Gene Page:EPC2

总结?
GeneID 26122
Symbol EPC2
Synonyms EPC-LIKE
Description enhancer of polycomb homolog 2
Reference MIM:611000|HGNC: HGNC: 24543|Ensembl:ENSG00000135999|HPRD:13274|Vega:OTTHUMG00000153739
Gene type protein-coding
Map location 2q23.1
Pascal p-value 0.049
Sherlock p-value 0.642
Fetal beta 1.189
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGC128 Genome-wide Association Study A multi-stage schizophrenia GWAS of up to 36,989 cases and 113,075 controls. Reported by the Schizophrenia Working Group of PGC. 128 independent associations spanning 108 loci
CV:PGCnp Genome-wide Association Study GWAS
CV:PheWAS Phenome-wide association studies (PheWAS) 157 SNPs associated with schizophrenia 2
GSMA_I Genome scan meta-analysis Psr: 0.023
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.02395

Section I. Genetics and epigenetics annotation

@CV:PGC128

SNP ID Chromosome Position Allele P Function Gene Up/Down Distance

@CV:PheWAS

SNP ID Chromosome Position Allele P Function Gene Up/Down Distance
rs4499362 2 149284866 null 1.804 EPC2 null
rs2121433 2 149274330 null 1.474 EPC2 null

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs1561519 chr2 35823020 EPC2 26122 0.19 trans
rs7591339 chr2 35825597 EPC2 26122 0.19 trans
rs7570146 chr2 35844751 EPC2 26122 0.19 trans
rs1439691 chr2 35851281 EPC2 26122 0.19 trans
rs1257641 chr14 99480394 EPC2 26122 0.2 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Biological process GO term Evidence Neuro keywords PubMed ID
GO:0006355 regulation of transcription, DNA-dependent IEA -
GO:0006350 transcription IEA -
去:0006281 DNA repair IEA -
GO:0016568 chromatin modification IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005634 nucleus IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
WAMUNYOKOLI OVARIAN CANCER LMP DN 199 124 All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS UP 344 180 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022 619 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
RAY TUMORIGENESIS BY ERBB2 CDC25A DN 159 105 All SZGR 2.0 genes in this pathway
CARD MIR302A TARGETS 77 62 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
IKEDA MIR30 TARGETS UP 116 87 All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 227 149 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-130/301 1109 1115 1A hsa-miR-130abrain CAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301 CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrain CAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3p UAGUGCAAUAUUGCUUAUAGGGUUU
hsa-miR-130abrain CAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301 CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrain CAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3p UAGUGCAAUAUUGCUUAUAGGGUUU
miR-181 652 659 1A,m8 hsa-miR-181abrain AACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZ AACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrain AACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrain AACAUUCAUUGUUGUCGGUGGGUU
miR-186 291 298 1A,m8 hsa-miR-186 CAAAGAAUUCUCCUUUUGGGCUU
miR-188 596 602 m8 hsa-miR-188 CAUCCCUUGCAUGGUGGAGGGU
miR-19 251 257 m8 hsa-miR-19a UGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19b UGUGCAAAUCCAUGCAAAACUGA
miR-190 1178 1185 1A,m8 hsa-miR-190 UGAUAUGUUUGAUAUAUUAGGU
miR-194 1132 1138 m8 hsa-miR-194 UGUAACAGCAACUCCAUGUGGA
hsa-miR-194 UGUAACAGCAACUCCAUGUGGA
miR-196 174 180 m8 hsa-miR-196a UAGGUAGUUUCAUGUUGUUGG
hsa-miR-196b UAGGUAGUUUCCUGUUGUUGG
miR-203.1 535 541 1A hsa-miR-203 UGAAAUGUUUAGGACCACUAG
miR-224 1044 1050 m8 hsa-miR-224 CAAGUCACUAGUGGUUCCGUUUA
miR-25/32/92/363/367 870 876 1A hsa-miR-25brain CAUUGCACUUGUCUCGGUCUGA
hsa-miR-32 UAUUGCACAUUACUAAGUUGC
hsa-miR-92 UAUUGCACUUGUCCCGGCCUG
hsa-miR-367 AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZ UAUUGCACUCGUCCCGGCCUC
miR-26 256 262 1A hsa-miR-26abrain UUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZ UUCAAGUAAUUCAGGAUAGGUU
hsa-miR-26abrain UUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZ UUCAAGUAAUUCAGGAUAGGUU
miR-30-5p 359 366 1A,m8 hsa-miR-30a-5p UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain UGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZ UGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZ UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
miR-331 589 595 1A hsa-miR-331brain GCCCCUGGGCCUAUCCUAGAA
miR-382 1122 1128 m8 hsa-miR-382brain GAAGUUGUUCGUGGUGGAUUCG
miR-384 714 720 1A hsa-miR-384 AUUCCUAGAAAUUGUUCAUA
hsa-miR-384 AUUCCUAGAAAUUGUUCAUA
miR-433-3p 304 310 m8 hsa-miR-433brain AUCAUGAUGGGCUCCUCGGUGU
miR-494 488 494 1A hsa-miR-494brain UGAAACAUACACGGGAAACCUCUU
hsa-miR-494brain UGAAACAUACACGGGAAACCUCUU
miR-495 1100 1106 m8 hsa-miR-495brain AAACAAACAUGGUGCACUUCUUU
miR-543 1096 1102 m8 hsa-miR-543 AAACAUUCGCGGUGCACUUCU