Gene Page:GLRA1

Summary?
GeneID 2741
Symbol GLRA1
Synonyms HKPX1|STHE
Description glycine receptor alpha 1
Reference MIM:138491|HGNC:HGNC:4326|Ensembl:ENSG00000145888|HPRD:00719|Vega:OTTHUMG00000130121
Gene type protein-coding
Map location 5q32
Pascal p-value 0.407
eGene Cerebellar Hemisphere
Cerebellum

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search 系统搜索PubMed的基因co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I Genome scan meta-analysis Psr: 0.0032
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.00459
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.01718
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 9

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0030594 neurotransmitter receptor activity IEA Neurotransmitter (GO term level: 5) -
GO:0004890 GABA-A receptor activity IEA GABA (GO term level: 7) -
GO:0004872 receptor activity IEA -
GO:0005515 protein binding 新闻学会 11929858
GO:0005216 ion channel activity IEA -
GO:0005230 extracellular ligand-gated ion channel activity IEA -
GO:0016934 extracellular-glycine-gated chloride channel activity IDA 2155780|8137830
GO:0016594 glycine binding IDA 2155780|15748848
GO:0030977 taurine binding IDA 15748848
GO:0031404 chloride ion binding IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0051970 negative regulation of transmission of nerve impulse IMP neuron (GO term level: 7) 11973623
GO:0060080 regulation of inhibitory postsynaptic membrane potential IEA neuron, Synap (GO term level: 10) -
GO:0007268 synaptic transmission IEA neuron, Synap, Neurotransmitter (GO term level: 6) -
GO:0060012 synaptic transmission, glycinergic IEA neuron, Synap, Neurotransmitter (GO term level: 8) -
GO:0007218 neuropeptide signaling pathway IDA Neurotransmitter (GO term level: 8) 2155780
GO:0002087 regulation of respiratory gaseous exchange by neurological process IEA Brain (GO term level: 6) -
GO:0001508 regulation of action potential IEA -
GO:0001964 startle response IMP 8298642|11973623
GO:0007628 adult walking behavior IEA -
GO:0007601 visual perception IEA -
GO:0006821 chloride transport IDA 8137830
GO:0006811 ion transport IDA 2155780
GO:0006936 muscle contraction IMP 11973623
GO:0007340 acrosome reaction IEA -
GO:0060013 righting reflex IEA -
GO:0050884 neuromuscular process controlling posture IEA -
GO:0043576 regulation of respiratory gaseous exchange IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0045211 postsynaptic membrane IEA Synap, Neurotransmitter (GO term level: 5) -
GO:0045202 synapse IEA neuron, Synap, Neurotransmitter, Glial (GO term level: 2) -
GO:0005622 intracellular IEA -
GO:0005624 membrane fraction IEA -
GO:0009897 external side of plasma membrane IEA -
GO:0005886 plasma membrane IEA -
GO:0005887 integral to plasma membrane IDA 7506679
GO:0005887 integral to plasma membrane IMP 11973623
GO:0005887 integral to plasma membrane NAS 2155780
GO:0030054 cell junction IEA -
GO:0043231 intracellular membrane-bounded organelle IDA 7506679

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272 195 All SZGR 2.0 genes in this pathway
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413 270 All SZGR 2.0 genes in this pathway
REACTOME ION CHANNEL TRANSPORT 55 42 All SZGR 2.0 genes in this pathway
REACTOME LIGAND GATED ION CHANNEL TRANSPORT 21 21 All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS DN 357 212 All SZGR 2.0 genes in this pathway
HILLION HMGA1 TARGETS 90 71 All SZGR 2.0 genes in this pathway
LEIN MIDBRAIN MARKERS 82 55 All SZGR 2.0 genes in this pathway
LEIN PONS MARKERS 89 59 All SZGR 2.0 genes in this pathway
LEIN MEDULLA MARKERS 81 48 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
MIKKELSEN IPS HCP WITH H3 UNMETHYLATED 80 50 All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3 UNMETHYLATED 228 119 All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 3 UP 170 97 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-150 25 31 1A hsa-miR-150 UCUCCCAACCCUUGUACCAGUG