Gene Page:ang

概括?
基因 283
象征 ang
Synonyms ALS9|HEL168|RAA1|RNASE4|RNASE5
Description angiogenin, ribonuclease, RNase A family, 5
Reference MIM:105850|HGNC：HGNC：483|Ensembl:ENSG00000214274|HPRD:00105|Vega:OTTHUMG00000029576
Gene type protein-coding
Map location 14q11.1-q11.2
Sherlock p-value 0.091
Fetal beta 0.286
eGene Myers' cis & trans

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I Genome scan meta-analysis Psr: 0.047
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias,schizotypal Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations 与神经相关关键字的命中：3

第一节遗传学和表观遗传学注释

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs10958910 chr9 10134759 ang 283 0.15 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
KCNC1 0.82 0.85
SLC45A4 0.82 0.83
STX1B 0.78 0.82
RNF157 0.77 0.82
KCNC3 0.77 0.72
ATP2B3 0.77 0.82
KLC2 0.77 0.79
CAMTA1 0.76 0.79
IFFO1 0.76 0.78
STXBP1 0.76 0.81
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RHOC -0.45 -0.56
DBI -0.43 -0.53
GNG11 -0.43 -0.54
C1orf54 -0.42 -0.56
C1orf61 -0.42 -0.55
AF347015.21 -0.41 -0.48
RAB34 -0.39 -0.47
MYL12A -0.38 -0.48
VAMP5 -0.37 -0.46
IL32 -0.37 -0.47

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005102 receptor binding IDA Neurotransmitter (GO term level: 4) 9122172
GO:0003779 actin binding IDA 7679494|11782452
GO:0003676 nucleic acid binding IEA -
GO:0003677 DNA binding IC 10649442
GO:0005507 copper ion binding IDA 9245697
GO:0004540 核糖核酸酶活性 IDA 2424496|2730651
GO:0004519 endonuclease activity IEA -
GO:0004519 endonuclease activity TAS 10103013
GO:0004522 pancreatic ribonuclease activity IEA -
GO:0016787 hydrolase activity IEA -
GO:0008201 heparin binding IDA 10103013
GO:0019843 rRNA binding TAS 2457905
GO:0042277 peptide binding IDA 11782452
生物过程 去的术语 Evidence Neuro keywords PubMed ID
GO:0001556 oocyte maturation NAS 11438326
GO:0001525 angiogenesis IMP 2479414|17125737
GO:0001525 angiogenesis TAS 16567967
GO:0001666 response to hypoxia IDA 10999833|15979542|16490744
GO:0001666 response to hypoxia NAS 15776477
GO:0001541 ovarian follicle development NAS 12770725
GO:0001890 placenta development NAS 11984825
GO:0001938 positive regulation of endothelial cell proliferation IDA 9122172|9707554
去：0007202 activation of phospholipase C activity IMP 2457905
GO:0007154 cell communication NAS 10103013
GO:0009303 rRNA transcription IMP 15735021
GO:0009725 response to hormone stimulus IDA 10999833
GO:0006651 diacylglycerol biosynthetic process IDA 2457905
GO:0007275 multicellular organismal development IEA -
GO:0042327 positive regulation of phosphorylation IDA 17125737
GO:0016477 cell migration IMP 17125737
GO:0030154 cell differentiation IEA -
GO:0042592 homeostatic process NAS 15166501
GO:0030041 actin filament polymerization ISS -
GO:0032431 activation of phospholipase A2 IMP 2646638
GO:0032148 activation of protein kinase B activity IMP 17125737
GO:0017148 negative regulation of translation IEA -
GO:0050714 positive regulation of protein secretion IDA 2646638
GO:0050714 positive regulation of protein secretion ISS -
GO:0048662 negative regulation of smooth muscle cell proliferation IDA 10103013
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0043025 cell soma ISS axon, dendrite (GO term level: 4) -
GO:0030426 growth cone ISS axon, dendrite (GO term level: 5) -
GO:0005576 extracellular region IEA -
GO:0005605 basal lamina IDA 15166501
GO:0005615 extracellular space IDA 3663649|16461950|16490744
GO:0005634 nucleus IDA 10649442|15735021
GO:0005730 nucleolus ISS -
GO:0032311 angiogenin-PRI complex 新闻学会 3470787

V.途径注释

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
BARRIER COLON CANCER RECURRENCE UP 42 28 该途径中的所有SZGR 2.0基因
埃尔维奇缺氧 171 112 该途径中的所有SZGR 2.0基因
ELVIDGE HYPOXIA BY DMOG UP 130 85 该途径中的所有SZGR 2.0基因
ELVIDGE HIF1A TARGETS DN 91 58 该途径中的所有SZGR 2.0基因
Elvidge HIF1A和HIF2A靶向DN 104 72 该途径中的所有SZGR 2.0基因
ENK UV RESPONSE EPIDERMIS DN 508 354 该途径中的所有SZGR 2.0基因
GAUSSMANN MLL AF4 FUSION TARGETS G UP 238 135 该途径中的所有SZGR 2.0基因
RASHI RESPONSE TO IONIZING RADIATION 5 147 89 该途径中的所有SZGR 2.0基因
RANKIN ANGIOGENIC TARGETS OF VHL HIF2A UP 5 5 该途径中的所有SZGR 2.0基因
RICKMAN METASTASIS UP 344 180 该途径中的所有SZGR 2.0基因
GEORGES TARGETS OF MIR192 AND MIR215 893 528 该途径中的所有SZGR 2.0基因
ONDER CDH1 TARGETS 1 UP 140 85 该途径中的所有SZGR 2.0基因
TARTE PLASMA CELL VS PLASMABLAST DN 309 206 该途径中的所有SZGR 2.0基因
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 该途径中的所有SZGR 2.0基因
SANSOM APC TARGETS UP 126 84 该途径中的所有SZGR 2.0基因
HSIAO LIVER SPECIFIC GENES 244 154 该途径中的所有SZGR 2.0基因
MENSE缺氧了 98 71 该途径中的所有SZGR 2.0基因
BOQUEST STEM CELL CULTURED VS FRESH UP 425 298 该途径中的所有SZGR 2.0基因
VART KSHV INFECTION ANGIOGENIC MARKERS DN 138 92 该途径中的所有SZGR 2.0基因
Mizukami缺氧 12 12 该途径中的所有SZGR 2.0基因
CHEN METABOLIC SYNDROM NETWORK 1210 725 该途径中的所有SZGR 2.0基因
肌肉DN中的罗马胰岛素靶标 204 114 该途径中的所有SZGR 2.0基因
开罗肝母细胞瘤DN 267 160 该途径中的所有SZGR 2.0基因
SERVITJA LIVER HNF1A TARGETS DN 157 105 该途径中的所有SZGR 2.0基因
KRIEG HYPOXIA NOT VIA KDM3A 770 480 该途径中的所有SZGR 2.0基因
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 该途径中的所有SZGR 2.0基因