Gene Page:GPC1
概括?
| 基因 | 2817 |
| Symbol | GPC1 |
| Synonyms | glypican |
| Description | glypican 1 |
| Reference | MIM:600395|HGNC:HGNC:4449|Ensembl:ENSG00000063660|HPRD:02671|Vega:OTTHUMG00000133349 |
| Gene type | protein-coding |
| Map location | 2q35-q37 |
| Pascal p-value | 0.005 |
| Sherlock p-value | 7.521E-5 |
| Fetal beta | 0.126 |
| eGene | Cerebellum Myers' cis & trans |
| Support | CELL ADHESION AND TRANSSYNAPTIC SIGNALING |
数据源中的基因
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias | Click to show details |
第一节遗传学和表观遗传学注释
Differentially methylated gene
Differentially methylated gene| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg11574092 | 2 | 241394528 | MIR149;PP14571;GPC1 | 1.657E-4 | 0.361 | 0.033 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs2366847 | chr3 | 59705953 | GPC1 | 2817 | 0.03 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| PCDH8 | 0.63 | 0.74 |
| ZSCAN18 | 0.60 | 0.68 |
| PCDHGC5 | 0.56 | 0.63 |
| PGAP3 | 0.56 | 0.67 |
| MAN2B2 | 0.55 | 0.67 |
| SESN2 | 0.55 | 0.66 |
| ZER1 | 0.55 | 0.67 |
| AMPD2 | 0.55 | 0.66 |
| SGSM1 | 0.55 | 0.65 |
| DMWD | 0.55 | 0.65 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.21 | -0.40 | -0.40 |
| MT-CO2 | -0.38 | -0.37 |
| AF347015.18 | -0.37 | -0.38 |
| AF347015.8 | -0.37 | -0.36 |
| AC098691.2 | -0.37 | -0.42 |
| AF347015.2 | -0.37 | -0.32 |
| AF347015.31 | -0.36 | -0.37 |
| MT-CYB | -0.35 | -0.35 |
| MT-ATP8 | -0.35 | -0.37 |
| GNG11 | -0.34 | -0.42 |
Section III. Gene Ontology annotation
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005576 | extracellular region | IEA | - | |
| GO:0005578 | 蛋白质细胞外基质 | IEA | - | |
| GO:0005615 | extracellular space | TAS | 2148568 | |
| GO:0005886 | plasma membrane | IEA | - | |
| GO:0005887 | integral to plasma membrane | TAS | 2148568 | |
| GO:0031225 | anchored to membrane | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PID GLYPICAN 1PATHWAY | 27 | 20 | 该途径中的所有SZGR 2.0基因 |
| REACTOME DEVELOPMENTAL BIOLOGY | 396 | 292 | 该途径中的所有SZGR 2.0基因 |
| REACTOME HS GAG DEGRADATION | 20 | 15 | 该途径中的所有SZGR 2.0基因 |
| REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM | 49 | 33 | 该途径中的所有SZGR 2.0基因 |
| REACTOME HS GAG BIOSYNTHESIS | 31 | 17 | 该途径中的所有SZGR 2.0基因 |
| REACTOME HEPARAN SULFATE HEPARIN HS GAG METABOLISM | 52 | 33 | 该途径中的所有SZGR 2.0基因 |
| REACTOME GLYCOSAMINOGLYCAN METABOLISM | 111 | 69 | 该途径中的所有SZGR 2.0基因 |
| REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | 25 | 17 | 该途径中的所有SZGR 2.0基因 |
| REACTOME AXON GUIDANCE | 251 | 188 | 该途径中的所有SZGR 2.0基因 |
| REACTOME ACTIVATION OF RAC | 14 | 11 | 该途径中的所有SZGR 2.0基因 |
| REACTOME SIGNALING BY ROBO RECEPTOR | 30 | 26 | 该途径中的所有SZGR 2.0基因 |
| REACTOME METABOLISM OF CARBOHYDRATES | 247 | 154 | 该途径中的所有SZGR 2.0基因 |
| BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER DN | 169 | 118 | 该途径中的所有SZGR 2.0基因 |
| ZHOU INFLAMMATORY RESPONSE LIVE UP | 485 | 293 | 该途径中的所有SZGR 2.0基因 |
| DOANE RESPONSE TO ANDROGEN DN | 241 | 146 | 该途径中的所有SZGR 2.0基因 |
| SENESE HDAC1 AND HDAC2 TARGETS DN | 232 | 139 | 该途径中的所有SZGR 2.0基因 |
| RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP | 633 | 376 | 该途径中的所有SZGR 2.0基因 |
| CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS CDC25 UP | 58 | 39 | 该途径中的所有SZGR 2.0基因 |
| CHIARADONNA NEOPLASTIC TRANSFORMATION CDC25 DN | 153 | 100 | 该途径中的所有SZGR 2.0基因 |
| GAUSSMANN MLL AF4 FUSION TARGETS D DN | 9 | 6 | 该途径中的所有SZGR 2.0基因 |
| BERENJENO改变了RHOA UP | 536 | 340 | 该途径中的所有SZGR 2.0基因 |
| WANG ESOPHAGUS CANCER VS NORMAL DN | 101 | 66 | 该途径中的所有SZGR 2.0基因 |
| HEIDENBLAD AMPLICON 8Q24 DN | 46 | 28 | 该途径中的所有SZGR 2.0基因 |
| DAIRKEE TERT TARGETS UP | 380 | 213 | 该途径中的所有SZGR 2.0基因 |
| GRUETZMANN PANCREATIC CANCER UP | 358 | 245 | 该途径中的所有SZGR 2.0基因 |
| Schaeffer前列腺开发6小时DN | 514 | 330 | 该途径中的所有SZGR 2.0基因 |
| KOYAMA SEMA3B TARGETS DN | 411 | 249 | 该途径中的所有SZGR 2.0基因 |
| ONDER CDH1 TARGETS 1 UP | 140 | 85 | 该途径中的所有SZGR 2.0基因 |
| TARTE PLASMA CELL VS PLASMABLAST UP | 398 | 262 | 该途径中的所有SZGR 2.0基因 |
| MANALO HYPOXIA UP | 207 | 145 | 该途径中的所有SZGR 2.0基因 |
| GOLDRATH IMMUNE MEMORY | 65 | 42 | 该途径中的所有SZGR 2.0基因 |
| WANG TARGETS OF MLL CBP FUSION UP | 44 | 26 | 该途径中的所有SZGR 2.0基因 |
| LI WILMS TUMOR VS FETAL KIDNEY 1 DN | 163 | 115 | 该途径中的所有SZGR 2.0基因 |
| KUMAR TARGETS OF MLL AF9 FUSION | 405 | 264 | 该途径中的所有SZGR 2.0基因 |
| IVANOVA HEMATOPOIESIS LATE PROGENITOR | 544 | 307 | 该途径中的所有SZGR 2.0基因 |
| CUI TCF21 TARGETS 2 DN | 830 | 547 | 该途径中的所有SZGR 2.0基因 |
| WANG CISPLATIN RESPONSE AND XPC DN | 228 | 146 | 该途径中的所有SZGR 2.0基因 |
| KAAB HEART ATRIUM VS VENTRICLE DN | 261 | 183 | 该途径中的所有SZGR 2.0基因 |
| DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN | 287 | 208 | 该途径中的所有SZGR 2.0基因 |
| 转移DN期间的clasper淋巴管 | 36 | 23 | 该途径中的所有SZGR 2.0基因 |
| MONNIER POSTRADIATION TUMOR ESCAPE UP | 393 | 244 | 该途径中的所有SZGR 2.0基因 |
| Hillion HMGA1B目标 | 92 | 68 | 该途径中的所有SZGR 2.0基因 |
| 伽玛辐射2G后的生存率不佳 | 171 | 96 | 该途径中的所有SZGR 2.0基因 |
| GRADE COLON AND RECTAL CANCER DN | 101 | 65 | 该途径中的所有SZGR 2.0基因 |
| Labbe TGFB1靶向 | 102 | 64 | 该途径中的所有SZGR 2.0基因 |
| LABBE TARGETS OF TGFB1 AND WNT3A UP | 111 | 70 | 该途径中的所有SZGR 2.0基因 |
| BRUECKNER TARGETS OF MIRLET7A3 DN | 78 | 49 | 该途径中的所有SZGR 2.0基因 |
| BOYLAN MULTIPLE MYELOMA C D DN | 252 | 155 | 该途径中的所有SZGR 2.0基因 |
| MILI PSEUDOPODIA HAPTOTAXIS DN | 668 | 419 | 该途径中的所有SZGR 2.0基因 |
| CAIRO LIVER DEVELOPMENT UP | 166 | 105 | 该途径中的所有SZGR 2.0基因 |
| DANG REGULATED BY MYC DN | 253 | 192 | 该途径中的所有SZGR 2.0基因 |
| LI INDUCED T TO NATURAL KILLER UP | 307 | 182 | 该途径中的所有SZGR 2.0基因 |
| CHICAS RB1 TARGETS CONFLUENT | 567 | 365 | 该途径中的所有SZGR 2.0基因 |
| Smad2或Smad3的Koinuma目标 | 824 | 528 | 该途径中的所有SZGR 2.0基因 |
| PEDERSEN METASTASIS BY ERBB2 ISOFORM 7 | 403 | 240 | 该途径中的所有SZGR 2.0基因 |
| NABA ECM附属 | 171 | 89 | 该途径中的所有SZGR 2.0基因 |
| NABA MATRISOME ASSOCIATED | 753 | 411 | 该途径中的所有SZGR 2.0基因 |
| NABA MATRISOME | 1028 | 559 | 该途径中的所有SZGR 2.0基因 |