SZGR2 - Beplay体育中心

概括?

基因	27185
象征	DISC1
Synonyms	C1orf136\|SCZD9
Description	disrupted in schizophrenia 1
参考	MIM：605210\|HGNC:HGNC:2888\|ENSEMBL：ENSG00000162946\|HPRD:05553\|Vega:OTTHUMG00000037835
Gene type	protein-coding
Map location	1q42.1
Sherlock P值	0.155
eGene	迈尔斯的顺式和跨性别

数据源中的基因

Gene set name	Method of gene set	Description	Info
DMG：Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Association	A combined odds ratio method (Sun et al. 2008），协会研究	3	Link to SZGene
文学	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias	Click to show details
Network	人蛋白蛋白质相互作用网络中核心基因的最短路径距离	Contribution to shortest path in PPI network: 32.3086

第一节遗传学和表观遗传学注释

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg16366945	1	231970657	DISC1; TSNAX-DISC1	2.808E-4	0.238	0.039	DMG：Wockner_2014

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	EQTL类型
rs1521516	chr12	51055707	DISC1	27185		0.18		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

大脑区域没有共表达基因

Section III. Gene Ontology annotation

分子功能	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005515	蛋白质结合	新闻学会		12812986\|15094396\|17043677
生物过程	GO term	Evidence	Neuro keywords	PubMed ID
GO:0008150	生物_Process	nd		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
去：0005813	centrosome	IEA		-
GO:0005856	cytoskeleton	IEA		-
GO:0005874	microtubule	IEA		-
GO:0005575	cellular_component	nd		-
GO:0005737	细胞质	IEA		-

第四节。蛋白质蛋白相互作用注释

互动者	Aliases B	Official full name B	Experimental	资源	PubMed ID
ACTN2	CMD1AA	actinin, alpha 2	DISC-1 interacts with alpha-actinin 2.	BIND	12812986
ACTN2	CMD1AA	actinin, alpha 2	-	HPRD,BioGRID	12812986
ankhd1	MASK \| VBARP	Ankyrin重复和包含1的KH结构域	Disc-1与APAP2相互作用。	BIND	12812986
ATF4	CREB-2 \|creb2 \|TAXREB67 \|txreb	activating transcription factor 4 (tax-responsive enhancer element B67)	-	HPRD,BioGRID	12812986
ATF4	CREB-2 \|creb2 \|TAXREB67 \|txreb	activating transcription factor 4 (tax-responsive enhancer element B67)	An unspecified isoform of DISC1 interacts with ATF4.	BIND	14623284
ATF4	CREB-2 \|creb2 \|TAXREB67 \|txreb	activating transcription factor 4 (tax-responsive enhancer element B67)	Disc-1与ATF4相互作用。	BIND	12812986
ATF5	ATFX \| FLJ34666 \| HMFN0395	activating transcription factor 5	-	HPRD,BioGRID	12812986
ATF5	ATFX \| FLJ34666 \| HMFN0395	activating transcription factor 5	DISC-1 interacts with ATF5.	BIND	12812986
atf7ip	FLJ10139 \| FLJ10688 \| MCAF \| p621	激活转录因子7相互作用蛋白	DISC-1 interacts with ATF7ip.	BIND	12812986
atf7ip	FLJ10139 \| FLJ10688 \| MCAF \| p621	激活转录因子7相互作用蛋白	两个杂交	BioGRID	12812986
CCDC141	FLJ26337 \| FLJ39502 \| MGC134803	coiled-coil domain containing 141	两个杂交	BioGRID	12812986
CEP290	3H11Ag \| BBS14 \| FLJ13615 \| FLJ21979 \| JBTS5 \| JBTS6 \| KIAA0373 \| LCA10 \| MKS4 \| NPHP6 \| SLSN6 \| rd16	中心蛋白290KDA	An unspecified isoform of DISC1 interacts with KIAA0373.	BIND	14623284
CEP63	FLJ13386 \| MGC78416	centrosomal protein 63kDa	Affinity Capture-Western 两个杂交	BioGRID	12812986
CIT	CRIK \| KIAA0949 \| STK21	Citron（Rho Interacting，丝氨酸/苏氨酸激酶21）	两个杂交	BioGRID	12506198
COL4A1	逮捕	胶原蛋白，IV型，Alpha 1	两个杂交	BioGRID	12812986
EIF3A	EIF3 \| EIF3S10 \| KIAA0139 \| P167 \| TIF32 \| eIF3-p170 \| eIF3-theta \| p180 \| p185	eukaryotic translation initiation factor 3, subunit A	Affinity Capture-Western 两个杂交	BioGRID	12812986
EIF3H	EIF3S3 \| MGC102958 \| eIF3-gamma \| eIF3-p40	eukaryotic translation initiation factor 3, subunit H	DISC-1 interacts with EIF3.	BIND	12812986
EIF3H	EIF3S3 \| MGC102958 \| eIF3-gamma \| eIF3-p40	eukaryotic translation initiation factor 3, subunit H	两个杂交	BioGRID	12812986
EPB49	DMT \| FLJ78462 \| FLJ98848	erythrocyte membrane protein band 4.9 (dematin)	An unspecified isoform of DISC1 interacts with DMT.	BIND	14623284
FEZ1	-	fasciculation and elongation protein zeta 1 (zygin I)	-	HPRD,BioGRID	12874605
GOLGA2	GM130 \| MGC20672	golgi autoantigen, golgin subfamily a, 2	Disc1的未指定同工型与GM130相互作用。	BIND	14623284
immt	DKFZP779P1653 \|HMP \|MGC111146 \|P87 \|P87/89 \|P89 \|Pig4 \|PIG52	inner membrane protein, mitochondrial (mitofilin)	Disc1的未指定同工型与IMMT相互作用。	BIND	14623284
ITSN1	它的\|MGC134948 \|MGC134949 \|SH3D1A \|SH3P17	intersectin 1 (SH3 domain protein)	Disc-1与ITS互动。	BIND	12812986
ITSN1	它的\|MGC134948 \|MGC134949 \|SH3D1A \|SH3P17	intersectin 1 (SH3 domain protein)	两个杂交	BioGRID	12812986
KALRN	DUET \| FLJ16443 \| HAPIP \| TRAD \| duo	kalirin, RhoGEF kinase	Disc1的未指定同工型与HAPIP相互作用。	BIND	14623284
KATNAL1	MGC2599	katanin p60亚基A样1	An unspecified isoform of DISC1 interacts with MGC2599.	BIND	14623284
KCNQ5	Kv7.5	potassium voltage-gated channel, KQT-like subfamily, member 5	两个杂交	BioGRID	12506198
KIAA1377	-	KIAA1377	两个杂交	BioGRID	12812986
MAP1A	FLJ77111 \|map1l \|mtap1a	微管相关蛋白1a	-	HPRD,BioGRID	12812986
MAP1A	FLJ77111 \|map1l \|mtap1a	微管相关蛋白1a	DISC-1 interacts with MAP1A.	BIND	12812986
MGAT3	FLJ43371 \|gnt-iii \|gnt3 \|MGC141943 \|MGC142278	mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase	An unspecified isoform of DISC1 interacts with MGAT3.	BIND	14623284
myo1a	BBMI \|DFNA48 \|mihc \|myhl	肌球蛋白	两个杂交	BioGRID	12812986
ndE1	FLJ20101 \|Hom-Tes-87 \|裸体\|nude1	裸核基因E同族体1(一个分布。nidulans)	An unspecified isoform of DISC1 interacts with NUDE.	BIND	14623284
ndEL1	DKFZp451M0318 \| EOPA \| MITAP1 \| NUDEL	裸核分布基因E同源物（A. nidulans）类似1	-	HPRD,BioGRID	12506198
ndEL1	DKFZp451M0318 \| EOPA \| MITAP1 \| NUDEL	裸核分布基因E同源物（A. nidulans）类似1	DISC-1 interacts with NUDEL.	BIND	12812986
PCNT	KEN \| MOPD2 \| PCN \| PCNT2 \| PCNTB \| PCTN2 \| SCKL4	pericentrin	DISC1 interacts with kendrin.	BIND	15094396
PPFIA4	-	蛋白酪氨酸磷酸酶，受体类型，F多肽（PTPRF），相互作用蛋白（Liprin），α4	An unspecified isoform of DISC1 interacts with PPFIA4.	BIND	14623284
RANBP9	RANBPM	RAN binding protein 9	-	HPRD,BioGRID	12812986
RANBP9	RANBPM	RAN binding protein 9	Disc-1与RANBPM相互作用。	BIND	12812986
RASSF7	C11orf13 \| HRAS1 \| HRC1 \| MGC126069 \| MGC126070	RAS协会（RALGDS/AF-6）域家族（N末端）成员7	两个杂交	BioGRID	12812986
Smarce1	BAF57	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	An unspecified isoform of DISC1 interacts with SMARCE1.	BIND	14623284
SPTAN1	(ALPHA)II-SPECTRIN \| FLJ44613 \| NEAS	光谱，α，非肉毒细胞1（阿尔法 - - - - - - - --------）	An unspecified isoform of DISC1 interacts with SPTAN1.	BIND	14623284
SPTBN4	KIAA1642 \|QV \|SPNB4 \|SPTBN3	spectrin, beta, non-erythrocytic 4	-	HPRD,BioGRID	12506198\|12812986
SPTBN4	KIAA1642 \|QV \|SPNB4 \|SPTBN3	spectrin, beta, non-erythrocytic 4	Disc-1与B4光谱蛋白相互作用。	BIND	12812986
Syne1	8b \|CPG2 \|DKFZP781J13156 \|FLJ30878 \|FLJ41140 \|KIAA0796 \|KIAA1262 \|KIAA1756 \|myne1 \|疤痕8	spectrin repeat containing, nuclear envelope 1	-	HPRD,BioGRID	12812986
TRAF3IP1	DKFZP434F124 \|MIP-T3 \|MIPT3	TNF receptor-associated factor 3 interacting protein 1	DISC-1 interacts with MIP-T3.	BIND	12812986
TRAF3IP1	DKFZP434F124 \|MIP-T3 \|MIPT3	TNF receptor-associated factor 3 interacting protein 1	Affinity Capture-Western 两个杂交	BioGRID	12812986
是的	14-3-3GAMMA	酪氨酸3-单加氧酶/色氨酸5-单加氧酶激活蛋白，伽马多肽	-	HPRD,BioGRID	12506198

V.途径注释

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
Doane对雄激素的反应	184	125	该途径中的所有SZGR 2.0基因
Borczuk恶性间皮瘤DN	104	59	该途径中的所有SZGR 2.0基因
Amundson遗传毒性签名	105	68	该途径中的所有SZGR 2.0基因
ACEVEDO METHYLATED IN LIVER CANCER DN	940	425	该途径中的所有SZGR 2.0基因
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3	1069	729	该途径中的所有SZGR 2.0基因
YOSHIOKA LIVER CANCER EARLY RECURRENCE DN	65	31	该途径中的所有SZGR 2.0基因
DELACROIX RAR BOUND ES	462	273	该途径中的所有SZGR 2.0基因
KRIEG HYPOXIA NOT VIA KDM3A	770	480	该途径中的所有SZGR 2.0基因
Pedrioli mir31靶向DN	418	245	该途径中的所有SZGR 2.0基因

Gene Page:DISC1