基因页：gnaq

Summary?
基因 2776
象征 gnaq
同义词 CMC1|G-ALPHA-q|GAQ|SWS
描述 G蛋白亚基alpha Q
参考 MIM:600998|HGNC：HGNC：4390|Ensembl:ENSG00000156052|HPRD：02998|Vega：Otthumg00000020059
基因type protein-coding
地图位置 9Q21
Pascal P值 0.549
Fetal beta 1.238
eGene 小脑半球
Cerebellum
支持 G-PROTEIN RELAY
代谢性谷氨酸受体
G2Cdb.human_mGluR5
G2CDB.HUMANPSP
Potential synaptic genes

基因in Data Sources
基因set name 基因组方法 描述 Info
简历：PGCNP 全基因组协会研究 GWAS
PMID:cooccur 高通量文献搜索 Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
李terature 高通量文献搜索 与精神分裂症关键词共同存在：精神分裂症，精神分裂症 Click to show details
go_annotation Mapping neuro-related keywords to Gene Ontology annotations 与神经相关关键字的命中：4
网络 Shortest path distance of core genes in the Human protein-protein interaction network PPI网络中最短路径的贡献：1.3158

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

基因ral gene expression (GTEx)

无法使用

Devlopment期间的基因表达（BrainCloud）

Footnote:
总共绘制了269个时间点，n = 38个胎儿样品（x = 1：38）。每个三角形代表一个时间点。

基因expression of temporal and spatial changes (BrainSpan)

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

前10个积极共表达的基因
基因 皮尔逊的相关性 斯皮尔曼的相关性
COX7A1 0.46 0.33
TAF13 0.41 0.31
AC099797.1 0.41 0.24
ACYP2 0.41 0.34
PNKD 0.40 0.34
C9orf3 0.40 0.35
TSPAN8 0.40 0.34
P2RX6 0.39 0.29
BRP44L 0.39 0.28
OLR1 0.39 0.27
前10个负共表达基因
基因 皮尔逊的相关性 斯皮尔曼的相关性
Gprin1 -0.30 -0.28
GMIP -0.30 -0.29
SNX26 -0.30 -0.28
FAM171A2 -0.30 -0.28
isyna1 -0.29 -0.31
SHF -0.29 -0.27
CRMP1 -0.29 -0.26
C19orf57 -0.29 -0.26
KIAA1543 -0.29 -0.26
FARP1 -0.29 -0.28

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0000166 核苷酸结合 IEA -
GO:0004871 signal transducer activity IEA -
去：0003924 GTPase activity 塔斯 9238049
GO:0005525 GTP结合 IEA -
去：0019001 guanyl nucleotide binding IEA -
生物过程 GO term Evidence Neuro keywords PubMed ID
GO:0016322 neuron remodeling IEA neuron, axon, dendrite (GO term level: 11) -
GO:0060158 多巴胺受体，磷脂酶C激活途径 IEA dopamine (GO term level: 10) -
GO:0007215 glutamate signaling pathway IEA 谷氨酸（GO期限：7） -
GO：0021884 forebrain neuron development IEA 神经元，大脑（GO期限：11） -
去：0001501 骨骼系统开发 IEA -
去：0001508 regulation of action potential IEA -
去：0007202 磷脂酶C活性的激活 塔斯 8825633
去：0007189 G-protein signaling, adenylate cyclase activating pathway IEA -
去：0007186 G蛋白偶联受体蛋白信号通路 IEA -
去：0006471 蛋白氨基酸ADP-核糖基化 IEA -
去：0007165 signal transduction IEA -
去：0009791 后发育 IEA -
GO：0048066 发育过程中的色素沉着 IEA -
GO:0007507 heart development IEA -
GO:0007610 behavior IEA -
去：0007596 血液凝血 塔斯 9238049
GO:0042733 胚胎数字形态发生 IEA -
GO：0045634 regulation of melanocyte differentiation IEA -
细胞分量 GO term Evidence Neuro keywords PubMed ID
GO:0005737 cytoplasm 塔斯 9175863
GO:0005886 质膜 经验 1851174|2841328|9198220
GO:0005886 质膜 塔斯 9175863|10633085

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ADRBK1 BARK1 | BETA-ARK1 | FLJ16718 | GRK2 肾上腺素，β，受体激酶1 - HPRD，Biogrid 12885252
AKAP13 AKAP-Lbc | BRX | FLJ11952 | FLJ43341 | HA-3 | Ht31 | LBC | PROTO-LB | PROTO-LBC | c-lbc 激酶（PRKA）锚蛋白13 - HPRD，Biogrid 11278452
btk AGMX1 | AT | ATK | BPK | IMD1 | MGC126261 | MGC126262 | PSCTK1 | XLA Bruton agammaglobulinemia tyrosine kinase - HPRD，Biogrid 9770463
CHRM3 HM3 cholinergic receptor, muscarinic 3 - HPRD 7629074
CRHR1 CRF-R |CRF1 |CRFR1 |CRH-R1H |CRHR |CRHR1F corticotropin releasing hormone receptor 1 - HPRD，Biogrid 10598591
FFAR1 FFA1R | GPCR40 | GPR40 free fatty acid receptor 1 - HPRD，Biogrid 12496284|12629551
FFAR2 FFA2R | GPR43 free fatty acid receptor 2 - HPRD 12711604
GALR2 GALNR2 | MGC125983 | MGC125984 galanin receptor 2 - HPRD 9685625
GRM2 GLUR2 | GPRC1B | MGLUR2 | mGlu2 谷氨酸受体，代谢2 - HPRD 8863838
GRM4 GPRC1D | MGLUR4 | mGlu4 谷氨酸受体，代谢4 - HPRD 8863838
GRM7 FLJ40498 |Glur7 |gprc1g |mglur7 |mglu7 谷氨酸受体，代谢7 - HPRD，Biogrid 10550060
HTR2A 5-HT2A | HTR2 5-羟色胺（5-羟色胺）受体2A - HPRD 11916537
HTR2B 5-HT（2b）|5-HT2B 5-羟色胺（5-羟色胺）受体2B - HPRD 11916537
PIK3CA MGC142161 |MGC142163 |PI3K |p110-alpha phosphoinositide-3-kinase, catalytic, alpha polypeptide - HPRD，Biogrid 12704201
PIK3R1 grb1 |P85 |p85-alpha phosphoinositide-3-kinase, regulatory subunit 1 (alpha) Affinity Capture-Western BioGRID 12704201
PLCB1 FLJ45792 |pi-plc |PLC-154 |Plc-i |PLC154 磷脂酶C，β1（磷酸肌醇特异性） - HPRD，Biogrid 11753430|12193606
PLCB2 FLJ38135 phospholipase C, beta 2 - HPRD 11753430
PTGIR IP | MGC102830 | PRIPR prostaglandin I2 (prostacyclin) receptor (IP) - HPRD 10446129
PTGIR IP | MGC102830 | PRIPR prostaglandin I2 (prostacyclin) receptor (IP) Affinity Capture-Western BioGRID 11443126
RGS16 A28-RGS14 | A28-RGS14P | RGS-R G蛋白信号的调节剂16 Affinity Capture-Western
Reconstituted Complex		 BioGRID 14634662
RGS18 RGS13 G蛋白信号传导的调节剂18 - HPRD，Biogrid 11955952
RGS2 G0S8 regulator of G-protein signaling 2, 24kDa Reconstituted Complex BioGRID 12885252
RGS2 G0S8 regulator of G-protein signaling 2, 24kDa - HPRD 9405622
RGS4 DKFZp761F1924 | MGC2124 | MGC60244 | RGP4 | SCZD9 G蛋白信号传导的调节剂4 - HPRD 9405622|9660808
RGS4 DKFZp761F1924 | MGC2124 | MGC60244 | RGP4 | SCZD9 G蛋白信号传导的调节剂4 Affinity Capture-Western
Reconstituted Complex		 BioGRID 9660808|14634662
RGS5 MST092 | MST106 | MST129 | MSTP032 | MSTP092 | MSTP106 | MSTP129 G蛋白信号传导的调节剂5 - HPRD，Biogrid 11253162
RGS7 - G蛋白信号传导的调节剂7 - HPRD，Biogrid 12670932
RIC8A MGC104517 |MGC131931 |MGC148073 |MGC148074 |ric8 |Synembryn resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) - HPRD，Biogrid 12509430|12652642
RIC8B FLJ10620 | MGC39476 | RIC8 | hSyn resistance to inhibitors of cholinesterase 8 homolog B (C. elegans) - HPRD 12652642
S1PR2 AGR16 |EDG-5 |EDG5 |GPCR13 |H218 |LPB2 |S1P2 鞘氨醇1-磷酸受体2 - HPRD 10488065
S1PR3 EDG-3 |EDG3 |FLJ37523 |FLJ93220 |LPB3 |MGC71696 |S13 鞘氨醇1-磷酸受体3 - HPRD 10488065
SLC9A3R1 EBP50 |nherf |nherf1 |nphlop2 溶质载体家族9（钠/氢交换器），成员3调节器1 - HPRD，Biogrid 12193606
TBXA2R TXA2-R thromboxane A2 receptor - HPRD，Biogrid 9152406|12193606
TSHR CHNG1 | LGR3 | MGC75129 | hTSHR-I 甲状腺刺激激素受体 - HPRD 8188646
TTC1 FLJ46404 | TPR1 tetratricopeptide repeat domain 1 G-Alpha-Q与TPR1相互作用。 BIND 12748287
TTC1 FLJ46404 | TPR1 tetratricopeptide repeat domain 1 - HPRD，Biogrid 12748287
VIPR1 FLJ41949 | HVR1 | II | PACAP-R-2 | RDC1 | VAPC1 | VIPR | VIRG | VPAC1 | VPCAP1R 血管活性肠受体1 - HPRD，Biogrid 11812005


Section V. Pathway annotation

Pathway name Pathway size ＃szgr 2.0基因 Info
KEGG CALCIUM SIGNALING PATHWAY 178 134 All SZGR 2.0 genes in this pathway
KEGG VASCULAR SMOOTH MUSCLE CONTRACTION 115 81 All SZGR 2.0 genes in this pathway
kegg间隙交界处 90 68 All SZGR 2.0 genes in this pathway
kegg长期增强 70 57 All SZGR 2.0 genes in this pathway
KEGG LONG TERM DEPRESSION 70 53 All SZGR 2.0 genes in this pathway
KEGG GNRH SIGNALING PATHWAY 101 77 All SZGR 2.0 genes in this pathway
KEGG MELANOGENESIS 102 80 All SZGR 2.0 genes in this pathway
Kegg阿尔茨海默氏病 169 110 All SZGR 2.0 genes in this pathway
Kegg Huntingtons病 185 109 All SZGR 2.0 genes in this pathway
Biocarta AT1R途径 36 28 All SZGR 2.0 genes in this pathway
BIOCARTA CCR3 PATHWAY 23 21 All SZGR 2.0 genes in this pathway
BIOCARTA CXCR4 PATHWAY 24 22 All SZGR 2.0 genes in this pathway
BIOCARTA CALCINEURIN PATHWAY 21 17 All SZGR 2.0 genes in this pathway
BIOCARTA PYK2 PATHWAY 31 24 All SZGR 2.0 genes in this pathway
BIOCARTA VIP PATHWAY 29 26 All SZGR 2.0 genes in this pathway
BIOCARTA CCR5 PATHWAY 20 16 All SZGR 2.0 genes in this pathway
BIOCARTA MYOSIN PATHWAY 31 22 All SZGR 2.0 genes in this pathway
BIOCARTA GPCR PATHWAY 37 31 All SZGR 2.0 genes in this pathway
Biocarta PAR1途径 37 28 All SZGR 2.0 genes in this pathway
PC12细胞中的ST分化途径 45 35 All SZGR 2.0 genes in this pathway
ST颗粒细胞存活途径 27 23 All SZGR 2.0 genes in this pathway
ST ADRENERGIC 36 29 All SZGR 2.0 genes in this pathway
St GAQ途径 28 22 All SZGR 2.0 genes in this pathway
ST PAC1受体途径 7 5 All SZGR 2.0 genes in this pathway
St Myocyte广告路径 27 25 All SZGR 2.0 genes in this pathway
PID ENDOTHELIN PATHWAY 63 52 All SZGR 2.0 genes in this pathway
PID LYSOPHOSPHOLIPID PATHWAY 66 53 All SZGR 2.0 genes in this pathway
PID ER非原始组途径 41 35 All SZGR 2.0 genes in this pathway
PID S1P S1P3 PATHWAY 29 24 All SZGR 2.0 genes in this pathway
PID ARF6 PATHWAY 35 27 All SZGR 2.0 genes in this pathway
PID TXA2 Pathway 57 43 All SZGR 2.0 genes in this pathway
PID THROMBIN PAR4 PATHWAY 15 11 All SZGR 2.0 genes in this pathway
PID S1P META PATHWAY 21 14 All SZGR 2.0 genes in this pathway
PID THROMBIN PAR1 PATHWAY 43 32 All SZGR 2.0 genes in this pathway
PID S1P S1P2途径 24 19 All SZGR 2.0 genes in this pathway
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 205 136 All SZGR 2.0 genes in this pathway
GPCR的反应组信号传导 920 449 All SZGR 2.0 genes in this pathway
REACTOME中国ATION OF ENERGY METABOLISM 120 84 All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Q SIGNALLING EVENTS 184 116 All SZGR 2.0 genes in this pathway
胰岛素分泌的反应组调节 93 65 All SZGR 2.0 genes in this pathway
乙酰胆碱对胰岛素分泌的反应组调节 11 9 All SZGR 2.0 genes in this pathway
REACTOME ADP SIGNALLING THROUGH P2RY1 25 16 All SZGR 2.0 genes in this pathway
Reactome GPCR下游信号传导 805 368 All SZGR 2.0 genes in this pathway
REACTOME SIGNAL AMPLIFICATION 31 19 All SZGR 2.0 genes in this pathway
REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 23 14 All SZGR 2.0 genes in this pathway
通过蛋白酶激活受体PAR的反应组凝血酶信号传导 32 20 All SZGR 2.0 genes in this pathway
反应组止血 466 331 All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 208 138 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 1 DN 126 86 All SZGR 2.0 genes in this pathway
Mullighan NPM1签名3 DN 162 116 All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS DN 139 76 All SZGR 2.0 genes in this pathway
多德鼻咽癌起来 1821年 933 All SZGR 2.0 genes in this pathway
甲状腺癌变性DN 537 339 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485 334 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2A DN 141 84 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER WITH LOH IN CHR9Q 116 71 All SZGR 2.0 genes in this pathway
Mattioli多发性骨髓瘤，有14q32易位 36 25 All SZGR 2.0 genes in this pathway
Dacosta UV响应通过ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN 483 336 All SZGR 2.0 genes in this pathway
Wood EBV EBNA1目标DN 47 33 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
通过ELK3 UP总缺氧 209 139 All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP 769 437 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP 424 268 All SZGR 2.0 genes in this pathway
皮肤伤口dn的嗜中性粒细胞 225 163 All SZGR 2.0 genes in this pathway
Taci的Moreaux多发性骨髓瘤 412 249 All SZGR 2.0 genes in this pathway
MOREAUX B LYMPHOCYTE MATURATION BY TACI UP 92 58 All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN 50 32 All SZGR 2.0 genes in this pathway
葡萄病毒感染的Debiasi凋亡 314 201 All SZGR 2.0 genes in this pathway
lu衰老的脑dn 153 120 All SZGR 2.0 genes in this pathway
击倒卡路里限制肌肉DN 87 59 All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P3 160 103 All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS DN 120 81 All SZGR 2.0 genes in this pathway
黄成人组织茎模块 721 492 All SZGR 2.0 genes in this pathway
Gabriely miR21靶标 289 187 All SZGR 2.0 genes in this pathway
Pilon KLF1靶向DN 1972年 1213 All SZGR 2.0 genes in this pathway
CHANGOLKAR H2AFY TARGETS UP 48 28 All SZGR 2.0 genes in this pathway
ewsr1 fli1融合的骨靶标 271 165 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658 397 All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN 784 464 All SZGR 2.0 genes in this pathway

第六节。microRNA注释

miRNA family 目标位置 mirna id miRNA seq
UTR start UTR end Match method
mir-142-3p 851 858 1a,m8 HSA-MIR-142-3P uguaguuuccuacuuuaugga
mir-182 997 1004 1a,m8 hsa-miR-182 uuuggcaaugguagaacucaca
miR-378 469 475 m8 hsa-miR-378 cuccugacuccaggucugugu
mir-96 998 1004 1a HSA-MIR-96脑 UUUGGCACUAGCACAUUUUUGC