SZGR2 - Beplay体育中心

概括?

基因ID	25843
Symbol	MOB4
同义词	2C4D\|CGI-95\|MOB1\|MOB3\|MOBKL3\|PHOCN\|PREI3
描述	暴民家庭成员4，Phocein
参考	MIM:609361\|HGNC：HGNC：17261\|ENSEMBL：ENSG00000115540\|HPRD：10165\|Vega:OTTHUMG00000132748
基因type	protein-coding
地图位置	2q33.1
Pascal P值	9.062e-11
Sherlock P值	0.125

数据源中的基因

基因集name	基因组方法	描述	Info
简历：PGCNP	全基因组协会研究	GWAS

第一节遗传学和表观遗传学注释

Section II. Transcriptome annotation

基因ral gene expression (GTEx)

基因expression of temporal and spatial changes (BrainSpan)

脚注：
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
基因	皮尔逊的相关性	Spearman's Correlation
ZNF324B	0.90	0.91
EIF2B5	0.89	0.89
TRIM3	0.88	0.90
ZFYVE27	0.88	0.90
斯特拉达	0.87	0.88
Acad8	0.87	0.89
SMYD5	0.87	0.88
ATG4B	0.87	0.88
ERCC3	0.87	0.88
COPS7B	0.86	0.87

前10个负共表达基因
基因	皮尔逊的相关性	Spearman's Correlation
AF347015.31	-0.76	-0.77
MT-CO2	-0.76	-0.78
AF347015.8	-0.75	-0.78
AF347015.33	-0.75	-0.75
AF347015.27	-0.74	-0.77
MT-CYB	-0.74	-0.75
AF347015.21	-0.73	-0.82
AF347015.15	-0.72	-0.74
AF347015.2	-0.72	-0.74
AF347015.26	-0.71	-0.75

Section III. Gene Ontology annotation

Molecular function	去的术语	Evidence	Neuro keywords	PubMed ID
GO:0005515	protein binding	IEA		-
GO:0005515	protein binding	新闻学会		17353931
去：0008270	zinc ion binding	IEA		-
GO:0046872	金属离子结合	IEA		-
Biological process	去的术语	Evidence	Neuro keywords	PubMed ID
去：0006810	transport	IEA		-
细胞分量	去的术语	Evidence	Neuro keywords	PubMed ID
GO:0005794	Golgi apparatus	IEA		-
GO:0005737	细胞质	IEA		-
GO:0016020	膜	IEA		-

第四节。蛋白质蛋白相互作用注释

Interactors	Aliases B	Official full name B	Experimental	资源	PubMed ID
Arhgef15	Argef15 \|FLJ13791 \|KIAA0915 \|MGC44868 \|VSM-RHOGEF	Rho guanine nucleotide exchange factor (GEF) 15	两个杂交	BioGRID	16189514
C1orf103	FLJ11269 \|RIF1 \|RP11-96K19.1	chromosome 1 open reading frame 103	两个杂交	BioGRID	16169070
CAB39	CGI-66 \| FLJ22682 \| MO25	钙结合蛋白39	亲和力捕获ms	BioGRID	17353931
CCDC59	BR22 \| DKFZp686K1021 \| FLJ10294 \| HSPC128 \| TAP26	包含59	亲和力捕获ms	BioGRID	17353931
CCDC85B	DIPA	包含85b	两个杂交	BioGRID	16189514
CCT2	99D8.1 \| CCT-beta \| CCTB \| MGC142074 \| MGC142076 \| PRO1633 \| TCP-1-beta	chaperonin containing TCP1, subunit 2 (beta)	亲和力捕获ms	BioGRID	18782753
CCT3	CCT-gamma \| CCTG \| PIG48 \| TCP-1-gamma \| TRIC5	chaperonin containing TCP1, subunit 3 (gamma)	亲和力捕获ms	BioGRID	18782753
CCT5	cct-epsilon \|CCTE \|KIAA0098 \|TCP-1- epsilon	chaperonin containing TCP1, subunit 5 (epsilon)	亲和力捕获ms	BioGRID	18782753
CCT6A	CCT-Zeta \|CCT-ZETA-1 \|CCT6 \|CCTZ \|htr3 \|MGC126214 \|MGC126215 \|modp-2 \|TCP-1-Zeta \|TCP20 \| TCPZ \| TTCP20	chaperonin containing TCP1, subunit 6A (zeta 1)	亲和力捕获ms	BioGRID	18782753
CCT7	CCT-ETA \| Ccth \| MGC110985 \| Nip7-1 \| TCP-1-eta	chaperonin containing TCP1, subunit 7 (eta)	亲和力捕获ms	BioGRID	18782753
CCT8	C21orf112 \|CCTQ \|D21S246 \|KIAA0002 \|PED71	伴侣素含有TCP1，亚基8（Theta）	亲和力捕获ms	BioGRID	18782753
CRMP1	DPYSL1 \| DRP-1 \| DRP1	折叠蛋白反应介质蛋白1	两个杂交	BioGRID	16169070
CTTNBP2	C7orf8 \|cortbp2 \|FLJ34229 \|KIAA1758 \|MGC104579 \|ORF4	cortactin binding protein 2	亲和力捕获ms	BioGRID	18782753
CTTNBP2NL	DKFZp547A023 \| FLJ13278	cttnbp2 n末端	亲和力捕获ms Affinity Capture-Western	BioGRID	18782753
DNM1	DNM	Dynamin 1	-	HPRD	11872741
fadd	Gig3 \|MGC8528 \|Mort1	FAS（TNFRSF6）通过死亡域关联	两个杂交	BioGRID	16169070
FAM40A	FLJ14743 \| KIAA1761 \| MGC148091 \| RP4-773N10.1	family with sequence similarity 40, member A	亲和力捕获ms	BioGRID	18782753
FAM40B	-	family with sequence similarity 40, member B	亲和力捕获ms	BioGRID	18782753
FGFR1OP2	DKFZp564O1863 \| HSPC123-like	FGFR1 oncogene partner 2	亲和力捕获ms	BioGRID	18782753
GDF9	-	growth differentiation factor 9	两个杂交	BioGRID	16169070
KIDINS220	武器\|MGC163482	kinase D-interacting substrate, 220kDa	两个杂交	BioGRID	16169070
MCM2	BM28 \|ccnl1 \|CDCL1 \|D3S3194 \|KIAA0030 \|MGC10606 \|米托蛋白\|CDC19	minichromosome maintenance complex component 2	两个杂交	BioGRID	16169070
MED10	L6 \|MGC5309 \|nut2 \|TRG20	中介复合体亚基10	两个杂交	BioGRID	16169070
MED31	3110004H13rik \|CGI-125 \|FLJ27436 \|FLJ36714 \|SOH1	中介复合体亚基31	两个杂交	BioGRID	16169070
MYL6	ESMLC \| LC17-GI \| LC17-NM \| LC17A \| LC17B \| MLC1SM \| MLC3NM \| MLC3SM	肌球蛋白，轻链6，碱，平滑肌和非肌肉	两个杂交	BioGRID	16169070
NME2	MGC111212 \| NDPK-B \| NDPKB \| NM23-H2 \| NM23B \| puf	non-metastatic cells 2, protein (NM23B) expressed in	-	HPRD	11872741
PAICS	ADE2 \|ADE2H1 \|AIRC \|DKFZP781N1372 \|MGC1343 \|MGC5024 \|佩斯	磷酸氨基氨基咪唑羧化酶，磷酸氨基氨基咪唑辅助辅助酰胺合成酶合成酶	两个杂交	BioGRID	16169070
PDCD10	CCM3 \|MGC1212 \|MGC24477 \|TFAR15	programmed cell death 10	亲和力捕获ms	BioGRID	18782753
PLEKHM1	AP162 \| B2 \| KIAA0356 \| OPTB6	pleckstrin homology domain containing, family M (with RUN domain) member 1	两个杂交	BioGRID	16169070
PPP2CA	PP2Ac \| PP2CA \| RP-C	蛋白质磷酸酶2（以前为2A），催化亚基，α同工型	亲和力捕获ms	BioGRID	18782753
PPP2CB	pp2cb	protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform	亲和力捕获ms	BioGRID	18782753
PPP2R1A	MGC786 \| PR65A	protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform	亲和力捕获ms	BioGRID	18782753
PPP2R1B	MGC26454 \|PR65B	蛋白质磷酸酶2（以前为2A），调节亚基A，β同工型	亲和力捕获ms	BioGRID	18782753
PTPR	PTPSIGMA	protein tyrosine phosphatase, receptor type, S	两个杂交	BioGRID	16169070
rb1cc1	CC1 \| DRAGOU14 \| FIP200	RB1诱导的盘绕线圈1	亲和力捕获ms	BioGRID	17353931
RP5-1000E10.4	DKFZp686A0768 \| FLJ21168 \| SIKE	suppressor of IKK epsilon	亲和力捕获ms	BioGRID	18782753
RP6-213H19.1	MASK \| MST4	serine/threonine protein kinase MST4	亲和力捕获ms	BioGRID	18782753
SCMH1	SCML3	性梳子上的Midleg同源1（果蝇）	两个杂交	BioGRID	16169070
setDB1	eset \|kg1t \|KIAA0067 \|KMT1E	SET domain, bifurcated 1	两个杂交	BioGRID	16169070
SLMAP	FLJ42206 \|KIAA1601 \|MGC138760 \|MGC138761 \|拍击	肌纤维膜相关蛋白	亲和力捕获ms	BioGRID	18782753
STK24	MST-3 \| MST3 \| MST3B \| STE20 \| STK3	丝氨酸/苏氨酸激酶24（Ste20同源物，酵母）	亲和力捕获ms	BioGRID	17353931\|18782753
STK25	DKFZP686J1430 \|sok1 \|YSK1	serine/threonine kinase 25 (STE20 homolog, yeast)	亲和力捕获ms	BioGRID	18782753
STRN	MGC125642 \| SG2NA	纹状体，钙调蛋白结合蛋白	亲和力捕获ms Affinity Capture-Western	BioGRID	18782753
strn3	SG2NA	纹状体，钙调蛋白结合蛋白3	亲和力捕获ms	BioGRID	18782753
strn4	FLJ35594 \|Zin \|Zinedin	纹状体，钙调蛋白结合蛋白4	亲和力捕获ms	BioGRID	18782753
TCP1	CCT-Alpha \|CCT1 \|CCTA \|D6S230E \|TCP-1-Alpha	t-complex 1	亲和力捕获ms	BioGRID	18782753
TIMM13	TIM13 \| TIM13B \| TIMM13A \| TIMM13B \| ppv1	线粒体膜的易位酶13同源物（酵母）	亲和力捕获ms	BioGRID	17353931
TRAF3IP3	DJ434O14.3 \|FLJ44151 \|MGC117354 \|MGC163289 \|T3JAM	TRAF3 interacting protein 3	亲和力捕获ms Affinity Capture-Western	BioGRID	18782753
ube2v2	DDVIT1 \| DDVit-1 \| EDAF-1 \| EDPF-1 \| EDPF1 \| MMS2 \| UEV-2 \| UEV2	ubiquitin-conjugating enzyme E2 variant 2	两个杂交	BioGRID	16169070
VHL	HRCA1 \|RCA1 \|VHL1	von Hippel-Lindau肿瘤抑制剂	亲和力捕获ms	BioGRID	17353931

V.途径注释

Pathway name	Pathway size	＃szgr 2.0基因	Info
PUIFFE INVASION INHIBITED BY ASCITES DN	145	91	该途径中的所有SZGR 2.0基因
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP	722	443	该途径中的所有SZGR 2.0基因
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	该途径中的所有SZGR 2.0基因
WEI MYCN TARGETS WITH E BOX	795	478	该途径中的所有SZGR 2.0基因
SHEN SMARCA2 TARGETS UP	424	268	该途径中的所有SZGR 2.0基因
葡萄病毒感染的Debiasi凋亡	314	201	该途径中的所有SZGR 2.0基因
BLALOCK ALZHEIMERS DISEASE DN	1237	837	该途径中的所有SZGR 2.0基因
Mitsiades对aplidin的反应	439	257	该途径中的所有SZGR 2.0基因
张乳腺癌祖细胞	425	253	该途径中的所有SZGR 2.0基因
BONCI TARGETS OF MIR15A AND MIR16 1	91	75	该途径中的所有SZGR 2.0基因
MILI PSEUDOPODIA HAPTOTAXIS UP	518	299	该途径中的所有SZGR 2.0基因
金双相情感障碍少突胶质细胞密度相关	682	440	该途径中的所有SZGR 2.0基因
KIM ALL DISORDERS CALB1 CORR UP	548	370	该途径中的所有SZGR 2.0基因
Pilon KLF1靶向DN	1972年	1213	该途径中的所有SZGR 2.0基因
BRUINS UVC RESPONSE EARLY LATE	317	190	该途径中的所有SZGR 2.0基因
FEVR CTNNB1靶向	682	433	该途径中的所有SZGR 2.0基因
KOINUMA TARGETS OF SMAD2 OR SMAD3	824	528	该途径中的所有SZGR 2.0基因
FORTSCHEGGER PHF8 TARGETS DN	784	464	该途径中的所有SZGR 2.0基因
Rao由Sall4绑定	227	149	该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family	目标位置			mirna id	miRNA seq
miRNA family	UTR start	UTR end	Match method	mirna id	miRNA seq
let-7/98	822	828	1A	HSA-LET-7A^脑	UGAGGUAGUAGGUUGUAUAGUU
				HSA-LET-7B^脑	UGAGGUAGUAGGUUGUGUGGUU
				HSA-LET-7C^脑	ugagguaguagguuguaugguu
				HSA-LET-7D^脑	agagguaguagguugcauagu
				HSA-LET-7E^脑	UGAGGUAGGAGGUUGUAUAGU
				HSA-LET-7F^脑	ugagguagauuguauauaguu
				hsa-miR-98^脑	UGAGGUAGUAAGUUGUAUUGUU
				HSA-LET-7G^SZ	ugagguaguuguuguacagu
				HSA-LET-7I^脑	UGAGGUAGUAGUUUGUGCUGU
miR-101	45	52	1A,m8	HSA-MIR-101	UACAGUACUGUGAUAACUGAAG
mir-142-3p	845	852	1A,m8	hsa-miR-142-3p	uguaguuuccuacuuuaugga
mir-144	46	52	1A	hsa-miR-144	uacaguauagauguauguaguag
mir-15/16/195/424/497	269	276	1A,m8	hsa-miR-15a^脑	UAGCAGCACAUAAUGGUUUGUG
				HSA-MIR-16^脑	uagcagcacguaaauauuggcg
				hsa-miR-15b^脑	uagcagcacaucaugguuaca
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				HSA-MIR-424	Cagcagcaauucauguuuugaa
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
MiR-200BC/429	215	221	1A	HSA-MIR-200B	uaauacugccugguaaugaugac
				HSA-MIR-200C	uaauacugccggguaaugaugg
				HSA-MIR-429	uaauacuguguguguguguaaaaaccgu
miR-219	278	284	1A	HSA-MIR-219^脑	ugauuguccaaacgcaauucu
miR-369-3p	86	92	1A	HSA-MIR-369-3P	AAUAAUACAUGGUUGAUCUUU
miR-369-3p	86	92	1A	HSA-MIR-369-3P	AAUAAUACAUGGUUGAUCUUU
mir-374	86	92	m8	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
mir-383	23	29	1A	hsa-miR-383^脑	AGAUCAGAAGGUGAUUGUGGCU
miR-503	270	276	1A	HSA-MIR-503	uagcagcgggaacaguucugcag

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click这里查看与SZ相关的miRNA列表。
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click这里to see the list of brain related miRNAs.

基因页：MOB4