Gene Page:GCLC

Summary?
GeneID 2729
Symbol GCLC
Synonyms GCL|GCS|GLCL|GLCLC
Description glutamate-cysteine ligase catalytic subunit
Reference MIM:606857|HGNC:HGNC:4311|Ensembl:ENSG00000001084|HPRD:06032|Vega:OTTHUMG00000160220
Gene type protein-coding
Map location 6p12
Pascal p-value 0.442
Sherlock p-value 0.919
Fetal beta -1.403
eGene Cerebellum
Cortex
Hippocampus
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.04433
Literature High-throughput literature-search 与精神分裂症Co-occurance关键词:schizophrenia,schizophrenic,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 5

Section I. Genetics and epigenetics annotation

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type Sift CG46 Trait Study
GCLC chr6 53387293 T C NM_001197115
NM_001498		 .
.		 silent
silent		 Schizophrenia DNM:Gulsuner_2013

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs6632306 chrX 35590460 GCLC 2729 0.07 trans
rs1935404 chrX 35605181 GCLC 2729 0.1 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene 皮尔森的软木relation Spearman's Correlation
GLUD2 0.95 0.95
GPC5 0.91 0.88
SUCLG2 0.90 0.88
GJA1 0.90 0.86
S1PR1 0.89 0.81
PLSCR4 0.89 0.89
ITM2C 0.87 0.88
ADD3 0.86 0.88
KCNJ16 0.86 0.83
NT5E 0.85 0.86
Top 10 negatively co-expressed genes
Gene 皮尔森的软木relation Spearman's Correlation
RTF1 -0.53 -0.57
CCAR1 -0.50 -0.59
DPF1 -0.49 -0.48
MPP3 -0.49 -0.49
GMIP -0.49 -0.47
RP9 -0.49 -0.58
ZNF821 -0.49 -0.48
PHF14 -0.49 -0.56
AC011491.1 -0.48 -0.56
CHD3 -0.48 -0.47

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0016595 glutamate binding IDA glutamate (GO term level: 5) 9841880
GO:0004357 glutamate-cysteine ligase activity IDA glutamate (GO term level: 6) 8104187|11972604
GO:0004357 glutamate-cysteine ligase activity IMP glutamate (GO term level: 6) 16183645
GO:0000287 magnesium ion binding IDA 24639
GO:0016874 ligase activity IEA -
GO:0050662 coenzyme binding 新闻学会 9675072|9841880
GO:0046982 protein heterodimerization activity IEA -
GO:0043531 ADP binding IDA 24639
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0006536 glutamate metabolic process IDA glutamate (GO term level: 8) 2294991|12663448
GO:0006534 cysteine metabolic process IDA 2294991
GO:0019852 L-ascorbic acid metabolic process IEA -
GO:0009410 response to xenobiotic stimulus IEA -
GO:0009408 response to heat IDA 8104187
GO:0009725 response to hormone stimulus IDA 8104187
GO:0006750 glutathione biosynthetic process IDA 8104187|10395918
GO:0006750 glutathione biosynthetic process IMP 12663448
GO:0006979 response to oxidative stress IDA 10395918|11972604
GO:0006916 anti-apoptosis IDA 10439045
GO:0016481 negative regulation of transcription IDA 10439045
GO:0031397 negative regulation of protein ubiquitination IEA -
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA -
GO:0050880 regulation of blood vessel size IMP 12598062
GO:0046685 response to arsenic IEA -
GO:0045454 cell redox homeostasis IDA 10439045
GO:0051900 regulation of mitochondrial depolarization IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0017109 glutamate-cysteine ligase complex IEA glutamate (GO term level: 8) -
GO:0005829 cytosol IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG GLUTATHIONE METABOLISM 50 34 All SZGR 2.0 genes in this pathway
REACTOME SULFUR AMINO ACID METABOLISM 24 17 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES 200 136 All SZGR 2.0 genes in this pathway
REACTOME BIOLOGICAL OXIDATIONS 139 91 All SZGR 2.0 genes in this pathway
REACTOME GLUTATHIONE CONJUGATION 23 13 All SZGR 2.0 genes in this pathway
REACTOME PHASE II CONJUGATION 70 42 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP 233 161 All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS YELLOW UP 32 25 All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN 228 137 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION DN 234 147 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL TGFB1 TARGETS DN 62 44 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR UP 176 115 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP 487 286 All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775 494 All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP 223 140 All SZGR 2.0 genes in this pathway
MORI EMU MYC LYMPHOMA BY ONSET TIME UP 110 69 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN 464 276 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 UP 140 85 All SZGR 2.0 genes in this pathway
UEDA PERIFERAL CLOCK 169 111 All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C2 54 39 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR UP 156 101 All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK DN 318 220 All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE UP 393 244 All SZGR 2.0 genes in this pathway
SINGH NFE2L2 TARGETS 15 12 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY GAMMA AND UV RADIATION 88 65 All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE UP 226 164 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673 430 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN 543 317 All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593 372 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN 591 366 All SZGR 2.0 genes in this pathway
ITO PTTG1 TARGETS UP 12 9 All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP 285 167 All SZGR 2.0 genes in this pathway
LABBE TGFB1 TARGETS DN 108 64 All SZGR 2.0 genes in this pathway
LABBE TARGETS OF TGFB1 AND WNT3A DN 108 68 All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G1 DN 40 26 All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED 351 238 All SZGR 2.0 genes in this pathway
FONTAINE FOLLICULAR THYROID ADENOMA UP 75 43 All SZGR 2.0 genes in this pathway
GUTIERREZ CHRONIC LYMPHOCYTIC LEUKEMIA DN 56 39 All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103 714 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682 433 All SZGR 2.0 genes in this pathway
IKEDA MIR1 TARGETS UP 53 39 All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770 480 All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS UP 279 155 All SZGR 2.0 genes in this pathway
ROESSLER LIVER CANCER METASTASIS UP 107 72 All SZGR 2.0 genes in this pathway
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF 516 308 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family 目标位置 miRNA ID miRNA seq
UTR start UTR end Match method
miR-1/206 332 338 1A hsa-miR-1 UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZ UGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613 AGGAAUGUUCCUUCUUUGCC
miR-18 519 526 1A,m8 hsa-miR-18a UAAGGUGCAUCUAGUGCAGAUA
hsa-miR-18b UAAGGUGCAUCUAGUGCAGUUA
miR-433-3p 1002 1009 1A,m8 hsa-miR-433brain AUCAUGAUGGGCUCCUCGGUGU