Gene Page:年代LC7A8

年代ummary?
GeneID 23428
象征 年代LC7A8
年代ynonyms LAT2|LPI-PC1
Description solute carrier family 7 member 8
Reference MIM:604235|HGNC:HGNC:11066|Ensembl:ENSG00000092068|HPRD:11971|Vega:OTTHUMG00000028720
Gene type protein-coding
Map location 14q11.2
Pascal p-value 0.123
年代herlock p-value 0.749
Fetal beta -0.798
DMG 1 (# studies)
eGene Caudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
GSMA_I Genome scan meta-analysis Psr: 0.047

部分遗传学和epigenet iics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) 年代tudy
cg05357695 14 23623480 年代LC7A8 4.14E-5 0.326 0.021 DMG:Wockner_2014

@eQTL annotation

年代NP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs4242746 chr10 3202064 年代LC7A8 23428 0.01 trans
rs7092621 chr10 3223178 年代LC7A8 23428 0.19 trans

年代ection II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
年代C: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
年代T1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


年代ection III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0015171 amino acid transmembrane transporter activity IEA -
去:0015175 neutral amino acid transmembrane transporter activity TAS 10391915
GO:0015179 L-amino acid transmembrane transporter activity IEA -
GO:0042605 peptide antigen binding ISS -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006520 amino acid metabolic process TAS 10391915
GO:0015807 L-amino acid transport IEA -
GO:0015804 neutral amino acid transport ISS -
GO:0006810 transport IEA -
GO:0006810 transport TAS 10391915
GO:0006865 amino acid transport IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005737 cytoplasm IEA -
GO:0016020 membrane IEA -
GO:0016021 integral to membrane IEA -
GO:0005886 plasma membrane TAS 10391915
GO:0005887 integral to plasma membrane TAS 10391915
GO:0016323 basolateral plasma membrane IEA -

年代ection V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 91 65 All SZGR 2.0 genes in this pathway
REACTOME BASIGIN INTERACTIONS 30 23 All SZGR 2.0 genes in this pathway
REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 31 21 All SZGR 2.0 genes in this pathway
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413 270 All SZGR 2.0 genes in this pathway
REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT 241 157 All SZGR 2.0 genes in this pathway
REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 94 65 All SZGR 2.0 genes in this pathway
REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 49 36 All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466 331 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783 507 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN 526 357 All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN 493 298 All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579 346 All SZGR 2.0 genes in this pathway
PUIFFE INVASION INHIBITED BY ASCITES UP 82 51 All SZGR 2.0 genes in this pathway
DEURIG T细胞PROLYMPHOCYTIC白血病 368 234 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL UP 380 215 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL UP 450 256 All SZGR 2.0 genes in this pathway
DOANE BREAST CANCER ESR1 UP 112 72 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D DN 142 90 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN 537 339 All SZGR 2.0 genes in this pathway
LUI THYROID CANCER PAX8 PPARG UP 44 29 All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER BASAL VS LULMINAL 330 215 All SZGR 2.0 genes in this pathway
LUI THYROID CANCER CLUSTER 2 42 31 All SZGR 2.0 genes in this pathway
YANG BREAST CANCER ESR1 UP 36 22 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN 464 276 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546 351 All SZGR 2.0 genes in this pathway
年代ANSOM APC TARGETS DN 366 238 All SZGR 2.0 genes in this pathway
BROWN MYELOID CELL DEVELOPMENT DN 129 86 All SZGR 2.0 genes in this pathway
NOUZOVA METHYLATED IN APL 68 39 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS MATURE CELL 293 160 All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE UP 156 92 All SZGR 2.0 genes in this pathway
年代MID BREAST CANCER RELAPSE IN BRAIN DN 85 58 All SZGR 2.0 genes in this pathway
年代MID BREAST CANCER BASAL DN 701 446 All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210 725 All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 6 UP 140 81 All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824 528 All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP 364 236 All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL DN 308 187 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 All SZGR 2.0 genes in this pathway

年代ection VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-124.1 1689 1695 m8 hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 1689 1695 1A hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
miR-133 1612 1618 m8 hsa-miR-133a UUGGUCCCCUUCAACCAGCUGU
hsa-miR-133b UUGGUCCCCUUCAACCAGCUA
hsa-miR-133a UUGGUCCCCUUCAACCAGCUGU
hsa-miR-133b UUGGUCCCCUUCAACCAGCUA
miR-182 722 728 1A hsa-miR-182 UUUGGCAAUGGUAGAACUCACA
miR-214 1376 1382 m8 hsa-miR-214brain ACAGCAGGCACAGACAGGCAG
miR-544 672 679 1A,m8 hsa-miR-544 AUUCUGCAUUUUUAGCAAGU
miR-9 174 180 1A hsa-miR-9年代Z UCUUUGGUUAUCUAGCUGUAUGA
miR-96 721 728 1A,m8 hsa-miR-96brain UUUGGCACUAGCACAUUUUUGC