Gene Page:SIRT1

Summary?
GeneID 23411
Symbol SIRT1
Synonyms SIR2|SIR2L1|SIR2alpha
Description sirtuin 1
Reference MIM:604479|HGNC:HGNC:14929|Ensembl:ENSG00000096717|HPRD:08381|Vega:OTTHUMG00000018340
Gene type protein-coding
Map location 10q21.3
Pascal p-value 0.112
Sherlock p-value 0.004
Fetal beta 1.189
Support Chromatin Remodeling Genes

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AC008073.1 0.90 0.89
ERH 0.90 0.91
RPL17P20 0.87 0.88
SARNP 0.87 0.87
PSMA2 0.86 0.87
C18orf21 0.86 0.86
RPL6P10 0.85 0.87
RPL26L1 0.85 0.87
PSMB7 0.85 0.86
EIF3M 0.85 0.88
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.15 -0.61 -0.71
AF347015.8 -0.60 -0.69
AF347015.27 -0.60 -0.68
MT-CYB -0.60 -0.69
TINAGL1 -0.60 -0.69
AF347015.26 -0.59 -0.73
SLC6A12 -0.59 -0.68
AF347015.2 -0.59 -0.70
EPAS1 -0.59 -0.70
AF347015.33 -0.58 -0.67

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0003950 NAD+ ADP-ribosyltransferase activity TAS 10381378
GO:0003677 DNA binding IEA -
GO:0008270 zinc ion binding IEA -
GO:0008022 protein C-terminus binding IPI 18203716
GO:0017136 NAD-dependent histone deacetylase activity IDA 16959573
GO:0016564 transcription repressor activity IEA -
GO:0051287 NAD binding IEA -
GO:0019213 deacetylase activity IDA 18203716
GO:0046872 metal ion binding IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0007519 skeletal muscle development IEA neuron (GO term level: 8) -
GO:0001542 ovulation from ovarian follicle IEA -
GO:0006355 regulation of transcription, DNA-dependent IEA -
GO:0006471 protein amino acid ADP-ribosylation TAS 10381378
GO:0006342 chromatin silencing TAS 10381378
GO:0007283 spermatogenesis IEA -
GO:0006974 response to DNA damage stimulus IDA 18203716
GO:0006915 apoptosis IEA -
去:0007275 multicellular organismal development IEA -
GO:0016481 negative regulation of transcription IEA -
GO:0030154 cell differentiation IEA -
GO:0033158 regulation of protein import into nucleus, translocation IMP 18203716
GO:0051097 negative regulation of helicase activity IDA 18203716
GO:0016575 histone deacetylation IEA -
GO:0044419 interspecies interaction between organisms IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005634 nucleus IEA -
GO:0005677 chromatin silencing complex IEA -
GO:0005737 cytoplasm IDA 18029348

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
BIOCARTA PML PATHWAY 17 12 All SZGR 2.0 genes in this pathway
PID P73PATHWAY 79 59 All SZGR 2.0 genes in this pathway
PID HDAC CLASSIII PATHWAY 25 20 All SZGR 2.0 genes in this pathway
PID E2F PATHWAY 74 48 All SZGR 2.0 genes in this pathway
PID HIF2PATHWAY 34 29 All SZGR 2.0 genes in this pathway
PID HDAC CLASSI PATHWAY 66 50 All SZGR 2.0 genes in this pathway
PID FOXO PATHWAY 49 43 All SZGR 2.0 genes in this pathway
PID AR TF PATHWAY 53 38 All SZGR 2.0 genes in this pathway
PID RB 1PATHWAY 65 46 All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463 290 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
GARGALOVIC应对氧化磷脂LIGHTYELLOW UP 11 8 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN 459 276 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508 354 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142 669 All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800 473 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 All SZGR 2.0 genes in this pathway
BENPORATH ES 1 379 235 All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX 230 156 All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893 528 All SZGR 2.0 genes in this pathway
SHEPARD BMYB MORPHOLINO UP 205 126 All SZGR 2.0 genes in this pathway
MCCLUNG COCAIN REWARD 4WK 75 47 All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN DN 271 175 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER WITH H3K9ME3 UP 141 75 All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER POOR SURVIVAL UP 31 22 All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING 510 309 All SZGR 2.0 genes in this pathway
MATZUK OVULATION 14 10 All SZGR 2.0 genes in this pathway
MATZUK SPERMATOZOA 114 77 All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN 546 362 All SZGR 2.0 genes in this pathway
MUELLER PLURINET 299 189 All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103 714 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725 838 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family 目标位置 miRNA ID miRNA seq
UTR start UTR end Match method
miR-124.1 1211 1218 1A,m8 hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 1211 1217 1A hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
miR-128 849 855 m8 hsa-miR-128a UCACAGUGAACCGGUCUCUUUU
hsa-miR-128b UCACAGUGAACCGGUCUCUUUC
miR-132/212 1614 1620 m8 hsa-miR-212SZ UAACAGUCUCCAGUCACGGCC
hsa-miR-132brain UAACAGUCUACAGCCAUGGUCG
miR-135 358 364 m8 hsa-miR-135a UAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135b UAUGGCUUUUCAUUCCUAUGUG
miR-138 32 39 1A,m8 hsa-miR-138brain AGCUGGUGUUGUGAAUC
miR-141/200a 1728 1734 m8 hsa-miR-141 UAACACUGUCUGGUAAAGAUGG
hsa-miR-200a UAACACUGUCUGGUAACGAUGU
miR-153 907 913 1A hsa-miR-153 UUGCAUAGUCACAAAAGUGA
miR-181 63 69 m8 hsa-miR-181abrain AACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZ AACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrain AACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrain AACAUUCAUUGUUGUCGGUGGGUU
miR-186 1400 1406 1A hsa-miR-186 CAAAGAAUUCUCCUUUUGGGCUU
miR-199 507 513 m8 hsa-miR-199a CCCAGUGUUCAGACUACCUGUUC
hsa-miR-199b CCCAGUGUUUAGACUAUCUGUUC
miR-204/211 384 391 1A,m8 hsa-miR-204brain UUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211 UUCCCUUUGUCAUCCUUCGCCU
miR-217 1519 1526 1A,m8 hsa-miR-217 UACUGCAUCAGGAACUGAUUGGAU
miR-22 530 537 1A,m8 hsa-miR-22brain AAGCUGCCAGUUGAAGAACUGU
miR-23 899 906 1A,m8 hsa-miR-23abrain AUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrain AUCACAUUGCCAGGGAUUACC
miR-30-5p 67 73 m8 hsa-miR-30a-5p UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ UGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZ UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
miR-34/449 1434 1440 1A hsa-miR-34abrain UGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34c AGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449 UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449b AGGCAGUGUAUUGUUAGCUGGC
miR-369-3p 1113 1119 m8 hsa-miR-369-3p AAUAAUACAUGGUUGAUCUUU
miR-448 906 913 1A,m8 hsa-miR-448 UUGCAUAUGUAGGAUGUCCCAU
miR-485-3p 280 286 m8 hsa-miR-485-3p GUCAUACACGGCUCUCCUCUCU
miR-494 765 772 1A,m8 hsa-miR-494brain UGAAACAUACACGGGAAACCUCUU
miR-496 380 386 1A hsa-miR-496 AUUACAUGGCCAAUCUC
miR-543 367 374 1A,m8 hsa-miR-543 AAACAUUCGCGGUGCACUUCU
hsa-miR-543 AAACAUUCGCGGUGCACUUCU
miR-9 404 411 1A,m8 hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA