Gene Page:GABRA5

Summary?
GeneID 2558
Symbol GABRA5
Synonyms -
Description gamma-aminobutyric acid type A receptor alpha5 subunit
Reference MIM:137142|HGNC:HGNC:4079|Ensembl:ENSG00000186297|HPRD:08840|Vega:OTTHUMG00000171824
Gene type protein-coding
Map location 15q12
Pascal p-value 1.066E-4
Sherlock p-value 0.128
Fetal beta -2.408
eGene Myers' cis & trans
Support LIGAND GATED ION SIGNALING
Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene set Description Info
CNV:YES Copy number variation studies Manual curation
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search 系统的搜索in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 4

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs216269 chr19 3012882 GABRA5 2558 0.09 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0030594 neurotransmitter receptor activity IEA Neurotransmitter (GO term level: 5) -
GO:0004890 GABA-A receptor activity IEA GABA (GO term level: 7) -
GO:0005254 chloride channel activity IEA -
GO:0005215 transporter activity TAS 1321750
GO:0005216 ion channel activity IEA -
GO:0005230 extracellular ligand-gated ion channel activity IEA -
GO:0031404 chloride ion binding IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007214 gamma-aminobutyric acid signaling pathway IEA GABA, Neurotransmitter (GO term level: 8) -
GO:0001662 行为恐惧反应 IEA -
GO:0007165 signal transduction TAS 1321750
GO:0008306 associative learning IEA -
GO:0006821 chloride transport IEA -
GO:0006811 ion transport IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0045211 postsynaptic membrane IEA Synap, Neurotransmitter (GO term level: 5) -
GO:0045202 synapse IEA neuron, Synap, Neurotransmitter, Glial (GO term level: 2) -
GO:0005886 plasma membrane IEA -
GO:0005887 integral to plasma membrane TAS 1321750
GO:0030054 cell junction IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272 195 All SZGR 2.0 genes in this pathway
BIOCARTA GABA PATHWAY 10 10 All SZGR 2.0 genes in this pathway
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES 186 155 All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM 279 221 All SZGR 2.0 genes in this pathway
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 137 110 All SZGR 2.0 genes in this pathway
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413 270 All SZGR 2.0 genes in this pathway
REACTOME GABA A RECEPTOR ACTIVATION 12 12 All SZGR 2.0 genes in this pathway
REACTOME GABA RECEPTOR ACTIVATION 52 40 All SZGR 2.0 genes in this pathway
REACTOME ION CHANNEL TRANSPORT 55 42 All SZGR 2.0 genes in this pathway
REACTOME LIGAND GATED ION CHANNEL TRANSPORT 21 21 All SZGR 2.0 genes in this pathway
LIEN BREAST CARCINOMA METAPLASTIC VS DUCTAL UP 83 51 All SZGR 2.0 genes in this pathway
BENPORATH ES 1 379 235 All SZGR 2.0 genes in this pathway
MARCHINI TRABECTEDIN RESISTANCE DN 49 34 All SZGR 2.0 genes in this pathway
CROONQUIST STROMAL STIMULATION UP 60 42 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 AND H3K27ME3 349 234 All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435 318 All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K27ME3 341 243 All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590 403 All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP 548 370 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP D 280 158 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-30-5p 271 277 1A hsa-miR-30a-5p UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ UGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZ UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
miR-378 101 107 1A hsa-miR-378 CUCCUGACUCCAGGUCCUGUGU
miR-493-5p 128 135 1A,m8 hsa-miR-493-5p UUGUACAUGGUAGGCUUUCAUU
miR-494 150 156 m8 hsa-miR-494brain UGAAACAUACACGGGAAACCUCUU
hsa-miR-494brain UGAAACAUACACGGGAAACCUCUU