Gene Page:GP1BB

Summary?
GeneID 2812
Symbol GP1BB
Synonyms BDPLT1|BS|CD42C|GPIBB|GPIbbeta
Description glycoprotein Ib platelet beta subunit
Reference MIM:138720|HGNC:HGNC:4440|HPRD:00729|Vega:OTTHUMG00000150397
Gene type protein-coding
Map location 22q11.21
Sherlock p-value 0.82
Fetal beta -0.103
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CNV:YES Copy number variation studies Manual curation
GSMA_I Genome scan meta-analysis Psr: 0.031

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs11960343 chr5 39770955 GP1BB 2812 0.17 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception凌晨ks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0004888 transmembrane receptor activity NAS 3353370
GO:0005515 protein binding 新闻学会 11943773
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007155 cell adhesion IEA -
GO:0007166 cell surface receptor linked signal transduction NAS 3353370
GO:0030168 platelet activation NAS 12871509
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005886 plasma membrane EXP 1939645|8608228
GO:0005887 integral to plasma membrane NAS 3353370
GO:0031092 platelet alpha granule membrane EXP 8608228

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG ECM RECEPTOR INTERACTION 84 53 All SZGR 2.0 genes in this pathway
KEGG HEMATOPOIETIC CELL LINEAGE 88 60 All SZGR 2.0 genes in this pathway
REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN 12 8 All SZGR 2.0 genes in this pathway
REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE 32 22 All SZGR 2.0 genes in this pathway
REACTOME PLATELET AGGREGATION PLUG FORMATION 36 23 All SZGR 2.0 genes in this pathway
REACTOME INTRINSIC PATHWAY 17 12 All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466 331 All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 208 138 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION DN 234 147 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION DN 84 54 All SZGR 2.0 genes in this pathway
PEREZ TP63 TARGETS 355 243 All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION DN 517 309 All SZGR 2.0 genes in this pathway
STARK HYPPOCAMPUS 22Q11 DELETION DN 20 19 All SZGR 2.0 genes in this pathway
ADDYA ERYTHROID DIFFERENTIATION BY HEMIN 73 47 All SZGR 2.0 genes in this pathway
BANDRES RESPONSE TO CARMUSTIN MGMT 48HR DN 161 105 All SZGR 2.0 genes in this pathway
ENGELMANN CANCER PROGENITORS DN 70 44 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 491 319 All SZGR 2.0 genes in this pathway
SETLUR PROSTATE CANCER TMPRSS2 ERG FUSION UP 67 48 All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590 403 All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS DN 213 127 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682 433 All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION DN 321 200 All SZGR 2.0 genes in this pathway
HUANG GATA2 TARGETS DN 72 52 All SZGR 2.0 genes in this pathway