Gene Page:GRIP1
Summary?
| GeneID | 23426 |
| Symbol | GRIP1 |
| Synonyms | GRIP |
| Description | 谷氨酸receptor interacting protein 1 |
| Reference | MIM:604597|HGNC:HGNC:18708|Ensembl:ENSG00000155974|织女:OTTHUMG00000169019 |
| Gene type | protein-coding |
| Map location | 12q14.3 |
| Pascal p-value | 0.336 |
| Fetal beta | 1.787 |
| Support | G2Cdb.human_mGluR5 Ascano FMRP targets Potential synaptic genes |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias | Click to show details |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 1 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ATAD1 | 0.93 | 0.93 |
| AZIN1 | 0.93 | 0.94 |
| CNOT7 | 0.92 | 0.93 |
| AASDHPPT | 0.92 | 0.92 |
| RAB2A | 0.92 | 0.91 |
| PPP1CB | 0.92 | 0.93 |
| CMPK1 | 0.92 | 0.91 |
| ARCN1 | 0.91 | 0.91 |
| USP33 | 0.91 | 0.92 |
| CLASP2 | 0.91 | 0.91 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MT-CO2 | -0.70 | -0.70 |
| FXYD1 | -0.69 | -0.70 |
| AF347015.8 | -0.67 | -0.68 |
| AF347015.33 | -0.67 | -0.67 |
| AF347015.21 | -0.66 | -0.63 |
| AF347015.31 | -0.66 | -0.67 |
| AF347015.2 | -0.66 | -0.67 |
| HIGD1B | -0.66 | -0.66 |
| EIF4EBP3 | -0.66 | -0.69 |
| MT-CYB | -0.65 | -0.66 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0004872 | receptor activity | IEA | - | |
| GO:0003713 | transcription coactivator activity | NAS | 15572661 | |
| GO:0005515 | protein binding | IEA | - | |
| GO:0005515 | protein binding | NAS | 10197531 | |
| GO:0030159 | receptor signaling complex scaffold activity | NAS | 10197531 | |
| GO:0050681 | androgen receptor binding | NAS | 15572661 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0007242 | intracellular signaling cascade | NAS | 10197531 | |
| GO:0030521 | androgen receptor signaling pathway | NAS | 15572661 | |
| GO:0045893 | positive regulation of transcription, DNA-dependent | NAS | 15572661 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0045211 | postsynaptic membrane | IEA | Synap, Neurotransmitter (GO term level: 5) | - |
| GO:0045202 | synapse | IEA | neuron, Synap, Neurotransmitter, Glial (GO term level: 2) | - |
| GO:0005783 | endoplasmic reticulum | IEA | - | |
| GO:0005886 | plasma membrane | IEA | - | |
| GO:0030054 | cell junction | IEA | - | |
| GO:0031410 | cytoplasmic vesicle | IEA | - |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| AR | AIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFM | androgen receptor | Two-hybrid | BioGRID | 10607837 |
| GRIA1 | GLUH1 | GLUR1 | GLURA | HBGR1 | MGC133252 | 谷氨酸receptor, ionotropic, AMPA 1 | Reconstituted Complex | BioGRID | 11891216 |
| GRIA2 | GLUR2 | GLURB | GluR-K2 | HBGR2 | 谷氨酸receptor, ionotropic, AMPA 2 | Reconstituted Complex Two-hybrid |
BioGRID | 11891216 |
| GRIA3 | GLUR-C | GLUR-K3 | GLUR3 | GLURC | MRX94 | 谷氨酸receptor, ionotrophic, AMPA 3 | Reconstituted Complex Two-hybrid |
BioGRID | 11891216 |
| GRIA4 | GLUR4 | GLUR4C | GLURD | 谷氨酸受体,ionotrophic, AMPA 4 | Reconstituted Complex Two-hybrid |
BioGRID | 11891216 |
| GRIK1 | EAA3 | EEA3 | GLR5 | GLUR5 | 谷氨酸receptor, ionotropic, kainate 1 | Reconstituted Complex | BioGRID | 12597860 |
| GRIK2 | EAA4 | GLR6 | GLUK6 | GLUR6 | MGC74427 | MRT6 | 谷氨酸receptor, ionotropic, kainate 2 | Reconstituted Complex | BioGRID | 11891216|12597860 |
| GRIK3 | EAA5 | GLR7 | GLUR7 | GluR7a | 谷氨酸receptor, ionotropic, kainate 3 | Reconstituted Complex Two-hybrid |
BioGRID | 11891216 |
| GRM3 | GLUR3 | GPRC1C | MGLUR3 | mGlu3 | 谷氨酸receptor, metabotropic 3 | Reconstituted Complex Two-hybrid |
BioGRID | 11891216 |
| GRM7 | FLJ40498 | GLUR7 | GPRC1G | MGLUR7 | mGlu7 | 谷氨酸receptor, metabotropic 7 | GRIP interacts with mGluR7b. This interaction was modeled on a demonstrated interaction between GRIP from an unspecified species and human mGluR7b. | BIND | 11891216 |
| NR2F1 | COUP-TFI | EAR-3 | EAR3 | ERBAL3 | NR2F2 | SVP44 | TCFCOUP1 | TFCOUP1 | nuclear receptor subfamily 2, group F, member 1 | Two-hybrid | BioGRID | 10652338 |
| PRLHR | GPR10 | GR3 | MGC126539 | MGC126541 | PrRPR | prolactin releasing hormone receptor | Affinity Capture-Western | BioGRID | 11641419 |
| TES | DKFZp586B2022 | MGC1146 | TESS | TESS-2 | testis derived transcript (3 LIM domains) | TES interacts with GRIP1. This interaction was modelled on a demonstrated interaction between human TES and mouse GRIP1. | BIND | 12571287 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| BIOCARTA CARM ER PATHWAY | 35 | 27 | All SZGR 2.0 genes in this pathway |
| BIOCARTA HER2 PATHWAY | 22 | 17 | All SZGR 2.0 genes in this pathway |
| DARWICHE SKIN TUMOR PROMOTER DN | 185 | 115 | All SZGR 2.0 genes in this pathway |
| DARWICHE PAPILLOMA RISK LOW DN | 165 | 107 | All SZGR 2.0 genes in this pathway |
| DARWICHE乳头状瘤风险高的DN | 180 | 110 | All SZGR 2.0 genes in this pathway |
| DARWICHE SQUAMOUS CELL CARCINOMA DN | 181 | 107 | All SZGR 2.0 genes in this pathway |
| MARTORIATI MDM4 TARGETS FETAL LIVER UP | 227 | 137 | All SZGR 2.0 genes in this pathway |
| TOMLINS METASTASIS DN | 20 | 16 | All SZGR 2.0 genes in this pathway |
| CUI TCF21 TARGETS 2 UP | 428 | 266 | All SZGR 2.0 genes in this pathway |
| RIZKI TUMOR INVASIVENESS 3D UP | 210 | 124 | All SZGR 2.0 genes in this pathway |
| YAUCH HEDGEHOG SIGNALING PARACRINE DN | 264 | 159 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MCV6 HCP WITH H3K27ME3 | 435 | 318 | All SZGR 2.0 genes in this pathway |
| WANG MLL TARGETS | 289 | 188 | All SZGR 2.0 genes in this pathway |
| RAO BOUND BY SALL4 ISOFORM A | 182 | 108 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | All SZGR 2.0 genes in this pathway |