SZGR2 - Beplay体育中心

概括?

基因ID	27040
Symbol	LAT
同义词	LAT1\|pp36
描述	激活T细胞的链接器
参考	MIM:602354\|HGNC:HGNC:18874\|Ensembl:ENSG00000213658\|HPRD:03832\|Vega:OTTHUMG00000131761
基因type	protein-coding
地图位置	16p11.2
Pascal P值	0.274
Fetal beta	0.013
eGene	迈尔斯的顺式和跨性别

数据源中的基因

基因set name	基因组方法	描述	Info
简历：PGCNP	全基因组协会研究	GWAS
PMID:cooccur	高通量文献搜索	系统的搜索在酒吧Med for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IIE	基因组扫描荟萃分析（欧洲官方样品）	PSR：0.01775
文学	高通量文献搜索	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias,schizotypal	Click to show details
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 2

第一节遗传学和表观遗传学注释

eQTL annotation

SNP ID	Chromosome	Position	eGene	基因Entrez ID	qvalue	eQTL type
rs6687849	chr1	175904808	LAT	27040	0.15	trans
RS2502827	chr1	176044216	LAT	27040	0.01	trans
rs16829545	chr2	151977407	LAT	27040	0	trans
RS3845734	chr2	171125572	LAT	27040	0	trans
rs7584986	chr2	184111432	LAT	27040	2.313E-4	trans
rs2090117	chr4	54300590	LAT	27040	0.08	trans
rs504836	chr4	56285304	LAT	27040	0.13	trans
RS534654	chr4	56290219	LAT	27040	0.16	trans
rs10491487	chr5	80323367	LAT	27040	0.07	trans
RS1368303	chr5	147672388	LAT	27040	0.01	trans
RS17263352	chr9	124811572	LAT	27040	0.04	trans
rs17104720	chr14	77127308	LAT	27040	0.01	trans
RS16955618	chr15	29937543	LAT	27040	2.165e-9	trans
RS749043	chr20	46995700	LAT	27040	0.18	trans

Section II. Transcriptome annotation

基因ral gene expression (GTEx)

基因expression during devlopment (BrainCloud)

脚注：
总共绘制了269个时间点，n = 38个胎儿样品（x = 1：38）。每个三角形代表一个时间点。

基因expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
基因	皮尔逊的相关性	Spearman's Correlation
CCDC8	0.82	0.49
EFNA4	0.80	0.62
NECAP2	0.80	0.62
PDPN	0.78	0.52
RASSF10	0.77	0.52
CD99	0.77	0.66
ABHD4	0.77	0.64
RFX2	0.76	0.51
六	0.76	0.62
SULT1C4	0.75	0.62

前10个负共表达基因
基因	皮尔逊的相关性	Spearman's Correlation
NDRG1	-0.37	-0.50
FBXW7	-0.37	-0.50
AC016910.1	-0.36	-0.53
AC079953.2	-0.34	-0.50
MEF2C	-0.34	-0.51
ARHGAP20	-0.33	-0.48
DOCK9	-0.32	-0.44
C1orf115	-0.32	-0.40
LMO7	-0.32	-0.50
dync1i1	-0.32	-0.48

Section III. Gene Ontology annotation

Molecular function	去的术语	Evidence	Neuro keywords	PubMed ID
GO:0005070	SH3/SH2适配器活动	IDA		9489702
GO:0005515	protein binding	新闻学会		16938345
Biological process	去的术语	Evidence	Neuro keywords	PubMed ID
GO:0043303	mast cell degranulation	IEA	serotonin (GO term level: 9)	-
GO:0007265	Ras protein signal transduction	小鬼		12646565
GO:0007242	intracellular signaling cascade	IDA		12646565
GO:0007229	integrin-mediated signaling pathway	IDA		15100278
GO:0006955	immune response	IDA		15100278
GO:0019722	calcium-mediated signaling	小鬼		12646565
GO：0050863	调节T细胞激活	小鬼		12646565
细胞分量	去的术语	Evidence	Neuro keywords	PubMed ID
去：0001772	immunological synapse	IDA	Synap (GO term level: 7)	12646565
GO:0016021	integral to membrane	IDA		12646565
GO:0005886	质膜	EXP		11048639\|11607830\|17652306
GO:0005886	质膜	IEA		-
GO：0045121	膜筏	塔斯		14722116

第四节。蛋白质蛋白相互作用注释

Interactors	Aliases B	Official full name B	Experimental	资源	PubMed ID
CD244	2B4 \|指甲\|NKR2B4 \|NMRK \|slamf4	CD244 molecule, natural killer cell receptor 2B4	-	HPRD	12077228
CD4	CD4mut	CD4molecule	-	HPRD	10562325
CD8A	CD8 \| Leu2 \| MAL \| p32	CD8a molecule	-	HPRD	10562325
CLYBL	CLB \| bA134O15.1	citrate lyase beta like	Affinity Capture-Western	BioGRID	11368773
FCGR1A	CD64 \| CD64A \| FCRI \| FLJ18345 \| IGFR1	Fc fragment of IgG, high affinity Ia, receptor (CD64)	-	HPRD，Biogrid	10781611
FCGR2A	CD32 \|CD32A \|CDW32 \|FCG2 \|FCGR2 \|FCGR2A1 \|FCGR \|IGFR2 \|MGC23887 \|MGC30032	Fc fragment of IgG, low affinity IIa, receptor (CD32)	-	HPRD，Biogrid	10781611
GAB2	KIAA0571	GRB2相关的结合蛋白2	-	HPRD，Biogrid	11572860
GRAP	MGC64880	GRB2-related adaptor protein	Affinity Capture-Western Reconstituted Complex	BioGRID	9489702\|12186560
GRAP2	GADS \| GRAP-2 \| GRB2L \| GRBLG \| GRID \| GRPL \| GrbX \| Grf40 \| Mona \| P38	与GRB2相关的衔接蛋白2	-	HPRD，Biogrid	10021361
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	-	HPRD	9489702\|12359715
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	Affinity Capture-Western Reconstituted Complex	BioGRID	9489702\|11368773 \|12186560
ITK	EMT \| LYK \| MGC126257 \| MGC126258 \| PSCTK2	IL2诱导的T细胞激酶	-	HPRD	10506192\|12186560
ITK	EMT \| LYK \| MGC126257 \| MGC126258 \| PSCTK2	IL2诱导的T细胞激酶	Affinity Capture-Western Biochemical Activity	BioGRID	10506192\|12186560
LCP2	SLP-76 \| SLP76	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	-	HPRD	9489702
PIK3R1	grb1 \|P85 \|p85-alpha	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	Affinity Capture-Western Reconstituted Complex	BioGRID	11368773
PLCG1	PLC-II \| PLC1 \| PLC148 \| PLCgamma1	phospholipase C, gamma 1	-	HPRD，Biogrid	9729044\|11368773
PLCG1	PLC-II \| PLC1 \| PLC148 \| PLCgamma1	phospholipase C, gamma 1	LAT interacts with an unspecified isoform of PLC-gamma-1.	BIND	15696170
PLCG2	-	磷脂酶C，伽马2（磷脂酰肌醇特异性）	-	HPRD，Biogrid	10469124
PTPRJ	CD148 \|dep1 \|hptpeta \|R-PTP-ETA \|SCC1	protein tyrosine phosphatase, receptor type, J	-	HPRD，Biogrid	11259588
SH3BP2	3BP2 \| CRBM \| CRPM \| FLJ42079 \| RES4-23	SH3-domain binding protein 2	-	HPRD，Biogrid	11390470
SHB	RP11-3J10.8 \|BA3J10.2	Src homology 2 domain containing adaptor protein B	-	HPRD，Biogrid	12084069
SLA	SLA1 \| SLAP	Src-like-adaptor	-	HPRD，Biogrid	10449770
Syk	DKFZp313N1010 \| FLJ25043 \| FLJ37489	spleen tyrosine kinase	Biochemical Activity	BioGRID	11368773
Syk	DKFZp313N1010 \| FLJ25043 \| FLJ37489	spleen tyrosine kinase	-	HPRD	9891970
vav1	VAV	vav 1 guanine nucleotide exchange factor	-	HPRD，Biogrid	11368773
ZAP70	FLJ17670 \| FLJ17679 \| SRK \| STD \| TZK \| ZAP-70	zeta-chain (TCR) associated protein kinase 70kDa	Biochemical Activity	BioGRID	11368773\|12186560

V.途径注释

Pathway name	Pathway size	＃szgr 2.0基因	Info
KEGG NATURAL KILLER CELL MEDIATED CYTOTOXICITY	137	92	该途径中的所有SZGR 2.0基因
kegg t细胞受体信号通路	108	89	该途径中的所有SZGR 2.0基因
KEGG FC EPSILON RI SIGNALING PATHWAY	79	58	该途径中的所有SZGR 2.0基因
KEGG FC GAMMA R MEDIATED PHAGOCYTOSIS	97	71	该途径中的所有SZGR 2.0基因
BIOCARTA NKCELLS PATHWAY	20	13	该途径中的所有SZGR 2.0基因
Biocarta TCR途径	49	37	该途径中的所有SZGR 2.0基因
St T细胞信号转导	45	33	该途径中的所有SZGR 2.0基因
PID FCER1 PATHWAY	62	43	该途径中的所有SZGR 2.0基因
PID TCR PATHWAY	66	51	该途径中的所有SZGR 2.0基因
PID PTP1B PATHWAY	52	40	该途径中的所有SZGR 2.0基因
PID CD8 TCR PATHWAY	53	42	该途径中的所有SZGR 2.0基因
PID PI3KCI PATHWAY	49	40	该途径中的所有SZGR 2.0基因
PID TCR JNK PATHWAY	14	11	该途径中的所有SZGR 2.0基因
REACTOME TCR SIGNALING	54	46	该途径中的所有SZGR 2.0基因
REACTOME GENERATION OF SECOND MESSENGER MOLECULES	27	25	该途径中的所有SZGR 2.0基因
REACTOME GPVI MEDIATED ACTIVATION CASCADE	31	25	该途径中的所有SZGR 2.0基因
REACTOME HEMOSTASIS	466	331	该途径中的所有SZGR 2.0基因
Reactome免疫系统	933	616	该途径中的所有SZGR 2.0基因
REACTOME ADAPTIVE IMMUNE SYSTEM	539	350	该途径中的所有SZGR 2.0基因
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION	208	138	该途径中的所有SZGR 2.0基因
KIM MYC AMPLIFICATION TARGETS UP	201	127	该途径中的所有SZGR 2.0基因
Nuytten EZH2靶向DN	1024	594	该途径中的所有SZGR 2.0基因
Moreira对TSA DN的响应	18	16	该途径中的所有SZGR 2.0基因
Qi Plasmacytoma Up	259	185	该途径中的所有SZGR 2.0基因
VILIMAS NOTCH1 TARGETS UP	52	41	该途径中的所有SZGR 2.0基因
MIKKELSEN ES ICP WITH H3K4ME3	718	401	该途径中的所有SZGR 2.0基因
HUANG GATA2 TARGETS DN	72	52	该途径中的所有SZGR 2.0基因
KRIEG HYPOXIA NOT VIA KDM3A	770	480	该途径中的所有SZGR 2.0基因
BOSCO INTERFERON INDUCED ANTIVIRAL MODULE	78	48	该途径中的所有SZGR 2.0基因

基因页：LAT