Gene Page:GJA4

Summary?
GeneID 2701
Symbol GJA4
Synonyms CX37
Description gap junction protein alpha 4
Reference MIM:121012|HGNC:HGNC:4278|Ensembl:ENSG00000187513|HPRD:08509|Vega:OTTHUMG00000004050
Gene type protein-coding
Map location 1p35.1
Pascal p-value 0.451
Fetal beta 0.124
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWAScat Genome-wide Association Studies This data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs6424930 chr1 184158795 GJA4 2701 0.06 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
DDX56 0.84 0.83
ING4 0.83 0.88
BCS1L 0.83 0.85
PCID2 0.83 0.83
RFC2 0.83 0.85
STX5 0.83 0.85
DDX47 0.82 0.84
PRMT5 0.82 0.86
POLR1C 0.82 0.83
HDAC3 0.82 0.82
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.26 -0.74 -0.81
AF347015.33 -0.73 -0.77
AF347015.8 -0.72 -0.76
MT-CO2 -0.72 -0.74
MT-CYB -0.71 -0.76
AF347015.15 -0.71 -0.76
AF347015.27 -0.71 -0.75
AF347015.2 -0.71 -0.78
AF347015.31 -0.70 -0.73
AIFM3 -0.64 -0.70

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME MEMBRANE TRAFFICKING 129 74 All SZGR 2.0 genes in this pathway
REACTOME GAP JUNCTION TRAFFICKING 27 19 All SZGR 2.0 genes in this pathway
REACTOME GAP JUNCTION ASSEMBLY 18 12 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D DN 205 127 All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443 294 All SZGR 2.0 genes in this pathway
WATTEL AUTONOMOUS THYROID ADENOMA UP 73 47 All SZGR 2.0 genes in this pathway
ROSS AML OF FAB M7 TYPE 68 44 All SZGR 2.0 genes in this pathway
YAGI AML FAB MARKERS 191 131 All SZGR 2.0 genes in this pathway
WESTON VEGFA TARGETS 6HR 59 38 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR DN 148 102 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN 298 200 All SZGR 2.0 genes in this pathway
WESTON VEGFA TARGETS 108 71 All SZGR 2.0 genes in this pathway
WESTON VEGFA TARGETS 3HR 74 47 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476 285 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701 446 All SZGR 2.0 genes in this pathway
MATZUK MEIOTIC AND DNA REPAIR 39 26 All SZGR 2.0 genes in this pathway
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE DN 72 47 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 30MIN DN 150 99 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 4HR DN 254 158 All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS DN 213 127 All SZGR 2.0 genes in this pathway