Gene Page:LARP1

Summary?
GeneID 23367
Symbol LARP1
Synonyms LARP
Description La ribonucleoprotein domain family member 1
Reference MIM:612059|HGNC:HGNC:29531|Ensembl:ENSG00000155506|HPRD:11225|Vega:OTTHUMG00000130191
Gene type protein-coding
Map location 5q33.2
Pascal p-value 0.117
Sherlock p-value 0.045
Fetal beta -0.353
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
GSMA_I Genome scan meta-analysis Psr: 0.0032
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.00459
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.01718

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs4864466 chr4 54403975 LARP1 23367 0.1 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
TCF20 0.94 0.97
CHD8 0.94 0.96
UBTF 0.93 0.94
SETD2 0.93 0.95
RNASEN 0.93 0.94
CDC2L5 0.93 0.95
YLPM1 0.92 0.95
SCAPER 0.92 0.93
GON4L 0.92 0.95
三人组 0.92 0.94
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.31 -0.79 -0.90
MT-CO2 -0.76 -0.88
AF347015.27 -0.74 -0.85
IFI27 -0.74 -0.86
HIGD1B -0.74 -0.88
FXYD1 -0.74 -0.85
COPZ2 -0.73 -0.81
S100B -0.73 -0.82
AF347015.33 -0.73 -0.82
MT-CYB -0.73 -0.84

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0003723 RNA binding IEA -
GO:0005515 protein binding 新闻学会 17353931

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
LIU SOX4 TARGETS DN 309 191 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783 507 All SZGR 2.0 genes in this pathway
CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 UP 146 86 All SZGR 2.0 genes in this pathway
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS DN 68 49 All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS TOP50 UP 38 27 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
DEURIG T细胞PROLYMPHOCYTIC白血病 368 234 All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN 335 193 All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER 20Q13 AMPLIFICATION DN 180 101 All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP 233 161 All SZGR 2.0 genes in this pathway
SCHLOSSER MYC AND SERUM RESPONSE SYNERGY 32 22 All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747 453 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024 594 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN 428 306 All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS DN 411 249 All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648 385 All SZGR 2.0 genes in this pathway
MCCLUNG COCAINE REWARD 5D 79 62 All SZGR 2.0 genes in this pathway
DASU IL6 SIGNALING SCAR UP 30 21 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN 292 189 All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871 505 All SZGR 2.0 genes in this pathway
MELLMAN TUT1 TARGETS UP 19 11 All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS UP 221 135 All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE M G1 148 95 All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682 440 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882 538 All SZGR 2.0 genes in this pathway
ALFANO MYC TARGETS 239 156 All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 COMPLETE 227 151 All SZGR 2.0 genes in this pathway
HOLLEMAN DAUNORUBICIN B ALL UP 10 9 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-101 2202 2209 1A,m8 hsa-miR-101 UACAGUACUGUGAUAACUGAAG
miR-124.1 914 920 m8 hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 914 920 1A hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
miR-129-5p 3471 3477 1A hsa-miR-129brain CUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5p CUUUUUGCGGUCUGGGCUUGCU
miR-143 2384 2391 1A,m8 hsa-miR-143brain UGAGAUGAAGCACUGUAGCUCA
miR-144 2203 2209 1A hsa-miR-144 UACAGUAUAGAUGAUGUACUAG
miR-153 412 418 m8 hsa-miR-153 UUGCAUAGUCACAAAAGUGA
miR-214 548 554 m8 hsa-miR-214brain ACAGCAGGCACAGACAGGCAG
hsa-miR-214brain ACAGCAGGCACAGACAGGCAG
miR-26 3337 3344 1A,m8 hsa-miR-26abrain UUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZ UUCAAGUAAUUCAGGAUAGGUU
hsa-miR-26abrain UUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZ UUCAAGUAAUUCAGGAUAGGUU
hsa-miR-26abrain UUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZ UUCAAGUAAUUCAGGAUAGGUU
miR-30-5p 2502 2508 1A hsa-miR-30a-5p UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ UGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZ UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
miR-326 675 682 1A,m8 hsa-miR-326 CCUCUGGGCCCUUCCUCCAG
miR-369-3p 3352 3359 1A,m8 hsa-miR-369-3p AAUAAUACAUGGUUGAUCUUU
miR-374 3353 3360 1A,m8 hsa-miR-374 UUAUAAUACAACCUGAUAAGUG
miR-381 3349 3355 m8 hsa-miR-381 UAUACAAGGGCAAGCUCUCUGU
miR-410 267 273 1A hsa-miR-410 AAUAUAACACAGAUGGCCUGU
miR-496 3329 3335 1A hsa-miR-496 AUUACAUGGCCAAUCUC
miR-9 594 600 m8 hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA