Gene Page:GAPDH

Summary?
GeneID 2597
Symbol GAPDH
Synonyms G3PD|GAPD|HEL-S-162eP
Description glyceraldehyde-3-phosphate dehydrogenase
Reference MIM:138400|HGNC:HGNC:4141|Ensembl:ENSG00000111640|HPRD:00713|Vega:OTTHUMG00000137379
Gene type protein-coding
Map location 12p13
Pascal p-value 0.733
Sherlock p-value 0.995
Fetal beta -0.26
DMG 1 (# studies)
eGene Frontal Cortex BA9
Support CELL METABOLISM
G2Cdb.human_mitochondria
G2Cdb.humanNRC
G2Cdb.humanPSD
G2Cdb.humanPSP
CompositeSet

Gene in Data Sources
Gene set name Method of gene set Description Info
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias Click to show details
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.6677

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg20917484 12 6644066 GAPDH 4.748E-4 -0.237 0.046 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去后m Evidence Neuro keywords PubMed ID
GO:0003824 catalytic activity IEA -
GO:0005488 binding IEA -
GO:0005515 protein binding 新闻学会 17540579
GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity IEA -
GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity NAS 3170585|7030790
GO:0016491 oxidoreductase activity IEA -
GO:0051287 NAD binding IEA -
Biological process 去后m Evidence Neuro keywords PubMed ID
GO:0006096 glycolysis NAS -
GO:0006006 glucose metabolic process IEA -
GO:0008152 metabolic process IEA -
GO:0055114 oxidation reduction IEA -
Cellular component 去后m Evidence Neuro keywords PubMed ID
GO:0005737 cytoplasm NAS -
GO:0016020 membrane IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
APP AAA | ABETA | ABPP | AD1 | APPI | CTFgamma | CVAP | PN2 amyloid beta (A4) precursor protein - HPRD 8473906
AR AIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFM androgen receptor - HPRD,BioGRID 8872471
ARL15 ARFRP2 | FLJ20051 ADP-ribosylation factor-like 15 Two-hybrid BioGRID 16169070
ATXN1 ATX1 | D6S504E | SCA1 ataxin 1 - HPRD,BioGRID 8872471
BPGM - 2,3-bisphosphoglycerate mutase - HPRD 9308888
BTBD2 - BTB (POZ) domain containing 2 Two-hybrid BioGRID 16169070
DYNLL1 DLC1 | DLC8 | DNCL1 | DNCLC1 | LC8 | LC8a | MGC126137 | MGC126138 | PIN | hdlc1 dynein, light chain, LC8-type 1 - HPRD 14760703
GAPDH G3PD | GAPD | MGC88685 glyceraldehyde-3-phosphate dehydrogenase - HPRD 10617673
GRM1 GPRC1A | GRM1A | MGLUR1 | MGLUR1A | mGlu1 glutamate receptor, metabotropic 1 - HPRD 9886087
HBXIP MGC71071 | XIP hepatitis B virus x interacting protein Two-hybrid BioGRID 16169070
HTT 高清| IT15 huntingtin - HPRD,BioGRID 8612237
LAMA4 DKFZp686D23145 | LAMA3 | LAMA4*-1 laminin, alpha 4 Two-hybrid BioGRID 16169070
NPAT E14 nuclear protein, ataxia-telangiectasia locus Affinity Capture-Western BioGRID 12887926
PAFAH1B3 - platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa Two-hybrid BioGRID 16169070
PCDHA4 CNR1 | CNRN1 | CRNR1 | MGC138307 | MGC142169 | PCDH-ALPHA4 protocadherin alpha 4 Two-hybrid BioGRID 16169070
PDIA2 PDA2 | PDI | PDIP | PDIR protein disulfide isomerase family A, member 2 - HPRD,BioGRID 11488911
PGK1 MGC117307 | MGC142128 | MGC8947 | MIG10 | PGKA phosphoglycerate kinase 1 - HPRD,BioGRID 8075252
PLD2 - phospholipase D2 - HPRD,BioGRID 12753082
POU2F1 OCT1 | OTF1 POU class 2 homeobox 1 Affinity Capture-Western
Reconstituted Complex		 BioGRID 12887926
POU2F2 OCT2 | OTF2 | Oct-2 POU class 2 homeobox 2 Reconstituted Complex BioGRID 12887926
PRDX1 MSP23 | NKEFA | PAG | PAGA | PAGB | PRX1 | PRXI | TDPX2 peroxiredoxin 1 Two-hybrid BioGRID 16169070
PRKCI DXS1179E | MGC26534 | PKCI | nPKC-iota protein kinase C, iota - HPRD,BioGRID 11724794
PRKG1 CGKI | DKFZp686K042 | FLJ36117 | MGC71944 | PGK | PKG | PRKG1B | PRKGR1B | cGKI-BETA | cGKI-alpha protein kinase, cGMP-dependent, type I Affinity Capture-Western BioGRID 9308888
PSMD11 MGC3844 | Rpn6 | S9 | p44.5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 Two-hybrid BioGRID 16169070
QRICH2 DKFZp434P0316 glutamine rich 2 Affinity Capture-MS BioGRID 17353931
RPA2 REPA2 | RPA32 复制蛋白A2, 32 kda Two-hybrid BioGRID 16169070
S100A6 2A9 | 5B10 | CABP | CACY | PRA S100 calcium binding protein A6 - HPRD 1999197
SERPINB9 CAP-3 | CAP3 | PI9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 Two-hybrid BioGRID 16169070
SLC2A1 DYT17 | DYT18 | GLUT | GLUT1 | MGC141895 | MGC141896 | PED solute carrier family 2 (facilitated glucose transporter), member 1 - HPRD,BioGRID 2394733
STIP1 HOP | IEF-SSP-3521 | P60 | STI1 | STI1L stress-induced-phosphoprotein 1 Affinity Capture-Western BioGRID 12887926
SYNCRIP GRY-RBP | HNRPQ1 | NSAP1 | RP1-3J17.2 | dJ3J17.2 | hnRNP-Q | pp68 synaptotagmin binding, cytoplasmic RNA interacting protein NSAP-1 interacts with GAPDH. BIND 15479637
TK1 TK2 thymidine kinase 1, soluble Two-hybrid BioGRID 16169070
TXN DKFZp686B1993 | MGC61975 | TRX | TRX1 thioredoxin Affinity Capture-MS BioGRID 17353931


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG GLYCOLYSIS GLUCONEOGENESIS 62 41 All SZGR 2.0 genes in this pathway
KEGG ALZHEIMERS DISEASE 169 110 All SZGR 2.0 genes in this pathway
BIOCARTA MTA3 PATHWAY 19 10 All SZGR 2.0 genes in this pathway
BIOCARTA GLYCOLYSIS PATHWAY 10 9 All SZGR 2.0 genes in this pathway
WNT SIGNALING 89 71 All SZGR 2.0 genes in this pathway
PID MYCACTIV PATHWAY 79 62 All SZGR 2.0 genes in this pathway
REACTOME GLYCOLYSIS 29 18 All SZGR 2.0 genes in this pathway
REACTOME GLUCONEOGENESIS 34 21 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF CARBOHYDRATES 247 154 All SZGR 2.0 genes in this pathway
REACTOME GLUCOSE METABOLISM 69 42 All SZGR 2.0 genes in this pathway
WINTER HYPOXIA UP 92 57 All SZGR 2.0 genes in this pathway
KORKOLA EMBRYONAL CARCINOMA UP 41 27 All SZGR 2.0 genes in this pathway
KORKOLA YOLK SAC TUMOR UP 20 14 All SZGR 2.0 genes in this pathway
KORKOLA CHORIOCARCINOMA UP 6 5 All SZGR 2.0 genes in this pathway
KORKOLA SEMINOMA UP 44 27 All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663 425 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA DN 116 79 All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN 362 238 All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 2HR UP 27 19 All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 6HR UP 55 34 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485 334 All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS CDC25 UP 58 39 All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP 536 340 All SZGR 2.0 genes in this pathway
DACOSTA LOW DOSE UV RESPONSE VIA ERCC3 XPCS DN 9 6 All SZGR 2.0 genes in this pathway
DIRMEIER LMP1 RESPONSE LATE DN 32 22 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
ALCALA APOPTOSIS 88 60 All SZGR 2.0 genes in this pathway
GROSS HIF1A TARGETS DN 25 15 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA HIF1A DN 110 78 All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX 230 156 All SZGR 2.0 genes in this pathway
MORI PRE BI LYMPHOCYTE UP 80 54 All SZGR 2.0 genes in this pathway
MORI SMALL PRE BII LYMPHOCYTE DN 76 52 All SZGR 2.0 genes in this pathway
SHIPP DLBCL CURED VS FATAL DN 45 30 All SZGR 2.0 genes in this pathway
GNATENKO PLATELET SIGNATURE 48 28 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK UP 87 58 All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT REJECTED VS OK DN 51 35 All SZGR 2.0 genes in this pathway
GALINDO IMMUNE RESPONSE TO ENTEROTOXIN 85 67 All SZGR 2.0 genes in this pathway
FERRANDO T ALL WITH MLL ENL FUSION DN 87 57 All SZGR 2.0 genes in this pathway
MUNSHI MULTIPLE MYELOMA UP 81 52 All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION 405 264 All SZGR 2.0 genes in this pathway
TRAYNOR RETT SYNDROM UP 45 33 All SZGR 2.0 genes in this pathway
BRACHAT RESPONSE TO METHOTREXATE DN 27 19 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
HARRIS HYPOXIA 81 64 All SZGR 2.0 genes in this pathway
NATSUME RESPONSE TO INTERFERON BETA DN 52 33 All SZGR 2.0 genes in this pathway
MACLACHLAN BRCA1 TARGETS UP 21 16 All SZGR 2.0 genes in this pathway
BRACHAT RESPONSE TO CAMPTOTHECIN DN 46 31 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 6HR UP 71 48 All SZGR 2.0 genes in this pathway
SEMENZA HIF1 TARGETS 36 32 All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND ENDOTHELIUM 66 47 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673 430 All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602 364 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601 369 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN 270 181 All SZGR 2.0 genes in this pathway
DAIRKEE CANCER PRONE RESPONSE BPA E2 118 65 All SZGR 2.0 genes in this pathway
HONMA DOCETAXEL RESISTANCE 34 23 All SZGR 2.0 genes in this pathway
WHITEFORD PEDIATRIC CANCER MARKERS 116 63 All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871 505 All SZGR 2.0 genes in this pathway
西方肾上腺皮质肿瘤了 294 199 All SZGR 2.0 genes in this pathway
WINTER HYPOXIA METAGENE 242 168 All SZGR 2.0 genes in this pathway
MOOTHA PGC 420 269 All SZGR 2.0 genes in this pathway
GOLDRATH ANTIGEN RESPONSE 346 192 All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER ESR1 DN 240 153 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491 316 All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6 456 285 All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389 245 All SZGR 2.0 genes in this pathway
NGO MALIGNANT GLIOMA 1P LOH 17 13 All SZGR 2.0 genes in this pathway
DANG MYC TARGETS UP 143 100 All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103 714 All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS UP 221 135 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 14 143 86 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 16 79 47 All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756 494 All SZGR 2.0 genes in this pathway
GREGORY SYNTHETIC LETHAL WITH IMATINIB 145 83 All SZGR 2.0 genes in this pathway
WANG ADIPOGENIC GENES REPRESSED BY SIRT1 28 21 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898 516 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP D 280 158 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137 655 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882 506 All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770 480 All SZGR 2.0 genes in this pathway
PECE MAMMARY STEM CELL UP 146 75 All SZGR 2.0 genes in this pathway
HOLLEMAN PREDNISOLONE RESISTANCE B ALL DN 12 8 All SZGR 2.0 genes in this pathway