基因页面:CKAP2

Summary?
GeneID 26586
Symbol CKAP2
Synonyms LB1|TMAP|se20-10
Description cytoskeleton associated protein 2
Reference MIM:611569|HGNC:HGNC:1990|Ensembl:ENSG00000136108|HPRD:10832|Vega:OTTHUMG00000016967
Gene type protein-coding
Map location 13q14
Pascal p-value 0.041
Fetal beta -0.499
DMG 1 (# studies)
eGene Anterior cingulate cortex BA24
Caudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
Frontal Cortex BA9
Hippocampus
Hypothalamus
Nucleus accumbens basal ganglia

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 3
DNM:Gulsuner_2013 Whole Exome Sequencing analysis 155 DNMs identified by exome sequencing of quads or trios of schizophrenia individuals and their parents.

Section I. Genetics and epigenetics annotation

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type Sift CG46 Trait Study
CKAP2 chr13 53035036 G C NM_001098525
NM_018204
NM_018204		 p.54R>T
.
p.53R>T		 missense
splice
missense		 Schizophrenia DNM:Gulsuner_2013

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg07898084 13 53029385 CKAP2 2.19E-10 -0.026 5.94E-7 DMG:Jaffe_2016
cg14425257 13 53029355 CKAP2 7.68E-9 -0.013 3.75E-6 DMG:Jaffe_2016
cg11298616 13 53029954 CKAP2 1.69E-8 -0.011 6.16E-6 DMG:Jaffe_2016

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs4369550 13 52744910 CKAP2 ENSG00000136108.10 3.582E-6 0 -284654 gtex_brain_ba24
rs56033750 13 52747278 CKAP2 ENSG00000136108.10 2.716E-7 0 -282286 gtex_brain_ba24
rs9535895 13 52765847 CKAP2 ENSG00000136108.10 1.27E-6 0 -263717 gtex_brain_ba24
rs61957257 13 52769702 CKAP2 ENSG00000136108.10 3.918E-7 0 -259862 gtex_brain_ba24
rs56304200 13 52781763 CKAP2 ENSG00000136108.10 1.19E-7 0 -247801 gtex_brain_ba24
rs3866534 13 52786236 CKAP2 ENSG00000136108.10 1.39E-7 0 -243328 gtex_brain_ba24
rs9535914 13 52791751 CKAP2 ENSG00000136108.10 8.174E-8 0 -237813 gtex_brain_ba24
rs11148246 13 52797537 CKAP2 ENSG00000136108.10 1.393 e - 0 -232027 gtex_brain_ba24
rs61957304 13 52798423 CKAP2 ENSG00000136108.10 4.417E-8 0 -231141 gtex_brain_ba24
rs4545703 13 52802822 CKAP2 ENSG00000136108.10 1.351E-7 0 -226742 gtex_brain_ba24
rs138123023 13 52835439 CKAP2 ENSG00000136108.10 1.485E-8 0 -194125 gtex_brain_ba24
rs9568720 13 52836444 CKAP2 ENSG00000136108.10 5.987E-7 0 -193120 gtex_brain_ba24
rs77466241 13 52862914 CKAP2 ENSG00000136108.10 3.852E-8 0 -166650 gtex_brain_ba24
rs9536006 13 52887707 CKAP2 ENSG00000136108.10 1.485E-7 0 -141857 gtex_brain_ba24
rs6561662 13 52909774 CKAP2 ENSG00000136108.10 7.689E-8 0 -119790 gtex_brain_ba24
rs6561663 13 52909775 CKAP2 ENSG00000136108.10 1.711E-7 0 -119789 gtex_brain_ba24
rs201579381 13 52909775 CKAP2 ENSG00000136108.10 1.842E-7 0 -119789 gtex_brain_ba24
rs6561664 13 52912099 CKAP2 ENSG00000136108.10 2.652E-8 0 -117465 gtex_brain_ba24
rs7981732 13 52912217 CKAP2 ENSG00000136108.10 8.343E-8 0 -117347 gtex_brain_ba24
rs7400602 13 52916665 CKAP2 ENSG00000136108.10 1.048E-7 0 -112899 gtex_brain_ba24
rs6561666 13 52930045 CKAP2 ENSG00000136108.10 3.309E-8 0 -99519 gtex_brain_ba24
rs7334583 13 52930352 CKAP2 ENSG00000136108.10 3.309E-8 0 -99212 gtex_brain_ba24
rs9596649 13 52934610 CKAP2 ENSG00000136108.10 3.309E-8 0 -94954 gtex_brain_ba24
rs9596651 13 52938582 CKAP2 ENSG00000136108.10 9.334E-8 0 -90982 gtex_brain_ba24
rs7993748 13 52941631 CKAP2 ENSG00000136108.10 2.098E-8 0 -87933 gtex_brain_ba24
rs9568728 13 52946593 CKAP2 ENSG00000136108.10 1.138E-7 0 -82971 gtex_brain_ba24
rs3886077 13 52949053 CKAP2 ENSG00000136108.10 1.137E-7 0 -80511 gtex_brain_ba24
rs4884452 13 52949784 CKAP2 ENSG00000136108.10 1.137E-7 0 -79780 gtex_brain_ba24
rs79917517 13 52954465 CKAP2 ENSG00000136108.10 1.491E-7 0 -75099 gtex_brain_ba24
rs7987115 13 52962097 CKAP2 ENSG00000136108.10 1.137E-7 0 -67467 gtex_brain_ba24
rs1815669 13 52968645 CKAP2 ENSG00000136108.10 1.137E-7 0 -60919 gtex_brain_ba24
rs7399631 13 52975580 CKAP2 ENSG00000136108.10 2.181E-7 0 -53984 gtex_brain_ba24
rs9526913 13 52975837 CKAP2 ENSG00000136108.10 1.222E-7 0 -53727 gtex_brain_ba24
rs4885953 13 52976491 CKAP2 ENSG00000136108.10 1.358E-7 0 -53073 gtex_brain_ba24
rs9536066 13 52983981 CKAP2 ENSG00000136108.10 1.072E-7 0 -45583 gtex_brain_ba24
rs1056335 13 52989863 CKAP2 ENSG00000136108.10 2.526E-6 0 -39701 gtex_brain_ba24
rs4886018 13 52990717 CKAP2 ENSG00000136108.10 1.391E-7 0 -38847 gtex_brain_ba24
rs9568732 13 52993412 CKAP2 ENSG00000136108.10 2.233E-8 0 -36152 gtex_brain_ba24
rs11620062 13 52994026 CKAP2 ENSG00000136108.10 9.971E-8 0 -35538 gtex_brain_ba24
rs9536069 13 52994756 CKAP2 ENSG00000136108.10 2.981E-6 0 -34808 gtex_brain_ba24
rs7985262 13 52997161 CKAP2 ENSG00000136108.10 1.544E-6 0 -32403 gtex_brain_ba24
rs4886077 13 52998697 CKAP2 ENSG00000136108.10 2.526E-6 0 -30867 gtex_brain_ba24
rs8001624 13 53002995 CKAP2 ENSG00000136108.10 2.526E-6 0 -26569 gtex_brain_ba24
rs9568734 13 53004222 CKAP2 ENSG00000136108.10 2.233E-8 0 -25342 gtex_brain_ba24
rs7323666 13 53006058 CKAP2 ENSG00000136108.10 2.526E-6 0 -23506 gtex_brain_ba24
rs11148252 13 53009048 CKAP2 ENSG00000136108.10 1.391E-7 0 -20516 gtex_brain_ba24
rs4884354 13 53017474 CKAP2 ENSG00000136108.10 2.526E-6 0 -12090 gtex_brain_ba24
rs7990581 13 53019433 CKAP2 ENSG00000136108.10 2.297E-8 0 -10131 gtex_brain_ba24
rs4286007 13 53022518 CKAP2 ENSG00000136108.10 8.646E-7 0 -7046 gtex_brain_ba24
rs3892337 13 53029485 CKAP2 ENSG00000136108.10 2.2E-8 0 -79 gtex_brain_ba24
rs9536079 13 53030565 CKAP2 ENSG00000136108.10 2.2E-8 0 1001 gtex_brain_ba24
rs7328653 13 53032735 CKAP2 ENSG00000136108.10 2.2E-8 0 3171 gtex_brain_ba24
rs139530789 13 53040041 CKAP2 ENSG00000136108.10 1.821E-6 0 10477 gtex_brain_ba24
rs7321964 13 53040822 CKAP2 ENSG00000136108.10 5.087E-8 0 11258 gtex_brain_ba24
rs59203904 13 53043727 CKAP2 ENSG00000136108.10 1.892E-6 0 14163 gtex_brain_ba24
rs11618716 13 53046836 CKAP2 ENSG00000136108.10 8.625E-7 0 17272 gtex_brain_ba24
rs9526927 13 53051627 CKAP2 ENSG00000136108.10 7.393E-7 0 22063 gtex_brain_ba24
rs9536236 13 53255012 CKAP2 ENSG00000136108.10 3.511E-6 0 225448 gtex_brain_ba24
rs9526975 13 53255804 CKAP2 ENSG00000136108.10 3.515E-6 0 226240 gtex_brain_ba24

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Biological process GO term Evidence Neuro keywords PubMed ID
GO:0007049 cell cycle IEA -
GO:0006915 apoptosis IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005874 microtubule IEA -
GO:0005737 cytoplasm IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
HORIUCHI WTAP TARGETS DN 310 188 All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY UP 430 232 All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY DN 367 220 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN 459 276 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP 633 376 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722 443 All SZGR 2.0 genes in this pathway
林格伦膀胱癌CLUSTER 3 UP 329 196 All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN 228 137 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142 669 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612 367 All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP 536 340 All SZGR 2.0 genes in this pathway
MATTIOLI MGUS VS PCL 116 62 All SZGR 2.0 genes in this pathway
MATTIOLI MGUS VS MULTIPLE MYELOMA 16 11 All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER CLUSTER 1 44 23 All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM UP 176 111 All SZGR 2.0 genes in this pathway
FURUKAWA DUSP6 TARGETS PCI35 DN 74 40 All SZGR 2.0 genes in this pathway
FERREIRA EWINGS SARCOMA UNSTABLE VS STABLE UP 167 92 All SZGR 2.0 genes in this pathway
NAKAYAMA FRA2 TARGETS 43 27 All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648 385 All SZGR 2.0 genes in this pathway
SHEPARD BMYB MORPHOLINO DN 200 112 All SZGR 2.0 genes in this pathway
SHEPARD BMYB TARGETS 74 41 All SZGR 2.0 genes in this pathway
SHEPARD CRUSH AND BURN MUTANT DN 185 111 All SZGR 2.0 genes in this pathway
MAGRANGEAS MULTIPLE MYELOMA IGLL VS IGLK DN 24 18 All SZGR 2.0 genes in this pathway
MARIADASON RESPONSE TO CURCUMIN SULINDAC 7 19 10 All SZGR 2.0 genes in this pathway
HENDRICKS SMARCA4 TARGETS DN 53 34 All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES DN 245 144 All SZGR 2.0 genes in this pathway
WANG CISPLATIN RESPONSE AND XPC UP 202 115 All SZGR 2.0 genes in this pathway
MCLACHLAN DENTAL CARIES UP 253 147 All SZGR 2.0 genes in this pathway
WALLACE PROSTATE CANCER RACE UP 299 167 All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN DN 249 165 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BONE DN 315 197 All SZGR 2.0 genes in this pathway
乳腺癌萧述三腔的DN 564 326 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476 285 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP 648 398 All SZGR 2.0 genes in this pathway
WHITEFORD PEDIATRIC CANCER MARKERS 116 63 All SZGR 2.0 genes in this pathway
BOHN PRIMARY IMMUNODEFICIENCY SYNDROM DN 40 31 All SZGR 2.0 genes in this pathway
GOLDRATH ANTIGEN RESPONSE 346 192 All SZGR 2.0 genes in this pathway
CHANG CYCLING GENES 148 83 All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6 456 285 All SZGR 2.0 genes in this pathway
GUTIERREZ WALDENSTROEMS MACROGLOBULINEMIA 2 13 9 All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE 335 193 All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G2 182 102 All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G2 M 216 124 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918 550 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553 343 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP 570 339 All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP 364 236 All SZGR 2.0 genes in this pathway
ZHOU CELL CYCLE GENES IN IR RESPONSE 24HR 128 73 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 All SZGR 2.0 genes in this pathway