Gene Page:BIN1

Summary?
GeneID 274
Symbol BIN1
Synonyms AMPH2|AMPHL|SH3P9
Description bridging integrator 1
Reference MIM:601248|HGNC:HGNC:1052|Ensembl:ENSG00000136717|HPRD:03150|Vega:OTTHUMG00000131465
Gene type protein-coding
Map location 2q14
Pascal p-value 0.009
Sherlock p-value 0.956
Fetal beta -1.322
DMG 2 (# studies)
eGene Cerebellar Hemisphere
Cerebellum
Myers' cis & trans
Support G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.human_clathrin
G2Cdb.human_Synaptosome
CompositeSet

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:vanEijk_2014 Genome-wide DNA methylation analysis This dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 3
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 3
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I Genome scan meta-analysis Psr: 0.023
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.00755
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias Click to show details
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.005

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position 最近的基因 P (dis) Beta (dis) FDR (dis) Study
cg06021088 2 127822551 BIN1 4.214E-4 -0.36 0.045 DMG:Wockner_2014
cg17105014 2 127413363 BIN1 3.03E-5 4.909 DMG:vanEijk_2014
cg17105014 2 127413363 BIN1 9.35E-5 4.417 DMG:vanEijk_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs1578978 chr8 118196802 BIN1 274 0.18 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0005515 protein binding IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0030100 regulation of endocytosis IEA -
GO:0008283 cell proliferation TAS 8782822
GO:0007275 multicellular organismal development IEA -
GO:0030154 cell differentiation IEA -
GO:0045786 negative regulation of cell cycle IEA -
GO:0044419 interspecies interaction between organisms IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005634 nucleus IEA -
GO:0005737 cytoplasm IEA -
GO:0015629 actin cytoskeleton TAS 9182667

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ABL1 ABL | JTK7 | bcr/abl | c-ABL | p150 | v-abl c-abl oncogene 1, receptor tyrosine kinase - HPRD 9356459
AMPH AMPH1 amphiphysin - HPRD,BioGRID 9348539
AP2A1 ADTAA | AP2-ALPHA | CLAPA1 adaptor-related公关otein complex 2, alpha 1 subunit - HPRD 9280305
AP2A2 ADTAB | CLAPA2 | HIP9 | HYPJ adaptor-related公关otein complex 2, alpha 2 subunit - HPRD 10430869
BIN1 AMPH2 | AMPHL | DKFZp547F068 | MGC10367 | SH3P9 bridging integrator 1 - HPRD,BioGRID 10391921
CUX1 CASP | CDP | CDP/Cut | CDP1 | COY1 | CUTL1 | CUX | Clox | Cux/CDP | GOLIM6 | Nbla10317 | p100 | p110 | p200 | p75 cut-like homeobox 1 Two-hybrid BioGRID 16169070
DNM1 DNM dynamin 1 - HPRD,BioGRID 9195986|9280305
ITGA1 CD49a | VLA1 integrin, alpha 1 - HPRD,BioGRID 10094488
ITGA3 CD49C | FLJ34631 | FLJ34704 | GAP-B3 | GAPB3 | MSK18 | VCA-2 | VL3A | VLA3a integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) - HPRD,BioGRID 10094488
MAP4K3 GLK | MAPKKKK3 | RAB8IPL1 mitogen-activated protein kinase kinase kinase kinase 3 - HPRD 11384986
PLD1 - phospholipase D1, phosphatidylcholine-specific Phenotypic Suppression
Reconstituted Complex		 BioGRID 10764771
PLD2 - phospholipase D2 - HPRD,BioGRID 10764771
PTK2 FADK | FAK | FAK1 | pp125FAK PTK2 protein tyrosine kinase 2 - HPRD,BioGRID 12558988
RIN2 RASSF4 Ras and Rab interactor 2 - HPRD 12972505
RIN3 DKFZp762H1613 | FLJ11700 | FLJ22439 Ras and Rab interactor 3 - HPRD,BioGRID 12972505
SH3GL2 CNSA2 | EEN-B1 | FLJ20276 | FLJ25015 | SH3D2A | SH3P4 SH3-domain GRB2-like 2 - HPRD 9315708
SH3GL2 CNSA2 | EEN-B1 | FLJ20276 | FLJ25015 | SH3D2A | SH3P4 SH3-domain GRB2-like 2 Reconstituted Complex BioGRID 12456676
SH3GLB1 Bif-1 | CGI-61 | KIAA0491 | dJ612B15.2 SH3-domain GRB2-like endophilin B1 - HPRD,BioGRID 12456676
SNX4 - sorting nexin 4 - HPRD,BioGRID 12668730
SYN1 SYN1a | SYN1b | SYNI synapsin I - HPRD,BioGRID 10899172
SYNJ1 INPP5G synaptojanin 1 - HPRD,BioGRID 9195986|9341169
XRCC5 FLJ39089 | KARP-1 | KARP1 | KU80 | KUB2 | Ku86 | NFIV X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) Co-purification BioGRID 17671430
XRCC6 CTC75 | CTCBF | G22P1 | KU70 | ML8 | TLAA X-ray repair complementing defective repair in Chinese hamster cells 6 Co-purification BioGRID 17671430


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
BIOCARTA NDKDYNAMIN PATHWAY 21 15 All SZGR 2.0 genes in this pathway
PID P73PATHWAY 79 59 All SZGR 2.0 genes in this pathway
PID ARF6贩卖路径WAY 49 34 All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567 375 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783 507 All SZGR 2.0 genes in this pathway
PRAMOONJAGO SOX4 TARGETS DN 51 35 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN 455 304 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN 460 312 All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL UP 133 78 All SZGR 2.0 genes in this pathway
RODRIGUES NTN1 TARGETS DN 158 102 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 DN 242 165 All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS UP 456 228 All SZGR 2.0 genes in this pathway
BIDUS METASTASIS DN 161 93 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
BEGUM TARGETS OF PAX3 FOXO1 FUSION DN 45 34 All SZGR 2.0 genes in this pathway
EBAUER TARGETS OF PAX3 FOXO1 FUSION UP 207 128 All SZGR 2.0 genes in this pathway
EBAUER MYOGENIC TARGETS OF PAX3 FOXO1 FUSION 50 26 All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION UP 195 138 All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 480 HELA 164 118 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 UP 256 159 All SZGR 2.0 genes in this pathway
ONDER CDH1 SIGNALING VIA CTNNB1 83 58 All SZGR 2.0 genes in this pathway
ASTON MAJOR DEPRESSIVE DISORDER DN 160 110 All SZGR 2.0 genes in this pathway
BASSO B LYMPHOCYTE NETWORK 143 96 All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS B LYMPHOCYTE DN 38 25 All SZGR 2.0 genes in this pathway
FERRANDO T ALL WITH MLL ENL FUSION UP 87 67 All SZGR 2.0 genes in this pathway
BROWN MYELOID CELL DEVELOPMENT DN 129 86 All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA UP 98 64 All SZGR 2.0 genes in this pathway
MODY HIPPOCAMPUS POSTNATAL 63 50 All SZGR 2.0 genes in this pathway
RAMALHO STEMNESS DN 74 55 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
DELASERNA MYOD TARGETS UP 89 51 All SZGR 2.0 genes in this pathway
JACKSON DNMT1 TARGETS UP 77 57 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720 440 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP 461 298 All SZGR 2.0 genes in this pathway
AMBROSINI FLAVOPIRIDOL TREATMENT TP53 109 63 All SZGR 2.0 genes in this pathway
乳腺癌萧述三腔的DN 564 326 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476 285 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER ESR1 DN 240 153 All SZGR 2.0 genes in this pathway
WALLACE JAK2 TARGETS UP 26 15 All SZGR 2.0 genes in this pathway
HOFFMANN PRE BI TO LARGE PRE BII LYMPHOCYTE DN 75 61 All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422 277 All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756 494 All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682 440 All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS DN 213 127 All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 UP 344 215 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-22 362 368 m8 hsa-miR-22brain AAGCUGCCAGUUGAAGAACUGU
miR-377 27 33 1A hsa-miR-377 AUCACACAAAGGCAACUUUUGU
miR-9 147 153 1A hsa-miR-9深圳 UCUUUGGUUAUCUAGCUGUAUGA