Gene Page:CADM2

Summary?
GeneID 253559
Symbol CADM2
Synonyms IGSF4D|NECL3|Necl-3|SynCAM 2|synCAM2
Description cell adhesion molecule 2
Reference MIM: 609938|HGNC:HGNC:29849|Ensembl:ENSG00000175161|HPRD:11046|Vega:OTTHUMG00000158990
Gene type protein-coding
Map location 3p12.1
Pascal p-value 0.146
DMG 1 (# studies)
eGene Cortex
Myers' cis & trans
Support CELL ADHESION AND TRANSSYNAPTIC SIGNALING

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.04359
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.04047
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg04416247 3 85213671 CADM2 2.455E-4 0.511 0.037 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs16894557 chr6 28999825 CADM2 253559 0.18 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Cellular component 去term Evidence Neuro keywords PubMed ID
GO:0016020 membrane IEA -
GO:0016021 integral to membrane IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME CELL CELL COMMUNICATION 120 77 All SZGR 2.0 genes in this pathway
REACTOME ADHERENS JUNCTIONS INTERACTIONS 27 20 All SZGR 2.0 genes in this pathway
REACTOME CELL CELL JUNCTION ORGANIZATION 56 31 All SZGR 2.0 genes in this pathway
REACTOME CELL JUNCTION ORGANIZATION 78 43 All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS DN 120 81 All SZGR 2.0 genes in this pathway
ZHENG GLIOBLASTOMA PLASTICITY UP 250 168 All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE UP 149 85 All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE DN 264 159 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080 713 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-101 176 182 1A hsa-miR-101 UACAGUACUGUGAUAACUGAAG
miR-124.1 261 267 1A hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-140 1180 1186 1A hsa-miR-140brain AGUGGUUUUACCCUAUGGUAG
miR-141/200a 1974 1980 1A hsa-miR-141 UAACACUGUCUGGUAAAGAUGG
hsa - mir - 200 a UAACACUGUCUGGUAACGAUGU
miR-143 277 283 m8 hsa-miR-143brain UGAGAUGAAGCACUGUAGCUCA
miR-144 176 182 1A hsa-miR-144 UACAGUAUAGAUGAUGUACUAG
miR-153 1345 1351 m8 hsa-miR-153 UUGCAUAGUCACAAAAGUGA
miR-17-5p/20/93.mr/106/519.d 1929 1935 m8 hsa-miR-17-5p CAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519d CAAAGUGCCUCCCUUUAGAGUGU
miR-182 1276 1283 1A,m8 hsa-miR-182 UUUGGCAAUGGUAGAACUCACA
miR-186 166 173 1A,m8 hsa-miR-186 CAAAGAAUUCUCCUUUUGGGCUU
hsa-miR-186 CAAAGAAUUCUCCUUUUGGGCUU
miR-203.1 199 205 m8 hsa-miR-203 UGAAAUGUUUAGGACCACUAG
miR-21 1140 1146 1A hsa-miR-21brain UAGCUUAUCAGACUGAUGUUGA
hsa-miR-590 GAGCUUAUUCAUAAAAGUGCAG
miR-218 1111 1118 1A,m8 hsa-miR-218brain UUGUGCUUGAUCUAACCAUGU
miR-30-5p 457 463 1A hsa-miR-30a-5p UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ UGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZ UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
miR-338 39 46 1A,m8 hsa-miR-338brain UCCAGCAUCAGUGAUUUUGUUGA
miR-34b 816 822 1A hsa-miR-34b UAGGCAGUGUCAUUAGCUGAUUG
miR-369-3p 1006 1012 1A hsa-miR-369-3p AAUAAUACAUGGUUGAUCUUU
miR-374 1006 1013 1A,m8 hsa-miR-374 UUAUAAUACAACCUGAUAAGUG
miR-485-5p 1159 1166 1A,m8 hsa-miR-485-5p AGAGGCUGGCCGUGAUGAAUUC
miR-495 1096 1102 1A hsa-miR-495brain AAACAAACAUGGUGCACUUCUUU
miR-543 565 571 m8 hsa-miR-543 AAACAUUCGCGGUGCACUUCU
hsa-miR-543 AAACAUUCGCGGUGCACUUCU
hsa-miR-543 AAACAUUCGCGGUGCACUUCU
miR-93.hd/291-3p/294/295/302/372/373/520 1928 1934 m8 hsa-miR-93brain AAAGUGCUGUUCGUGCAGGUAG
hsa-miR-302a UAAGUGCUUCCAUGUUUUGGUGA
hsa-miR-302b UAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302c UAAGUGCUUCCAUGUUUCAGUGG
hsa-miR-302d UAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372 AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373 GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520e AAAGUGCUUCCUUUUUGAGGG
hsa-miR-520a AAAGUGCUUCCCUUUGGACUGU
hsa-miR-520b AAAGUGCUUCCUUUUAGAGGG
hsa-miR-520c AAAGUGCUUCCUUUUAGAGGGUU
hsa-miR-520d AAAGUGCUUCUCUUUGGUGGGUU
miR-96 1277 1283 1A hsa-miR-96brain UUUGGCACUAGCACAUUUUUGC