Gene Page:LAMA1
Summary?
| GeneID | 284217 |
| Symbol | LAMA1 |
| Synonyms | LAMA|PTBHS|S-LAM-alpha |
| Description | 层粘连蛋白亚基α1 |
| Reference | MIM:150320|HGNC:HGNC:6481|Ensembl:ENSG00000101680|HPRD:01033|Vega:OTTHUMG00000133478 |
| Gene type | protein-coding |
| Map location | 18p11.3 |
| Pascal p-value | 0.178 |
| Fetal beta | 1.883 |
| eGene | Cortex |
| Support | CompositeSet |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DNM:Girard_2011 | Whole Exome Sequencing analysis | The data set included 15 DNMs found from the exomes of 14 schizophrenia probands and their parents. | |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 1 |
Section I. Genetics and epigenetics annotation
DNM table
DNM table| Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
|---|---|---|---|---|---|---|---|---|---|---|---|
| LAMA1 | chr18 | 6974966 | T | C | NM_005559 | p.2187T>A | missense | Schizophrenia | DNM:Girard_2011 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005102 | receptor binding | IEA | Neurotransmitter (GO term level: 4) | - |
| GO:0005201 | extracellular matrix structural constituent | TAS | 14557481 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0002011 | morphogenesis of an epithelial sheet | IEA | - | |
| GO:0007166 | cell surface receptor linked signal transduction | IEA | - | |
| GO:0009888 | tissue development | IEA | - | |
| GO:0007275 | multicellular organismal development | NAS | - | |
| GO:0030155 | regulation of cell adhesion | IEA | - | |
| GO:0030334 | regulation of cell migration | IEA | - | |
| GO:0045198 | establishment of epithelial cell apical/basal polarity | IEA | - | |
| GO:0050679 | positive regulation of epithelial cell proliferation | TAS | 14557481 | |
| GO:0045995 | regulation of embryonic development | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005576 | extracellular region | IEA | - | |
| GO:0005604 | basement membrane | IEA | - | |
| GO:0005606 | laminin-1 complex | NAS | - | |
| GO:0005608 | laminin-3 complex | NAS | - |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| ACHE | ARACHE | N-ACHE | YT | acetylcholinesterase (Yt blood group) | - | HPRD | 12524166 |
| 应用程序 | AAA | ABETA | ABPP | AD1 | APPI | CTFgamma | CVAP | PN2 | amyloid beta (A4) precursor protein | - | HPRD | 9136074 |
| FBLN2 | - | fibulin 2 | - | HPRD,BioGRID | 9006922|10934193 |
| HSPG2 | PLC | PRCAN | SJA | SJS | SJS1 | heparan sulfate proteoglycan 2 | - | HPRD,BioGRID | 9688542 |
| ITGA1 | CD49a | VLA1 | integrin, alpha 1 | - | HPRD,BioGRID | 9688542 |
| ITGA2 | BR | CD49B | GPIa | VLA-2 | VLAA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | - | HPRD,BioGRID | 9688542 |
| ITGB1 | CD29 | FNRB | GPIIA | MDF2 | MSK12 | VLA-BETA | VLAB | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | - | HPRD,BioGRID | 9688542 |
| MEP1A | PPHA | meprin A, alpha (PABA peptide hydrolase) | - | HPRD,BioGRID | 10620696 |
| PLAT | DKFZp686I03148 | T-PA | TPA | 质inogen activator, tissue | - | HPRD,BioGRID | 8360181 |
| PLG | DKFZp779M0222 | 质inogen | - | HPRD,BioGRID | 8360181 |
| TMPRSS6 | IRIDA | transmembrane protease, serine 6 | - | HPRD | 12149247 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG FOCAL ADHESION | 201 | 138 | All SZGR 2.0 genes in this pathway |
| KEGG ECM RECEPTOR INTERACTION | 84 | 53 | All SZGR 2.0 genes in this pathway |
| KEGG PATHWAYS IN CANCER | 328 | 259 | All SZGR 2.0 genes in this pathway |
| KEGG SMALL CELL LUNG CANCER | 84 | 67 | All SZGR 2.0 genes in this pathway |
| PID INTEGRIN1 PATHWAY | 66 | 44 | All SZGR 2.0 genes in this pathway |
| PID GLYPICAN 1PATHWAY | 27 | 20 | All SZGR 2.0 genes in this pathway |
| PID INTEGRIN4 PATHWAY | 11 | 5 | All SZGR 2.0 genes in this pathway |
| PID SYNDECAN 4通道 | 32 | 25 | All SZGR 2.0 genes in this pathway |
| PID A6B1 A6B4 INTEGRIN PATHWAY | 46 | 35 | All SZGR 2.0 genes in this pathway |
| PID SYNDECAN 2 PATHWAY | 33 | 27 | All SZGR 2.0 genes in this pathway |
| REACTOME DEVELOPMENTAL BIOLOGY | 396 | 292 | All SZGR 2.0 genes in this pathway |
| REACTOME INTEGRIN CELL SURFACE INTERACTIONS | 79 | 48 | All SZGR 2.0 genes in this pathway |
| REACTOME AXON GUIDANCE | 251 | 188 | All SZGR 2.0 genes in this pathway |
| REACTOME L1CAM INTERACTIONS | 86 | 62 | All SZGR 2.0 genes in this pathway |
| SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 DN | 175 | 82 | All SZGR 2.0 genes in this pathway |
| SABATES COLORECTAL ADENOMA DN | 291 | 176 | All SZGR 2.0 genes in this pathway |
| HERNANDEZ MITOTIC ARREST BY DOCETAXEL 2 UP | 64 | 45 | All SZGR 2.0 genes in this pathway |
| NUYTTEN NIPP1 TARGETS UP | 769 | 437 | All SZGR 2.0 genes in this pathway |
| FERREIRA EWINGS SARCOMA UNSTABLE VS STABLE UP | 167 | 92 | All SZGR 2.0 genes in this pathway |
| FRIDMAN SENESCENCE DN | 13 | 6 | All SZGR 2.0 genes in this pathway |
| 里克曼头颈癌 | 100 | 63 | All SZGR 2.0 genes in this pathway |
| IYENGAR RESPONSE TO ADIPOCYTE FACTORS | 10 | 8 | All SZGR 2.0 genes in this pathway |
| YAMAZAKI TCEB3 TARGETS UP | 175 | 116 | All SZGR 2.0 genes in this pathway |
| MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 | 1069 | 729 | All SZGR 2.0 genes in this pathway |
| MEISSNER NPC HCP WITH H3K4ME2 AND H3K27ME3 | 349 | 234 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN NPC HCP WITH H3K4ME3 AND H3K27ME3 | 210 | 148 | All SZGR 2.0 genes in this pathway |
| PASINI SUZ12 TARGETS UP | 112 | 65 | All SZGR 2.0 genes in this pathway |
| WANG MLL TARGETS | 289 | 188 | All SZGR 2.0 genes in this pathway |
| LIM MAMMARY STEM CELL UP | 489 | 314 | All SZGR 2.0 genes in this pathway |
| LIM MAMMARY LUMINAL MATURE DN | 99 | 74 | All SZGR 2.0 genes in this pathway |
| NABA ECM GLYCOPROTEINS | 196 | 99 | All SZGR 2.0 genes in this pathway |
| NABA CORE MATRISOME | 275 | 148 | All SZGR 2.0 genes in this pathway |
| NABA BASEMENT MEMBRANES | 40 | 22 | All SZGR 2.0 genes in this pathway |
| NABA MATRISOME | 1028 | 559 | All SZGR 2.0 genes in this pathway |