Gene Page:GNA11

Summary?
GeneID 2767
Symbol GNA11
Synonyms FBH|FBH2|FHH2|GNA-11|HHC2|HYPOC2
Description G protein subunit alpha 11
Reference MIM:139313|HGNC:HGNC:4379|Ensembl:ENSG00000088256|HPRD:00759|Vega:OTTHUMG00000180631
Gene type protein-coding
Map location 19p13.3
Pascal p-value 0.702
Sherlock p-value 0.388
Fetal beta 0.708
DMG 1 (# studies)
eGene Myers' cis & trans
Support G-PROTEIN RELAY
METABOTROPIC GLUTAMATE RECEPTOR

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.6384

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg02261780 19 3097728 GNA11 1.98E-4 0.323 0.035 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs17542473 chr4 111182451 GNA11 2767 0.14 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MAMDC4 0.91 0.85
PLA2G4B 0.91 0.89
CCDC57 0.91 0.88
JMJD7-PLA2G4B 0.90 0.82
NEIL1 0.89 0.84
CSAD 0.89 0.86
TGM1 0.89 0.81
CCNL2 0.88 0.81
AC135050.2 0.88 0.81
AC011511.1 0.88 0.82
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
ITM2A -0.45 -0.50
HLA-C -0.45 -0.40
ABCG2 -0.43 -0.41
B2M -0.42 -0.42
TM4SF1 -0.42 -0.42
ITM2B -0.42 -0.40
AF347015.31 -0.42 -0.44
TM4SF18 -0.42 -0.42
SRGN -0.41 -0.43
FAM162A -0.41 -0.38

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0003774 motor activity IEA -
GO:0004871 signal transducer activity IEA -
GO:0003924 GTPase activity TAS 8530500
GO:0005525 GTP binding IEA -
GO:0019001 guanyl nucleotide binding IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0060158 dopamine receptor, phospholipase C activating pathway IEA dopamine (GO term level: 10) -
GO:0001501 skeletal system development IEA -
GO:0001508 regulation of action potential IEA -
GO:0007186 G-protein coupled receptor protein signaling pathway IEA -
GO:0006471 protein amino acid ADP-ribosylation IEA -
GO:0007165 signal transduction TAS 8530500
GO:0048066 pigmentation during development IEA -
GO:0007507 heart development IEA -
GO:0006941 striated muscle contraction IEA -
GO:0045634 regulation of melanocyte differentiation IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005863 striated muscle thick filament IEA -
GO:0005737 cytoplasm IEA -
GO:0005737 cytoplasm TAS 9175863
GO:0005886 plasma membrane TAS 9175863
GO:0016459 myosin complex IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ADRA1B ADRA1 | ALPHA1BAR adrenergic, alpha-1B-, receptor - HPRD 9481484
ADRB2 ADRB2R | ADRBR | B2AR | BAR | BETA2AR adrenergic, beta-2-, receptor, surface - HPRD 7797501
CCR2 CC-CKR-2 | CCR2A | CCR2B | CD192 | CKR2 | CKR2A | CKR2B | CMKBR2 | MCP-1-R chemokine (C-C motif) receptor 2 Affinity Capture-Western BioGRID 11350939
CHRM2 FLJ43243 | HM2 | MGC120006 | MGC120007 cholinergic receptor, muscarinic 2 - HPRD 7797501
EDNRA ETA | ETRA endothelin receptor type A - HPRD,BioGRID 10789830
EDNRB ABCDS | ETB | ETBR | ETRB | HSCR | HSCR2 endothelin receptor type B - HPRD,BioGRID 10789830
HTR2A 5-HT2A | HTR2 5 -羟色胺(血清素)受体2 a - HPRD 11916537
MTNR1A MEL-1A-R | MT1 melatonin receptor 1A - HPRD,BioGRID 10598579
PTGIR IP | MGC102830 | PRIPR prostaglandin I2 (prostacyclin) receptor (IP) - HPRD 10446129
RGS3 C2PA | FLJ20370 | FLJ31516 | FLJ90496 | PDZ-RGS3 | RGP3 regulator of G-protein signaling 3 - HPRD,BioGRID 9858594
TBXA2R TXA2-R thromboxane A2 receptor - HPRD 9152406
TRPC3 TRP3 transient receptor potential cation channel, subfamily C, member 3 - HPRD 15623527
TRPC3 TRP3 transient receptor potential cation channel, subfamily C, member 3 - HPRD 11524429


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CALCIUM SIGNALING PATHWAY 178 134 All SZGR 2.0 genes in this pathway
KEGG VASCULAR SMOOTH MUSCLE CONTRACTION 115 81 All SZGR 2.0 genes in this pathway
KEGG GAP JUNCTION 90 68 All SZGR 2.0 genes in this pathway
KEGG LONG TERM DEPRESSION 70 53 All SZGR 2.0 genes in this pathway
KEGG GNRH SIGNALING PATHWAY 101 77 All SZGR 2.0 genes in this pathway
BIOCARTA BIOPEPTIDES PATHWAY 45 35 All SZGR 2.0 genes in this pathway
ST ADRENERGIC 36 29 All SZGR 2.0 genes in this pathway
PID ENDOTHELIN PATHWAY 63 52 All SZGR 2.0 genes in this pathway
PID LYSOPHOSPHOLIPID PATHWAY 66 53 All SZGR 2.0 genes in this pathway
PID ER NONGENOMIC PATHWAY 41 35 All SZGR 2.0 genes in this pathway
PID S1P S1P3 PATHWAY 29 24 All SZGR 2.0 genes in this pathway
PID ARF6 PATHWAY 35 27 All SZGR 2.0 genes in this pathway
PID TXA2PATHWAY 57 43 All SZGR 2.0 genes in this pathway
PID THROMBIN PAR4 PATHWAY 15 11 All SZGR 2.0 genes in this pathway
PID S1P META PATHWAY 21 14 All SZGR 2.0 genes in this pathway
PID THROMBIN PAR1 PATHWAY 43 32 All SZGR 2.0 genes in this pathway
PID S1P S1P2 PATHWAY 24 19 All SZGR 2.0 genes in this pathway
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 205 136 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOME INTEGRATION OF ENERGY METABOLISM 120 84 All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Q SIGNALLING EVENTS 184 116 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF INSULIN SECRETION 93 65 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE 11 9 All SZGR 2.0 genes in this pathway
REACTOME ADP SIGNALLING THROUGH P2RY1 25 16 All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805 368 All SZGR 2.0 genes in this pathway
REACTOME SIGNAL AMPLIFICATION 31 19 All SZGR 2.0 genes in this pathway
REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 23 14 All SZGR 2.0 genes in this pathway
REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 32 20 All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466 331 All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 208 138 All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN 493 298 All SZGR 2.0 genes in this pathway
DEURIG T细胞PROLYMPHOCYTIC白血病 368 234 All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP UP 265 158 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821 933 All SZGR 2.0 genes in this pathway
OUELLET OVARIAN CANCER INVASIVE VS LMP DN 11 8 All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174 695 All SZGR 2.0 genes in this pathway
PEREZ TP63 TARGETS 355 243 All SZGR 2.0 genes in this pathway
PEREZ TP53 AND TP63 TARGETS 205 145 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 UP 209 139 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 AND HIF1A DN 103 71 All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN 848 527 All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION DN 206 136 All SZGR 2.0 genes in this pathway
KENNY CTNNB1 TARGETS UP 50 30 All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP 398 262 All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366 238 All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP 412 249 All SZGR 2.0 genes in this pathway
MOREAUX B LYMPHOCYTE MATURATION BY TACI UP 92 58 All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS DN 96 71 All SZGR 2.0 genes in this pathway
AMUNDSON POOR SURVIVAL AFTER GAMMA RADIATION 8G 95 62 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 2D UP 69 46 All SZGR 2.0 genes in this pathway
AMBROSINI FLAVOPIRIDOL TREATMENT TP53 109 63 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540 340 All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER DN 101 65 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
她DDEN LUNG CANCER GOOD SURVIVAL A5 70 32 All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857 456 All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS UP 295 155 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B 549 316 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682 433 All SZGR 2.0 genes in this pathway
FOSTER KDM1A TARGETS DN 211 119 All SZGR 2.0 genes in this pathway