Gene Page:POLA2

Summary?
GeneID 23649
Symbol POLA2
Synonyms -
Description polymerase (DNA) alpha 2, accessory subunit
Reference HGNC:HGNC:30073|Ensembl:ENSG00000014138|HPRD:10160|Vega:OTTHUMG00000165951
Gene type protein-coding
Map location 11q13.1
Pascal p-value 0.157
Sherlock p-value 0.412
Fetal beta 0.34
DMG 1 (# studies)
eGene Caudate basal ganglia
Cortex
元

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg21257117 11 65029643 POLA2 2.45E-8 -0.011 7.95E-6 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
AKTIP FT1 | FTS AKT interacting protein Two-hybrid BioGRID 16169070
ASCC2 ASC1p100 activating signal cointegrator 1 complex subunit 2 Two-hybrid BioGRID 16169070
ATP5C1 ATP5C | ATP5CL1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 Two-hybrid BioGRID 16169070
C8orf30A FLJ40907 chromosome 8 open reading frame 30A Two-hybrid BioGRID 16169070
C9orf25 FLJ39031 | bA573M23.5 chromosome 9 open reading frame 25 Two-hybrid BioGRID 16169070
CPE - carboxypeptidase E Two-hybrid BioGRID 16169070
CRELD1 AVSD2 | CIRRIN | DKFZp566D213 cysteine-rich with EGF-like domains 1 Two-hybrid BioGRID 16169070
DDX24 - DEAD (Asp-Glu-Ala-Asp) box polypeptide 24 Two-hybrid BioGRID 16169070
DHX34 DDX34 | HRH1 | KIAA0134 DEAH (Asp-Glu-Ala-His) box polypeptide 34 Two-hybrid BioGRID 16169070
EIF6 2 | CAB | EIF3A | ITGB4BP | b | b(2)gcn | gcn | p27BBP eukaryotic translation initiation factor 6 Two-hybrid BioGRID 16169070
EZH2 ENX-1 | EZH1 | KMT6 | MGC9169 enhancer of zeste homolog 2 (Drosophila) Two-hybrid BioGRID 16169070
FGFR3 ACH | CD333 | CEK2 | HSFGFR3EX | JTK4 fibroblast growth factor receptor 3 Two-hybrid BioGRID 16169070
HELB - helicase (DNA) B - HPRD,BioGRID 12181327
IGFBP3 BP-53 | IBP3 insulin-like growth factor binding protein 3 Two-hybrid BioGRID 16169070
KLF6 BCD1 | COPEB | CPBP | DKFZp686N0199 | GBF | PAC1 | ST12 | ZF9 Kruppel-like factor 6 Two-hybrid BioGRID 16169070
LRPAP1 A2MRAP | A2RAP | HBP44 | MGC138272 | MRAP | RAP low density lipoprotein receptor-related protein associated protein 1 Two-hybrid BioGRID 16169070
NHP2L1 15.5K | FA-1 | FA1 | NHPX | OTK27 | SNU13 | SPAG12 | SSFA1 NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae) Two-hybrid BioGRID 16169070
PARP1 ADPRT | ADPRT1 | PARP | PARP-1 | PPOL | pADPRT-1 poly (ADP-ribose) polymerase 1 - HPRD,BioGRID 9518481
POLA1 DKFZp686K1672 | POLA | p180 polymerase (DNA directed), alpha 1, catalytic subunit - HPRD,BioGRID 8223465|12546699
PRIM1 MGC12308 | p49 引发酶、DNA、多肽1 (49 kda) - HPRD 9705292
PRIM2 MGC75142 | PRIM2A | p58 primase, DNA, polypeptide 2 (58kDa) - HPRD 9705292
PRPF38A FLJ14936 | MGC3320 | RP5-965L7.1 PRP38 pre-mRNA processing factor 38 (yeast) domain containing A Two-hybrid BioGRID 16169070
RBM23 CAPERbeta | FLJ10482 | MGC4458 | PP239 | RNPC4 RNA binding motif protein 23 Two-hybrid BioGRID 16169070
SETDB1 ESET | KG1T | KIAA0067 | KMT1E SET domain, bifurcated 1 Two-hybrid BioGRID 16169070
STK40 MGC4796 | RP11-268J15.4 | SHIK | SgK495 serine/threonine kinase 40 Two-hybrid BioGRID 16169070
ULK2 KIAA0623 | Unc51.2 unc-51-like kinase 2 (C. elegans) Two-hybrid BioGRID 16169070
XPNPEP1 SAMP | XPNPEP | XPNPEPL | XPNPEPL1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble Two-hybrid BioGRID 16169070


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG PURINE METABOLISM 159 96 All SZGR 2.0 genes in this pathway
KEGG PYRIMIDINE METABOLISM 98 53 All SZGR 2.0 genes in this pathway
KEGG DNA REPLICATION 36 21 All SZGR 2.0 genes in this pathway
反应OME ACTIVATION OF THE PRE REPLICATIVE COMPLEX 31 16 All SZGR 2.0 genes in this pathway
反应OME CELL CYCLE 421 253 All SZGR 2.0 genes in this pathway
反应OME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND 15 10 All SZGR 2.0 genes in this pathway
反应OME CELL CYCLE MITOTIC 325 185 All SZGR 2.0 genes in this pathway
反应OME M G1 TRANSITION 81 45 All SZGR 2.0 genes in this pathway
反应OME G1 S TRANSITION 112 63 All SZGR 2.0 genes in this pathway
反应OME POL SWITCHING 13 9 All SZGR 2.0 genes in this pathway
反应OME SYNTHESIS OF DNA 92 53 All SZGR 2.0 genes in this pathway
反应OME MITOTIC G1 G1 S PHASES 137 79 All SZGR 2.0 genes in this pathway
反应OME MITOTIC M M G1 PHASES 172 98 All SZGR 2.0 genes in this pathway
反应OME CHROMOSOME MAINTENANCE 122 80 All SZGR 2.0 genes in this pathway
反应OME LAGGING STRAND SYNTHESIS 19 12 All SZGR 2.0 genes in this pathway
反应OME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 13 6 All SZGR 2.0 genes in this pathway
反应OME DNA REPLICATION 192 110 All SZGR 2.0 genes in this pathway
反应OME E2F MEDIATED REGULATION OF DNA REPLICATION 35 17 All SZGR 2.0 genes in this pathway
反应OME TELOMERE MAINTENANCE 75 57 All SZGR 2.0 genes in this pathway
反应OME EXTENSION OF TELOMERES 27 17 All SZGR 2.0 genes in this pathway
反应OME S PHASE 109 66 All SZGR 2.0 genes in this pathway
反应OME DNA STRAND ELONGATION 30 18 All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN 431 263 All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663 425 All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL DN 244 153 All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS UP 290 177 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530 342 All SZGR 2.0 genes in this pathway
BERENJENO通过RHOA转换 536 340 All SZGR 2.0 genes in this pathway
ROSTY CERVICAL CANCER PROLIFERATION CLUSTER 140 73 All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP 414 287 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP 479 299 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 UP 209 139 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN 637 377 All SZGR 2.0 genes in this pathway
CAFFAREL RESPONSE TO THC 8HR 3 DN 10 7 All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893 528 All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPAIR GENES 230 137 All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPLICATION GENES 147 87 All SZGR 2.0 genes in this pathway
MANALO HYPOXIA DN 289 166 All SZGR 2.0 genes in this pathway
REN BOUND BY E2F 61 40 All SZGR 2.0 genes in this pathway
FERRANDO T ALL WITH MLL ENL FUSION DN 87 57 All SZGR 2.0 genes in this pathway
KANG DOXORUBICIN RESISTANCE UP 54 33 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR UP 180 125 All SZGR 2.0 genes in this pathway
LEE AGING MUSCLE DN 46 29 All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN 287 208 All SZGR 2.0 genes in this pathway
KALMA E2F1 TARGETS 11 7 All SZGR 2.0 genes in this pathway
王顺铂RESPONSE AND XPC UP 202 115 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS PEAK AT 16HR 40 24 All SZGR 2.0 genes in this pathway
SANSOM APC MYC TARGETS 217 138 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN 270 181 All SZGR 2.0 genes in this pathway
FUJII YBX1 TARGETS DN 202 132 All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN 342 220 All SZGR 2.0 genes in this pathway
FRASOR RESPONSE TO SERM OR FULVESTRANT DN 50 29 All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR DN 277 166 All SZGR 2.0 genes in this pathway
KOBAYASHI EGFR SIGNALING 24HR DN 251 151 All SZGR 2.0 genes in this pathway
ZEMBUTSU SENSITIVITY TO METHOTREXATE 18 9 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 6HR UP 229 149 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR UP 324 193 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP 570 339 All SZGR 2.0 genes in this pathway
FOSTER KDM1A TARGETS DN 211 119 All SZGR 2.0 genes in this pathway