Gene Page:VPS41

Summary?
GeneID 27072
Symbol VPS41
Synonyms HVPS41|HVSP41|hVps41p
Description VPS41, HOPS complex subunit
Reference MIM:605485|HGNC:HGNC:12713|Ensembl:ENSG00000006715|HPRD:10402|Vega:OTTHUMG00000023629
Gene type protein-coding
Map location 7p14-p13
Pascal p-value 0.002
Sherlock p-value 0.511
Fetal beta -0.592
eGene Cerebellar Hemisphere
Myers' cis & trans
Support G2Cdb.humanPSD
G2Cdb.humanPSP
CompositeSet
Darnell FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs2190699 chr17 12846294 VPS41 27072 0.03 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
CHD2 0.95 0.95
MACF1 0.95 0.95
BPTF 0.94 0.95
SETD5 0.94 0.93
RBM28 0.94 0.93
SPEN 0.94 0.94
ZFYVE26 0.94 0.93
ZC3H11A 0.93 0.93
GON4L 0.93 0.92
TAF1 0.93 0.93
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.31 -0.68 -0.76
IFI27 -0.67 -0.74
HIGD1B -0.65 -0.76
MT-CO2 -0.64 -0.73
AF347015.27 -0.64 -0.70
AF347015.21 -0.64 -0.81
FXYD1 -0.63 -0.70
MYL3 -0.63 -0.74
ENHO -0.62 -0.73
VAMP5 -0.62 -0.75

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS UP 306 188 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508 354 All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA DN 394 258 All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584 356 All SZGR 2.0 genes in this pathway
XU HGF SIGNALING NOT VIA AKT1 48HR DN 20 12 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584 395 All SZGR 2.0 genes in this pathway
DING LUNG CANCER EXPRESSION BY COPY NUMBER 100 62 All SZGR 2.0 genes in this pathway
NOUZOVA TRETINOIN AND H4 ACETYLATION 143 85 All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION 405 264 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN 298 200 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 20HR DN 101 70 All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL OPTIMAL DEBULKING 246 152 All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR UP 294 199 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518 299 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SURVIVAL DN 113 76 All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 718 401 All SZGR 2.0 genes in this pathway
MIKKELSEN NPC ICP WITH H3K4ME3 445 257 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682 433 All SZGR 2.0 genes in this pathway
ROESSLER LIVER CANCER METASTASIS UP 107 72 All SZGR 2.0 genes in this pathway