Gene Page:ABL2
Summary？
| 基因 | 27 |
| 象征 | ABL2 |
| Synonyms | abll | arg |
| Description | ABL原型癌基因2，非受体酪氨酸激酶 |
| Reference | MIM：164690|HGNC:HGNC:77|ENSEMBL：ENSG00000143322|HPRD：01259|Vega:OTTHUMG00000035199 |
| 基因类型 | 蛋白质编码 |
| Map location | 1q25.2 |
| 胎儿β | 0.187 |
| DMG | 1(# studies) |
| 主持人 | Caudate basal ganglia 小脑 皮质 Frontal Cortex BA9 伏隔核基底神经节 Putamen basal ganglia |
Gene in Data Sources
| 基因集名称 | Method of gene set | Description | 信息 |
|---|---|---|---|
| CV:PGCnp | 全基因组Association Study | GWAS | |
| DMG：Nishioka_2013 | 全基因组DNA甲基化分析 | 作者研究了来自18例第一期精神分裂症（FESZ）和15个正常对照的18例外周血细胞中DNA的甲基化谱。 | 1 |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.0114 |
Section I. Genetics and epigenetics annotation
差异甲基化基因
差异甲基化基因| Probe | 染色体 | 位置 | 最近的基因 | p（dis） | Beta (dis) | fdr（dis） | 学习 |
|---|---|---|---|---|---|---|---|
| CG04691540 | 1 | 179198414 | ABL2 | -0.03 | 0.34 | DMG：Nishioka_2013 |
EQTL注释
| SNP ID | 染色体 | 位置 | 主持人 | Gene Entrez ID | pvalue | QVALUE | TSS距离 | EQTL类型 |
|---|---|---|---|---|---|---|---|---|
| rs10913690 | 1 | 179067071 | ABL2 | ENSG00000143322.15 | 3.501E-6 | 0.01 | 131748 | gtex_brain_putamen_basal |
| rs3813642 | 1 | 179070120 | ABL2 | ENSG00000143322.15 | 3.555e-6 | 0.01 | 128699 | gtex_brain_putamen_basal |
| rs3813643 | 1 | 179070334 | ABL2 | ENSG00000143322.15 | 3.57E-6 | 0.01 | 128485 | gtex_brain_putamen_basal |
| RS4651012 | 1 | 179071865 | ABL2 | ENSG00000143322.15 | 3.501E-6 | 0.01 | 126954 | gtex_brain_putamen_basal |
| RS4651013 | 1 | 179072966 | ABL2 | ENSG00000143322.15 | 3.501E-6 | 0.01 | 125853 | gtex_brain_putamen_basal |
| RS12130276 | 1 | 179082525 | ABL2 | ENSG00000143322.15 | 1.016E-6 | 0.01 | 116294 | gtex_brain_putamen_basal |
| RS4652357 | 1 | 179083000 | ABL2 | ENSG00000143322.15 | 2.235E-6 | 0.01 | 115819 | gtex_brain_putamen_basal |
| rs10913695 | 1 | 179083469 | ABL2 | ENSG00000143322.15 | 9.166e-7 | 0.01 | 115350 | gtex_brain_putamen_basal |
| RS397694195 | 1 | 179083665 | ABL2 | ENSG00000143322.15 | 1.822E-6 | 0.01 | 115154 | gtex_brain_putamen_basal |
| rs2171959 | 1 | 179087934 | ABL2 | ENSG00000143322.15 | 8.161E-7 | 0.01 | 110885 | gtex_brain_putamen_basal |
| rs10913696 | 1 | 179088721 | ABL2 | ENSG00000143322.15 | 7.681E-7 | 0.01 | 110098 | gtex_brain_putamen_basal |
| rs10913697 | 1 | 179088744 | ABL2 | ENSG00000143322.15 | 8.154E-7 | 0.01 | 110075 | gtex_brain_putamen_basal |
| rs1858551 | 1 | 179089213 | ABL2 | ENSG00000143322.15 | 8.145e-7 | 0.01 | 109606 | gtex_brain_putamen_basal |
| rs9726961 | 1 | 179089475 | ABL2 | ENSG00000143322.15 | 8.145e-7 | 0.01 | 109344 | gtex_brain_putamen_basal |
| RS9728480 | 1 | 179089491 | ABL2 | ENSG00000143322.15 | 8.145e-7 | 0.01 | 109328 | gtex_brain_putamen_basal |
| RS9727252 | 1 | 179089518 | ABL2 | ENSG00000143322.15 | 5.674E-7 | 0.01 | 109301 | gtex_brain_putamen_basal |
| RS9727861 | 1 | 179092612 | ABL2 | ENSG00000143322.15 | 1.447E-6 | 0.01 | 106207 | gtex_brain_putamen_basal |
| RS9729199 | 1 | 179092613 | ABL2 | ENSG00000143322.15 | 1.608E-6 | 0.01 | 106206 | gtex_brain_putamen_basal |
| RS2793798 | 1 | 179094843 | ABL2 | ENSG00000143322.15 | 8.145e-7 | 0.01 | 103976 | gtex_brain_putamen_basal |
| RS2793797 | 1 | 179097206 | ABL2 | ENSG00000143322.15 | 8.145e-7 | 0.01 | 101613 | gtex_brain_putamen_basal |
| rs2486995 | 1 | 179098475 | ABL2 | ENSG00000143322.15 | 8.145e-7 | 0.01 | 100344 | gtex_brain_putamen_basal |
| rs2486997 | 1 | 179098770 | ABL2 | ENSG00000143322.15 | 6.302E-7 | 0.01 | 100049 | gtex_brain_putamen_basal |
| rs2493124 | 1 | 179099021 | ABL2 | ENSG00000143322.15 | 8.132E-7 | 0.01 | 99798 | gtex_brain_putamen_basal |
| RS1856968 | 1 | 179100045 | ABL2 | ENSG00000143322.15 | 8.145e-7 | 0.01 | 98774 | gtex_brain_putamen_basal |
| RS1856967 | 1 | 179100121 | ABL2 | ENSG00000143322.15 | 5.913E-7 | 0.01 | 98698 | gtex_brain_putamen_basal |
| RS2816187 | 1 | 179101606 | ABL2 | ENSG00000143322.15 | 8.016E-7 | 0.01 | 97213 | gtex_brain_putamen_basal |
| RS2793796 | 1 | 179103687 | ABL2 | ENSG00000143322.15 | 6.35E-7 | 0.01 | 95132 | gtex_brain_putamen_basal |
| RS2636287 | 1 | 179103701 | ABL2 | ENSG00000143322.15 | 2.322E-6 | 0.01 | 95118 | gtex_brain_putamen_basal |
| RS2816196 | 1 | 179103877 | ABL2 | ENSG00000143322.15 | 7.365E-7 | 0.01 | 94942 | gtex_brain_putamen_basal |
| RS2636274 | 1 | 179106899 | ABL2 | ENSG00000143322.15 | 8.145e-7 | 0.01 | 91920 | gtex_brain_putamen_basal |
| rs2791943 | 1 | 179107430 | ABL2 | ENSG00000143322.15 | 8.145e-7 | 0.01 | 91389 | gtex_brain_putamen_basal |
| rs2791942 | 1 | 179108081 | ABL2 | ENSG00000143322.15 | 2.099E-6 | 0.01 | 90738 | gtex_brain_putamen_basal |
| RS2636276 | 1 | 179111060 | ABL2 | ENSG00000143322.15 | 8.124e-7 | 0.01 | 87759 | gtex_brain_putamen_basal |
| rs2791941 | 1 | 179112435 | ABL2 | ENSG00000143322.15 | 8.119E-7 | 0.01 | 86384 | gtex_brain_putamen_basal |
| RS2258221 | 1 | 179113369 | ABL2 | ENSG00000143322.15 | 1.071E-6 | 0.01 | 85450 | gtex_brain_putamen_basal |
| RS2258217 | 1 | 179113508 | ABL2 | ENSG00000143322.15 | 2.635E-6 | 0.01 | 85311 | gtex_brain_putamen_basal |
| rs2791940 | 1 | 179115485 | ABL2 | ENSG00000143322.15 | 8.145e-7 | 0.01 | 83334 | gtex_brain_putamen_basal |
| RS2816183 | 1 | 179116474 | ABL2 | ENSG00000143322.15 | 8.145e-7 | 0.01 | 82345 | gtex_brain_putamen_basal |
| RS2816185 | 1 | 179117740 | ABL2 | ENSG00000143322.15 | 8.476E-7 | 0.01 | 81079 | gtex_brain_putamen_basal |
| RS2816186 | 1 | 179122779 | ABL2 | ENSG00000143322.15 | 8.104e-7 | 0.01 | 76040 | gtex_brain_putamen_basal |
| RS965401 | 1 | 179133221 | ABL2 | ENSG00000143322.15 | 4.983E-7 | 0.01 | 65598 | gtex_brain_putamen_basal |
| RS2816189 | 1 | 179136269 | ABL2 | ENSG00000143322.15 | 5.592E-7 | 0.01 | 62550 | gtex_brain_putamen_basal |
| rs2087559 | 1 | 179139933 | ABL2 | ENSG00000143322.15 | 6.454e-7 | 0.01 | 58886 | gtex_brain_putamen_basal |
| RS2793793 | 1 | 179140145 | ABL2 | ENSG00000143322.15 | 6.44e-7 | 0.01 | 58674 | gtex_brain_putamen_basal |
| RS2636280 | 1 | 179156375 | ABL2 | ENSG00000143322.15 | 6.465e-7 | 0.01 | 42444 | gtex_brain_putamen_basal |
| RS2816197 | 1 | 179158406 | ABL2 | ENSG00000143322.15 | 5.68e-7 | 0.01 | 40413 | gtex_brain_putamen_basal |
| RS2816198 | 1 | 179158736 | ABL2 | ENSG00000143322.15 | 6.465e-7 | 0.01 | 40083 | gtex_brain_putamen_basal |
| RS2816199 | 1 | 179158932 | ABL2 | ENSG00000143322.15 | 6.465e-7 | 0.01 | 39887 | gtex_brain_putamen_basal |
| RS2793812 | 1 | 179159399 | ABL2 | ENSG00000143322.15 | 6.45e-7 | 0.01 | 39420 | gtex_brain_putamen_basal |
| RS2816202 | 1 | 179162437 | ABL2 | ENSG00000143322.15 | 6.479E-7 | 0.01 | 36382 | gtex_brain_putamen_basal |
| RS2816203 | 1 | 179163857 | ABL2 | ENSG00000143322.15 | 6.407E-7 | 0.01 | 34962 | gtex_brain_putamen_basal |
| RS2816204 | 1 | 179164558 | ABL2 | ENSG00000143322.15 | 6.457E-7 | 0.01 | 34261 | gtex_brain_putamen_basal |
| RS2816206 | 1 | 179168805 | ABL2 | ENSG00000143322.15 | 2.219E-6 | 0.01 | 30014 | gtex_brain_putamen_basal |
| RS2816208 | 1 | 179171248 | ABL2 | ENSG00000143322.15 | 7.655e-7 | 0.01 | 27571 | gtex_brain_putamen_basal |
| RS2816209 | 1 | 179171494 | ABL2 | ENSG00000143322.15 | 2.268E-6 | 0.01 | 27325 | gtex_brain_putamen_basal |
| RS2066279 | 1 | 179172856 | ABL2 | ENSG00000143322.15 | 8.087E-7 | 0.01 | 25963 | gtex_brain_putamen_basal |
| RS2793806 | 1 | 179180424 | ABL2 | ENSG00000143322.15 | 2.495E-6 | 0.01 | 18395 | gtex_brain_putamen_basal |
| RS2130576 | 1 | 179181102 | ABL2 | ENSG00000143322.15 | 6.455e-7 | 0.01 | 17717 | gtex_brain_putamen_basal |
| RS2816214 | 1 | 179181546 | ABL2 | ENSG00000143322.15 | 6.455e-7 | 0.01 | 17273 | gtex_brain_putamen_basal |
| RS2816213 | 1 | 179183766 | ABL2 | ENSG00000143322.15 | 7.157E-7 | 0.01 | 15053 | gtex_brain_putamen_basal |
| RS2636281 | 1 | 179184140 | ABL2 | ENSG00000143322.15 | 2.483E-6 | 0.01 | 14679 | gtex_brain_putamen_basal |
| RS2636282 | 1 | 179184620 | ABL2 | ENSG00000143322.15 | 7.53e-7 | 0.01 | 14199 | gtex_brain_putamen_basal |
| RS2816211 | 1 | 179192238 | ABL2 | ENSG00000143322.15 | 6.465e-7 | 0.01 | 6581 | gtex_brain_putamen_basal |
| RS2816210 | 1 | 179193932 | ABL2 | ENSG00000143322.15 | 1.376E-6 | 0.01 | 4887 | gtex_brain_putamen_basal |
| RS2636265 | 1 | 179199076 | ABL2 | ENSG00000143322.15 | 6.138E-7 | 0.01 | -257 | gtex_brain_putamen_basal |
| RS2816167 | 1 | 179200657 | ABL2 | ENSG00000143322.15 | 2.421E-6 | 0.01 | -1838 | gtex_brain_putamen_basal |
| RS2793803 | 1 | 179201438 | ABL2 | ENSG00000143322.15 | 6.465e-7 | 0.01 | -2619 | gtex_brain_putamen_basal |
| RS2793799 | 1 | 179202209 | ABL2 | ENSG00000143322.15 | 2.39E-6 | 0.01 | -3390 | gtex_brain_putamen_basal |
| RS5779012 | 1 | 179214631 | ABL2 | ENSG00000143322.15 | 3.228E-6 | 0.01 | -15812 | gtex_brain_putamen_basal |
| RS2816170 | 1 | 179214726 | ABL2 | ENSG00000143322.15 | 8.045e-7 | 0.01 | -15907 | gtex_brain_putamen_basal |
| rs390018 | 1 | 179215747 | ABL2 | ENSG00000143322.15 | 9.645E-7 | 0.01 | -16928 | gtex_brain_putamen_basal |
| RS422684 | 1 | 179215918 | ABL2 | ENSG00000143322.15 | 3.397E-7 | 0.01 | -17099 | gtex_brain_putamen_basal |
| rs1687165 | 1 | 179217236 | ABL2 | ENSG00000143322.15 | 8.467E-7 | 0.01 | -18417 | gtex_brain_putamen_basal |
| RS60293082 | 1 | 179217317 | ABL2 | ENSG00000143322.15 | 3.045e-6 | 0.01 | -18498 | gtex_brain_putamen_basal |
| rs380474 | 1 | 179217448 | ABL2 | ENSG00000143322.15 | 8.467E-7 | 0.01 | -18629 | gtex_brain_putamen_basal |
| RS400976 | 1 | 179217582 | ABL2 | ENSG00000143322.15 | 8.467E-7 | 0.01 | -18763 | gtex_brain_putamen_basal |
| RS1173077 | 1 | 179220878 | ABL2 | ENSG00000143322.15 | 8.467E-7 | 0.01 | -22059 | gtex_brain_putamen_basal |
| RS451088 | 1 | 179222840 | ABL2 | ENSG00000143322.15 | 2.627E-7 | 0.01 | -24021 | gtex_brain_putamen_basal |
| rs1078872 | 1 | 179223726 | ABL2 | ENSG00000143322.15 | 4.237E-7 | 0.01 | -24907 | gtex_brain_putamen_basal |
| rs915337 | 1 | 179223751 | ABL2 | ENSG00000143322.15 | 4.237E-7 | 0.01 | -24932 | gtex_brain_putamen_basal |
| RS377785 | 1 | 179224067 | ABL2 | ENSG00000143322.15 | 4.244E-7 | 0.01 | -25248 | gtex_brain_putamen_basal |
| rs434283 | 1 | 179224180 | ABL2 | ENSG00000143322.15 | 4.251E-7 | 0.01 | -25361 | gtex_brain_putamen_basal |
| rs411266 | 1 | 179224861 | ABL2 | ENSG00000143322.15 | 4.292E-7 | 0.01 | -26042 | gtex_brain_putamen_basal |
| RS2816176 | 1 | 179247494 | ABL2 | ENSG00000143322.15 | 3.341E-6 | 0.01 | -48675 | gtex_brain_putamen_basal |
| RS2816177 | 1 | 179248952 | ABL2 | ENSG00000143322.15 | 3.334e-6 | 0.01 | -50133 | gtex_brain_putamen_basal |
| RS372675 | 1 | 179249358 | ABL2 | ENSG00000143322.15 | 3.18e-6 | 0.01 | -50539 | gtex_brain_putamen_basal |
| RS2816178 | 1 | 179249538 | ABL2 | ENSG00000143322.15 | 3.101E-6 | 0.01 | -50719 | gtex_brain_putamen_basal |
第二节。转录组注释
一般基因表达（GTEX）
Devlopment期间的基因表达（BrainCloud）
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
时间变化的基因表达（brainspan）
Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。
大脑区域的顶级共表达基因
| 前10个积极共表达的基因 | ||
| Gene | Pearson's Correlation | 斯皮尔曼的相关性 |
| pycr2 | 0.77 | 0.80 |
| SIL1 | 0.74 | 0.75 |
| DNPEP | 0.74 | 0.72 |
| ACO2 | 0.71 | 0.73 |
| COQ9 | 0.71 | 0.70 |
| CD81 | 0.70 | 0.73 |
| NDUFAF3 | 0.70 | 0.70 |
| 忍者 | 0.70 | 0.71 |
| HS1BP3 | 0.69 | 0.70 |
| ENO1 | 0.69 | 0.68 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | 斯皮尔曼的相关性 |
| FAM159B | -0.42 | -0.52 |
| EIF5B | -0.40 | -0.45 |
| ankrd12 | -0.39 | -0.35 |
| PHF14 | -0.36 | -0.36 |
| thoc2 | -0.36 | -0.35 |
| KIAA2022 | -0.35 | -0.20 |
| WNK3 | -0.34 | -0.16 |
| AC016138.1 | -0.34 | -0.23 |
| SEC62 | -0.34 | -0.31 |
| CEP170 | -0.34 | -0.16 |
第三节。基因本体论注释
| 分子功能 | 去学期 | 证据 | 神经关键字 | PubMed ID |
|---|---|---|---|---|
| 去：0000166 | nucleotide binding | IEA | - | |
| 去：0000287 | 镁离子结合 | 艾达 | 15886098 | |
| 去：0005515 | 蛋白质结合 | IEA | - | |
| 去：0005515 | 蛋白质结合 | IPI | 15886098 | |
| 去：0005524 | ATP binding | IEA | - | |
| GO:0004713 | 蛋白酪氨酸激酶活性 | IEA | - | |
| GO:0004715 | 非膜跨度蛋白酪氨酸激酶活性 | IEA | - | |
| GO：0016740 | 转移酶活性 | IEA | - | |
| GO：0035014 | 磷酸肌醇3-激酶调节剂活性 | IEA | - | |
| GO：0030145 | 锰离子结合 | 艾达 | 15886098 | |
| 生物过程 | 去学期 | 证据 | 神经关键字 | PubMed ID |
| GO:0007155 | cell adhesion | IEA | - | |
| 去：0006464 | 蛋白质修饰过程 | TAS | 2198571 | |
| 去：0006468 | protein amino acid phosphorylation | IEA | - | |
| GO:0007165 | 信号转导 | TAS | 2198571 | |
| GO：0018108 | peptidyl-tyrosine phosphorylation | 艾达 | 15886098 | |
| GO：0051353 | 氧化还原酶活性的阳性调节 | 艾达 | 12893824 | |
| Cellular component | 去学期 | 证据 | 神经关键字 | PubMed ID |
| 去：0005856 | 细胞骨架 | IEA | - | |
| 去：0005737 | cytoplasm | IEA | - | |
| GO:0005942 | phosphoinositide 3-kinase complex | IEA | - |