Gene Page:DSTYK
Summary?
| GeneID | 25778 |
| Symbol | DSTYK |
| Synonyms | CAKUT1|DustyPK|HDCMD38P|RIP5|RIPK5 |
| 描述 | dual serine/threonine and tyrosine protein kinase |
| Reference | MIM:612666|HGNC:HGNC:29043|Ensembl:ENSG00000133059|HPRD:11495|Vega:OTTHUMG00000037102 |
| Gene type | protein-coding |
| Map location | 1q32.1 |
| Sherlock p-value | 0.18 |
| Fetal beta | -0.717 |
| eGene | Caudate basal ganglia Frontal Cortex BA9 Hippocampus Nucleus accumbens basal ganglia Putamen basal ganglia Myers' cis & trans |
| Support | Ascano FMRP targets |
Gene in Data Sources
| 基因集名称 | Method of gene set | 描述 | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
eQTL annotation| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs31452 | chr5 | 16929982 | DSTYK | 25778 | 0.18 | trans | ||
| rs4950978 | 1 | 205024573 | DSTYK | ENSG00000133059.12 | 4.094E-6 | 0.01 | 156154 | gtex_brain_putamen_basal |
| rs112673145 | 1 | 205049371 | DSTYK | ENSG00000133059.12 | 6.167E-7 | 0.01 | 131356 | gtex_brain_putamen_basal |
| rs11240352 | 1 | 205051711 | DSTYK | ENSG00000133059.12 | 4.644E-7 | 0.01 | 129016 | gtex_brain_putamen_basal |
| rs7520752 | 1 | 205054114 | DSTYK | ENSG00000133059.12 | 6.167E-7 | 0.01 | 126613 | gtex_brain_putamen_basal |
| rs12139373 | 1 | 205054879 | DSTYK | ENSG00000133059.12 | 6.08E-7 | 0.01 | 125848 | gtex_brain_putamen_basal |
| rs1130311 | 1 | 205056525 | DSTYK | ENSG00000133059.12 | 6.85E-7 | 0.01 | 124202 | gtex_brain_putamen_basal |
| rs10158848 | 1 | 205061192 | DSTYK | ENSG00000133059.12 | 6.25E-7 | 0.01 | 119535 | gtex_brain_putamen_basal |
| rs11576867 | 1 | 205064676 | DSTYK | ENSG00000133059.12 | 6.189E-7 | 0.01 | 116051 | gtex_brain_putamen_basal |
| rs11240355 | 1 | 205065298 | DSTYK | ENSG00000133059.12 | 6.178E-7 | 0.01 | 115429 | gtex_brain_putamen_basal |
| rs11577406 | 1 | 205065733 | DSTYK | ENSG00000133059.12 | 6.167E-7 | 0.01 | 114994 | gtex_brain_putamen_basal |
| rs6593922 | 1 | 205071167 | DSTYK | ENSG00000133059.12 | 6.221E-7 | 0.01 | 109560 | gtex_brain_putamen_basal |
| rs3738155 | 1 | 205074424 | DSTYK | ENSG00000133059.12 | 2.686E-7 | 0.01 | 106303 | gtex_brain_putamen_basal |
| rs12125465 | 1 | 205074854 | DSTYK | ENSG00000133059.12 | 6.502E-7 | 0.01 | 105873 | gtex_brain_putamen_basal |
| rs112943386 | 1 | 205075707 | DSTYK | ENSG00000133059.12 | 6.57E-7 | 0.01 | 105020 | gtex_brain_putamen_basal |
| rs61822565 | 1 | 205077332 | DSTYK | ENSG00000133059.12 | 6.718E-7 | 0.01 | 103395 | gtex_brain_putamen_basal |
| rs61822567 | 1 | 205078725 | DSTYK | ENSG00000133059.12 | 6.849E-7 | 0.01 | 102002 | gtex_brain_putamen_basal |
| rs72757512 | 1 | 205079203 | DSTYK | ENSG00000133059.12 | 6.896E-7 | 0.01 | 101524 | gtex_brain_putamen_basal |
| rs112653854 | 1 | 205079251 | DSTYK | ENSG00000133059.12 | 6.85E-7 | 0.01 | 101476 | gtex_brain_putamen_basal |
| rs61822568 | 1 | 205081166 | DSTYK | ENSG00000133059.12 | 7.092E-7 | 0.01 | 99561 | gtex_brain_putamen_basal |
| rs199518138 | 1 | 205082818 | DSTYK | ENSG00000133059.12 | 7.274E-7 | 0.01 | 97909 | gtex_brain_putamen_basal |
| rs61036585 | 1 | 205082819 | DSTYK | ENSG00000133059.12 | 7.274E-7 | 0.01 | 97908 | gtex_brain_putamen_basal |
| rs12239712 | 1 | 205082976 | DSTYK | ENSG00000133059.12 | 7.29E-7 | 0.01 | 97751 | gtex_brain_putamen_basal |
| rs11240360 | 1 | 205083865 | DSTYK | ENSG00000133059.12 | 3.167E-7 | 0.01 | 96862 | gtex_brain_putamen_basal |
| rs72757524 | 1 | 205086473 | DSTYK | ENSG00000133059.12 | 7.422E-7 | 0.01 | 94254 | gtex_brain_putamen_basal |
| rs61822619 | 1 | 205090885 | DSTYK | ENSG00000133059.12 | 3.172E-7 | 0.01 | 89842 | gtex_brain_putamen_basal |
| rs17344537 | 1 | 205091427 | DSTYK | ENSG00000133059.12 | 9.922E-7 | 0.01 | 89300 | gtex_brain_putamen_basal |
| rs200390744 | 1 | 205092520 | DSTYK | ENSG00000133059.12 | 6.159E-7 | 0.01 | 88207 | gtex_brain_putamen_basal |
| rs58061807 | 1 | 205092522 | DSTYK | ENSG00000133059.12 | 4.149E-7 | 0.01 | 88205 | gtex_brain_putamen_basal |
| rs12130384 | 1 | 205105981 | DSTYK | ENSG00000133059.12 | 1.279E-6 | 0.01 | 74746 | gtex_brain_putamen_basal |
| rs4092141 | 1 | 205108083 | DSTYK | ENSG00000133059.12 | 2.905E-7 | 0.01 | 72644 | gtex_brain_putamen_basal |
| rs4394715 | 1 | 205108393 | DSTYK | ENSG00000133059.12 | 3.155E-7 | 0.01 | 72334 | gtex_brain_putamen_basal |
| rs2836 | 1 | 205111761 | DSTYK | ENSG00000133059.12 | 4.089E-7 | 0.01 | 68966 | gtex_brain_putamen_basal |
| rs11240369 | 1 | 205115099 | DSTYK | ENSG00000133059.12 | 6.563E-7 | 0.01 | 65628 | gtex_brain_putamen_basal |
| rs11240370 | 1 | 205118336 | DSTYK | ENSG00000133059.12 | 7.859E-7 | 0.01 | 62391 | gtex_brain_putamen_basal |
| rs61822626 | 1 | 205118441 | DSTYK | ENSG00000133059.12 | 6.563E-7 | 0.01 | 62286 | gtex_brain_putamen_basal |
| rs12123773 | 1 | 205122420 | DSTYK | ENSG00000133059.12 | 9.232E-7 | 0.01 | 58307 | gtex_brain_putamen_basal |
| rs113699533 | 1 | 205122895 | DSTYK | ENSG00000133059.12 | 1E-6 | 0.01 | 57832 | gtex_brain_putamen_basal |
| rs12123922 | 1 | 205140436 | DSTYK | ENSG00000133059.12 | 2.088E-6 | 0.01 | 40291 | gtex_brain_putamen_basal |
| rs61822659 | 1 | 205142847 | DSTYK | ENSG00000133059.12 | 2.055E-6 | 0.01 | 37880 | gtex_brain_putamen_basal |
| rs11579220 | 1 | 205144363 | DSTYK | ENSG00000133059.12 | 2.09E-6 | 0.01 | 36364 | gtex_brain_putamen_basal |
| rs6692706 | 1 | 205158561 | DSTYK | ENSG00000133059.12 | 7.943E-7 | 0.01 | 22166 | gtex_brain_putamen_basal |
| rs71917468 | 1 | 205164254 | DSTYK | ENSG00000133059.12 | 1.118E-6 | 0.01 | 16473 | gtex_brain_putamen_basal |
| rs147957741 | 1 | 205171245 | DSTYK | ENSG00000133059.12 | 7.942E-7 | 0.01 | 9482 | gtex_brain_putamen_basal |
| rs60159462 | 1 | 205179563 | DSTYK | ENSG00000133059.12 | 8.043E-7 | 0.01 | 1164 | gtex_brain_putamen_basal |
| rs17345153 | 1 | 205179997 | DSTYK | ENSG00000133059.12 | 8.038E-7 | 0.01 | 730 | gtex_brain_putamen_basal |
| rs12143121 | 1 | 205199142 | DSTYK | ENSG00000133059.12 | 1.923E-6 | 0.01 | -18415 | gtex_brain_putamen_basal |
| rs748012 | 1 | 205216573 | DSTYK | ENSG00000133059.12 | 2.926E-6 | 0.01 | -35846 | gtex_brain_putamen_basal |
| rs1151786 | 1 | 205227760 | DSTYK | ENSG00000133059.12 | 1.674E-6 | 0.01 | -47033 | gtex_brain_putamen_basal |
| rs113306045 | 1 | 205230498 | DSTYK | ENSG00000133059.12 | 2.081E-6 | 0.01 | -49771 | gtex_brain_putamen_basal |
| rs1151785 | 1 | 205232299 | DSTYK | ENSG00000133059.12 | 2.743E-6 | 0.01 | -51572 | gtex_brain_putamen_basal |
| rs1151784 | 1 | 205232447 | DSTYK | ENSG00000133059.12 | 2.793E-6 | 0.01 | -51720年 | gtex_brain_putamen_basal |
| rs1180721 | 1 | 205232696 | DSTYK | ENSG00000133059.12 | 2.8E-6 | 0.01 | -51969 | gtex_brain_putamen_basal |
| rs1172111 | 1 | 205232980 | DSTYK | ENSG00000133059.12 | 2.806E-6 | 0.01 | -52253 | gtex_brain_putamen_basal |
| rs7367930 | 1 | 205235512 | DSTYK | ENSG00000133059.12 | 2.9E-6 | 0.01 | -54785 | gtex_brain_putamen_basal |
| rs1668873 | 1 | 205235990 | DSTYK | ENSG00000133059.12 | 2.92E-6 | 0.01 | -55263年 | gtex_brain_putamen_basal |
| rs1668872 | 1 | 205236069 | DSTYK | ENSG00000133059.12 | 2.923 e-6 | 0.01 | -55342 | gtex_brain_putamen_basal |
| rs1768587 | 1 | 205236432 | DSTYK | ENSG00000133059.12 | 2.929E-6 | 0.01 | -55705 | gtex_brain_putamen_basal |
| rs1768586 | 1 | 205238275 | DSTYK | ENSG00000133059.12 | 2.933E-6 | 0.01 | -57548 | gtex_brain_putamen_basal |
| rs1779411 | 1 | 205238530 | DSTYK | ENSG00000133059.12 | 2.937E-6 | 0.01 | -57803 | gtex_brain_putamen_basal |
| rs1668870 | 1 | 205239031 | DSTYK | ENSG00000133059.12 | 2.935E-6 | 0.01 | -58304 | gtex_brain_putamen_basal |
| rs35344321 | 1 | 205239185 | DSTYK | ENSG00000133059.12 | 2.936E-6 | 0.01 | -58458 | gtex_brain_putamen_basal |
| rs1668869 | 1 | 205239779 | DSTYK | ENSG00000133059.12 | 2.941E-6 | 0.01 | -59052 | gtex_brain_putamen_basal |
| rs1668867 | 1 | 205240251 | DSTYK | ENSG00000133059.12 | 3.264E-6 | 0.01 | -59524 | gtex_brain_putamen_basal |
| rs4951184 | 1 | 205240659 | DSTYK | ENSG00000133059.12 | 2.938E-6 | 0.01 | -59932 | gtex_brain_putamen_basal |
| rs1172138 | 1 | 205246019 | DSTYK | ENSG00000133059.12 | 2.978E-6 | 0.01 | -65292 | gtex_brain_putamen_basal |
| rs1172137 | 1 | 205246061 | DSTYK | ENSG00000133059.12 | 2.493E-6 | 0.01 | -65334 | gtex_brain_putamen_basal |
| rs1172136 | 1 | 205247097 | DSTYK | ENSG00000133059.12 | 3.074E-6 | 0.01 | -66370 | gtex_brain_putamen_basal |
| rs1172135 | 1 | 205247160 | DSTYK | ENSG00000133059.12 | 1.204E-6 | 0.01 | -66433 | gtex_brain_putamen_basal |
| rs56284855 | 1 | 205247315 | DSTYK | ENSG00000133059.12 | 2.485E-6 | 0.01 | -66588 | gtex_brain_putamen_basal |
| rs1779410 | 1 | 205248759 | DSTYK | ENSG00000133059.12 | 4.618E-7 | 0.01 | -68032 | gtex_brain_putamen_basal |
| rs1668864 | 1 | 205248799 | DSTYK | ENSG00000133059.12 | 3.269E-6 | 0.01 | -68072 | gtex_brain_putamen_basal |
| rs1668863 | 1 | 205248917 | DSTYK | ENSG00000133059.12 | 4.574E-7 | 0.01 | -68190 | gtex_brain_putamen_basal |
| rs9660992 | 1 | 205249450 | DSTYK | ENSG00000133059.12 | 4.469E-7 | 0.01 | -68723 | gtex_brain_putamen_basal |
| rs55671824 | 1 | 205249814 | DSTYK | ENSG00000133059.12 | 3.407E-6 | 0.01 | -69087 | gtex_brain_putamen_basal |
| rs55673946 | 1 | 205250475 | DSTYK | ENSG00000133059.12 | 1.764E-6 | 0.01 | -69748 | gtex_brain_putamen_basal |
| rs12092492 | 1 | 205251880 | DSTYK | ENSG00000133059.12 | 1.893E-6 | 0.01 | -71153 | gtex_brain_putamen_basal |
| rs72745207 | 1 | 205251991 | DSTYK | ENSG00000133059.12 | 3.765E-6 | 0.01 | -71264 | gtex_brain_putamen_basal |
| rs3851296 | 1 | 205253839 | DSTYK | ENSG00000133059.12 | 6.052E-7 | 0.01 | -73112 | gtex_brain_putamen_basal |
| rs1151787 | 1 | 205254238 | DSTYK | ENSG00000133059.12 | 4.238E-6 | 0.01 | -73511 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| ATP5F1 | MGC24431 | PIG47 | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1 | Affinity Capture-MS | BioGRID | 17353931 |
| DDT | DDCT | D-dopachrome tautomerase | Affinity Capture-MS | BioGRID | 17353931 |
| HSPE1 | CPN10 | GROES | HSP10 | heat shock 10kDa protein 1 (chaperonin 10) | Affinity Capture-MS | BioGRID | 17353931 |
| IKBKE | IKK-i | IKKE | IKKI | KIAA0151 | MGC125294 | MGC125295 | MGC125297 | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | Affinity Capture-MS | BioGRID | 17353931 |
| LSM12 | FLJ30656 | MGC104211 | PNAS-135 | LSM12 homolog (S. cerevisiae) | Affinity Capture-MS | BioGRID | 17353931 |
| MAD2L1 | HSMAD2 | MAD2 | MAD2 mitotic arrest deficient-like 1 (yeast) | Affinity Capture-MS | BioGRID | 17353931 |
| MTPN | FLJ31098 | FLJ99857 | GCDP | V-1 | myotrophin | Affinity Capture-MS | BioGRID | 17353931 |
| PSMB1 | FLJ25321 | HC5 | KIAA1838 | PMSB1 | PSC5 | proteasome (prosome, macropain) subunit, beta type, 1 | Affinity Capture-MS | BioGRID | 17353931 |
| PSMB3 | HC10-II | MGC4147 | proteasome (prosome, macropain) subunit, beta type, 3 | Affinity Capture-MS | BioGRID | 17353931 |
| RAB14 | FBP | RAB-14 | RAB14, member RAS oncogene family | Affinity Capture-MS | BioGRID | 17353931 |
| RAB5C | MGC117217 | MGC138857 | RAB5CL | RABL | RAB5C, member RAS oncogene family | Affinity Capture-MS | BioGRID | 17353931 |
| RPS9 | - | ribosomal protein S9 | Affinity Capture-MS | BioGRID | 17353931 |
| UBE2K | DKFZp564C1216 | DKFZp686J24237 | E2-25K | HIP2 | HYPG | LIG | ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast) | Affinity Capture-MS | BioGRID | 17353931 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP | 233 | 161 | All SZGR 2.0 genes in this pathway |
| PEREZ TP53 TARGETS | 1174 | 695 | All SZGR 2.0 genes in this pathway |
| GEORGES TARGETS OF MIR192 AND MIR215 | 893 | 528 | All SZGR 2.0 genes in this pathway |
| GOTTWEIN TARGETS OF KSHV MIR K12 11 | 63 | 45 | All SZGR 2.0 genes in this pathway |
| AFFAR YY1 TARGETS UP | 214 | 133 | All SZGR 2.0 genes in this pathway |
| CUI TCF21 TARGETS 2 DN | 830 | 547 | All SZGR 2.0 genes in this pathway |
| MARTINEZ RB1 TARGETS DN | 543 | 317 | All SZGR 2.0 genes in this pathway |
| MARTINEZ TP53 TARGETS DN | 593 | 372 | All SZGR 2.0 genes in this pathway |
| MARTINEZ RB1 AND TP53 TARGETS DN | 591 | 366 | All SZGR 2.0 genes in this pathway |
| CHEN LIVER METABOLISM QTL CIS | 93 | 40 | All SZGR 2.0 genes in this pathway |