Gene Page:AGO2
Summary?
| GeneID | 27161 |
| Symbol | AGO2 |
| Synonyms | EIF2C2|Q10 |
| Description | argonaute 2, RISC catalytic component |
| Reference | MIM:606229|HGNC:HGNC:3263|Ensembl:ENSG00000123908|HPRD:06943|Vega:OTTHUMG00000164232 |
| Gene type | protein-coding |
| Map location | 8q24 |
| Pascal p-value | 0.006 |
| DMG | 1 (# studies) |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Montano_2016 | Genome-wide DNA methylation analysis | This dataset includes 172 replicated associations between CpGs with schizophrenia. | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Differentially methylated gene| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg14827056 | 8 | 141550539 | AGO2 | 3.78E-6 | 0.006 | 0.028 | DMG:Montano_2016 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs16829545 | chr2 | 151977407 | EIF2C2 | 27161 | 0.1 | trans | ||
| rs6835548 | chr4 | 140644143 | EIF2C2 | 27161 | 0.17 | trans | ||
| rs9637082 | chr21 | 21213235 | EIF2C2 | 27161 | 0.04 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.