Gene Page:QPRT

Summary?
GeneID 23475
Symbol QPRT
Synonyms HEL-S-90n|QPRTase
Description quinolinate phosphoribosyltransferase
Reference MIM: 606248|HGNC:HGNC:9755|HPRD:06950|
Gene type protein-coding
Map location 16p11.2
Pascal p-value 0.361
Fetal beta -0.895
DMG 1 (# studies)
eGene Anterior cingulate cortex BA24
Cortex
Frontal Cortex BA9
Myers' cis & trans
元

Gene in Data Sources
Gene set name Method of gene set Description Info
CNV:YES Copy number variation studies Manual curation
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.01775
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg05000199 16 29701173 QPRT 4.716E-4 0.259 0.046 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs10994209 chr10 61877705 QPRT 23475 0.07 trans
rs62059023 16 29681707 QPRT ENSG00000103485.13 1.346E-6 0 -8622 gtex_brain_ba24
rs62059024 16 29681734 QPRT ENSG00000103485.13 1.342E-6 0 -8595 gtex_brain_ba24
rs12447415 16 29682945 QPRT ENSG00000103485.13 2.932E-7 0 -7384 gtex_brain_ba24
rs17842268 16 29684180 QPRT ENSG00000103485.13 3.045E-7 0 -6149 gtex_brain_ba24
rs8058049 16 29684572 QPRT ENSG00000103485.13 3.053E-7 0 -5757 gtex_brain_ba24
rs9940440 16 29684788 QPRT ENSG00000103485.13 2.932E-7 0 -5541 gtex_brain_ba24
rs79706398 16 29688045 QPRT ENSG00000103485.13 4.66E-7 0 -2284 gtex_brain_ba24
rs9933310 16 29690904 QPRT ENSG00000103485.13 4.876E-7 0 575 gtex_brain_ba24
rs62059025 16 29692277 QPRT ENSG00000103485.13 1.046E-6 0 1948 gtex_brain_ba24
rs148320072 16 29694389 QPRT ENSG00000103485.13 2.029E-7 0 4060 gtex_brain_ba24
rs141987948 16 29694390 QPRT ENSG00000103485.13 2.028E-7 0 4061 gtex_brain_ba24
rs145634669 16 29694391 QPRT ENSG00000103485.13 2.028E-7 0 4062 gtex_brain_ba24
rs11644909 16 29694414 QPRT ENSG00000103485.13 1.824E-7 0 4085 gtex_brain_ba24

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity EXP 9473669
GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity IDA 3409840|9473669|17868694
GO:0016757 transferase activity, transferring glycosyl groups IEA -
GO:0042803 protein homodimerization activity IDA 17868694
生物过程 去的术语 Evidence Neuro keywords PubMed ID
GO:0009435 NAD biosynthetic process IEA -
GO:0008152 metabolic process IEA -
GO:0034213 quinolinate catabolic process IDA 9473669
GO:0051259 protein oligomerization IDA 17868694
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005829 cytosol EXP 9473669
GO:0005575 cellular_component ND -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG NICOTINATE AND NICOTINAMIDE METABOLISM 24 16 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF VITAMINS AND COFACTORS 51 36 All SZGR 2.0 genes in this pathway
通过CD40 DN HOLLMANN细胞凋亡 267 178 All SZGR 2.0 genes in this pathway
SOTIRIOU BREAST CANCER GRADE 1 VS 3 UP 151 84 All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663 425 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D UP 182 110 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC UP 185 126 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION MONOCYTE UP 204 140 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION ERYTHROCYTE UP 157 104 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION SUSTAINED IN MONOCYTE UP 21 15 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION SUSTAINDED IN ERYTHROCYTE UP 44 30 All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS DN 232 139 All SZGR 2.0 genes in this pathway
LEE NEURAL CREST STEM CELL UP 146 99 All SZGR 2.0 genes in this pathway
PROVENZANI METASTASIS UP 194 112 All SZGR 2.0 genes in this pathway
KOINUMA COLON CANCER MSI DN 8 5 All SZGR 2.0 genes in this pathway
MISSIAGLIA REGULATED BY METHYLATION UP 126 78 All SZGR 2.0 genes in this pathway
DARWICHE皮肤肿瘤推广应用ER DN 185 115 All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW DN 165 107 All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH DN 180 110 All SZGR 2.0 genes in this pathway
DARWICHE SQUAMOUS CELL CARCINOMA DN 181 107 All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS LUMINAL 326 213 All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP 414 287 All SZGR 2.0 genes in this pathway
DAIRKEE TERT TARGETS UP 380 213 All SZGR 2.0 genes in this pathway
WATTEL AUTONOMOUS THYROID ADENOMA UP 73 47 All SZGR 2.0 genes in this pathway
ALCALA APOPTOSIS 88 60 All SZGR 2.0 genes in this pathway
ROZANOV MMP14 TARGETS UP 266 171 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546 351 All SZGR 2.0 genes in this pathway
ALCALAY AML BY NPM1 LOCALIZATION UP 140 83 All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED UP 183 111 All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1 419 273 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER ERBB2 UP 147 83 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP 338 225 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF DN 235 144 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN 245 150 All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 3 33 12 All SZGR 2.0 genes in this pathway
VALK AML WITH FLT3 ITD 40 22 All SZGR 2.0 genes in this pathway
YAGI AML WITH T 9 11 TRANSLOCATION 130 87 All SZGR 2.0 genes in this pathway
MIKKELSEN MEF ICP WITH H3K27ME3 206 108 All SZGR 2.0 genes in this pathway
CAIRO LIVER DEVELOPMENT DN 222 141 All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 718 401 All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS CONFLUENT 567 365 All SZGR 2.0 genes in this pathway
OHGUCHI LIVER HNF4A TARGETS DN 149 85 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745 475 All SZGR 2.0 genes in this pathway
VANLOO SP3 TARGETS DN 89 47 All SZGR 2.0 genes in this pathway