Gene Page:CNTNAP2

Summary?
GeneID 26047
Symbol CNTNAP2
Synonyms AUTS15|CASPR2|CDFE|NRXN4|PTHSL1
Description contactin associated protein-like 2
Reference MIM:604569|HGNC:HGNC:13830|Ensembl:ENSG00000174469|HPRD:05197|Vega:OTTHUMG00000152743
Gene type protein-coding
Map location 7q35
Sherlock p-value 0.809
Fetal beta -0.806
DMG 1 (# studies)
Support CELL ADHESION AND TRANSSYNAPTIC SIGNALING

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWAScat Genome-wide Association Studies This data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search 与精神分裂症Co-occurance keywords: schizophrenia,schizophrenic,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 3

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg16254309 7 145814152 CNTNAP2 6.25E-8 -0.013 1.56E-5 DMG:Jaffe_2016
cg24887139 7 145813494 CNTNAP2 9.61E-8 -0.011 2.15E-5 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0005102 receptor binding IEA Neurotransmitter (GO term level: 4) -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0008038 neuron recognition NAS neuron (GO term level: 4) 10624965
GO:0019226 transmission of nerve impulse NAS neuron (GO term level: 5) 11352571
GO:0007155 cell adhesion IEA -
GO:0007165 signal transduction IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0016020 membrane IEA -
GO:0016021 integral to membrane NAS 11352571

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CELL ADHESION MOLECULES CAMS 134 93 所有SZGR 2.0基因通路
HUTTMANN B慢性淋巴细胞白血病POOR SURVIVAL DN 60 39 所有SZGR 2.0基因通路
DOANE RESPONSE TO ANDROGEN UP 184 125 所有SZGR 2.0基因通路
BILBAN B CLL LPL DN 42 25 所有SZGR 2.0基因通路
LEE NEURAL CREST STEM CELL DN 118 79 所有SZGR 2.0基因通路
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 所有SZGR 2.0基因通路
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 所有SZGR 2.0基因通路
SILIGAN TARGETS OF EWS FLI1 FUSION DN 18 9 所有SZGR 2.0基因通路
FARMER BREAST CANCER APOCRINE VS BASAL 330 217 所有SZGR 2.0基因通路
HUI MAPK14 TARGETS UP 21 11 所有SZGR 2.0基因通路
RICKMAN HEAD AND NECK CANCER B 48 22 所有SZGR 2.0基因通路
BENPORATH ES 1 379 235 所有SZGR 2.0基因通路
ONDER CDH1 TARGETS 2 DN 464 276 所有SZGR 2.0基因通路
BLALOCK ALZHEIMERS DISEASE DN 1237 837 所有SZGR 2.0基因通路
DOUGLAS BMI1 TARGETS UP 566 371 所有SZGR 2.0基因通路
HELLER SILENCED BY METHYLATION UP 282 183 所有SZGR 2.0基因通路
HELLER HDAC TARGETS SILENCED BY METHYLATION UP 461 298 所有SZGR 2.0基因通路
SMID BREAST CANCER BASAL DN 701 446 所有SZGR 2.0基因通路
TAVAZOIE METASTASIS 108 68 所有SZGR 2.0基因通路
POOLA INVASIVE BREAST CANCER UP 288 168 所有SZGR 2.0基因通路
MIKKELSEN MEF LCP WITH H3K27ME3 70 35 所有SZGR 2.0基因通路
MIKKELSEN IPS ICP WITH H3K27ME3 54 32 所有SZGR 2.0基因通路
MIKKELSEN IPS LCP WITH H3K4ME3 174 100 所有SZGR 2.0基因通路
MIKKELSEN MEF HCP WITH H3 UNMETHYLATED 228 119 所有SZGR 2.0基因通路
FOSTER KDM1A TARGETS UP 266 142 所有SZGR 2.0基因通路
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 所有SZGR 2.0基因通路

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-142-5p 190 196 1A hsa-miR-142-5p CAUAAAGUAGAAAGCACUAC
miR-181 5300 5306 m8 hsa-miR-181abrain AACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZ AACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrain AACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrain AACAUUCAUUGUUGUCGGUGGGUU
miR-183 1110 1116 1A hsa-miR-183 UAUGGCACUGGUAGAAUUCACUG
miR-186 5292 5298 m8 hsa-miR-186 CAAAGAAUUCUCCUUUUGGGCUU
hsa-miR-186 CAAAGAAUUCUCCUUUUGGGCUU
miR-204/211 1803 1810 1A,m8 hsa-miR-204brain UUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211 UUCCCUUUGUCAUCCUUCGCCU
miR-218 106 112 1A hsa-miR-218brain UUGUGCUUGAUCUAACCAUGU
miR-27 5206 5212 1A hsa-miR-27abrain UUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrain UUCACAGUGGCUAAGUUCUGC
miR-34/449 1107 1114 1A,m8 hsa-miR-34abrain UGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34c AGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449 UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449b AGGCAGUGUAUUGUUAGCUGGC
miR-496 5246 5253 1A,m8 hsa-miR-496 AUUACAUGGCCAAUCUC