Gene Page:SETBP1

Summary?
GeneID 26040
Symbol SETBP1
Synonyms MRD29|SEB
Description SET binding protein 1
Reference MIM:611060|HGNC:HGNC:15573|Ensembl:ENSG00000152217|HPRD:10224|Vega:OTTHUMG00000132613
Gene type protein-coding
Map location 18q21.1
Pascal p-value 0.296
Sherlock p-value 0.309
Fetal beta 2.515
DMG 1 (# studies)
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg24983248 18 42644213 SETBP1 5.573E-4 0.401 0.049 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs1011531 chr9 13755191 SETBP1 26040 0.14 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
C11orf70 0.85 0.50
DNALI1 0.83 0.47
AKAP14 0.82 0.40
FOXJ1 0.81 0.34
C6orf118 0.81 0.37
RIBC2 0.81 0.38
ARMC4 0.81 0.37
C19orf51 0.81 0.32
MORN5 0.80 0.25
C6orf165 0.80 0.39
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MGLL -0.25 -0.27
MUC5B -0.24 -0.35
PK4P -0.24 -0.30
BCL2L2 -0.24 -0.29
AF347015.15 -0.24 -0.31
HR -0.23 -0.33
AF347015.2 -0.23 -0.30
CABLES1 -0.23 -0.31
ARRDC2 -0.22 -0.34
AF347015.8 -0.22 -0.26

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
CORRE MULTIPLE MYELOMA DN 62 41 All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY DN 367 220 All SZGR 2.0 genes in this pathway
HOEBEKE LYMPHOID STEM CELL UP 95 64 All SZGR 2.0 genes in this pathway
SABATES COLORECTAL ADENOMA DN 291 176 All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER DN 232 154 All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP 769 437 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 12HR UP 116 79 All SZGR 2.0 genes in this pathway
NOUZOVA METHYLATED IN APL 68 39 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL LONG TERM 302 191 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN 292 189 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN 281 179 All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL UP 260 174 All SZGR 2.0 genes in this pathway
SHAFFER IRF4 TARGETS IN ACTIVATED DENDRITIC CELL 65 49 All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 10 33 22 All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824 528 All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN 784 464 All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS DN 418 245 All SZGR 2.0 genes in this pathway
GENTLES LEUKEMIC STEM CELL UP 29 15 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 All SZGR 2.0 genes in this pathway