Gene Page:GGT7

Summary?
GeneID 2686
Symbol GGT7
Synonyms D20S101|GGT4|GGTL3|GGTL5|dJ18C9.2
Description gamma-glutamyltransferase 7
Reference MIM:612342|HGNC:HGNC:4259|Ensembl:ENSG00000131067|HPRD:07488|Vega:OTTHUMG00000032314
Gene type protein-coding
Map location 20q11.22
Pascal p-value 0.022
Sherlock p-value 0.72
Fetal beta 0.963
DMG 1 (# studies)
eGene Cerebellum
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg00333622 20 33459477 GGT7 2.54E-5 0.354 0.017 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs1507047 chr16 50932778 GGT7 2686 0.19 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
TBX18 0.73 0.72
COL8A1 0.66 0.71
VWF 0.64 0.74
C7orf58 0.63 0.65
AOC3 0.63 0.64
CYP1B1 0.63 0.68
LAMA2 0.63 0.63
ITGA1 0.62 0.60
MYOF 0.61 0.69
ASPN 0.61 0.57
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SNHG12 -0.37 -0.49
C8orf59 -0.32 -0.51
MTIF3 -0.32 -0.43
CHMP4A -0.32 -0.39
C12orf45 -0.30 -0.45
NDUFAF2 -0.29 -0.45
MRPS18C -0.29 -0.39
VRK2 -0.29 -0.40
C11orf51 -0.29 -0.33
ATP5E -0.29 -0.46

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG TAURINE AND HYPOTAURINE METABOLISM 10 7 All SZGR 2.0 genes in this pathway
KEGG SELENOAMINO ACID METABOLISM 26 18 All SZGR 2.0 genes in this pathway
KEGG GLUTATHIONE METABOLISM 50 34 All SZGR 2.0 genes in this pathway
KEGG ARACHIDONIC ACID METABOLISM 58 36 All SZGR 2.0 genes in this pathway
REACTOME BIOLOGICAL OXIDATIONS 139 91 All SZGR 2.0 genes in this pathway
REACTOME GLUTATHIONE CONJUGATION 23 13 All SZGR 2.0 genes in this pathway
REACTOME PHASE II CONJUGATION 70 42 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821 933 All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA PROGRESSION RISK 74 44 All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH VS LOW DN 32 21 All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS MODERATELY UP 109 69 All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS UP 344 180 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 20Q11 AMPLICON 31 18 All SZGR 2.0 genes in this pathway
MARIADASON REGULATED BY HISTONE ACETYLATION UP 83 49 All SZGR 2.0 genes in this pathway
MEISSNER ES ICP WITH H3K4ME3 AND H3K27ME3 14 8 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN ICP WITH H3K4ME3 32 17 All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 ICP WITH H3K27ME3 74 46 All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 AND H3K27ME3 137 85 All SZGR 2.0 genes in this pathway
KATSANOU ELAVL1 TARGETS DN 148 88 All SZGR 2.0 genes in this pathway
RATTENBACHER BOUND BY CELF1 467 251 All SZGR 2.0 genes in this pathway