基因页：ACAP2
Summary？
| 基因 | 23527 |
| 象征 | ACAP2 |
| Synonyms | centb2 | cnt-b2 |
| Description | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 |
| Reference | MIM:607766|HGNC：HGNC：16469|Ensembl:ENSG00000114331|HPRD:09681|Vega:OTTHUMG00000155885 |
| 基因类型 | 蛋白质编码 |
| 地图位置 | 3Q29 |
| Pascal P值 | 0.077 |
| 胎儿β | 0.754 |
| DMG | 1(# studies) |
| 主持人 | 前扣带回皮层BA24 尾状基底神经节 小脑半球 皮质 Frontal Cortex BA9 Hypothalamus 伏隔核基底神经节 Putamen basal ganglia 元 |
Gene in Data Sources
| 基因集名称 | 基因的方法设置 | Description | 信息 |
|---|---|---|---|
| 简历：PGCNP | 全基因组协会研究 | GWAS | |
| DMG：JAFFE_2016 | 全基因组DNA甲基化分析 | 该数据集包括与SZ患者相关的2,104个探针/CPG（n = 108），而在Bonferroni调整后的P <0.05时，其中136个对照。 | 1 |
Section I. Genetics and epigenetics annotation
差异甲基化基因
差异甲基化基因| 探测 | 染色体 | 位置 | 最近的基因 | p（dis） | Beta (dis) | fdr（dis） | 学习 |
|---|---|---|---|---|---|---|---|
| CG09474336 | 3 | 195163530 | ACAP2 | 3.1E-8 | -0.013 | 9.43E-6 | DMG：JAFFE_2016 |
EQTL注释
| SNP ID | 染色体 | 位置 | 主持人 | Gene Entrez ID | PVALUE | QVALUE | TSS距离 | EQTL类型 |
|---|---|---|---|---|---|---|---|---|
| RS6781643 | 3 | 194985678 | ACAP2 | ENSG00000114331.8 | 3.404e-8 | 0 | 178129 | gtex_brain_ba24 |
| RS6791943 | 3 | 194986167 | ACAP2 | ENSG00000114331.8 | 2.912E-7 | 0 | 177640 | gtex_brain_ba24 |
| rs6792029 | 3 | 194986224 | ACAP2 | ENSG00000114331.8 | 2.909E-7 | 0 | 177583 | gtex_brain_ba24 |
| RS6780743 | 3 | 194988441 | ACAP2 | ENSG00000114331.8 | 2.849E-7 | 0 | 175366 | gtex_brain_ba24 |
| rs12695049 | 3 | 194988940 | ACAP2 | ENSG00000114331.8 | 9.02e-8 | 0 | 174867 | gtex_brain_ba24 |
| RS34354069 | 3 | 194989328 | ACAP2 | ENSG00000114331.8 | 1.585E-6 | 0 | 174479 | gtex_brain_ba24 |
| rs7640099 | 3 | 194991220 | ACAP2 | ENSG00000114331.8 | 2.765E-7 | 0 | 172587 | gtex_brain_ba24 |
| RS7640100 | 3 | 194991221 | ACAP2 | ENSG00000114331.8 | 3.911E-7 | 0 | 172586 | gtex_brain_ba24 |
| RS1832667 | 3 | 194992039 | ACAP2 | ENSG00000114331.8 | 7.926E-7 | 0 | 171768 | gtex_brain_ba24 |
| RS7649142 | 3 | 194993295 | ACAP2 | ENSG00000114331.8 | 5.691E-7 | 0 | 170512 | gtex_brain_ba24 |
| RS13072883 | 3 | 194994754 | ACAP2 | ENSG00000114331.8 | 7.612E-7 | 0 | 169053 | gtex_brain_ba24 |
| RS9863901 | 3 | 194996737 | ACAP2 | ENSG00000114331.8 | 5.87 e - | 0 | 167070 | gtex_brain_ba24 |
| rs200598935 | 3 | 194998809 | ACAP2 | ENSG00000114331.8 | 1.616E-6 | 0 | 164998 | gtex_brain_ba24 |
| rs3087885 | 3 | 194999609 | ACAP2 | ENSG00000114331.8 | 1.724E-6 | 0 | 164198 | gtex_brain_ba24 |
| RS7610022 | 3 | 19499996 | ACAP2 | ENSG00000114331.8 | 5.87 e - | 0 | 163811 | gtex_brain_ba24 |
| RS2050810 | 3 | 195001730 | ACAP2 | ENSG00000114331.8 | 5.87 e - | 0 | 162077 | gtex_brain_ba24 |
| rs9823964 | 3 | 195004904 | ACAP2 | ENSG00000114331.8 | 7.612E-7 | 0 | 158903 | gtex_brain_ba24 |
| RS9810077 | 3 | 195005422 | ACAP2 | ENSG00000114331.8 | 7.612E-7 | 0 | 158385 | gtex_brain_ba24 |
| RS3773418 | 3 | 195006791 | ACAP2 | ENSG00000114331.8 | 1.062E-6 | 0 | 157016 | gtex_brain_ba24 |
| RS2410839 | 3 | 195007260 | ACAP2 | ENSG00000114331.8 | 5.87 e - | 0 | 156547 | gtex_brain_ba24 |
| RS1538767 | 3 | 195007852 | ACAP2 | ENSG00000114331.8 | 1.902E-7 | 0 | 155955 | gtex_brain_ba24 |
| RS9832920 | 3 | 195011869 | ACAP2 | ENSG00000114331.8 | 1.023E-6 | 0 | 151938 | gtex_brain_ba24 |
| RS9840346 | 3 | 195011895 | ACAP2 | ENSG00000114331.8 | 6.715E-7 | 0 | 151912 | gtex_brain_ba24 |
| RS6778719 | 3 | 195015251 | ACAP2 | ENSG00000114331.8 | 2.028E-7 | 0 | 148556 | gtex_brain_ba24 |
| RS6791601 | 3 | 195019510 | ACAP2 | ENSG00000114331.8 | 1.352E-7 | 0 | 144297 | gtex_brain_ba24 |
| RS6795263 | 3 | 195020188 | ACAP2 | ENSG00000114331.8 | 1.023E-6 | 0 | 143619 | gtex_brain_ba24 |
| RS13099106 | 3 | 195022263 | ACAP2 | ENSG00000114331.8 | 5.198E-8 | 0 | 138544 | gtex_brain_ba24 |
| rs6437467 | 3 | 195026078 | ACAP2 | ENSG00000114331.8 | 1.025E-6 | 0 | 137729 | gtex_brain_ba24 |
| rs13059843 | 3 | 195028183 | ACAP2 | ENSG00000114331.8 | 3.605E-8 | 0 | 135624 | gtex_brain_ba24 |
| rs56132877 | 3 | 195036583 | ACAP2 | ENSG00000114331.8 | 8.422e-7 | 0 | 127224 | gtex_brain_ba24 |
| RS55927338 | 3 | 195036585 | ACAP2 | ENSG00000114331.8 | 8.422e-7 | 0 | 127222 | gtex_brain_ba24 |
| RS11706264 | 3 | 195037711 | ACAP2 | ENSG00000114331.8 | 8.728e-7 | 0 | 126096 | gtex_brain_ba24 |
| RS13062518 | 3 | 195038287 | ACAP2 | ENSG00000114331.8 | 3.579E-8 | 0 | 125520 | gtex_brain_ba24 |
| RS10933706 | 3 | 195043119 | ACAP2 | ENSG00000114331.8 | 1.023E-6 | 0 | 120688 | gtex_brain_ba24 |
| RS55672262 | 3 | 195047856 | ACAP2 | ENSG00000114331.8 | 3.587E-8 | 0 | 115951 | gtex_brain_ba24 |
| RS4677825 | 3 | 195047912 | ACAP2 | ENSG00000114331.8 | 1.023E-6 | 0 | 115895 | gtex_brain_ba24 |
| RS2050809 | 3 | 195048369 | ACAP2 | ENSG00000114331.8 | 1.023E-6 | 0 | 115438 | gtex_brain_ba24 |
| RS7633265 | 3 | 195048814 | ACAP2 | ENSG00000114331.8 | 3.587E-8 | 0 | 114993 | gtex_brain_ba24 |
| RS13091924 | 3 | 195051136 | ACAP2 | ENSG00000114331.8 | 3.587E-8 | 0 | 112671 | gtex_brain_ba24 |
| rs7638924 | 3 | 195052494 | ACAP2 | ENSG00000114331.8 | 1.023E-6 | 0 | 111313 | gtex_brain_ba24 |
| RS4677830 | 3 | 195060343 | ACAP2 | ENSG00000114331.8 | 1.024E-6 | 0 | 103464 | gtex_brain_ba24 |
| rs7644002 | 3 | 195064198 | ACAP2 | ENSG00000114331.8 | 1.025E-6 | 0 | 99609 | gtex_brain_ba24 |
| RS13072826 | 3 | 195064755 | ACAP2 | ENSG00000114331.8 | 5.181E-8 | 0 | 99052 | gtex_brain_ba24 |
| rs60767217 | 3 | 195069059 | ACAP2 | ENSG00000114331.8 | 5.184E-8 | 0 | 94748 | gtex_brain_ba24 |
| RS10804414 | 3 | 195072126 | ACAP2 | ENSG00000114331.8 | 5.189E-8 | 0 | 91681 | gtex_brain_ba24 |
| RS11718218 | 3 | 195072425 | ACAP2 | ENSG00000114331.8 | 1.023E-6 | 0 | 91382 | gtex_brain_ba24 |
| RS7611238 | 3 | 195072918 | ACAP2 | ENSG00000114331.8 | 2.081E-7 | 0 | 90889 | gtex_brain_ba24 |
| RS7634345 | 3 | 195073403 | ACAP2 | ENSG00000114331.8 | 5.19e-8 | 0 | 90404 | gtex_brain_ba24 |
| RS9860389 | 3 | 195074549 | ACAP2 | ENSG00000114331.8 | 1.029E-6 | 0 | 89258 | gtex_brain_ba24 |
| RS7612694 | 3 | 195075672 | ACAP2 | ENSG00000114331.8 | 1.033E-6 | 0 | 88135 | gtex_brain_ba24 |
| RS6437374 | 3 | 195076877 | ACAP2 | ENSG00000114331.8 | 2.199e-12 | 0 | 86930 | gtex_brain_ba24 |
| RS7651757 | 3 | 195077305 | ACAP2 | ENSG00000114331.8 | 3.615E-8 | 0 | 86502 | gtex_brain_ba24 |
| rs60976085 | 3 | 195082175 | ACAP2 | ENSG00000114331.8 | 4.687E-8 | 0 | 81632 | gtex_brain_ba24 |
| RS13324903 | 3 | 195086647 | ACAP2 | ENSG00000114331.8 | 5.172E-8 | 0 | 77160 | gtex_brain_ba24 |
| RS28375276 | 3 | 195088167 | ACAP2 | ENSG00000114331.8 | 1.023E-6 | 0 | 75640 | gtex_brain_ba24 |
| RS4677834 | 3 | 195093631 | ACAP2 | ENSG00000114331.8 | 3.587E-8 | 0 | 70176 | gtex_brain_ba24 |
| RS58204696 | 3 | 195094042 | ACAP2 | ENSG00000114331.8 | 1.023E-6 | 0 | 69765 | gtex_brain_ba24 |
| rs72065172 | 3 | 195094137 | ACAP2 | ENSG00000114331.8 | 1.023E-6 | 0 | 69670 | gtex_brain_ba24 |
| rs9878312 | 3 | 195096404 | ACAP2 | ENSG00000114331.8 | 1.023E-6 | 0 | 67403 | gtex_brain_ba24 |
| RS4677835 | 3 | 195096995 | ACAP2 | ENSG00000114331.8 | 2.073E-7 | 0 | 66812 | gtex_brain_ba24 |
| rs823302 | 3 | 195104741 | ACAP2 | ENSG00000114331.8 | 3.587E-8 | 0 | 59066 | gtex_brain_ba24 |
| rs823303 | 3 | 195105055 | ACAP2 | ENSG00000114331.8 | 1.023E-6 | 0 | 58752 | gtex_brain_ba24 |
| rs823304 | 3 | 195106012 | ACAP2 | ENSG00000114331.8 | 1.023E-6 | 0 | 57795 | gtex_brain_ba24 |
| rs823305 | 3 | 195106167 | ACAP2 | ENSG00000114331.8 | 1.023E-6 | 0 | 57640 | gtex_brain_ba24 |
| rs823306 | 3 | 195108320 | ACAP2 | ENSG00000114331.8 | 1.191E-7 | 0 | 55487 | gtex_brain_ba24 |
| rs823308 | 3 | 195111916 | ACAP2 | ENSG00000114331.8 | 1.023E-6 | 0 | 51891 | gtex_brain_ba24 |
| rs823309 | 3 | 195116255 | ACAP2 | ENSG00000114331.8 | 1.023E-6 | 0 | 47552 | gtex_brain_ba24 |
| RS823297 | 3 | 195120090 | ACAP2 | ENSG00000114331.8 | 1.023E-6 | 0 | 43717 | gtex_brain_ba24 |
| RS823298 | 3 | 195121072 | ACAP2 | ENSG00000114331.8 | 1.023E-6 | 0 | 42735 | gtex_brain_ba24 |
| RS823299 | 3 | 195122167 | ACAP2 | ENSG00000114331.8 | 1.023E-6 | 0 | 41640 | gtex_brain_ba24 |
| rs823300 | 3 | 195122328 | ACAP2 | ENSG00000114331.8 | 3.594E-8 | 0 | 41479 | gtex_brain_ba24 |
| rs823301 | 3 | 195123495 | ACAP2 | ENSG00000114331.8 | 3.594E-8 | 0 | 40312 | gtex_brain_ba24 |
| rs823310 | 3 | 195127093 | ACAP2 | ENSG00000114331.8 | 4.64e-8 | 0 | 36714 | gtex_brain_ba24 |
| RS1094677 | 3 | 195129744 | ACAP2 | ENSG00000114331.8 | 3.594E-8 | 0 | 34063 | gtex_brain_ba24 |
| rs823314 | 3 | 195132402 | ACAP2 | ENSG00000114331.8 | 3.556e-8 | 0 | 31405 | gtex_brain_ba24 |
| RS147522534 | 3 | 195133475 | ACAP2 | ENSG00000114331.8 | 7.199E-8 | 0 | 30332 | gtex_brain_ba24 |
| rs823313 | 3 | 195136251 | ACAP2 | ENSG00000114331.8 | 1.023E-6 | 0 | 27556 | gtex_brain_ba24 |
| rs823312 | 3 | 195139118 | ACAP2 | ENSG00000114331.8 | 1.023E-6 | 0 | 24689 | gtex_brain_ba24 |
| rs823311 | 3 | 195141029 | ACAP2 | ENSG00000114331.8 | 3.415e-8 | 0 | 22778 | gtex_brain_ba24 |
| RS2791603 | 3 | 195142939 | ACAP2 | ENSG00000114331.8 | 3.125E-8 | 0 | 20868 | gtex_brain_ba24 |
| RS4677671 | 3 | 195148149 | ACAP2 | ENSG00000114331.8 | 1.197E-6 | 0 | 15658 | gtex_brain_ba24 |
| RS9831944 | 3 | 195149742 | ACAP2 | ENSG00000114331.8 | 1.221E-6 | 0 | 14065 | gtex_brain_ba24 |
| RS73080837 | 3 | 195152149 | ACAP2 | ENSG00000114331.8 | 1.254E-6 | 0 | 11658 | gtex_brain_ba24 |
| RS73080839 | 3 | 195152167 | ACAP2 | ENSG00000114331.8 | 1.254E-6 | 0 | 11640 | gtex_brain_ba24 |
| RS57316916 | 3 | 195156861 | ACAP2 | ENSG00000114331.8 | 1.46E-6 | 0 | 6946 | gtex_brain_ba24 |
| RS200616554 | 3 | 195158757 | ACAP2 | ENSG00000114331.8 | 6.298E-7 | 0 | 5050 | gtex_brain_ba24 |
| RS201243710 | 3 | 195158759 | ACAP2 | ENSG00000114331.8 | 1.121E-6 | 0 | 5048 | gtex_brain_ba24 |
| RS1105165 | 3 | 195163917 | ACAP2 | ENSG00000114331.8 | 6.992E-8 | 0 | -110 | gtex_brain_ba24 |
| RS9288747 | 3 | 195165420 | ACAP2 | ENSG00000114331.8 | 9.832e-7 | 0 | -1613 | gtex_brain_ba24 |
| RS6437374 | 3 | 195076877 | ACAP2 | ENSG00000114331.8 | 3.484e-8 | 0 | 86930 | gtex_brain_putamen_basal |
第二节。转录组注释
一般基因表达（GTEX）
Devlopment期间的基因表达（BrainCloud）
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
时间变化的基因表达（brainspan）
Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。
大脑区域的顶级共表达基因
| 前10个积极共表达的基因 | ||
| Gene | 皮尔逊的相关性 | 斯皮尔曼的相关性 |
| EHMT1 | 0.98 | 0.95 |
| PHF2 | 0.98 | 0.97 |
| ZBED4 | 0.98 | 0.97 |
| Smarca4 | 0.97 | 0.96 |
| PHF12 | 0.97 | 0.97 |
| POGZ | 0.97 | 0.97 |
| ZXDC | 0.97 | 0.97 |
| ZNF646 | 0.97 | 0.96 |
| ILF3 | 0.97 | 0.97 |
| ARID1A | 0.96 | 0.97 |
| 前10个负共表达基因 | ||
| Gene | 皮尔逊的相关性 | 斯皮尔曼的相关性 |
| C5orf53 | -0.72 | -0.79 |
| AF347015.31 | -0.71 | -0.91 |
| HLA-F | -0.70 | -0.73 |
| AF347015.27 | -0.70 | -0.88 |
| S100B | -0.70 | -0.84 |
| AIFM3 | -0.70 | -0.74 |
| MT-CO2 | -0.69 | -0.90 |
| aldoc | -0.69 | -0.69 |
| B2M | -0.68 | -0.79 |
| FXYD1 | -0.68 | -0.86 |