SZGR2 - Beplay体育中心

Summary？

基因	23657
象征	SLC7A11
Synonyms	ccbr1 \| xct
Description	Solute Carrier家族7成员11
参考erence	MIM：607933\|HGNC：HGNC：11059\|ENSEMBL：ENSG00000151012\|HPRD：09720\|Vega：Otthumg00000133396
基因类型	蛋白质编码
Map location	4Q28.3
pascal p-value	0.263
Sherlock p-value	0.086
tADA p-value	0.01
胎儿β	-0.983
主持人	Myers' cis & trans 元

Gene in Data Sources

基因集名称	Method of gene set	Description	信息
CV:GWASdb	Genome-wide Association Studies	精神分裂症的GWASDB记录
CV:PGCnp	全基因组协会研究	GWAS
DNM：McCarthy_2014	全外显子组测序分析	Whole exome sequencing of 57 trios with sporadic or familial schizophrenia.
PMID：cooccur	High-throughput literature-search	PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	点击显示详细信息
go_annotation	将与神经相关的关键字映射到基因本体论注释	与神经相关的关键字的命中：1

Section I. Genetics and epigenetics annotation

DNM表

Gene	染色体	位置	参考	alt	成绩单	AA更改	Mutation type	筛	CG46	特征	学习
SLC7A11	CHR4	139104371	t	G	NM_014331	p.V335G	错过SNV	C	p	Schizophrenia	DNM：McCarthy_2014

EQTL注释

SNP ID	染色体	位置	主持人	Gene Entrez ID	pvalue	QVALUE	TSS距离	EQTL类型
RS5944690	Chrx	24873721	SLC7A11	23657		0.17		反式

第二节。转录组注释

一般基因表达（GTEX）

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

No co-expressed genes in brain regions

第三节。基因本体论注释

分子功能	去学期	证据	神经关键字	PubMed ID
GO：0015327	cystine:glutamate antiporter activity	tAS	glutamate (GO term level: 10)	10206947
GO：0015171	氨基酸跨膜转运蛋白活性	IEA		-
生物过程	去学期	证据	神经关键字	PubMed ID
GO:0006810	运输	IEA		-
去：0006865	氨基酸转运	IEA		-
Cellular component	去学期	证据	神经关键字	PubMed ID
去：0016020	membrane	IEA		-
GO：0016021	膜不可或缺	tAS		10206947

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
反应组细胞表面相互作用在血管壁	91	65	All SZGR 2.0 genes in this pathway
Reactome Basigin相互作用	30	23	All SZGR 2.0 genes in this pathway
REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	31	21	All SZGR 2.0 genes in this pathway
小分子的反应组跨膜转运	413	270	All SZGR 2.0 genes in this pathway
Reactome SLC介导的跨膜运输	241	157	All SZGR 2.0 genes in this pathway
REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	94	65	All SZGR 2.0 genes in this pathway
反应组氨基酸和寡肽SLC转运蛋白	49	36	All SZGR 2.0 genes in this pathway
反应组止血	466	331	All SZGR 2.0 genes in this pathway
NAKAMURA CANCER MICROENVIRONMENT DN	46	29	All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 UP	408	247	All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP	579	346	All SZGR 2.0 genes in this pathway
Gary CD5目标	473	314	All SZGR 2.0 genes in this pathway
纽曼ERCC6靶向	26	18	All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS DN	384	230	All SZGR 2.0 genes in this pathway
Gargalovic对氧化磷脂的反应绿松石	79	50	All SZGR 2.0 genes in this pathway
tONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC UP	185	126	All SZGR 2.0 genes in this pathway
runx1 runx1t1融合红细胞的TONKS目标	157	104	All SZGR 2.0 genes in this pathway
runx1 runx1t1融合的TONKS目标维持在红细胞中	44	30	All SZGR 2.0 genes in this pathway
Senese HDAC1靶向	457	269	All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP	501	327	All SZGR 2.0 genes in this pathway
Mayburd对L663536的回应	29	18	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP	633	376	All SZGR 2.0 genes in this pathway
甲状腺癌的甲状腺癌间变性	722	443	All SZGR 2.0 genes in this pathway
IGF1和IGF2的Pacher靶标	35	27	All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP	239	157	All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS C DN	19	11	All SZGR 2.0 genes in this pathway
KAN RESPONSE TO ARSENIC TRIOXIDE	123	80	All SZGR 2.0 genes in this pathway
roversi神经胶质瘤副本编号	100	75	All SZGR 2.0 genes in this pathway
牛津拉拉对准	9	7	All SZGR 2.0 genes in this pathway
Pujana ATM PCC网络	1442	892	All SZGR 2.0 genes in this pathway
通过ELK3 DN的缺氧总缺氧	156	106	All SZGR 2.0 genes in this pathway
仅通过ELK3的高缺氧	33	18	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN	1024	594	All SZGR 2.0 genes in this pathway
buytaert光动力疗法压力	811	508	All SZGR 2.0 genes in this pathway
狮子转移	539	324	All SZGR 2.0 genes in this pathway
FLI1和DAX1 DN的Garcia目标	176	104	All SZGR 2.0 genes in this pathway
里克曼头颈癌E	89	44	All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS	988	594	All SZGR 2.0 genes in this pathway
Benporath SOX2目标	734	436	All SZGR 2.0 genes in this pathway
Amit EGF响应240 HELA	60	43	All SZGR 2.0 genes in this pathway
Amit EGF响应240 MCF10A	20	13	All SZGR 2.0 genes in this pathway
Mir192和Mir215的Georges目标	893	528	All SZGR 2.0 genes in this pathway
Okumura炎症反应LPS	183	115	All SZGR 2.0 genes in this pathway
Zhan多发性骨髓瘤CD1	45	29	All SZGR 2.0 genes in this pathway
Zhan多发性骨髓瘤CD1 vs CD2 UP	66	47	All SZGR 2.0 genes in this pathway
麦克拉克兰牙齿龋齿DN	245	144	All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1	419	273	All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES UP	253	147	All SZGR 2.0 genes in this pathway
道格拉斯BMI1靶向DN	314	188	All SZGR 2.0 genes in this pathway
磷酸氨基酸剥夺	29	20	All SZGR 2.0 genes in this pathway
Krige对Tosedostat 6小时的反应	953	554	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP	783	442	All SZGR 2.0 genes in this pathway
促进耐受巨噬细胞	156	92	All SZGR 2.0 genes in this pathway
海勒被甲基化DN沉默	105	67	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN	292	189	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN	281	179	All SZGR 2.0 genes in this pathway
黄Foxa2靶向	45	28	All SZGR 2.0 genes in this pathway
tOYOTA TARGETS OF MIR34B AND MIR34C	463	262	All SZGR 2.0 genes in this pathway
IZADPANAH STEM CELL ADIPOSE VS BONE UP	126	92	All SZGR 2.0 genes in this pathway
Boquest干细胞培养与新鲜	425	298	All SZGR 2.0 genes in this pathway
西部肾上腺皮质肿瘤	294	199	All SZGR 2.0 genes in this pathway
podar对Apaphostin的反应	147	98	All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C CLUSTER DN	32	21	All SZGR 2.0 genes in this pathway
Takeer吉西他滨抗性DN	122	84	All SZGR 2.0 genes in this pathway
Lindstedt树突状细胞成熟A	67	52	All SZGR 2.0 genes in this pathway
Rutella对CSF2RB和IL4的响应	338	225	All SZGR 2.0 genes in this pathway
Rutella对HGF的反应	418	282	All SZGR 2.0 genes in this pathway
Rutella对HGF与CSF2RB和IL4的反应	408	276	All SZGR 2.0 genes in this pathway
张TLX目标36hr	221	150	All SZGR 2.0 genes in this pathway
Han Satb1靶向DN	442	275	All SZGR 2.0 genes in this pathway
MIKKELSEN NPC ICP WITH H3K4ME3	445	257	All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 UP	397	206	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN	918	550	All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS UP	259	159	All SZGR 2.0 genes in this pathway
Kim Pten的目标	18	9	All SZGR 2.0 genes in this pathway
ERBB2同工型的Pedersen转移1	46	33	All SZGR 2.0 genes in this pathway
Fortschegger PHF8靶向	279	155	All SZGR 2.0 genes in this pathway
Pedrioli mir31靶向DN	418	245	All SZGR 2.0 genes in this pathway
Smirnov对IR 2小时的回应	53	33	All SZGR 2.0 genes in this pathway
ghandhi直接辐照	110	68	All SZGR 2.0 genes in this pathway
ghandhi旁观者辐照	86	54	All SZGR 2.0 genes in this pathway
Zwang EGF间隔	105	46	All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族	target position			miRNA ID	mirna seq
mirna家族	UTR开始	UTR结束	匹配方法	miRNA ID	mirna seq
miR-128	402	408	1a	hsa-miR-128a	ucacagugaaccggucuuuu
miR-128	402	408	1a	hsa-miR-128b	ucacagugaaccggucuuc
mir - 142 - 3 - p	5397	5403	M8	HSA-MIR-142-3P	UGUAGUGUUUCCUACUUUAUGGA
miR-144	400	406	M8	HSA-MIR-144	UACAGUAUAGAUGAUGUACUAG
mir-148/152	6673	6679	M8	HSA-MIR-148A	ucagugcacuacaacuuugu
				HSA-MIR-152^brain	UCAGUGCAUGACACUUGGG
				HSA-MIR-148B	ucagugcaucacacaacuuugu
miR-26	7806	7813	1A，M8	HSA-MIR-26A^brain	UUCAAGUAAUCCAGGAUAGGC
miR-26	7806	7813	1A，M8	HSA-MIR-26B^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-27	402	409	1A，M8	HSA-MIR-27A^brain	uucacaguggcuaaguuccgc
miR-27	402	409	1A，M8	HSA-MIR-27B^brain	uucacaguggcuaaguucugc
mir-30-5p	7850	7856	1a	HSA-MIR-30A-5P	uguaaaacauccuccugagaag
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	uguaaacauccuaccucucagcu
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-375	564	570	1a	HSA-MIR-375	uuuguucguucggcucgcguga
mir-448	200	206	M8	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU

SZ：在精神分裂症患者的脑皮质中差异表达的miRNA与使用微阵列进行对照样品进行比较。点击hereto see the list of SZ related miRNAs.
大脑：基于miRNA微阵列表达研究在大脑中表达的miRNA。点击here查看与大脑相关的miRNA列表。

Gene Page:SLC7A11