Gene Page:MAT2B

Summary?
GeneID 27430
Symbol MAT2B
Synonyms MAT-II|MATIIbeta|Nbla02999|SDR23E1|TGR
Description methionine adenosyltransferase 2B
Reference MIM:605527|HGNC: HGNC:6905|Ensembl:ENSG00000038274|HPRD:05701|Vega:OTTHUMG00000130379
Gene type protein-coding
Map location 5q34
Pascal p-value 0.131
Fetal beta -1.037
DMG 1 (# studies)
eGene Caudate basal ganglia
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.01718
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.00459

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg14103574 5 162932455 MAT2B 1.06E-7 -0.011 2.32E-5 DMG:Jaffe_2016

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs1561519 chr2 35823020 MAT2B 27430 0.17 trans
rs7591339 chr2 35825597 MAT2B 27430 0.17 trans
rs7570146 chr2 35844751 MAT2B 27430 0.17 trans
rs1439691 chr2 35851281 MAT2B 27430 0.17 trans
rs3769074 chr2 238646252 MAT2B 27430 0.12 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003824 catalytic activity IEA -
GO:0005515 protein binding 新闻学会 10644686
GO:0005515 protein binding ISS -
GO:0008831 dTDP-4-dehydrorhamnose reductase activity IEA -
GO:0048270 methionine adenosyltransferase regulator activity IDA 10644686
GO:0048270 methionine adenosyltransferase regulator activity ISS -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0008152 metabolic process IEA -
GO:0006730 one-carbon compound metabolic process IEA -
GO:0006556 S-adenosylmethionine biosynthetic process IDA 10644686
GO:0006556 S-adenosylmethionine biosynthetic process ISS -
GO:0045226 extracellular polysaccharide biosynthetic process IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005622 intracellular IC 10644686
GO:0005634 nucleus IDA 11256614
GO:0048269 methionine adenosyltransferase complex IDA 10644686

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CYSTEINE AND METHIONINE METABOLISM 34 24 在这所有SZGR 2.0基因s pathway
KEGG SELENOAMINO ACID METABOLISM 26 18 在这所有SZGR 2.0基因s pathway
REACTOME SULFUR AMINO ACID METABOLISM 24 17 在这所有SZGR 2.0基因s pathway
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES 200 136 在这所有SZGR 2.0基因s pathway
REACTOME BIOLOGICAL OXIDATIONS 139 91 在这所有SZGR 2.0基因s pathway
REACTOME PHASE II CONJUGATION 70 42 在这所有SZGR 2.0基因s pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 在这所有SZGR 2.0基因s pathway
CHOI ATL CHRONIC VS ACUTE DN 18 10 在这所有SZGR 2.0基因s pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 在这所有SZGR 2.0基因s pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR UP 128 95 在这所有SZGR 2.0基因s pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR UP 117 84 在这所有SZGR 2.0基因s pathway
LINDGREN BLADDER CANCER CLUSTER 1 UP 121 71 在这所有SZGR 2.0基因s pathway
JOHANSSON GLIOMAGENESIS BY PDGFB DN 21 16 在这所有SZGR 2.0基因s pathway
RASHI RESPONSE TO IONIZING RADIATION 5 147 89 在这所有SZGR 2.0基因s pathway
JOHANSSON BRAIN CANCER EARLY VS LATE DN 45 35 在这所有SZGR 2.0基因s pathway
LIANG HEMATOPOIESIS STEM CELL NUMBER SMALL VS HUGE UP 38 29 在这所有SZGR 2.0基因s pathway
NUYTTEN NIPP1 TARGETS UP 769 437 在这所有SZGR 2.0基因s pathway
NUYTTEN EZH2 TARGETS UP 1037 673 在这所有SZGR 2.0基因s pathway
BENPORATH NANOG TARGETS 988 594 在这所有SZGR 2.0基因s pathway
BENPORATH SOX2 TARGETS 734 436 在这所有SZGR 2.0基因s pathway
BENPORATH MYC MAX TARGETS 775 494 在这所有SZGR 2.0基因s pathway
KEEN RESPONSE TO ROSIGLITAZONE DN 106 68 在这所有SZGR 2.0基因s pathway
MARSON BOUND BY FOXP3 STIMULATED 1022 619 在这所有SZGR 2.0基因s pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 在这所有SZGR 2.0基因s pathway
MOOTHA PGC 420 269 在这所有SZGR 2.0基因s pathway
DANG BOUND BY MYC 1103 714 在这所有SZGR 2.0基因s pathway
KARLSSON TGFB1 TARGETS DN 207 139 在这所有SZGR 2.0基因s pathway
VERHAAK GLIOBLASTOMA NEURAL 129 85 在这所有SZGR 2.0基因s pathway
BRUINS UVC RESPONSE EARLY LATE 317 190 在这所有SZGR 2.0基因s pathway
KRIEG KDM3A TARGETS NOT HYPOXIA 208 107 在这所有SZGR 2.0基因s pathway
FORTSCHEGGER PHF8 TARGETS UP 279 155 在这所有SZGR 2.0基因s pathway
RAO BOUND BY SALL4 ISOFORM B 517 302 在这所有SZGR 2.0基因s pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-130/301 134 141 1A,m8 hsa-miR-130abrain CAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301 CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrain CAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3p UAGUGCAAUAUUGCUUAUAGGGUUU
miR-142-5p 465 471 m8 hsa-miR-142-5p CAUAAAGUAGAAAGCACUAC
miR-17-5p/20/93.mr/106/519.d 52 58 m8 hsa-miR-17-5p CAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519d CAAAGUGCCUCCCUUUAGAGUGU
miR-485-3p 82 88 m8 hsa-miR-485-3p GUCAUACACGGCUCUCCUCUCU