Gene Page:RNF144B

Summary?
GeneID 255488
Symbol RNF144B
Synonyms IBRDC2|PIR2|bA528A10.3|p53RFP
Description ring finger protein 144B
Reference HGNC:HGNC:21578|Ensembl:ENSG00000137393|HPRD:17126|Vega:OTTHUMG00000014322
Gene type protein-coding
Map location 6p22.3
Pascal p-value 0.216
Sherlock p-value 0.649
Fetal beta -2.435
DMG 1 (# studies)
eGene Myers' cis & trans

基因数据urces
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:vanEijk_2014 Genome-wide DNA methylation analysis This dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 1
GSMA_I Genome scan meta-analysis Psr: 0.033

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg00772000 6 18123049 RNF144B 1.502E-4 -6.055 DMG:vanEijk_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs2804591 chr10 113787568 RNF144B 255488 0.08 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0005515 protein binding 新闻学会 12853982
GO:0004842 ubiquitin-protein ligase activity IDA 12853982
GO:0016874 ligase activity IEA -
GO:0008270 zinc ion binding IEA -
GO:0009055 electron carrier activity IEA -
GO:0046872 metal ion binding IEA -
GO:0051536 iron-sulfur cluster binding IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0006915 apoptosis IEA -
GO:0042787 protein ubiquitination during ubiquitin-dependent protein catabolic process IDA 12853982
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0000151 ubiquitin ligase complex IC 12853982
GO:0016020 membrane IEA -
GO:0016021 integral to membrane ISS -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PID P53 DOWNSTREAM PATHWAY 137 94 所有SZGR 2.0基因通路
REACTOME IMMUNE SYSTEM 933 616 所有SZGR 2.0基因通路
REACTOME适应性IMMUNE SYSTEM 539 350 所有SZGR 2.0基因通路
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 251 156 所有SZGR 2.0基因通路
REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 212 129 所有SZGR 2.0基因通路
ZHOU INFLAMMATORY RESPONSE LIVE UP 485 293 所有SZGR 2.0基因通路
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL UP 450 256 所有SZGR 2.0基因通路
CHARAFE BREAST CANCER BASAL VS MESENCHYMAL UP 121 45 所有SZGR 2.0基因通路
WANG LMO4 TARGETS UP 372 227 所有SZGR 2.0基因通路
ODONNELL TFRC TARGETS UP 456 228 所有SZGR 2.0基因通路
ZHOU INFLAMMATORY RESPONSE FIMA UP 544 308 所有SZGR 2.0基因通路
ZHOU INFLAMMATORY RESPONSE LPS UP 431 237 所有SZGR 2.0基因通路
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN 805 505 所有SZGR 2.0基因通路
GOZGIT ESR1 TARGETS DN 781 465 所有SZGR 2.0基因通路
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552 347 所有SZGR 2.0基因通路
GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION UP 211 136 所有SZGR 2.0基因通路
GAUSSMANN MLL AF4 FUSION TARGETS E UP 97 60 所有SZGR 2.0基因通路
PEREZ TP53 TARGETS 1174 695 所有SZGR 2.0基因通路
FALVELLA SMOKERS WITH LUNG CANCER 80 52 所有SZGR 2.0基因通路
NIKOLSKY BREAST CANCER 6P24 P22 AMPLICON 21 17 所有SZGR 2.0基因通路
SHEPARD CRUSH AND BURN MUTANT UP 197 110 所有SZGR 2.0基因通路
SHEPARD BMYB MORPHOLINO UP 205 126 所有SZGR 2.0基因通路
CREIGHTON ENDOCRINE THERAPY RESISTANCE 5 482 296 所有SZGR 2.0基因通路
KONDO EZH2 TARGETS 245 148 所有SZGR 2.0基因通路
MASSARWEH TAMOXIFEN RESISTANCE UP 578 341 所有SZGR 2.0基因通路
LEE RECENT THYMIC EMIGRANT 227 128 所有SZGR 2.0基因通路
MEISSNER NPC HCP WITH H3K4ME2 491 319 所有SZGR 2.0基因通路
DUTERTRE ESTRADIOL RESPONSE 6HR DN 91 56 所有SZGR 2.0基因通路
DUTERTRE ESTRADIOL RESPONSE 24HR DN 505 328 所有SZGR 2.0基因通路
PILON KLF1 TARGETS DN 1972 1213 所有SZGR 2.0基因通路
BHAT ESR1 TARGETS NOT VIA AKT1 DN 88 61 所有SZGR 2.0基因通路
BHAT ESR1 TARGETS VIA AKT1 DN 82 51 所有SZGR 2.0基因通路
WINZEN DEGRADED VIA KHSRP 100 70 所有SZGR 2.0基因通路
WANG MLL TARGETS 289 188 所有SZGR 2.0基因通路
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 所有SZGR 2.0基因通路

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-125/351 2060 2066 m8 hsa-miR-125bbrain UCCCUGAGACCCUAACUUGUGA
hsa-miR-125abrain UCCCUGAGACCCUUUAACCUGUG
miR-15/16/195/424/497 1643 1650 1A,m8 hsa-miR-15abrain UAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brain UAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrain UAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZ UAGCAGCACAGAAAUAUUGGC
hsa-miR-424 CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497 CAGCAGCACACUGUGGUUUGU
miR-182 90 96 m8 hsa-miR-182 UUUGGCAAUGGUAGAACUCACA
miR-31 89 95 1A hsa-miR-31 AGGCAAGAUGCUGGCAUAGCUG
miR-331 2062 2068 1A hsa-miR-331brain GCCCCUGGGCCUAUCCUAGAA
miR-503 1644 1650 1A hsa-miR-503 UAGCAGCGGGAACAGUUCUGCAG