Gene Page:FOSB
Summary?
| GeneID | 2354 |
| Symbol | FOSB |
| Synonyms | AP-1|G0S3|GOS3|GOSB |
| Description | FBJ murine osteosarcoma viral oncogene homolog B |
| Reference | MIM:164772|HGNC:HGNC:3797|Ensembl:ENSG00000125740|HPRD:01270|Vega:OTTHUMG00000182122 |
| Gene type | protein-coding |
| Map location | 19q13.32 |
| Pascal p-value | 0.7 |
| Sherlock p-value | 0.982 |
| Fetal beta | -1.177 |
| DMG | 1 (# studies) |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias | Click to show details |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Differentially methylated gene| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg02360514 | 19 | 45975990 | FOSB | 3.695E-4 | -0.48 | 0.043 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs983619 | chr1 | 39047418 | FOSB | 2354 | 0.15 | trans | ||
| rs7545984 | chr1 | 45003892 | FOSB | 2354 | 0.1 | trans | ||
| rs7554123 | chr1 | 45004203 | FOSB | 2354 | 0.1 | trans | ||
| rs12059674 | chr1 | 57630277 | FOSB | 2354 | 0.04 | trans | ||
| rs17126801 | chr1 | 65098162 | FOSB | 2354 | 0.02 | trans | ||
| rs7511937 | 0 | FOSB | 2354 | 0.01 | trans | |||
| rs2782784 | chr1 | 71195282 | FOSB | 2354 | 0.04 | trans | ||
| rs2257700 | chr1 | 71273516 | FOSB | 2354 | 0.07 | trans | ||
| rs7541092 | chr1 | 71362471 | FOSB | 2354 | 0.13 | trans | ||
| rs17689089 | chr1 | 77740105 | FOSB | 2354 | 0.05 | trans | ||
| rs17100231 | chr1 | 77761339 | FOSB | 2354 | 0.02 | trans | ||
| rs17100274 | chr1 | 77774412 | FOSB | 2354 | 5.262E-5 | trans | ||
| rs3015033 | chr1 | 79847235 | FOSB | 2354 | 0.13 | trans | ||
| rs17098656 | chr1 | 80098386 | FOSB | 2354 | 0.11 | trans | ||
| rs6664544 | chr1 | 92524192 | FOSB | 2354 | 0.03 | trans | ||
| rs17029293 | chr1 | 112567844 | FOSB | 2354 | 0.03 | trans | ||
| rs16837984 | chr1 | 157042626 | FOSB | 2354 | 0 | trans | ||
| rs16837989 | chr1 | 157046286 | FOSB | 2354 | 0.03 | trans | ||
| rs16838012 | chr1 | 157048974 | FOSB | 2354 | 0 | trans | ||
| rs16838014 | 0 | FOSB | 2354 | 0 | trans | |||
| rs4657385 | chr1 | 164939279 | FOSB | 2354 | 0.14 | trans | ||
| rs6666937 | chr1 | 170286842 | FOSB | 2354 | 1.084E-5 | trans | ||
| rs12071422 | chr1 | 185573879 | FOSB | 2354 | 0.07 | trans | ||
| rs16843112 | chr1 | 198420657 | FOSB | 2354 | 0.18 | trans | ||
| rs697455 | chr1 | 202512075 | FOSB | 2354 | 0.05 | trans | ||
| rs3748669 | chr1 | 207077022 | FOSB | 2354 | 0.08 | trans | ||
| rs6673109 | chr1 | 207253132 | FOSB | 2354 | 0 | trans | ||
| rs1796829 | chr1 | 239661818 | FOSB | 2354 | 0 | trans | ||
| rs12034521 | chr1 | 239717679 | FOSB | 2354 | 7.931E-4 | trans | ||
| snp_a-1990354 | 0 | FOSB | 2354 | 6.475E-5 | trans | |||
| rs939217 | chr2 | 12730751 | FOSB | 2354 | 0.1 | trans | ||
| rs6432434 | chr2 | 14160930 | FOSB | 2354 | 0.05 | trans | ||
| rs6712107 | chr2 | 14178653 | FOSB | 2354 | 0.14 | trans | ||
| rs16861129 | chr2 | 14201738 | FOSB | 2354 | 0.14 | trans | ||
| rs16861131 | chr2 | 14202085 | FOSB | 2354 | 0.14 | trans | ||
| rs12329305 | chr2 | 19552912 | FOSB | 2354 | 0.12 | trans | ||
| rs12611832 | chr2 | 31196248 | FOSB | 2354 | 0.12 | trans | ||
| rs12614732 | chr2 | 31199913 | FOSB | 2354 | 0.12 | trans | ||
| rs7560081 | chr2 | 62793238 | FOSB | 2354 | 0.02 | trans | ||
| rs17029079 | chr2 | 64736071 | FOSB | 2354 | 0.04 | trans | ||
| rs17038084 | chr2 | 85192280 | FOSB | 2354 | 6.868E-4 | trans | ||
| rs17024035 | chr2 | 100968559 | FOSB | 2354 | 0.01 | trans | ||
| rs7574684 | chr2 | 100992911 | FOSB | 2354 | 0.01 | trans | ||
| rs17024129 | chr2 | 100995144 | FOSB | 2354 | 0.01 | trans | ||
| rs17024136 | chr2 | 100995382 | FOSB | 2354 | 0.07 | trans | ||
| rs7585898 | chr2 | 100998292 | FOSB | 2354 | 0.01 | trans | ||
| rs6716367 | chr2 | 101000013 | FOSB | 2354 | 0.1 | trans | ||
| rs1370627 | chr2 | 101009384 | FOSB | 2354 | 0.01 | trans | ||
| rs4149509 | chr2 | 101023698 | FOSB | 2354 | 0.07 | trans | ||
| rs1840209 | chr2 | 125625401 | FOSB | 2354 | 0.14 | trans | ||
| rs6707117 | chr2 | 136855504 | FOSB | 2354 | 4.47E-9 | trans | ||
| rs10189091 | chr2 | 143471999 | FOSB | 2354 | 0.01 | trans | ||
| snp_a-2198363 | 0 | FOSB | 2354 | 0.08 | trans | |||
| rs707097 | chr2 | 155318814 | FOSB | 2354 | 0.14 | trans | ||
| rs16838911 | chr2 | 156087569 | FOSB | 2354 | 9.419E-4 | trans | ||
| rs7608942 | chr2 | 182820100 | FOSB | 2354 | 0.01 | trans | ||
| rs16848675 | chr2 | 213349996 | FOSB | 2354 | 0.13 | trans | ||
| rs16829292 | chr2 | 233447622 | FOSB | 2354 | 0.18 | trans | ||
| rs16829401 | chr2 | 233538391 | FOSB | 2354 | 0.01 | trans | ||
| rs17040622 | chr3 | 4440673 | FOSB | 2354 | 0.03 | trans | ||
| rs17684934 | chr3 | 4443547 | FOSB | 2354 | 7.427E-4 | trans | ||
| rs17040633 | chr3 | 4446836 | FOSB | 2354 | 7.427E-4 | trans | ||
| rs17756483 | chr3 | 4451309 | FOSB | 2354 | 7.427E-4 | trans | ||
| rs17685441 | chr3 | 4465165 | FOSB | 2354 | 7.427E-4 | trans | ||
| rs17015415 | chr3 | 24933888 | FOSB | 2354 | 0.09 | trans | ||
| rs12639503 | chr3 | 51860816 | FOSB | 2354 | 0.16 | trans | ||
| rs9863778 | chr3 | 55375950 | FOSB | 2354 | 0.05 | trans | ||
| rs997245 | chr3 | 61844600 | FOSB | 2354 | 1.696E-4 | trans | ||
| rs2875492 | chr3 | 86006209 | FOSB | 2354 | 0.03 | trans | ||
| rs16843128 | chr3 | 100713413 | FOSB | 2354 | 0 | trans | ||
| rs1381835 | chr3 | 110600595 | FOSB | 2354 | 0.09 | trans | ||
| rs16839796 | chr4 | 7188348 | FOSB | 2354 | 0.01 | trans | ||
| rs4631023 | chr4 | 8101794 | FOSB | 2354 | 0.09 | trans | ||
| rs7684087 | chr4 | 21673380 | FOSB | 2354 | 0.03 | trans | ||
| rs16989064 | chr4 | 33639397 | FOSB | 2354 | 0.05 | trans | ||
| rs4469113 | chr4 | 41461062 | FOSB | 2354 | 5.357E-4 | trans | ||
| rs2643038 | chr4 | 62313218 | FOSB | 2354 | 0.05 | trans | ||
| rs6817626 | chr4 | 78005836 | FOSB | 2354 | 0.15 | trans | ||
| rs6827713 | chr4 | 79936877 | FOSB | 2354 | 0.09 | trans | ||
| rs10011751 | chr4 | 93984994 | FOSB | 2354 | 0.03 | trans | ||
| rs6881821 | chr5 | 8578465 | FOSB | 2354 | 0 | trans | ||
| rs9312843 | chr5 | 13802997 | FOSB | 2354 | 0.06 | trans | ||
| rs1697073 | chr5 | 30907267 | FOSB | 2354 | 0.06 | trans | ||
| rs2115110 | chr5 | 38193428 | FOSB | 2354 | 3.131E-4 | trans | ||
| rs16873956 | chr5 | 44312488 | FOSB | 2354 | 0.03 | trans | ||
| rs10040715 | chr5 | 57594207 | FOSB | 2354 | 2.029E-9 | trans | ||
| rs16894149 | chr5 | 61013724 | FOSB | 2354 | 0.12 | trans | ||
| snp_a-4217300 | 0 | FOSB | 2354 | 3.518E-5 | trans | |||
| rs1862599 | chr5 | 82095088 | FOSB | 2354 | 0.03 | trans | ||
| rs163953 | chr5 | 92289536 | FOSB | 2354 | 0.04 | trans | ||
| rs17134275 | chr5 | 100634998 | FOSB | 2354 | 0.01 | trans | ||
| rs10063272 | chr5 | 103540974 | FOSB | 2354 | 0.13 | trans | ||
| rs2963232 | chr5 | 103713882 | FOSB | 2354 | 0.01 | trans | ||
| rs250323 | chr5 | 115646995 | FOSB | 2354 | 0.13 | trans | ||
| rs1350578 | chr5 | 116310282 | FOSB | 2354 | 0.16 | trans | ||
| rs2900115 | chr5 | 117414349 | FOSB | 2354 | 0.08 | trans | ||
| rs2141482 | chr5 | 136760477 | FOSB | 2354 | 1.689E-5 | trans | ||
| rs2189803 | chr5 | 137684661 | FOSB | 2354 | 1.097E-6 | trans | ||
| rs17209139 | chr5 | 142552525 | FOSB | 2354 | 0.16 | trans | ||
| rs17063216 | chr5 | 163777647 | FOSB | 2354 | 0.14 | trans | ||
| rs17063224 | chr5 | 163780687 | FOSB | 2354 | 0.14 | trans | ||
| rs259913 | chr5 | 169370782 | FOSB | 2354 | 6.313E-4 | trans | ||
| rs2116811 | chr5 | 171820051 | FOSB | 2354 | 0.01 | trans | ||
| rs258875 | chr5 | 173046554 | FOSB | 2354 | 0.12 | trans | ||
| rs195429 | chr6 | 37354434 | FOSB | 2354 | 0.05 | trans | ||
| rs17069168 | chr6 | 108335432 | FOSB | 2354 | 0.15 | trans | ||
| rs17069171 | chr6 | 108335593 | FOSB | 2354 | 0.07 | trans | ||
| rs4289676 | chr6 | 123999302 | FOSB | 2354 | 0.01 | trans | ||
| rs17055235 | chr6 | 128355263 | FOSB | 2354 | 0.07 | trans | ||
| rs2030024 | chr6 | 131014624 | FOSB | 2354 | 0.01 | trans | ||
| rs10485094 | chr6 | 131071433 | FOSB | 2354 | 0 | trans | ||
| rs17059517 | chr6 | 131076254 | FOSB | 2354 | 0.01 | trans | ||
| rs9402280 | chr6 | 131102770 | FOSB | 2354 | 0.02 | trans | ||
| rs7767456 | chr6 | 134356119 | FOSB | 2354 | 0.03 | trans | ||
| rs12176346 | chr6 | 136732663 | FOSB | 2354 | 0.03 | trans | ||
| rs9402819 | chr6 | 136848169 | FOSB | 2354 | 0.06 | trans | ||
| rs9389400 | chr6 | 136854803 | FOSB | 2354 | 0.06 | trans | ||
| rs2237264 | chr6 | 136919977 | FOSB | 2354 | 0.03 | trans | ||
| rs12164028 | chr6 | 136929934 | FOSB | 2354 | 0.13 | trans | ||
| rs17080121 | chr6 | 151009189 | FOSB | 2354 | 0.02 | trans | ||
| rs12529269 | chr6 | 153543829 | FOSB | 2354 | 0 | trans | ||
| rs10872699 | chr6 | 153544252 | FOSB | 2354 | 1.328E-4 | trans | ||
| rs1321606 | chr6 | 153545278 | FOSB | 2354 | 0 | trans | ||
| rs10945911 | chr6 | 164047509 | FOSB | 2354 | 3.469E-5 | trans | ||
| rs12540348 | chr7 | 25802146 | FOSB | 2354 | 0.18 | trans | ||
| rs6461881 | chr7 | 25837688 | FOSB | 2354 | 0.07 | trans | ||
| rs13239699 | chr7 | 26377619 | FOSB | 2354 | 0.07 | trans | ||
| rs6462054 | chr7 | 27886170 | FOSB | 2354 | 0.01 | trans | ||
| rs17156078 | chr7 | 27988688 | FOSB | 2354 | 0.03 | trans | ||
| rs12701006 | chr7 | 30147298 | FOSB | 2354 | 1.727E-4 | trans | ||
| rs1419793 | chr7 | 34697630 | FOSB | 2354 | 7.259E-4 | trans | ||
| rs17621151 | chr7 | 53572911 | FOSB | 2354 | 0 | trans | ||
| rs10245449 | chr7 | 80935100 | FOSB | 2354 | 0.04 | trans | ||
| rs12671672 | chr7 | 117614219 | FOSB | 2354 | 0.12 | trans | ||
| rs10487383 | chr7 | 117671737 | FOSB | 2354 | 0 | trans | ||
| rs6958821 | chr7 | 153253566 | FOSB | 2354 | 0.02 | trans | ||
| rs11779237 | chr8 | 1227664 | FOSB | 2354 | 0.12 | trans | ||
| rs1358128 | chr8 | 5268072 | FOSB | 2354 | 0.04 | trans | ||
| rs12682256 | chr8 | 5306138 | FOSB | 2354 | 0.08 | trans | ||
| rs1010895 | chr8 | 14580230 | FOSB | 2354 | 0.13 | trans | ||
| rs10109456 | chr8 | 19565941 | FOSB | 2354 | 0.03 | trans | ||
| rs17054681 | chr8 | 25814323 | FOSB | 2354 | 0.16 | trans | ||
| rs10102886 | chr8 | 51805574 | FOSB | 2354 | 0.02 | trans | ||
| rs1457032 | chr8 | 59290536 | FOSB | 2354 | 0 | trans | ||
| rs7465259 | 0 | FOSB | 2354 | 0.09 | trans | |||
| rs10104622 | chr8 | 63333773 | FOSB | 2354 | 0.09 | trans | ||
| rs2218911 | chr8 | 63371015 | FOSB | 2354 | 0.09 | trans | ||
| rs1551199 | chr8 | 63388117 | FOSB | 2354 | 0.09 | trans | ||
| rs1733950 | chr8 | 90062516 | FOSB | 2354 | 2.734E-9 | trans | ||
| rs1240028 | chr8 | 90093357 | FOSB | 2354 | 5.038E-4 | trans | ||
| rs1240087 | chr8 | 90113945 | FOSB | 2354 | 0 | trans | ||
| rs318307 | chr8 | 90185459 | FOSB | 2354 | 5.907E-4 | trans | ||
| rs1483373 | chr8 | 90186442 | FOSB | 2354 | 0.02 | trans | ||
| rs11776005 | chr8 | 90187416 | FOSB | 2354 | 0.01 | trans | ||
| rs1159499 | chr8 | 90196948 | FOSB | 2354 | 0.01 | trans | ||
| rs1355060 | chr8 | 118717710 | FOSB | 2354 | 0.03 | trans | ||
| rs2280828 | chr8 | 118762435 | FOSB | 2354 | 0.01 | trans | ||
| rs4976941 | chr8 | 142744439 | FOSB | 2354 | 8.236E-4 | trans | ||
| rs9298651 | chr9 | 10076275 | FOSB | 2354 | 3.661E-5 | trans | ||
| rs16931013 | chr9 | 10076859 | FOSB | 2354 | 3.661E-5 | trans | ||
| rs16931018 | chr9 | 10077048 | FOSB | 2354 | 3.661E-5 | trans | ||
| rs4415417 | chr9 | 17837857 | FOSB | 2354 | 0.15 | trans | ||
| rs2210327 | chr9 | 18109234 | FOSB | 2354 | 0.14 | trans | ||
| rs6476383 | chr9 | 32865568 | FOSB | 2354 | 0.15 | trans | ||
| rs11143622 | chr9 | 71370050 | FOSB | 2354 | 0.07 | trans | ||
| rs1109460 | chr9 | 79410224 | FOSB | 2354 | 0.19 | trans | ||
| rs11791891 | chr9 | 87512411 | FOSB | 2354 | 0.01 | trans | ||
| rs2165893 | chr9 | 87531423 | FOSB | 2354 | 0 | trans | ||
| rs17087869 | chr9 | 87535284 | FOSB | 2354 | 0.13 | trans | ||
| rs763623 | chr9 | 87539663 | FOSB | 2354 | 0.02 | trans | ||
| rs3780642 | chr9 | 87553144 | FOSB | 2354 | 1.114E-5 | trans | ||
| rs10992752 | chr9 | 96240578 | FOSB | 2354 | 0.04 | trans | ||
| rs10981864 | chr9 | 116416735 | FOSB | 2354 | 0.04 | trans | ||
| rs2807706 | chr9 | 121744331 | FOSB | 2354 | 0.01 | trans | ||
| rs2818297 | chr9 | 121757015 | FOSB | 2354 | 0.06 | trans | ||
| rs10739527 | chr9 | 121772512 | FOSB | 2354 | 0.08 | trans | ||
| rs6537944 | chr9 | 137312827 | FOSB | 2354 | 0.04 | trans | ||
| rs11103132 | chr9 | 138575901 | FOSB | 2354 | 0.12 | trans | ||
| rs6560840 | chr10 | 489655 | FOSB | 2354 | 0.18 | trans | ||
| rs11252514 | chr10 | 499572 | FOSB | 2354 | 0.01 | trans | ||
| rs2924269 | chr10 | 4884783 | FOSB | 2354 | 0.16 | trans | ||
| rs772394 | chr10 | 35980024 | FOSB | 2354 | 0.01 | trans | ||
| rs1908351 | chr10 | 57877117 | FOSB | 2354 | 0.02 | trans | ||
| rs3104871 | chr10 | 57878502 | FOSB | 2354 | 0 | trans | ||
| rs901309 | chr10 | 72571899 | FOSB | 2354 | 0.08 | trans | ||
| rs485305 | chr10 | 116048044 | FOSB | 2354 | 0.01 | trans | ||
| rs17540632 | chr10 | 118774194 | FOSB | 2354 | 0.18 | trans | ||
| rs4750827 | chr10 | 132547183 | FOSB | 2354 | 0.11 | trans | ||
| rs4750829 | chr10 | 132547260 | FOSB | 2354 | 0.1 | trans | ||
| rs11021918 | chr11 | 2269189 | FOSB | 2354 | 0.08 | trans | ||
| rs862785 | chr11 | 20175604 | FOSB | 2354 | 0.17 | trans | ||
| rs16911034 | chr11 | 23302320 | FOSB | 2354 | 0.02 | trans | ||
| rs619320 | chr11 | 81846219 | FOSB | 2354 | 0.15 | trans | ||
| rs11020043 | chr11 | 92470587 | FOSB | 2354 | 0.14 | trans | ||
| rs1789300 | chr11 | 95463631 | FOSB | 2354 | 0.02 | trans | ||
| rs1255149 | chr11 | 95484493 | FOSB | 2354 | 0.03 | trans | ||
| rs3748251 | chr11 | 95519156 | FOSB | 2354 | 0.02 | trans | ||
| rs16922543 | chr11 | 95526116 | FOSB | 2354 | 0.02 | trans | ||
| rs16922622 | chr11 | 95567387 | FOSB | 2354 | 0.02 | trans | ||
| rs3181323 | chr11 | 104878386 | FOSB | 2354 | 0.14 | trans | ||
| rs2109556 | chr12 | 3887300 | FOSB | 2354 | 0.19 | trans | ||
| rs733593 | chr12 | 6636391 | FOSB | 2354 | 0.03 | trans | ||
| rs374484 | chr12 | 27627159 | FOSB | 2354 | 0.01 | trans | ||
| rs451921 | chr12 | 27627499 | FOSB | 2354 | 0.2 | trans | ||
| rs10771436 | chr12 | 28744556 | FOSB | 2354 | 0.2 | trans | ||
| rs8490 | chr12 | 51453904 | FOSB | 2354 | 2.043E-5 | trans | ||
| rs1344796 | chr12 | 76397104 | FOSB | 2354 | 0 | trans | ||
| rs10850201 | chr12 | 109903061 | FOSB | 2354 | 0.04 | trans | ||
| rs7296098 | chr12 | 113228993 | FOSB | 2354 | 0.16 | trans | ||
| rs11833075 | chr12 | 122114592 | FOSB | 2354 | 2.814E-4 | trans | ||
| rs9300277 | chr12 | 128564195 | FOSB | 2354 | 0.13 | trans | ||
| rs3803214 | chr13 | 25740255 | FOSB | 2354 | 0.17 | trans | ||
| rs1041050 | chr13 | 26585121 | FOSB | 2354 | 0.14 | trans | ||
| rs17084271 | chr13 | 27089799 | FOSB | 2354 | 0.12 | trans | ||
| rs17084280 | chr13 | 27090872 | FOSB | 2354 | 0.12 | trans | ||
| rs7982110 | chr13 | 59723428 | FOSB | 2354 | 0 | trans | ||
| rs9528250 | chr13 | 61410190 | FOSB | 2354 | 0.01 | trans | ||
| rs7330331 | chr13 | 67403122 | FOSB | 2354 | 0.02 | trans | ||
| rs7327697 | chr13 | 83227456 | FOSB | 2354 | 0 | trans | ||
| rs7321205 | chr13 | 89949815 | FOSB | 2354 | 0.08 | trans | ||
| rs17667894 | chr13 | 92014308 | FOSB | 2354 | 0.02 | trans | ||
| rs7156088 | chr14 | 27821865 | FOSB | 2354 | 0.01 | trans | ||
| rs7147321 | chr14 | 45877904 | FOSB | 2354 | 0.09 | trans | ||
| rs1952728 | chr14 | 45893091 | FOSB | 2354 | 0.09 | trans | ||
| rs17116137 | chr14 | 45940865 | FOSB | 2354 | 0.09 | trans | ||
| rs7151829 | chr14 | 45971281 | FOSB | 2354 | 0.09 | trans | ||
| rs8022005 | chr14 | 61345380 | FOSB | 2354 | 4.004E-4 | trans | ||
| rs10148418 | chr14 | 67003872 | FOSB | 2354 | 0.05 | trans | ||
| rs4905035 | chr14 | 93489262 | FOSB | 2354 | 0.12 | trans | ||
| rs941539 | chr14 | 93561214 | FOSB | 2354 | 0.04 | trans | ||
| rs1885073 | chr14 | 104357181 | FOSB | 2354 | 1.634E-4 | trans | ||
| rs4465541 | chr14 | 105016846 | FOSB | 2354 | 0.07 | trans | ||
| rs16973929 | chr15 | 47395709 | FOSB | 2354 | 0.1 | trans | ||
| rs10518936 | chr15 | 58090522 | FOSB | 2354 | 0.09 | trans | ||
| rs2414703 | chr15 | 61904602 | FOSB | 2354 | 0.12 | trans | ||
| rs289171 | chr15 | 62576053 | FOSB | 2354 | 0 | trans | ||
| rs289161 | chr15 | 62589888 | FOSB | 2354 | 0.01 | trans | ||
| rs4777108 | chr15 | 69383464 | FOSB | 2354 | 0.15 | trans | ||
| rs9635390 | chr15 | 90809632 | FOSB | 2354 | 5.484E-4 | trans | ||
| rs16948375 | chr15 | 94236354 | FOSB | 2354 | 0.03 | trans | ||
| rs17140355 | chr16 | 6548831 | FOSB | 2354 | 0.12 | trans | ||
| rs8047151 | chr16 | 17209696 | FOSB | 2354 | 6.036E-8 | trans | ||
| rs4271578 | chr16 | 17213886 | FOSB | 2354 | 2.46E-6 | trans | ||
| rs7200513 | chr16 | 17219474 | FOSB | 2354 | 4.347E-4 | trans | ||
| rs3829495 | chr16 | 17221986 | FOSB | 2354 | 1.989E-5 | trans | ||
| rs7193763 | chr16 | 17225534 | FOSB | 2354 | 5.079E-5 | trans | ||
| rs4316748 | chr16 | 55781757 | FOSB | 2354 | 0.07 | trans | ||
| rs11861635 | chr16 | 82543377 | FOSB | 2354 | 0.14 | trans | ||
| rs276966 | chr16 | 86233753 | FOSB | 2354 | 0.07 | trans | ||
| rs1867231 | chr17 | 13678834 | FOSB | 2354 | 0.05 | trans | ||
| rs9903086 | chr17 | 39949515 | FOSB | 2354 | 0.18 | trans | ||
| rs7219986 | chr17 | 53263206 | FOSB | 2354 | 0.04 | trans | ||
| rs17817797 | chr17 | 53332496 | FOSB | 2354 | 0 | trans | ||
| rs16951770 | chr18 | 7444826 | FOSB | 2354 | 0.07 | trans | ||
| rs2851752 | chr18 | 25350684 | FOSB | 2354 | 0.16 | trans | ||
| rs7244394 | chr18 | 32223105 | FOSB | 2354 | 0.03 | trans | ||
| rs9646596 | chr18 | 53049211 | FOSB | 2354 | 0.18 | trans | ||
| rs1469489 | chr18 | 57228488 | FOSB | 2354 | 0.14 | trans | ||
| rs17074993 | chr18 | 63260128 | FOSB | 2354 | 0.03 | trans | ||
| rs9319807 | chr18 | 68766779 | FOSB | 2354 | 0.02 | trans | ||
| snp_a-1821751 | 0 | FOSB | 2354 | 3.87E-4 | trans | |||
| rs1942461 | chr18 | 70509159 | FOSB | 2354 | 0.04 | trans | ||
| rs1942462 | chr18 | 70509823 | FOSB | 2354 | 0.04 | trans | ||
| rs1942463 | chr18 | 70509841 | FOSB | 2354 | 0.04 | trans | ||
| rs1942464 | chr18 | 70509877 | FOSB | 2354 | 0 | trans | ||
| rs1942466 | chr18 | 70517154 | FOSB | 2354 | 0.04 | trans | ||
| rs2156494 | chr18 | 70518084 | FOSB | 2354 | 0.04 | trans | ||
| rs17056922 | chr18 | 73086804 | FOSB | 2354 | 0.06 | trans | ||
| rs1540051 | chr18 | 75049934 | FOSB | 2354 | 0.13 | trans | ||
| rs16980096 | chr19 | 15000921 | FOSB | 2354 | 0.08 | trans | ||
| snp_a-2138575 | 0 | FOSB | 2354 | 0.02 | trans | |||
| rs234363 | chr19 | 40474607 | FOSB | 2354 | 0.01 | trans | ||
| rs6417634 | chr20 | 6408617 | FOSB | 2354 | 0.12 | trans | ||
| rs6085552 | chr20 | 6409004 | FOSB | 2354 | 0.13 | trans | ||
| rs1797040 | chr20 | 23907743 | FOSB | 2354 | 0.05 | trans | ||
| rs2424603 | 0 | FOSB | 2354 | 0.05 | trans | |||
| rs6102879 | chr20 | 41138766 | FOSB | 2354 | 0.06 | trans | ||
| rs6026122 | chr20 | 56769083 | FOSB | 2354 | 0.01 | trans | ||
| rs6015452 | chr20 | 57782312 | FOSB | 2354 | 0.2 | trans | ||
| rs2847443 | chr21 | 14595263 | FOSB | 2354 | 0.11 | trans | ||
| rs2834872 | chr21 | 36634845 | FOSB | 2354 | 0.04 | trans | ||
| rs2834874 | chr21 | 36641270 | FOSB | 2354 | 0.15 | trans | ||
| rs2834875 | chr21 | 36656119 | FOSB | 2354 | 0.02 | trans | ||
| rs877910 | chr21 | 36658376 | FOSB | 2354 | 0.04 | trans | ||
| rs6586271 | chr21 | 44362641 | FOSB | 2354 | 0.1 | trans | ||
| rs134028 | chr22 | 28048448 | FOSB | 2354 | 0 | trans | ||
| rs5762317 | chr22 | 28094988 | FOSB | 2354 | 0.04 | trans | ||
| rs9968025 | chr22 | 32321588 | FOSB | 2354 | 0.06 | trans | ||
| rs5768165 | chr22 | 48318197 | FOSB | 2354 | 0.04 | trans | ||
| rs5768168 | chr22 | 48319334 | FOSB | 2354 | 0.04 | trans | ||
| rs5768173 | chr22 | 48321475 | FOSB | 2354 | 0.04 | trans | ||
| rs16978981 | chrX | 13538144 | FOSB | 2354 | 0.01 | trans | ||
| rs7879159 | chrX | 19481591 | FOSB | 2354 | 0.01 | trans | ||
| rs12006821 | chrX | 50424687 | FOSB | 2354 | 0.08 | trans | ||
| rs5977652 | chrX | 131315199 | FOSB | 2354 | 0.11 | trans | ||
| rs4824295 | chrX | 146496881 | FOSB | 2354 | 0.09 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | 去的术语 | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| : 0004252 | serine-type endopeptidase activity | IEA | glutamate (GO term level: 7) | - |
| : 0003700 | transcription factor activity | IEA | - | |
| : 0008134 | transcription factor binding | TAS | 1900040 | |
| : 0043565 | sequence-specific DNA binding | IEA | - | |
| : 0046983 | protein dimerization activity | IEA | - | |
| Biological process | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| : 0000122 | negative regulation of transcription from RNA polymerase II promoter | TAS | 1900040 | |
| : 0006355 | regulation of transcription, DNA-dependent | IEA | - | |
| : 0006508 | proteolysis | IEA | - | |
| : 0007610 | behavior | TAS | 8706134 | |
| 去:0007275 | multicellular organismal development | TAS | 8706134 | |
| Cellular component | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| : 0005634 | nucleus | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PID AP1 PATHWAY | 70 | 60 | All SZGR 2.0 genes in this pathway |
| WEST ADRENOCORTICAL TUMOR MARKERS DN | 20 | 14 | All SZGR 2.0 genes in this pathway |
| PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA DN | 136 | 86 | All SZGR 2.0 genes in this pathway |
| TURASHVILI BREAST NORMAL DUCTAL VS LOBULAR UP | 68 | 40 | All SZGR 2.0 genes in this pathway |
| TURASHVILI BREAST DUCTAL CARCINOMA VS DUCTAL NORMAL DN | 198 | 110 | All SZGR 2.0 genes in this pathway |
| TURASHVILI BREAST DUCTAL CARCINOMA VS LOBULAR NORMAL DN | 69 | 43 | All SZGR 2.0 genes in this pathway |
| CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA UP | 177 | 110 | All SZGR 2.0 genes in this pathway |
| CASORELLI APL SECONDARY VS DE NOVO UP | 39 | 25 | All SZGR 2.0 genes in this pathway |
| CHARAFE BREAST CANCER BASAL VS MESENCHYMAL UP | 121 | 45 | All SZGR 2.0 genes in this pathway |
| OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP | 233 | 161 | All SZGR 2.0 genes in this pathway |
| RHEIN ALL GLUCOCORTICOID THERAPY DN | 362 | 238 | All SZGR 2.0 genes in this pathway |
| NAGASHIMA NRG1 SIGNALING UP | 176 | 123 | All SZGR 2.0 genes in this pathway |
| NAGASHIMA EGF SIGNALING UP | 58 | 40 | All SZGR 2.0 genes in this pathway |
| ENK UV RESPONSE EPIDERMIS DN | 508 | 354 | All SZGR 2.0 genes in this pathway |
| GESERICK TERT TARGETS DN | 21 | 16 | All SZGR 2.0 genes in this pathway |
| DELYS THYROID CANCER DN | 232 | 154 | All SZGR 2.0 genes in this pathway |
| 绿草SMANN APOPTOSIS BY DOXORUBICIN UP | 1142 | 669 | All SZGR 2.0 genes in this pathway |
| 绿草SMANN RESPONSE TO MC AND DOXORUBICIN UP | 612 | 367 | All SZGR 2.0 genes in this pathway |
| WANG ESOPHAGUS CANCER VS NORMAL UP | 121 | 72 | All SZGR 2.0 genes in this pathway |
| RIZ ERYTHROID DIFFERENTIATION HBZ | 41 | 27 | All SZGR 2.0 genes in this pathway |
| CHASSOT SKIN WOUND | 10 | 9 | All SZGR 2.0 genes in this pathway |
| RIZ ERYTHROID DIFFERENTIATION HEMGN | 31 | 21 | All SZGR 2.0 genes in this pathway |
| ROVERSI GLIOMA COPY NUMBER UP | 100 | 75 | All SZGR 2.0 genes in this pathway |
| LUI THYROID CANCER CLUSTER 1 | 51 | 33 | All SZGR 2.0 genes in this pathway |
| CEBALLOS TARGETS OF TP53 AND MYC UP | 21 | 16 | All SZGR 2.0 genes in this pathway |
| TAGHAVI NEOPLASTIC TRANSFORMATION | 12 | 10 | All SZGR 2.0 genes in this pathway |
| AMIT EGF RESPONSE 60 HELA | 46 | 32 | All SZGR 2.0 genes in this pathway |
| AMIT SERUM RESPONSE 40 MCF10A | 32 | 21 | All SZGR 2.0 genes in this pathway |
| SHIN B CELL LYMPHOMA CLUSTER 2 | 30 | 23 | All SZGR 2.0 genes in this pathway |
| TARTE PLASMA CELL VS PLASMABLAST UP | 398 | 262 | All SZGR 2.0 genes in this pathway |
| JECHLINGER EPITHELIAL TO MESENCHYMAL TRANSITION DN | 66 | 47 | All SZGR 2.0 genes in this pathway |
| SMITH TERT TARGETS DN | 87 | 69 | All SZGR 2.0 genes in this pathway |
| SCHURINGA STAT5A TARGETS UP | 21 | 13 | All SZGR 2.0 genes in this pathway |
| CHIBA RESPONSE TO TSA UP | 52 | 33 | All SZGR 2.0 genes in this pathway |
| KANG DOXORUBICIN RESISTANCE UP | 54 | 33 | All SZGR 2.0 genes in this pathway |
| GEORGANTAS HSC MARKERS | 71 | 47 | All SZGR 2.0 genes in this pathway |
| BURTON ADIPOGENESIS PEAK AT 2HR | 51 | 36 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 10HR UP | 101 | 69 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY FOXP3 UNSTIMULATED | 1229 | 713 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER CANCER DN | 540 | 340 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE DN | 274 | 165 | All SZGR 2.0 genes in this pathway |
| MITSIADES RESPONSE TO APLIDIN UP | 439 | 257 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER LUMINAL A UP | 84 | 52 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER BASAL DN | 701 | 446 | All SZGR 2.0 genes in this pathway |
| ZHENG GLIOBLASTOMA PLASTICITY DN | 58 | 39 | All SZGR 2.0 genes in this pathway |
| BOQUEST STEM CELL CULTURED VS FRESH DN | 31 | 25 | All SZGR 2.0 genes in this pathway |
| WEST ADRENOCORTICAL TUMOR DN | 546 | 362 | All SZGR 2.0 genes in this pathway |
| CHEN HOXA5 TARGETS 9HR UP | 223 | 132 | All SZGR 2.0 genes in this pathway |
| BLUM RESPONSE TO SALIRASIB DN | 342 | 220 | All SZGR 2.0 genes in this pathway |
| MILI PSEUDOPODIA CHEMOTAXIS DN | 457 | 302 | All SZGR 2.0 genes in this pathway |
| CROONQUIST STROMAL STIMULATION UP | 60 | 42 | All SZGR 2.0 genes in this pathway |
| CROONQUIST NRAS VS STROMAL STIMULATION DN | 99 | 65 | All SZGR 2.0 genes in this pathway |
| CHIANG LIVER CANCER SUBCLASS UNANNOTATED UP | 85 | 50 | All SZGR 2.0 genes in this pathway |
| GUTIERREZ WALDENSTROEMS MACROGLOBULINEMIA 1 DN | 9 | 7 | All SZGR 2.0 genes in this pathway |
| TIAN TNF SIGNALING NOT VIA NFKB | 22 | 16 | All SZGR 2.0 genes in this pathway |
| WONG ADULT TISSUE STEM MODULE | 721 | 492 | All SZGR 2.0 genes in this pathway |
| NAKAYAMA SOFT TISSUE TUMORS PCA2 DN | 80 | 51 | All SZGR 2.0 genes in this pathway |
| CHANDRAN METASTASIS DN | 306 | 191 | All SZGR 2.0 genes in this pathway |
| MARTENS BOUND BY PML RARA FUSION | 456 | 287 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP B | 549 | 316 | All SZGR 2.0 genes in this pathway |
| ZWANG CLASS 3 TRANSIENTLY INDUCED BY EGF | 222 | 159 | All SZGR 2.0 genes in this pathway |
Section VI. microRNA annotation
| miRNA family | Target position | miRNA ID | miRNA seq | ||
|---|---|---|---|---|---|
| UTR start | UTR end | Match method | |||
| miR-1/206 | 1471 | 1478 | 1A,m8 | hsa-miR-1 | UGGAAUGUAAAGAAGUAUGUA |
| hsa-miR-206SZ | UGGAAUGUAAGGAAGUGUGUGG | ||||
| hsa-miR-613 | AGGAAUGUUCCUUCUUUGCC | ||||
| miR-103/107 | 1458 | 1464 | 1A | hsa-miR-103brain | AGCAGCAUUGUACAGGGCUAUGA |
| hsa-miR-107brain | AGCAGCAUUGUACAGGGCUAUCA | ||||
| miR-128 | 883 | 889 | 1A | hsa-miR-128a | UCACAGUGAACCGGUCUCUUUU |
| hsa-miR-128b | UCACAGUGAACCGGUCUCUUUC | ||||
| miR-144 | 881 | 887 | m8 | hsa-miR-144 | UACAGUAUAGAUGAUGUACUAG |
| miR-148/152 | 2133 | 2139 | m8 | hsa-miR-148a | UCAGUGCACUACAGAACUUUGU |
| hsa-miR-152brain | UCAGUGCAUGACAGAACUUGGG | ||||
| hsa-miR-148b | UCAGUGCAUCACAGAACUUUGU | ||||
| miR-203.1 | 532 | 538 | m8 | hsa-miR-203 | UGAAAUGUUUAGGACCACUAG |
| miR-224 | 228 | 234 | m8 | hsa-miR-224 | CAAGUCACUAGUGGUUCCGUUUA |
| miR-23 | 644 | 651 | 1A,m8 | hsa-miR-23abrain | AUCACAUUGCCAGGGAUUUCC |
| hsa-miR-23bbrain | AUCACAUUGCCAGGGAUUACC | ||||
| miR-27 | 883 | 890 | 1A,m8 | hsa-miR-27abrain | UUCACAGUGGCUAAGUUCCGC |
| hsa-miR-27bbrain | UUCACAGUGGCUAAGUUCUGC | ||||
| miR-323 | 644 | 650 | 1A | hsa-miR-323brain | GCACAUUACACGGUCGACCUCU |
| miR-326 | 414 | 420 | 1A | hsa-miR-326 | CCUCUGGGCCCUUCCUCCAG |
| miR-329 | 101 | 107 | m8 | hsa-miR-329brain | AACACACCUGGUUAACCUCUUU |
| miR-338 | 867 | 873 | 1A | hsa-miR-338brain | UCCAGCAUCAGUGAUUUUGUUGA |
| miR-369-3p | 1588 | 1594 | 1A | hsa-miR-369-3p | AAUAAUACAUGGUUGAUCUUU |
| miR-370 | 841 | 847 | m8 | hsa-miR-370brain | GCCUGCUGGGGUGGAACCUGG |
| miR-374 | 1588 | 1594 | m8 | hsa-miR-374 | UUAUAAUACAACCUGAUAAGUG |
| miR-409-3p | 1470 | 1476 | m8 | hsa-miR-409-3p | CGAAUGUUGCUCGGUGAACCCCU |
| miR-410 | 1590 | 1596 | 1A | hsa-miR-410 | AAUAUAACACAGAUGGCCUGU |