Gene Page:FKBP8

Summary?
GeneID 23770
Symbol FKBP8
Synonyms FKBP38|FKBPr38
Description FK506 binding protein 8
Reference MIM:604840|HGNC:HGNC:3724|Ensembl:ENSG00000105701|HPRD:05327|Vega:OTTHUMG00000183368
Gene type protein-coding
Map location 19p12
Pascal p-value 0.06
Sherlock p-value 0.025
Fetal beta -0.719
eGene Myers' cis & trans
Support CompositeSet
Darnell FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0265

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs17204260 chr18 67195940 FKBP8 23770 0.09 trans
rs17204309 chr18 67196019 FKBP8 23770 0.09 trans
rs17204373 chr18 67196110 FKBP8 23770 0.13 trans
rs17204401 chr18 67196217 FKBP8 23770 0.09 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IEA -
GO:0005488 binding IEA -
GO:0005509 calcium ion binding IEA -
GO:0016853 isomerase activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0001708 cell fate specification IEA -
GO:0006457 protein folding IEA -
GO:0007242 intracellular signaling cascade TAS 10197430
GO:0007224 smoothened signaling pathway IEA -
GO:0009953 dorsal/ventral pattern formation IEA -
GO:0006915 apoptosis IEA -
GO:0043010 camera-type eye development IEA -
GO:0044419 interspecies interaction between organisms IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005739 mitochondrion IEA -
GO:0016020 membrane IEA -
GO:0016021 integral to membrane IEA -
GO:0030176 integral to endoplasmic reticulum membrane IEA -
GO:0031966 mitochondrial membrane IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PID NFAT 3PATHWAY 54 47 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508 354 All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING VIA SMAD4 UP 108 66 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE UP 203 130 All SZGR 2.0 genes in this pathway
HEDENFALK BREAST CANCER BRACX DN 20 14 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
KAAB FAILED HEART ATRIUM UP 38 30 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504 323 All SZGR 2.0 genes in this pathway
KIM GASTRIC CANCER CHEMOSENSITIVITY 103 64 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR DN 178 121 All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING 510 309 All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871 505 All SZGR 2.0 genes in this pathway
YAGI AML WITH T 8 21 TRANSLOCATION 368 247 All SZGR 2.0 genes in this pathway
STEIN ESR1 TARGETS 85 55 All SZGR 2.0 genes in this pathway
NIELSEN GIST 98 66 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080 713 All SZGR 2.0 genes in this pathway