Gene Page:MTCH1

Summary?
GeneID 23787
Symbol MTCH1
Synonyms CGI-64|PIG60|PSAP|SLC25A49
Description mitochondrial carrier 1
Reference MIM:610449|HGNC:HGNC:17586|Ensembl:ENSG00000137409|HPRD:14787|Vega:OTTHUMG00000014614
Gene type protein-coding
Map location 6p21.2
Pascal p-value 0.304
Sherlock p-value 0.335
Fetal beta -1.887
DMG 1 (# studies)
eGene Hypothalamus
Myers' cis & trans
元
Support G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_mitochondria

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
GSMA_I Genome scan meta-analysis Psr: 0.033
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.04433
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg12592908 6 36954170 MTCH1 4.132E-4 -0.349 0.044 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs9366917 chr6 36790665 MTCH1 23787 0.14 cis

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005488 binding IEA -
GO:0005515 protein binding 新闻学会 12377771
GO:0005515 protein binding ISS -
GO:0030165 PDZ domain binding NAS 10551805
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0045161 neuronal ion channel clustering NAS neuron (GO term level: 11) 10551805
GO:0009966 regulation of signal transduction NAS 10551805
GO:0006810 transport IEA -
GO:0006919 caspase activation IMP 12377771
GO:0006919 caspase activation ISS -
GO:0043065 positive regulation of apoptosis IEP 12377771
GO:0043065 positive regulation of apoptosis ISS -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005622 intracellular NAS 10551805
GO:0005739 mitochondrion IMP 12377771
GO:0005739 mitochondrion ISS -
GO:0005743 mitochondrial inner membrane IEA -
GO:0016020 membrane IEA -
GO:0016021 integral to membrane IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
OSMAN BLADDER CANCER DN 406 230 All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP 557 331 All SZGR 2.0 genes in this pathway
ALCALA APOPTOSIS 88 60 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 12HR DN 57 45 All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE UP 157 105 All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475 313 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681 420 All SZGR 2.0 genes in this pathway
LEIN LOCALIZED TO PROXIMAL DENDRITES 37 26 All SZGR 2.0 genes in this pathway
STEARMAN LUNG CANCER EARLY VS LATE UP 125 89 All SZGR 2.0 genes in this pathway
MOOTHA HUMAN MITODB 6 2002 429 260 All SZGR 2.0 genes in this pathway
MOOTHA MITOCHONDRIA 447 277 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA D CLUSTER DN 40 26 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA D DN 78 34 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137 655 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-330 416 422 m8 hsa-miR-330brain GCAAAGCACACGGCCUGCAGAGA