Gene Page:PRKD2

Summary?
GeneID 25865
Symbol PRKD2
Synonyms HSPC187|PKD2|nPKC-D2
Description protein kinase D2
Reference MIM:607074|HGNC:HGNC:17293|Ensembl:ENSG00000105287|HPRD:09523|Vega:OTTHUMG00000183431
Gene type protein-coding
Map location 19q13.3
Pascal p-value 0.2
Sherlock p-value 0.494
Fetal beta 0.349
DMG 1 (# studies)
eGene Anterior cingulate cortex BA24
Caudate basal ganglia
Cerebellum
Cortex
Myers' cis & trans
元

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg27119358 19 47217696 PRKD2 1.449E-4 -0.498 0.031 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs10282425 chr7 129831082 PRKD2 25865 0.08 trans
rs12461848 19 47174893 PRKD2 ENSG00000105287.8 6.589E-10 0 45491 gtex_brain_ba24
rs874462 19 47176880 PRKD2 ENSG00000105287.8 6.516E-10 0 43504 gtex_brain_ba24
rs62134780 19 47188303 PRKD2 ENSG00000105287.8 6.532E-10 0 32081 gtex_brain_ba24
rs62134781 19 47188810 PRKD2 ENSG00000105287.8 6.516E-10 0 31574 gtex_brain_ba24
rs62134782 19 47205419 PRKD2 ENSG00000105287.8 6.321E-7 0 14965 gtex_brain_ba24
rs62134783 19 47206956 PRKD2 ENSG00000105287.8 3.814E-7 0 13428 gtex_brain_ba24
rs11083846 19 47207654 PRKD2 ENSG00000105287.8 2.431E-7 0 12730 gtex_brain_ba24
rs117579506 19 47209159 PRKD2 ENSG00000105287.8 3.88E-7 0 11225 gtex_brain_ba24
rs12461666 19 47217113 PRKD2 ENSG00000105287.8 4.144E-7 0 3271 gtex_brain_ba24
rs62134788 19 47217587 PRKD2 ENSG00000105287.8 4.167E-7 0 2797 gtex_brain_ba24
rs11668987 19 47227821 PRKD2 ENSG00000105287.8 7.579E-7 0 -7437 gtex_brain_ba24
rs3215087 19 47230393 PRKD2 ENSG00000105287.8 4.57E-7 0 -10009 gtex_brain_ba24
rs62134790 19 47237551 PRKD2 ENSG00000105287.8 4.071E-7 0 -17167 gtex_brain_ba24
rs56374620 19 47241599 PRKD2 ENSG00000105287.8 3.514E-7 0 -21215 gtex_brain_ba24
rs4802322 19 47242992 PRKD2 ENSG00000105287.8 1.608E-7 0 -22608 gtex_brain_ba24
rs11668563 19 47243621 PRKD2 ENSG00000105287.8 2.611E-7 0 -23237 gtex_brain_ba24
rs78887375 19 47247141 PRKD2 ENSG00000105287.8 1.823E-7 0 -26757 gtex_brain_ba24
rs7258782 19 47247781 PRKD2 ENSG00000105287.8 1.669E-7 0 -27397 gtex_brain_ba24
rs3786708 19 47248308 PRKD2 ENSG00000105287.8 2.023E-7 0 -27924 gtex_brain_ba24
rs62134793 19 47248585 PRKD2 ENSG00000105287.8 1.663E-7 0 -28201年 gtex_brain_ba24
rs62134820 19 47256344 PRKD2 ENSG00000105287.8 3.586E-7 0 -35960 gtex_brain_ba24
rs60104266 19 47257202 PRKD2 ENSG00000105287.8 9.667E-8 0 -36818 gtex_brain_ba24
rs7249039 19 47266635 PRKD2 ENSG00000105287.8 8.294E-9 0 -46251 gtex_brain_ba24
rs12459058 19 47274138 PRKD2 ENSG00000105287.8 3.608E-7 0 -53754 gtex_brain_ba24
rs1644339 19 47281255 PRKD2 ENSG00000105287.8 8.244E-7 0 -60871 gtex_brain_ba24

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463 290 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL UP 450 256 All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS UP 456 228 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142 669 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612 367 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 All SZGR 2.0 genes in this pathway
MAGRANGEAS MULTIPLE MYELOMA IGLL VS IGLK DN 24 18 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS DN 105 63 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY GAMMA AND UV RADIATION 88 65 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN 195 135 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973 570 All SZGR 2.0 genes in this pathway
FIRESTEIN PROLIFERATION 175 125 All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER UP 298 174 All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 10 33 22 All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS 535 325 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S1 237 159 All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA CLASSICAL 162 122 All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS DN 213 127 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 UP 430 288 All SZGR 2.0 genes in this pathway