAGAUUGUAUAGUU
HSA-MIR-98brain ugagguaaguuguauuguu
hsa-let-7gSZ ugagguaguuguuguacagu
hsa-let-7ibrain ugagguaguugugugugugcugu
miR-134 453 460 1A，M8 HSA-MIR-134brain ugugacuggugaccagaggg
miR-135 6013 6019 M8 HSA-MIR-135A UAUGGCUUUUUAUUCCUAUGUGA
HSA-MIR-135B Uauggcuuuucauuccuaugug
miR-136 6952 6959 1A，M8 HSA-MIR-136 Acuccauuuuuuugaugaugaugga
miR-138 5562 5568 1a HSA-MIR-138brain AGCUGGUGUUGUGAAUC
miR-139 1362 1368 1a HSA-MIR-139brain ucuacagugcacgugucu
miR-143 856 862 M8 HSA-MIR-143brain UGAGAUGAAGCACUGUAGCUCA
miR-145 382 388 M8 HSA-MIR-145 guccaguuucccaggaaucccuu
miR-18 215 221 M8 HSA-MIR-18A uaagguggaugugcagaua
HSA-MIR-18B UAAGGUGCAUCUAGUGCAGUUA
miR-186 5157 5163 1a HSA-MIR-186 caaagaauuuugggcuu
miR-23 438 444 1a HSA-MIR-23Abrain AUCACAUUGCCAGGGAUUUCC
HSA-MIR-23Bbrain AUCACAUUGCCAGGGAUUACC
miR-26 4462 4469 1A，M8 HSA-MIR-26Abrain UUCAAGUAAUCCAGGAUAGGC
HSA-MIR-26BSZ UUCAAGUAAUUCAGGAUAGGUU
mir-30-5p 8090 8096 1a HSA-MIR-30A-5P uguaaaacauccuccugagaag
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ UGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZ uguaaacauccuaccucucagcu
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
mir-335 167 174 1A，M8 hsa-miR-335brain UCAAGAGCAAUAACGAAAAAUAUGU
mir-338 578 584 1a hsa-miR-338brain uccagauuuuuguuga
miR-381 8129 8135 1a HSA-MIR-381 uauacaagggcaagcucucugu
mir-448 6084 6090 M8 hsa-miR-448 UUGCAUAUGUAGGAUGUCCCAU
miR-495 139 145 1a HSA-MIR-495brain Aaacaaacauggugcacuuuuu
miR-496 8390 8397 1A，M8 HSA-MIR-496 Auuacauggccaaucuc
mir-9 5474 5480 1a hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA