Gene Page:GMFB

Summary?
GeneID 2764
Symbol GMFB
Synonyms GMF
Description glia maturation factor beta
Reference MIM:601713|HGNC:HGNC:4373|Ensembl:ENSG00000197045|Vega:OTTHUMG00000140307
Gene type protein-coding
Map location 14q22.2
Pascal p-value 0.199
Sherlock p-value 0.274
Fetal beta -0.572
DMG 1 (# studies)
Support G2Cdb.human_Synaptosome
G2Cdb.humanPSD

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:vanEijk_2014 Genome-wide DNA methylation analysis This dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 1
去_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg24256211 14 55035215 GMFB 0.003 5.855 DMG:vanEijk_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MAST1 0.91 0.94
PACS1 0.90 0.95
GPRIN1 0.90 0.93
KIFC3 0.90 0.89
RASGEF1C 0.90 0.90
PIK3R2 0.89 0.93
MAPKBP1 0.89 0.93
AC079061.1 0.89 0.86
TMEM63B 0.89 0.94
RUSC1 0.88 0.94
十大负面中的基因
Gene Pearson's Correlation Spearman's Correlation
AF347015.31 -0.70 -0.82
MT-CO2 -0.70 -0.82
AF347015.27 -0.70 -0.81
AF347015.33 -0.68 -0.79
MT-CYB -0.68 -0.80
S100B -0.68 -0.78
AF347015.8 -0.67 -0.82
AC021016.1 -0.67 -0.82
COPZ2 -0.67 -0.76
FXYD1 -0.67 -0.77

Section III. Gene Ontology annotation

Molecular function 去term Evidence Neuro keywords PubMed ID
去:0003779 actin binding IEA -
去:0004871 signal transducer activity TAS 7598724|8798479
去:0004860 protein kinase inhibitor activity TAS 8639570
去:0008083 growth factor activity IEA -
去:0008047 enzyme activator activity TAS 8798479
Biological process 去term Evidence Neuro keywords PubMed ID
去:0007399 nervous system development TAS neurite (GO term level: 5) 1712830
去:0006468 protein amino acid phosphorylation TAS 7598724
去:0007165 signal transduction TAS 8798479
Cellular component 去term Evidence Neuro keywords PubMed ID
去:0005622 intracellular IEA -
去:0005634 nucleus IDA 18029348
去:0005730 nucleolus IDA 18029348
去:0005739 mitochondrion IDA 18029348

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
WINTER HYPOXIA UP 92 57 All SZGR 2.0 genes in this pathway
TURASHVILI BREAST LOBULAR CARCINOMA VS LOBULAR NORMAL DN 74 42 All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN 431 263 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
GRABARCZYK BCL11B TARGETS UP 81 40 All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS DN 310 188 All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP 557 331 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP 633 376 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722 443 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485 334 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770 415 All SZGR 2.0 genes in this pathway
OUELLET CULTURED OVARIAN CANCER INVASIVE VS LMP UP 69 40 All SZGR 2.0 genes in this pathway
CHOI ATL STAGE PREDICTOR 44 24 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712 443 All SZGR 2.0 genes in this pathway
CALVET IRINOTECAN SENSITIVE VS REVERTED UP 5 5 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584 395 All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP 769 437 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 All SZGR 2.0 genes in this pathway
WEI MIR34A TARGETS 148 97 All SZGR 2.0 genes in this pathway
BALDWIN PRKCI TARGETS UP 35 26 All SZGR 2.0 genes in this pathway
去LDRATH HOMEOSTATIC PROLIFERATION 171 102 All SZGR 2.0 genes in this pathway
DER IFN BETA RESPONSE UP 102 67 All SZGR 2.0 genes in this pathway
JIANG VHL TARGETS 138 91 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
ZHU CMV ALL UP 120 89 All SZGR 2.0 genes in this pathway
TAKAO RESPONSE TO UVB RADIATION DN 98 67 All SZGR 2.0 genes in this pathway
ZHU CMV 24 HR UP 93 65 All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434 302 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 5 482 296 All SZGR 2.0 genes in this pathway
HILLION HMGA1 TARGETS 90 71 All SZGR 2.0 genes in this pathway
HILLION HMGA1B TARGETS 92 68 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229 713 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973 570 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863 514 All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6 456 285 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518 299 All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G3 UP 188 121 All SZGR 2.0 genes in this pathway
NAKAMURA ADIPOGENESIS LATE UP 104 67 All SZGR 2.0 genes in this pathway
JIANG HYPOXIA VIA VHL 34 24 All SZGR 2.0 genes in this pathway
BAE BRCA1 TARGETS UP 75 47 All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682 440 All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP 548 370 All SZGR 2.0 genes in this pathway
PASINI SUZ12 TARGETS DN 315 215 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882 538 All SZGR 2.0 genes in this pathway
去BERT OLIGODENDROCYTE DIFFERENTIATION DN 1080 713 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658 397 All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN 784 464 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-124/506 791 797 m8 hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
miR-132/212 88 94 1A hsa-miR-212SZ UAACAGUCUCCAGUCACGGCC
hsa-miR-132brain UAACAGUCUACAGCCAUGGUCG
miR-135 2760 2766 1A hsa-miR-135a UAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135b UAUGGCUUUUCAUUCCUAUGUG
miR-145 3068 3074 1A hsa-miR-145 GUCCAGUUUUCCCAGGAAUCCCUU
hsa-miR-145 GUCCAGUUUUCCCAGGAAUCCCUU
miR-148/152 85 91 m8 hsa-miR-148a UCAGUGCACUACAGAACUUUGU
hsa-miR-152brain UCAGUGCAUGACAGAACUUGGG
hsa-miR-148b UCAGUGCAUCACAGAACUUUGU
miR-181 3157 3163 1A hsa-miR-181abrain AACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZ AACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrain AACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrain AACAUUCAUUGUUGUCGGUGGGUU
miR-182 2820 2827 1A,m8 hsa-miR-182 UUUGGCAAUGGUAGAACUCACA
miR-194 89 95 m8 hsa-miR-194 UGUAACAGCAACUCCAUGUGGA
miR-203.1 3121 3127 m8 hsa-miR-203 UGAAAUGUUUAGGACCACUAG
miR-217 111 117 1A hsa-miR-217 UACUGCAUCAGGAACUGAUUGGAU
miR-26 3329 3336 1A,m8 hsa-miR-26abrain UUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZ UUCAAGUAAUUCAGGAUAGGUU
miR-29 3562 3568 m8 hsa-miR-29aSZ UAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZ UAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZ UAGCACCAUUUGAAAUCGGU
miR-320 807 813 1A hsa-miR-320 AAAAGCUGGGUUGAGAGGGCGAA
miR-34/449 834 841 1A,m8 hsa-miR-34abrain UGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34c AGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449 UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449b AGGCAGUGUAUUGUUAGCUGGC
miR-375 147 153 1A hsa-miR-375 UUUGUUCGUUCGGCUCGCGUGA
miR-382 3095 3101 m8 hsa-miR-382brain GAAGUUGUUCGUGGUGGAUUCG
miR-384 2540 2546 1A hsa-miR-384 AUUCCUAGAAAUUGUUCAUA
miR-490 2462 2468 1A hsa-miR-490 CAACCUGGAGGACUCCAUGCUG
miR-495 101 107 m8 hsa-miR-495brain AAACAAACAUGGUGCACUUCUUU
miR-96 2821 2827 1A hsa-miR-96brain UUUGGCACUAGCACAUUUUUGC