Gene Page:RNF11

Summary?
GeneID 26994
Symbol RNF11
Synonyms CGI-123|SID1669
Description ring finger protein 11
Reference MIM:612598|HGNC:HGNC:10056|Ensembl:ENSG00000123091|HPRD:09955|织女:OTTHUMG00000008190
Gene type protein-coding
Map location 1p32
Pascal p-value 0.219
Fetal beta -1.177
eGene Myers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0972

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs1146358 chr1 116657767 RNF11 26994 0.17 trans
rs1620334 chr1 205697844 RNF11 26994 0.03 trans
rs823123 chr1 205725345 RNF11 26994 0.04 trans
rs823066 chr1 205771172 RNF11 26994 0.02 trans
rs11120206 chr1 206610593 RNF11 26994 0.09 trans
rs17012898 chr2 33601648 RNF11 26994 0.03 trans
rs17012916 chr2 33606031 RNF11 26994 0.04 trans
rs17012924 chr2 33612474 RNF11 26994 0.08 trans
rs2716734 chr2 39947720 RNF11 26994 9.419E-4 trans
rs2716736 chr2 39947946 RNF11 26994 9.419E-4 trans
rs10928499 chr2 135332354 RNF11 26994 0.06 trans
rs17044826 chr3 66620522 RNF11 26994 0.05 trans
rs16850133 chr3 140030776 RNF11 26994 0.13 trans
rs17023105 chr4 96074164 RNF11 26994 1.101的军医 trans
rs10516959 chr4 96088848 RNF11 26994 2.69E-4 trans
rs16869878 chr5 2523760 RNF11 26994 0 trans
rs467856 chr5 3128168 RNF11 26994 0 trans
rs6451640 chr5 20088127 RNF11 26994 0.11 trans
rs17103639 chr5 145081858 RNF11 26994 0.18 trans
snp_a-2169623 0 RNF11 26994 0 trans
rs13175086 chr5 174691428 RNF11 26994 0.07 trans
rs2016128 chr6 42442743 RNF11 26994 0 trans
rs9376870 chr6 145206590 RNF11 26994 0.09 trans
rs4947631 chr7 50603378 RNF11 26994 0.01 trans
rs870686 chr8 25253521 RNF11 26994 0.03 trans
rs10503771 chr8 25304019 RNF11 26994 0.02 trans
rs2513775 chr8 95111616 RNF11 26994 0.15 trans
rs12352894 chr9 38197383 RNF11 26994 0.17 trans
rs6559219 0 RNF11 26994 0.06 trans
rs12255258 chr10 106306927 RNF11 26994 5.656E-4 trans
rs4944475 chr11 83985410 RNF11 26994 0.01 trans
rs7298298 chr12 17810638 RNF11 26994 0 trans
rs998923 chr13 35507810 RNF11 26994 0.19 trans
rs4943304 chr13 36058065 RNF11 26994 0.04 trans
rs2518660 chr14 31271351 RNF11 26994 0.17 trans
rs4609787 chr15 61796043 RNF11 26994 0.09 trans
rs10512600 chr17 72812978 RNF11 26994 0.02 trans
rs17078828 chr18 65948765 RNF11 26994 0.05 trans
rs6040607 chr20 11371092 RNF11 26994 0.13 trans
rs225434 chr21 43724740 RNF11 26994 6.467E-4 trans
rs362166 chr22 35461382 RNF11 26994 0.18 trans
rs1882710 chrX 149894355 RNF11 26994 0.19 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
TAF7 0.94 0.93
COPS3 0.94 0.94
GTF2B 0.94 0.93
PSMD14 0.94 0.92
CCT4 0.94 0.95
MRPL44 0.93 0.93
ARF4 0.93 0.92
CCT2 0.93 0.94
CCT8 0.92 0.91
MRPL3 0.92 0.92
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.33 -0.72 -0.80
MT-CO2 -0.72 -0.77
AF347015.8 -0.71 -0.79
MT-CYB -0.71 -0.79
AF347015.26 -0.71 -0.82
AF347015.15 -0.71 -0.80
AF347015.2 -0.70 -0.79
AF347015.27 -0.70 -0.77
AF347015.31 -0.68 -0.74
HLA-F -0.68 -0.75

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003677 DNA binding TAS 10673045
GO:0005515 protein binding IDA 14755250
GO:0008270 zinc ion binding TAS 10673045
GO:0046872 metal ion binding IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0042787 protein ubiquitination during ubiquitin-dependent protein catabolic process IDA 14755250
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0000151 ubiquitin ligase complex IDA 14755250

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
EPS15 AF-1P | AF1P | MLLT5 epidermal growth factor receptor pathway substrate 15 Two-hybrid BioGRID 14755250
EPS15 AF-1P | AF1P | MLLT5 epidermal growth factor receptor pathway substrate 15 RNF11 interacts with EPS15. BIND 14755250
ITCH AIF4 | AIP4 | NAPP1 | dJ468O1.1 itchy E3 ubiquitin protein ligase homolog (mouse) RNF11 interacts with AIP4. BIND 14559117
RPS27A CEP80 | HUBCEP80 | UBA80 | UBCEP1 | UBCEP80 ribosomal protein S27a RNF11 interacts with RPS27A. BIND 14755250
RPS27A CEP80 | HUBCEP80 | UBA80 | UBCEP1 | UBCEP80 ribosomal protein S27a Two-hybrid BioGRID 14755250
SMURF2 DKFZp686F0270 | MGC138150 SMAD specific E3 ubiquitin protein ligase 2 RNF11 interacts with Smurf2. BIND 14562029
STAMBP AMSH | MGC126516 | MGC126518 STAM binding protein Affinity Capture-Western
Reconstituted Complex
Two-hybrid		 BioGRID 14755250
STAMBP AMSH | MGC126516 | MGC126518 STAM binding protein RNF11 interacts with AMSH. BIND 14755250
STAMBPL1 ALMalpha | AMSH-FP | AMSH-LP | FLJ31524 | KIAA1373 | bA399O19.2 STAM binding protein-like 1 Two-hybrid BioGRID 14755250
UBC HMG20 ubiquitin C RNF11 interacts with UbC. BIND 14755250
UBC HMG20 ubiquitin C Two-hybrid BioGRID 14755250
UBE2D1 E2(17)KB1 | SFT | UBC4/5 | UBCH5 | UBCH5A ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) RNF11 interacts with UbcH5a. BIND 14562029
UBE2D2 E2(17)KB2 | PUBC1 | UBC4 | UBC4/5 | UBCH5B ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) RNF11 interacts with UbcH5b. BIND 14562029
UBE2D3 E2(17)KB3 | MGC43926 | MGC5416 | UBC4/5 | UBCH5C ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) RNF11 interacts with UbcH5c. BIND 14562029
ZNF350 ZBRK1 | ZFQR zinc finger protein 350 RNF11 interacts with ZBRK1. BIND 14755250
ZNF350 ZBRK1 | ZFQR zinc finger protein 350 Two-hybrid BioGRID 14755250


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA DN 136 86 All SZGR 2.0 genes in this pathway
NAM FXYD5 TARGETS DN 18 11 All SZGR 2.0 genes in this pathway
DAVICIONI MOLECULAR ARMS VS ERMS UP 332 228 All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA UP 177 110 All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS DN 310 188 All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800 473 All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS LUMINAL 326 213 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712 443 All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN 848 527 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR UP 176 115 All SZGR 2.0 genes in this pathway
GOLDRATH HOMEOSTATIC PROLIFERATION 171 102 All SZGR 2.0 genes in this pathway
NEMETH INFLAMMATORY RESPONSE LPS UP 88 64 All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION 405 264 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
RUAN RESPONSE TO TNF TROGLITAZONE DN 42 24 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830 547 All SZGR 2.0 genes in this pathway
RUAN RESPONSE TO TNF DN 84 50 All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434 302 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 6 189 112 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 5 482 296 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022 619 All SZGR 2.0 genes in this pathway
AMUNDSON POOR SURVIVAL AFTER GAMMA RADIATION 8G 95 62 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN 270 181 All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN UP 439 257 All SZGR 2.0 genes in this pathway
BASSO HAIRY CELL LEUKEMIA DN 80 66 All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS DN 210 128 All SZGR 2.0 genes in this pathway
RAGHAVACHARI PLATELET SPECIFIC GENES 70 46 All SZGR 2.0 genes in this pathway
KARLSSON TGFB1 TARGETS DN 207 139 All SZGR 2.0 genes in this pathway
金所有DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756 494 All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682 440 All SZGR 2.0 genes in this pathway
金所有DISORDERS CALB1 CORR UP 548 370 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-124.1 526 532 m8 hsa - mir - 124 a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 526 532 1A hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
miR-129-5p 465 471 1A hsa-miR-129brain CUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5p CUUUUUGCGGUCUGGGCUUGCU
miR-130/301 682 688 1A hsa-miR-130abrain CAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301 CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrain CAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3p UAGUGCAAUAUUGCUUAUAGGGUUU
miR-141/200a 280 286 1A hsa-miR-141 UAACACUGUCUGGUAAAGAUGG
hsa-miR-200a UAACACUGUCUGGUAACGAUGU
miR-186 393 399 m8 hsa-miR-186 CAAAGAAUUCUCCUUUUGGGCUU
miR-19 487 494 1A,m8 hsa-miR-19a UGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19b UGUGCAAAUCCAUGCAAAACUGA
hsa-miR-19a UGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19b UGUGCAAAUCCAUGCAAAACUGA
miR-199 452 458 m8 hsa-miR-199a CCCAGUGUUCAGACUACCUGUUC
hsa-miR-199b CCCAGUGUUUAGACUAUCUGUUC
miR-24 62 68 m8 hsa-miR-24SZ UGGCUCAGUUCAGCAGGAACAG
miR-362 997 1003 1A hsa-miR-362 AAUCCUUGGAACCUAGGUGUGAGU
miR-369-3p 549 555 m8 hsa-miR-369-3p AAUAAUACAUGGUUGAUCUUU
miR-381 1170 1176 1A hsa-miR-381 UAUACAAGGGCAAGCUCUCUGU
miR-384 326 332 1A hsa-miR-384 AUUCCUAGAAAUUGUUCAUA
hsa-miR-384 AUUCCUAGAAAUUGUUCAUA
miR-496 200 206 1A hsa-miR-496 AUUACAUGGCCAAUCUC
miR-544 639 645 m8 hsa-miR-544 AUUCUGCAUUUUUAGCAAGU
miR-9 68 74 1A hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA