Gene Page:GNB3

Summary?
GeneID 2784
Symbol GNB3
Synonyms -
Description G protein subunit beta 3
Reference MIM:139130|HGNC:HGNC:4400|Ensembl:ENSG00000111664|HPRD:00743|Vega:OTTHUMG00000168517
Gene type protein-coding
Map location 12p13
Pascal p-value 0.205
Sherlock p-value 0.888
eGene Caudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
Hippocampus
Hypothalamus
Nucleus accumbens basal ganglia
Putamen basal ganglia
Myers' cis & trans
Meta
Support CANABINOID
DOPAMINE
G-PROTEIN RELAY
METABOTROPIC GLUTAMATE RECEPTOR
SEROTONIN

Gene in Data Sources
Gene set name Method of gene set Description Info
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Association A combined odds ratio method (Sun et al. 2008), association studies 1 Link to SZGene
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs3917788 chr1 169568718 GNB3 2784 0.18 trans
rs6666913 chr1 237092144 GNB3 2784 2.115的军医 trans
rs16865199 chr2 6621910 GNB3 2784 0.18 trans
rs9870631 chr3 29583547 GNB3 2784 0.12 trans
rs2324466 chr3 76100753 GNB3 2784 0 trans
rs17013713 chr3 76105150 GNB3 2784 3.197E-4 trans
rs17013722 chr3 76107656 GNB3 2784 0 trans
rs17013724 chr3 76107684 GNB3 2784 0 trans
rs7644174 chr3 112722325 GNB3 2784 0.05 trans
rs9882442 chr3 173644484 GNB3 2784 0.19 trans
rs11937178 chr4 148847598 GNB3 2784 0 trans
rs11934409 chr4 148848884 GNB3 2784 0 trans
rs9986296 chr5 3199318 GNB3 2784 0 trans
rs17463444 chr5 95174483 GNB3 2784 0.11 trans
rs1030668 chr5 166876426 GNB3 2784 0.06 trans
rs992435 chr7 97050802 GNB3 2784 0.18 trans
rs8190856 chr8 18079123 GNB3 2784 0.1 trans
rs16920368 chr8 55392852 GNB3 2784 0.07 trans
rs348150 chr8 73371619 GNB3 2784 0.04 trans
rs16938220 chr8 73377940 GNB3 2784 0.04 trans
rs16908622 chr8 139231604 GNB3 2784 0.06 trans
rs4878005 chr9 89316567 GNB3 2784 0.15 trans
rs12685165 chr9 89340049 GNB3 2784 0.1 trans
rs12686427 chr9 89340546 GNB3 2784 0.1 trans
rs10119434 chr9 110944789 GNB3 2784 0.11 trans
rs10982951 chr9 118609806 GNB3 2784 0.02 trans
rs11193467 chr10 109217296 GNB3 2784 0.14 trans
rs1002405 chr11 85572958 GNB3 2784 0.05 trans
rs2069410 chr12 56364644 GNB3 2784 0.04 trans
rs17834315 chr13 37991091 GNB3 2784 0.09 trans
rs11841288 chr13 60215833 GNB3 2784 0.16 trans
rs10498433 chr14 52289530 GNB3 2784 0 trans
rs1743505 chr14 96143407 GNB3 2784 0.06 trans
rs16946913 chr15 63653889 GNB3 2784 0.1 trans
snp_a-4250222 0 GNB3 2784 0.04 trans
rs6499075 chr16 66387395 GNB3 2784 0.03 trans
rs2826625 chr21 22341050 GNB3 2784 0.12 trans
rs2826648 chr21 22362498 GNB3 2784 0.12 trans
rs9980476 chr21 22365306 GNB3 2784 0.12 trans
rs1041786 chr21 22617710 GNB3 2784 0.02 trans
rs7055735 chrX 85687566 GNB3 2784 0.06 trans
rs1129649 12 6948468 GNB3 ENSG00000111664.6 2.596E-7 0.01 -907 gtex_brain_putamen_basal
rs5440 12 6948899 GNB3 ENSG00000111664.6 2.215E-6 0.01 -476 gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AL117209.1 0.91 0.90
AP3D1 0.91 0.90
EIF4G1 0.91 0.89
GRIPAP1 0.90 0.87
MPRIP 0.89 0.90
LARP1 0.89 0.89
ANKRD11 0.89 0.90
GOLGA3 0.89 0.92
VPS53 0.89 0.88
HERC2 0.89 0.89
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.21 -0.75 -0.71
C1orf54 -0.73 -0.73
AF347015.31 -0.71 -0.66
GNG11 -0.69 -0.67
VAMP5 -0.68 -0.62
HIGD1B -0.68 -0.63
MT-CO2 -0.67 -0.62
ENHO -0.66 -0.60
SAT1 -0.65 -0.62
S100A13 -0.65 -0.63

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003993 acid phosphatase activity IEA -
GO:0004871 signal transducer activity IEA -
GO:0003924 GTPase activity TAS 9425898
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007186 G-protein coupled receptor protein signaling pathway TAS 2107550
去:0008217 regulation of blood pressure TAS 9425898
GO:0007165 signal transduction IEA -
GO:0009755 hormone-mediated signaling EXP 12626323
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 nucleus IDA 18029348

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CHEMOKINE SIGNALING PATHWAY 190 128 All SZGR 2.0 genes in this pathway
KEGG TASTE TRANSDUCTION 52 28 All SZGR 2.0 genes in this pathway
PID CONE PATHWAY 23 8 All SZGR 2.0 genes in this pathway
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK 205 136 All SZGR 2.0 genes in this pathway
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES 186 155 All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM 279 221 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOME能量代谢的集成 120 84 All SZGR 2.0 genes in this pathway
REACTOME OPIOID SIGNALLING 78 56 All SZGR 2.0 genes in this pathway
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 137 110 All SZGR 2.0 genes in this pathway
REACTOME G PROTEIN ACTIVATION 27 15 All SZGR 2.0 genes in this pathway
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413 270 All SZGR 2.0 genes in this pathway
REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION 34 23 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 43 28 All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Q SIGNALLING EVENTS 184 116 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF INSULIN SECRETION 93 65 All SZGR 2.0 genes in this pathway
REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE 25 15 All SZGR 2.0 genes in this pathway
REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS 88 58 All SZGR 2.0 genes in this pathway
REACTOME GLUCAGON TYPE LIGAND RECEPTORS 33 22 All SZGR 2.0 genes in this pathway
REACTOME G ALPHA1213 SIGNALLING EVENTS 74 56 All SZGR 2.0 genes in this pathway
REACTOME ADP SIGNALLING THROUGH P2RY1 25 16 All SZGR 2.0 genes in this pathway
REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA 20 12 All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805 368 All SZGR 2.0 genes in this pathway
REACTOME G ALPHA I SIGNALLING EVENTS 195 114 All SZGR 2.0 genes in this pathway
REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA 25 15 All SZGR 2.0 genes in this pathway
REACTOME G ALPHA S SIGNALLING EVENTS 121 82 All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Z SIGNALLING EVENTS 44 29 All SZGR 2.0 genes in this pathway
REACTOME G PROTEIN BETA GAMMA SIGNALLING 28 18 All SZGR 2.0 genes in this pathway
REACTOME SIGNAL AMPLIFICATION 31 19 All SZGR 2.0 genes in this pathway
REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR 23 14 All SZGR 2.0 genes in this pathway
REACTOME ADP SIGNALLING THROUGH P2RY12 21 10 All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING 31 23 All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408 246 All SZGR 2.0 genes in this pathway
REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS 32 20 All SZGR 2.0 genes in this pathway
REACTOME PLATELET HOMEOSTASIS 78 49 All SZGR 2.0 genes in this pathway
REACTOME AQUAPORIN MEDIATED TRANSPORT 51 34 All SZGR 2.0 genes in this pathway
REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR 19 11 All SZGR 2.0 genes in this pathway
REACTOME INCRETIN SYNTHESIS SECRETION AND INACTIVATION 22 14 All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 19 12 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS 44 30 All SZGR 2.0 genes in this pathway
REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS 25 17 All SZGR 2.0 genes in this pathway
REACTOME GABA B RECEPTOR ACTIVATION 38 26 All SZGR 2.0 genes in this pathway
REACTOME GABA RECEPTOR ACTIVATION 52 40 All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466 331 All SZGR 2.0 genes in this pathway
REACTOME POTASSIUM CHANNELS 98 68 All SZGR 2.0 genes in this pathway
REACTOME INWARDLY RECTIFYING K CHANNELS 31 20 All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 208 138 All SZGR 2.0 genes in this pathway
KORKOLA SEMINOMA UP 44 27 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 DN 378 231 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 UP 329 196 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779 480 All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION UP 38 25 All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP 398 262 All SZGR 2.0 genes in this pathway
POMEROY MEDULLOBLASTOMA DESMOPLASIC VS CLASSIC UP 62 38 All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE UP 203 130 All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP 244 165 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 8HR UP 105 73 All SZGR 2.0 genes in this pathway
LABBE TARGETS OF TGFB1 AND WNT3A DN 108 68 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210 725 All SZGR 2.0 genes in this pathway
ZHAN VARIABLE EARLY DIFFERENTIATION GENES UP 15 9 All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN 841 431 All SZGR 2.0 genes in this pathway
ZWANG EGF INTERVAL UP 105 46 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-221/222 481 487 1A hsa-miR-221brain AGCUACAUUGUCUGCUGGGUUUC
hsa-miR-222brain AGCUACAUCUGGCUACUGGGUCUC