Gene Page:GNA12

Summary?
GeneID 2768
Symbol GNA12
Synonyms NNX3|RMP|gep
Description G protein subunit alpha 12
Reference MIM:604394|HGNC:HGNC:4380|Ensembl:ENSG00000146535|HPRD:05093|Vega:OTTHUMG00000023064
Gene type protein-coding
Map location 7p22.2
Pascal p-value 0.14
Fetal beta 0.739
DMG 1 (# studies)
eGene Caudate basal ganglia
Support G-PROTEIN RELAY
Ascano FMRP targets

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
PMID:cooccur High-throughput literature-search 系统搜索PubMed co-occ基因urring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg08933276 7 2770410 GNA12 2.4E-6 0.618 0.008 DMG:Wockner_2014
cg26247093 7 2773812 GNA12 1.466E-4 0.312 0.031 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
ATP6V1G2 0.87 0.90
ADAP1 0.86 0.88
PRKCZ 0.86 0.90
HMOX2 0.86 0.90
TMEM59L 0.86 0.91
CALM3 0.85 0.87
HAGH 0.85 0.89
FBXO44 0.85 0.88
CGREF1 0.85 0.88
PTGES2 0.85 0.88
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
GPR125 -0.47 -0.45
SMTN -0.46 -0.48
MAP4K4 -0.45 -0.39
ATAD2B -0.45 -0.31
IGF2BP2 -0.44 -0.40
CDC42EP4 -0.43 -0.42
SH2D2A -0.43 -0.45
RBMX2 -0.43 -0.44
VASH2 -0.43 -0.14
TXNIP -0.43 -0.37

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
AKAP13 AKAP-Lbc | BRX | FLJ11952 | FLJ43341 | HA-3 | Ht31 | LBC | PROTO-LB | PROTO-LBC | c-lbc A kinase (PRKA) anchor protein 13 - HPRD,BioGRID 11546812|14636890
ARHGEF1 GEF1 | LBCL2 | LSC | P115-RHOGEF | SUB1.5 Rho guanine nucleotide exchange factor (GEF) 1 Affinity Capture-Western
Reconstituted Complex		 BioGRID 14634662
ARHGEF11 DKFZp667F1223 | GTRAP48 | KIAA0380 | PDZ-RHOGEF Rho guanine nucleotide exchange factor (GEF) 11 - HPRD,BioGRID 10026210
ARHGEF12 DKFZp686O2372 | KIAA0382 | LARG | PRO2792 Rho guanine nucleotide exchange factor (GEF) 12 - HPRD,BioGRID 11094164
BTK AGMX1 | AT | ATK | BPK | IMD1 | MGC126261 | MGC126262 | PSCTK1 | XLA Bruton agammaglobulinemia tyrosine kinase in vitro
in vivo		 BioGRID 9796816
CDH1 Arc-1 | CD324 | CDHE | ECAD | LCAM | UVO cadherin 1, type 1, E-cadherin (epithelial) - HPRD,BioGRID 11136230
CDH15 CDH14 | CDH3 | CDHM | MCAD cadherin 15, type 1, M-cadherin (myotubule) - HPRD,BioGRID 11136230
CDH2 CD325 | CDHN | CDw325 | NCAD cadherin 2, type 1, N-cadherin (neuronal) - HPRD,BioGRID 11136230
DRD5 DBDR | DRD1B | DRD1L2 | MGC10601 dopamine receptor D5 - HPRD,BioGRID 12623966
F2R CF2R | HTR | PAR1 | TR coagulation factor II (thrombin) receptor - HPRD,BioGRID 8290554
HSP90AA1 FLJ31884 | HSP86 | HSP89A | HSP90A | HSP90N | HSPC1 | HSPCA | HSPCAL1 | HSPCAL4 | HSPN | Hsp89 | Hsp90 | LAP2 heat shock protein 90kDa alpha (cytosolic), class A member 1 in vitro
in vivo
Two-hybrid		 BioGRID 11598136|12117999
HSP90AA1 FLJ31884 | HSP86 | HSP89A | HSP90A | HSP90N | HSPC1 | HSPCA | HSPCAL1 | HSPCAL4 | HSPN | Hsp89 | Hsp90 | LAP2 heat shock protein 90kDa alpha (cytosolic), class A member 1 - HPRD 11598136|12117999
PPP2R1A MGC786 | PR65A protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform Galpha12 interacts with Aalpha. This interaction was modelled on a demonstrated interaction between mouse Galpha12 and human Aalpha. BIND 15525651
PPP5C FLJ36922 | PP5 | PPP5 protein phosphatase 5, catalytic subunit - HPRD,BioGRID 12176367
PRKCA AAG6 | MGC129900 | MGC129901 | PKC-alpha | PKCA | PRKACA protein kinase C, alpha - HPRD 8647866
PRKCB MGC41878 | PKC-beta | PKCB | PRKCB1 | PRKCB2 protein kinase C, beta Biochemical Activity BioGRID 8824244
PRKCD MAY1 | MGC49908 | PKCD | nPKC-delta protein kinase C, delta Biochemical Activity BioGRID 8824244
PRKCE MGC125656 | MGC125657 | PKCE | nPKC-epsilon protein kinase C, epsilon Biochemical Activity BioGRID 8824244
RASA2 GAP1M RAS p21 protein activator 2 - HPRD,BioGRID 9796816
RHOA ARH12 | ARHA | RHO12 | RHOH12 ras homolog gene family, member A Reconstituted Complex BioGRID 12515866
S1PR4 EDG6 | LPC1 | S1P4 | SLP4 sphingosine-1-phosphate receptor 4 Reconstituted Complex BioGRID 12761884
TBXA2R TXA2-R thromboxane A2 receptor - HPRD,BioGRID 8290554
TEC MGC126760 | MGC126762 | PSCTK4 tec protein tyrosine kinase - HPRD,BioGRID 12515866
TSHR CHNG1 | LGR3 | MGC75129 | hTSHR-I 促甲状腺激素受体 - HPRD 8552586


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG MAPK SIGNALING PATHWAY 267 205 All SZGR 2.0 genes in this pathway
KEGG VASCULAR SMOOTH MUSCLE CONTRACTION 115 81 All SZGR 2.0 genes in this pathway
KEGG LONG TERM DEPRESSION 70 53 All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON 216 144 All SZGR 2.0 genes in this pathway
BIOCARTA MYOSIN PATHWAY 31 22 All SZGR 2.0 genes in this pathway
BIOCARTA AKAP13 PATHWAY 12 11 All SZGR 2.0 genes in this pathway
BIOCARTA PAR1 PATHWAY 37 28 All SZGR 2.0 genes in this pathway
PID ENDOTHELIN PATHWAY 63 52 All SZGR 2.0 genes in this pathway
PID LYSOPHOSPHOLIPID PATHWAY 66 53 All SZGR 2.0 genes in this pathway
PID S1P S1P3 PATHWAY 29 24 All SZGR 2.0 genes in this pathway
PID S1P S1P4 PATHWAY 14 11 All SZGR 2.0 genes in this pathway
PID TXA2PATHWAY 57 43 All SZGR 2.0 genes in this pathway
PID AJDISS 2PATHWAY 48 38 All SZGR 2.0 genes in this pathway
PID S1P META PATHWAY 21 14 All SZGR 2.0 genes in this pathway
PID THROMBIN PAR1 PATHWAY 43 32 All SZGR 2.0 genes in this pathway
PID S1P S1P2 PATHWAY 24 19 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOME G ALPHA1213 SIGNALLING EVENTS 74 56 All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805 368 All SZGR 2.0 genes in this pathway
REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 32 20 All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466 331 All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 208 138 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL UP 380 215 All SZGR 2.0 genes in this pathway
ROY WOUND BLOOD VESSEL UP 50 30 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 UP 380 236 All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP 418 263 All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 UP 341 197 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770 415 All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747 453 All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN 514 319 All SZGR 2.0 genes in this pathway
INGRAM SHH TARGETS DN 64 41 All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775 494 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 7P22 AMPLICON 38 27 All SZGR 2.0 genes in this pathway
LIN APC TARGETS 77 55 All SZGR 2.0 genes in this pathway
FAELT B CLL WITH VH3 21 UP 44 30 All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS UP 175 116 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
GENTILE UV HIGH DOSE DN 312 203 All SZGR 2.0 genes in this pathway
HEDENFALK BREAST CANCER BRCA1 VS BRCA2 163 113 All SZGR 2.0 genes in this pathway
GENTILE UV RESPONSE CLUSTER D1 18 13 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 12HR UP 111 68 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673 430 All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602 364 All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593 372 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601 369 All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE UP 578 341 All SZGR 2.0 genes in this pathway
OUYANG PROSTATE CANCER PROGRESSION DN 21 16 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP 338 225 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP 418 282 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP 408 276 All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 15 31 19 All SZGR 2.0 genes in this pathway
VALK AML WITH CEBPA 37 27 All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103 714 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 12 79 54 All SZGR 2.0 genes in this pathway
TERAO AOX4 TARGETS HG UP 28 20 All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN 784 464 All SZGR 2.0 genes in this pathway