Gene Page:GPR12
Summary?
| GeneID | 2835 |
| Symbol | GPR12 |
| Synonyms | GPCR12|GPCR21|PPP1R84 |
| Description | G protein-coupled receptor 12 |
| Reference | MIM:600752|HGNC:HGNC:4466|Ensembl:ENSG00000132975|HPRD:15978|Vega:OTTHUMG00000016620 |
| Gene type | protein-coding |
| Map location | 13q12 |
| Pascal p-value | 0.703 |
| Fetal beta | 2.08 |
| DMG | 1 (# studies) |
| eGene | Cerebellar Hemisphere Cerebellum Nucleus accumbens basal ganglia |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 2 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Differentially methylated gene| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg21087108 | 13 | 27335360 | GPR12 | 1.861E-4 | 0.443 | 0.034 | DMG:Wockner_2014 |
| cg15905579 | 13 | 27335084 | GPR12 | 3.242E-4 | -0.206 | 0.04 | DMG:Wockner_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
某fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SLC6A12 | 0.91 | 0.92 |
| TBX2 | 0.87 | 0.83 |
| HLA-E | 0.86 | 0.89 |
| GPR37L1 | 0.84 | 0.88 |
| PRELP | 0.84 | 0.89 |
| HEPACAM | 0.82 | 0.85 |
| SFXN5 | 0.82 | 0.83 |
| ACSBG1 | 0.81 | 0.84 |
| SELENBP1 | 0.81 | 0.82 |
| GRIN2C | 0.81 | 0.81 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| FRG1 | -0.70 | -0.78 |
| GNL3 | -0.70 | -0.74 |
| SUPV3L1 | -0.69 | -0.76 |
| ZBED5 | -0.69 | -0.77 |
| MED19 | -0.69 | -0.73 |
| C11orf57 | -0.69 | -0.80 |
| DUSP12 | -0.68 | -0.73 |
| ZNF461 | -0.68 | -0.75 |
| ZNF239 | -0.68 | -0.73 |
| ASNSD1 | -0.68 | -0.72 |
Section III. Gene Ontology annotation
| Molecular function | 去的术语 | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0001619 | lysosphingolipid and lysophosphatidic acid receptor activity | IEA | - | |
| GO:0004872 | receptor activity | IEA | - | |
| Biological process | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0007186 | G-protein coupled receptor protein signaling pathway | TAS | 8530049 | |
| GO:0007165 | signal transduction | IEA | - | |
| GO:0006874 | cellular calcium ion homeostasis | IEA | - | |
| Cellular component | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0005886 | plasma membrane | IEA | - | |
| GO:0005887 | integral to plasma membrane | TAS | 8530049 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN | 493 | 298 | All SZGR 2.0 genes in this pathway |
| BENPORATH SUZ12 TARGETS | 1038 | 678 | All SZGR 2.0 genes in this pathway |
| BENPORATH EED TARGETS | 1062 | 725 | All SZGR 2.0 genes in this pathway |
| BENPORATH ES WITH H3K27ME3 | 1118 | 744 | All SZGR 2.0 genes in this pathway |
| BENPORATH PRC2 TARGETS | 652 | 441 | All SZGR 2.0 genes in this pathway |
| SHEN SMARCA2 TARGETS DN | 357 | 212 | All SZGR 2.0 genes in this pathway |
| SHIPP DLBCL CURED VS FATAL UP | 39 | 22 | All SZGR 2.0 genes in this pathway |
| SANSOM APC TARGETS DN | 366 | 238 | All SZGR 2.0 genes in this pathway |
| MOREAUX MULTIPLE MYELOMA BY TACI UP | 412 | 249 | All SZGR 2.0 genes in this pathway |
| SU SALIVARY GLAND | 16 | 9 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 48HR DN | 504 | 323 | All SZGR 2.0 genes in this pathway |
| JACKSON DNMT1 TARGETS UP | 77 | 57 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR | 681 | 420 | All SZGR 2.0 genes in this pathway |
| XU GH1 AUTOCRINE TARGETS UP | 268 | 157 | All SZGR 2.0 genes in this pathway |
| 阿塞维多甲基化在肝癌DN | 940 | 425 | All SZGR 2.0 genes in this pathway |
| HOFMANN MYELODYSPLASTIC SYNDROM HIGH RISK DN | 20 | 13 | All SZGR 2.0 genes in this pathway |
| MEISSNER NPC HCP WITH H3 UNMETHYLATED | 536 | 296 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MEF HCP WITH H3K27ME3 | 590 | 403 | All SZGR 2.0 genes in this pathway |
| MARTENS TRETINOIN RESPONSE UP | 857 | 456 | All SZGR 2.0 genes in this pathway |