Gene Page:RYBP

Summary？
基因 23429
象征 RYBP
Synonyms AAP1|APAP-1|DEDAF|YEAF1
Description RING1和YY1结合蛋白
Reference MIM:607535|HGNC:HGNC:10480|HPRD：09607|
基因类型 蛋白质编码
Map location 3P13
Pascal p-value 0.235
Sherlock p-value 0.962
胎儿β 0.544
主持人 Myers' cis & trans
元

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CV:GWASdb Genome-wide Association Studies 精神分裂症的GWASDB记录
CV:PGCnp Genome-wide Association Study GWAS
gsma_iie Genome scan meta-analysis (European-ancestry samples) PSR：0.04359
GSMA_IIA Genome scan meta-analysis (All samples) PSR：0.04047

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID 染色体 位置 主持人 Gene Entrez ID pvalue QVALUE TSS距离 EQTL类型
rs4677155 CHR3 72413686 RYBP 23429 6.735E-8 顺式
rs4677155 CHR3 72413686 RYBP 23429 1.51E-5 反式

第二节。转录组注释

一般基因表达（GTEX）

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
GNG13 0.89 0.66
CPNE9 0.86 0.74
WNT2 0.86 0.62
RDH12 0.85 0.64
DPY 0.83 0.60
FAM19A4 0.83 0.62
CASQ2 0.83 0.52
NPL 0.83 0.46
RGS16 0.82 0.30
CCDC136 0.82 0.36
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
WDR86 -0.37 -0.55
EMID1 -0.31 -0.47
PVRL2 -0.30 -0.55
plekho1 -0.30 -0.43
OLFM2 -0.29 -0.46
AC022098.2 -0.29 -0.46
NR2C2AP -0.28 -0.44
marcksl1 -0.28 -0.54
tubb2b -0.28 -0.62
SHF -0.28 -0.42

第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
去：0003677 DNA binding IEA -
GO:0003714 转录corepressor activity TAS 10369680
GO:0008270 锌离子结合 IEA -
GO:0046872 metal ion binding IEA -
生物过程 去学期 证据 神经关键字 PubMed ID
GO:0000122 RNA聚合酶II启动子的转录负调控 TAS 10369680
去：0006355 调节转录，DNA依赖性的调节 IEA -
去：0006350 转录 IEA -
GO:0006915 凋亡 IEA -
GO:0007275 multicellular organismal development TAS 10369680
Cellular component 去学期 证据 神经关键字 PubMed ID
去：0005622 细胞内 IEA -
去：0005634 nucleus IEA -
去：0005737 cytoplasm IEA -

Section IV. Protein-protein interaction annotation

互动者 别名b 官方全名b 实验 Source PubMed ID
ABL1 ABL |JTK7 |BCR/ABL |c-abl |P150 |V-ABL C-ABL癌基因1，受体酪氨酸激酶 Far Western
重构的复合物
Two-hybrid		 Biogrid 8943360
CASP10 ALPS2 | FLICE2 | MCH4 caspase 10，与凋亡相关的半胱氨酸肽酶 - HPRD,BioGRID 11395500
CASP8 ALPS2B |cap4 |弗里斯|FLJ17672 |马赫|MCH5 |MGC78473 caspase 8, apoptosis-related cysteine peptidase - HPRD 11395500
CBX2 CDCA6 |M33 |MGC10561 chromobox homolog 2 (Pc class homolog, Drosophila) 亲和力捕获 - 韦斯特恩
重构的复合物		 Biogrid 10369680
E2F2 E2F-2 E2F transcription factor 2 E2F2interacts with RYBP. 绑定 12411495
E2F2 E2F-2 E2F transcription factor 2 亲和力捕获 - 韦斯特恩
Two-hybrid		 Biogrid 12411495
E2F3 DKFZP686C18211 |E2F-3 |KIAA0075 |MGC104598 E2F transcription factor 3 亲和力捕获 - 韦斯特恩
Two-hybrid		 Biogrid 12411495
E2F3 DKFZP686C18211 |E2F-3 |KIAA0075 |MGC104598 E2F transcription factor 3 E2F3与RYBP相互作用。 绑定 12411495
E2F4 E2F-4 E2F转录因子4，P107/P130结合 Two-hybrid Biogrid 12411495
E2F6 E2F-6 |MGC111545 E2F transcription factor 6 亲和力捕获 - 韦斯特恩
重构的复合物
Two-hybrid		 Biogrid 11171983|12411495
FADD GIG3 | MGC8528 | MORT1 Fas (TNFRSF6)-associated via death domain 亲和力捕获 - 韦斯特恩 Biogrid 11395500
ring1 ring1a |RNF1 环手指蛋白1 - HPRD,BioGRID 10369680
yy1 DELTA | INO80S | NF-E1 | UCRBP | YIN-YANG-1 yy1转录factor - HPRD,BioGRID 10369680


Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
PID E2F途径 74 48 All SZGR 2.0 genes in this pathway
中村肿瘤区周围与中央DN 634 384 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN 526 357 All SZGR 2.0 genes in this pathway
GAZDA钻石黑芬贫血髓样DN 38 25 All SZGR 2.0 genes in this pathway
Puiffe入侵被腹水DN抑制 145 91 All SZGR 2.0 genes in this pathway
迪亚兹慢性巨态性白血病 1382 904 All SZGR 2.0 genes in this pathway
Gargalovic对氧化磷脂的反应蓝色 136 80 All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 1 UP 276 165 All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 2 UP 139 83 All SZGR 2.0 genes in this pathway
Mullighan NPM1签名3 341 197 All SZGR 2.0 genes in this pathway
DN UDAYAKUMAR MED1目标 240 171 All SZGR 2.0 genes in this pathway
Senese HDAC3靶向DN 536 332 All SZGR 2.0 genes in this pathway
Tien肠益生菌6小时DN 167 100 All SZGR 2.0 genes in this pathway
NAGASHIMA NRG1 SIGNALING DN 58 35 All SZGR 2.0 genes in this pathway
Nagashima EGF信号向上 58 40 All SZGR 2.0 genes in this pathway
Kim WT1靶向8小时 164 122 All SZGR 2.0 genes in this pathway
ENK UV响应表皮DN 508 354 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712 443 All SZGR 2.0 genes in this pathway
Dacosta UV响应通过ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN 848 527 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 All SZGR 2.0 genes in this pathway
Schaeffer前列腺开发48小时DN 428 306 All SZGR 2.0 genes in this pathway
阿米特血清反应120 MCF10A 65 44 All SZGR 2.0 genes in this pathway
KIM GERMINAL CENTER T HELPER DN 24 15 All SZGR 2.0 genes in this pathway
Jazaeri乳腺癌BRCA1 vs BRCA2 DN 43 31 All SZGR 2.0 genes in this pathway
WU HBX TARGETS 2 DN 16 11 All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314 201 All SZGR 2.0 genes in this pathway
WU HBX TARGETS 1 DN 23 14 All SZGR 2.0 genes in this pathway
阿尔茨海默氏症疾病 1691 1088 All SZGR 2.0 genes in this pathway
dazard对UV SCC DN的响应 123 86 All SZGR 2.0 genes in this pathway
外邦紫外线响应集群D2 41 30 All SZGR 2.0 genes in this pathway
GENTILE UV HIGH DOSE DN 312 203 All SZGR 2.0 genes in this pathway
江缺氧正常 311 205 All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN UP 439 257 All SZGR 2.0 genes in this pathway
CHEN HOXA5 TARGETS 9HR UP 223 132 All SZGR 2.0 genes in this pathway
LEE DIFFERENTIATING T LYMPHOCYTE 200 115 All SZGR 2.0 genes in this pathway
Shedden肺癌良好生存A12 317 177 All SZGR 2.0 genes in this pathway
米利假足 518 299 All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP 442 263 All SZGR 2.0 genes in this pathway
Kyng对H2O2的响应通过ERCC6 UP 40 30 All SZGR 2.0 genes in this pathway
raghavachari血小板特异性基因 70 46 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918 550 All SZGR 2.0 genes in this pathway
Krieg缺氧不是通过KDM3A 770 480 All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 227 149 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族 Target position miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
mir-1/206 2133 2139 M8 海关a-miR-1 UGGAAUGUAAAGAAGUAUGUA
海关a-miR-206SZ Uggaauguaaggaagugugugg
海关a-miR-613 AGGAAUGUUCCUUCUUUGCC
miR-10 32 38 1A 海关a-miR-10a UACCCUGUAGAUCCGAAUUUGUG
海关a-miR-10b uacccuguagaaccgaauuugu
mir-103/107 64 70 M8 海关a-miR-103brain agcagcauuguacggcuauga
海关a-miR-107brain AGCAGCAUUGUACAGGGCUAUCA
mir-124.1 3099 3105 M8 HSA-MIR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 3099 3105 1A 海关a-miR-506 UAAGGCACCCUUCUGAGUAGA
HSA-MIR-124brain UAAGGCACGCGGUGAAUGCC
miR-125/351 2173 2180 1A，M8 海关a-miR-125bbrain ucccugagacccuaacuuguga
海关a-miR-125abrain ucccugagacccuuaaccugug
miR-128 546 553 1A，M8 海关a-miR-128a ucacagugaaccggucuuuu
海关a-miR-128b ucacagugaaccggucuuc
海关a-miR-128a ucacagugaaccggucuuuu
海关a-miR-128b ucacagugaaccggucuuc
mir-130/301 2277 2283 M8 海关a-miR-130abrain cagugcaauguaaaaggggau
海关a-miR-301 cagugcaauaugucaaagc
海关a-miR-130bbrain Cagugcaaugaagggauggau
海关a-miR-454-3p UAGUGCAAUAUUGCUUAUAGGGUUU
miR-135 2194 2200 1A 海关a-miR-135a UAUGGCUUUUUAUUCCUAUGUGA
海关a-miR-135b Uauggcuuuucauuccuaugug
miR-136 3241 3247 M8 HSA-MIR-136 Acuccauuuuuuugaugaugaugga
miR-141/200a 2864 2871 1A，M8 HSA-MIR-141 uaacacugucugugugugugaugg
海关a-miR-200a UAACACUGUCUGGUAACGAUGU
miR-142-5p 3695 3701 M8 HSA-MIR-142-5P cauaaaguagaaagcacuac
mir-148/152 2278 2284 M8 海关a-miR-148a ucagugcacuacaacuuugu
HSA-MIR-152brain UCAGUGCAUGACACUUGGG
海关a-miR-148b ucagugcaucacacaacuuugu
miR-15/16/195/424/497 65 71 M8 HSA-MIR-15Abrain uagcagcacauaugguugug
海关a-miR-16brain UAGCAGCACGUAAAUAUUGGCG
HSA-MIR-15Bbrain UAGCAGCACAUCAUGGUUUACA
HSA-MIR-195SZ uagcagaaaaauauuggc
海关a-miR-424 CAGCAGCAAUUCAUGUUUUGAA
HSA-MIR-497 cagcagcacacuguguuugu
miR-17-5p/20/93.mr/106/519.d 3694 3700 1A 海关a-miR-17-5p caaagugcuuacugcagguagu
海关a-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
海关a-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
海关a-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
海关a-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
HSA-MIR-519D caaagugccucccuuuagugugu
海关a-miR-17-5p caaagugcuuacugcagguagu
海关a-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
海关a-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
海关a-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
海关a-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
HSA-MIR-519D caaagugccucccuuuagugugu
miR-19 3 9 1A HSA-MIR-19A UGUGCAAAUCUAUGCAAAACUGA
HSA-MIR-19B UGUGCAAAUCCAUGCAAAACUGA
mir-208 3583 3589 1A 海关a-miR-208 auaagacgaaaaaagcuugu
mir-217 2968 2974 M8 海关a-miR-217 uacugcaucagaacugauuggau
mir-218 2859 2865 M8 海关a-miR-218brain UUGUGCUUGAUCUAACCAUGU
mir-219 228 234 1A 海关a-miR-219brain UGAUUGUCCAAACGCAAUUCU
miR-23 724 730 M8 HSA-MIR-23Abrain AUCACAUUGCCAGGGAUUUCC
HSA-MIR-23Bbrain AUCACAUUGCCAGGGAUUACC
miR-27 547 554 1A，M8 HSA-MIR-27Abrain uucacaguggcuaaguuccgc
HSA-MIR-27Bbrain UUCACAGUGGCUAAGUUCUGC
miR-29 534 540 M8 HSA-MIR-29ASZ UAGCACCAUCUGAAAUCGGUU
HSA-MIR-29BSZ UAGCACCAUUUGAAAUCAGUGUU
HSA-MIR-29CSZ uagcaccauuugaaaucggu
mir-323 724 730 1A 海关a-miR-323brain gcacauuacggucgaccucu
miR-324-5p 1972 1979 1A，M8 海关a-miR-324-5p CGCAUCCCCUAGGGCAUUGGU
mir-330 812 818 1A 海关a-miR-330brain GCAAAGCACACGGCCUGCAGAGA
mir-335 183 189 1A 海关a-miR-335brain UCAAGAGCAAUAACGAAAAAUGU
miR-376 597 604 1A，M8 hsa - mir - 376 a aucauagaaaaauccacgu
海关a-miR-376b AUCAUAGAGGAAAAUCCAUGUU
hsa - mir - 376 a aucauagaaaaauccacgu
海关a-miR-376b AUCAUAGAGGAAAAUCCAUGUU
hsa - mir - 376 a aucauagaaaaauccacgu
海关a-miR-376b AUCAUAGAGGAAAAUCCAUGUU
miR-381 3457 3464 1A，M8 HSA-MIR-381 uauacaagggcaagcucucugu
HSA-MIR-381 uauacaagggcaagcucucugu
mir-410 493 499 1A 海关a-miR-410 aauauaacacagauggcugu
miR-485-3p 3285 3291 M8 海关a-miR-485-3p gucauacgggcucucucucucucu
miR-488 3035 3041 1A HSA-MIR-488 cccagauauggcacucucucaa
miR-493-5p 304 310 M8 HSA-MIR-493-5p uuguacaugguaggcuuucauu
miR-495 3407 3413 1A HSA-MIR-495brain Aaacaaacauggugcacuuuuu
HSA-MIR-495brain Aaacaaacauggugcacuuuuu
HSA-MIR-495brain Aaacaaacauggugcacuuuuu
miR-496 2355 2362 1A，M8 HSA-MIR-496 Auuacauggccaaucuc
miR-499 3583 3589 1A HSA-MIR-499 UUAAGACUUGCAGUGAUGUUUAA
HSA-MIR-499 UUAAGACUUGCAGUGAUGUUUAA
mir-7 433 439 1A 海关a-miR-7SZ UGGAAGACUAGUGAUUUUGUUG
mir-9 2027 2033 M8 海关a-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA