Gene Page:CACNG4

Summary?
GeneID 27092
Symbol CACNG4
Synonyms -
Description calcium voltage-gated channel auxiliary subunit gamma 4
Reference MIM:606404|HGNC:HGNC:1408|Ensembl:ENSG00000075461|HPRD:05911|Vega:OTTHUMG00000179550
Gene type protein-coding
Map location 17q24
Pascal p-value 0.081
Fetal beta 2.155
DMG 1 (# studies)
eGene 元
Support CANABINOID
DOPAMINE
EXCITABILITY
METABOTROPIC GLUTAMATE RECEPTOR
SEROTONIN
CompositeSet
Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWAScat Genome-wide Association Studies This data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccur High-throughput literature-search 系统搜索PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg03052970 17 64961530 CACNG4 5.758E-4 0.574 0.049 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MPP5 0.85 0.85
CCDC25 0.83 0.86
NAPEPLD 0.82 0.85
RALBP1 0.82 0.82
SLC25A40 0.81 0.86
SENP2 0.81 0.83
DNAJC21 0.80 0.77
USP8 0.80 0.82
KIAA1279 0.80 0.86
NDUFS1 0.79 0.85
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
TBC1D10A -0.43 -0.40
WDR86 -0.40 -0.43
EMID1 -0.40 -0.41
OLFM2 -0.40 -0.33
SIGIRR -0.40 -0.49
CLEC3B -0.38 -0.46
IL32 -0.37 -0.36
C1orf61 -0.36 -0.38
RAMP2 -0.36 -0.48
AC006276.2 -0.35 -0.42

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005509 calcium ion binding IEA -
GO:0005244 voltage-gated ion channel activity IEA -
GO:0005245 voltage-gated calcium channel activity TAS 10613843
GO:0005198 structural molecule activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0019226 transmission of nerve impulse IEA neuron (GO term level: 5) -
GO:0006816 calcium ion transport IEA -
GO:0006811 ion transport IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005923 tight junction IEA Brain (GO term level: 10) -
GO:0005886 plasma membrane EXP 8825650
GO:0005887 integral to plasma membrane TAS 10613843

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG MAPK SIGNALING PATHWAY 267 205 All SZGR 2.0 genes in this pathway
KEGG CARDIAC MUSCLE CONTRACTION 80 51 All SZGR 2.0 genes in this pathway
KEGG HYPERTROPHIC CARDIOMYOPATHY HCM 85 65 All SZGR 2.0 genes in this pathway
KEGG ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY ARVC 76 59 All SZGR 2.0 genes in this pathway
KEGG DILATED CARDIOMYOPATHY 92 68 All SZGR 2.0 genes in this pathway
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES 186 155 All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM 279 221 All SZGR 2.0 genes in this pathway
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 137 110 All SZGR 2.0 genes in this pathway
REACTOME TRAFFICKING OF AMPA RECEPTORS 28 23 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL UP 380 215 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL UP 450 256 All SZGR 2.0 genes in this pathway
DOANE RESPONSE TO ANDROGEN UP 184 125 All SZGR 2.0 genes in this pathway
DOANE BREAST CANCER ESR1 UP 112 72 All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS UP 372 227 All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER 20Q13 AMPLIFICATION UP 119 66 All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781 465 All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS NEUROEPITHELIUM DN 164 111 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON 335 181 All SZGR 2.0 genes in this pathway
XU GH1 AUTOCRINE TARGETS DN 142 94 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B UP 172 109 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701 446 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435 318 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898 516 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP 570 339 All SZGR 2.0 genes in this pathway
LIM MAMMARY LUMINAL MATURE UP 116 65 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
let-7/98 2017 2023 m8 hsa-let-7abrain UGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrain UGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrain UGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrain AGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrain UGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrain UGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brain UGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZ UGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrain UGAGGUAGUAGUUUGUGCUGU
miR-29 593 599 m8 hsa-miR-29aSZ UAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZ UAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZ UAGCACCAUUUGAAAUCGGU