Gene Page:GLRA2

Summary?
GeneID 2742
Symbol GLRA2
Synonyms GLR
Description glycine receptor alpha 2
Reference MIM:305990|HGNC:HGNC:4327|Ensembl:ENSG00000101958|HPRD:02379|Vega:OTTHUMG00000021166
Gene type protein-coding
Map location Xp22.2
Fetal beta 3.12
Support Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search 系统搜索PubMed co-o基因ccurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 4

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0030594 neurotransmitter receptor activity IEA Neurotransmitter (GO term level: 5) -
GO:0004890 GABA-A receptor activity IEA GABA (GO term level: 7) -
GO:0004891 glycine-inhibited chloride channel activity TAS 2155780
GO:0005216 ion channel activity IEA -
GO:0005230 extracellular ligand-gated ion channel activity IEA -
GO:0016934 extracellular-glycine-gated chloride channel activity IDA 2155780
GO:0016594 glycine binding IDA 2155780
GO:0031404 chloride ion binding IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007218 neuropeptide signaling pathway IDA Neurotransmitter (GO term level: 8) 2155780
GO:0006821 chloride transport IEA -
GO:0006811 ion transport IDA 2155780
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0045211 postsynaptic membrane IEA Synap, Neurotransmitter (GO term level: 5) -
GO:0045202 synapse IEA neuron, Synap, Neurotransmitter, Glial (GO term level: 2) -
GO:0005886 plasma membrane IEA -
GO:0005887 integral to plasma membrane NAS 2155780
GO:0030054 cell junction IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272 195 All SZGR 2.0 genes in this pathway
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413 270 All SZGR 2.0 genes in this pathway
REACTOME ION CHANNEL TRANSPORT 55 42 All SZGR 2.0 genes in this pathway
REACTOME LIGAND GATED ION CHANNEL TRANSPORT 21 21 All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL UP 133 78 All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423 265 All SZGR 2.0 genes in this pathway
HASLINGER B CLL WITH 11Q23 DELETION 23 18 All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP 244 165 All SZGR 2.0 genes in this pathway
LEIN MIDBRAIN MARKERS 82 55 All SZGR 2.0 genes in this pathway
LEIN PONS MARKERS 89 59 All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER LATE RECURRENCE DN 69 48 All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES 462 273 All SZGR 2.0 genes in this pathway
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF 516 308 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-101 1096 1102 m8 hsa-miR-101 UACAGUACUGUGAUAACUGAAG
miR-103/107 527 533 m8 hsa-miR-103brain AGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brain AGCAGCAUUGUACAGGGCUAUCA
miR-128 1098 1104 1A hsa-miR-128a UCACAGUGAACCGGUCUCUUUU
hsa-miR-128b UCACAGUGAACCGGUCUCUUUC
miR-133 506 512 1A hsa-miR-133a UUGGUCCCCUUCAACCAGCUGU
hsa-miR-133b UUGGUCCCCUUCAACCAGCUA
miR-136 919 925 1A hsa-miR-136 ACUCCAUUUGUUUUGAUGAUGGA
miR-142-5p 68 74 1A hsa-miR-142-5p CAUAAAGUAGAAAGCACUAC
miR-200bc/429 911 917 m8 hsa-miR-200b UAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200c UAAUACUGCCGGGUAAUGAUGG
hsa-miR-429 UAAUACUGUCUGGUAAAACCGU
miR-224 863 869 m8 hsa-miR-224 CAAGUCACUAGUGGUUCCGUUUA
miR-27 1098 1104 m8 hsa-miR-27abrain UUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrain UUCACAGUGGCUAAGUUCUGC
miR-325 995 1001 m8 hsa-miR-325 CCUAGUAGGUGUCCAGUAAGUGU
miR-329 927 933 m8 hsa-miR-329brain AACACACCUGGUUAACCUCUUU
miR-378 519 525 1A hsa-miR-378 CUCCUGACUCCAGGUCCUGUGU
miR-494 588 594 1A hsa-miR-494brain UGAAACAUACACGGGAAACCUCUU
miR-544 203 209 m8 hsa-miR-544 AUUCUGCAUUUUUAGCAAGU