Gene Page:DLL1

Summary?
GeneID 28514
Symbol DLL1
Synonyms DELTA1|DL1|Delta
Description delta-like 1 (Drosophila)
Reference MIM:606582|HGNC:HGNC:2908|Ensembl:ENSG00000198719|HPRD:05957|Vega:OTTHUMG00000016078
Gene type protein-coding
Map location 6q27
Pascal p-value 0.014
Sherlock p-value 0.421
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs6917521 chr6 170350611 DLL1 28514 0.16 cis
rs2068673 chr12 60333402 DLL1 28514 0.03 trans
rs870512 chr13 63223629 DLL1 28514 0.14 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0005112 Notch binding IPI 10079256|11823422
GO:0005509 calcium ion binding IEA -
GO:0005515 protein binding IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0001757 somite specification IEA -
GO:0001709 cell fate determination NAS 11581320
GO:0007154 cell communication IEA -
GO:0007386 compartment specification IEA -
GO:0007368 determination of left/right symmetry IEA -
GO:0007219 Notch signaling pathway NAS 10079256
GO:0007275 multicellular organismal development NAS -
GO:0030155 regulation of cell adhesion TAS 11912004
GO:0030097 hemopoiesis NAS 11581320
GO:0045608 negative regulation of auditory receptor cell differentiation IEA -
GO:0045596 negative regulation of cell differentiation IEA -
GO:0048839 inner ear development IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005576 extracellular region NAS 11823422
GO:0005886 plasma membrane IEA -
GO:0005887 integral to plasma membrane NAS 10079256
GO:0031410 cytoplasmic vesicle IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG NOTCH SIGNALING PATHWAY 47 35 All SZGR 2.0 genes in this pathway
BIOCARTA PS1通路 14 14 All SZGR 2.0 genes in this pathway
PID NOTCH PATHWAY 59 49 All SZGR 2.0 genes in this pathway
PID PS1 PATHWAY 46 39 All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS 27 18 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY NOTCH4 12 10 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY NOTCH2 12 10 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY NOTCH1 70 46 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY NOTCH3 12 10 All SZGR 2.0 genes in this pathway
REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR 12 8 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY NOTCH 103 64 All SZGR 2.0 genes in this pathway
HEDENFALK BREAST CANCER BRCA1 VS BRCA2 163 113 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681 420 All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS UP 280 183 All SZGR 2.0 genes in this pathway
《图片报》极品致癌签名 261 166 All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN 409 268 All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS DN 120 81 All SZGR 2.0 genes in this pathway
OSADA ASCL1 TARGETS UP 46 30 All SZGR 2.0 genes in this pathway
BONCI TARGETS OF MIR15A AND MIR16 1 91 75 All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS UP 165 118 All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS DN 138 92 All SZGR 2.0 genes in this pathway
FUKUSHIMA TNFSF11 TARGETS 16 14 All SZGR 2.0 genes in this pathway
CARD MIR302A TARGETS 77 62 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504 321 All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS NOT VIA AKT1 DN 88 61 All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS VIA AKT1 DN 82 51 All SZGR 2.0 genes in this pathway
WANG MLL TARGETS 289 188 All SZGR 2.0 genes in this pathway
PECE MAMMARY STEM CELL UP 146 75 All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL UP 489 314 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-103/107 73 79 m8 hsa - mir - 103brain AGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brain AGCAGCAUUGUACAGGGCUAUCA
miR-130/301 220 227 1A,m8 hsa-miR-130abrain CAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301 CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrain CAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3p UAGUGCAAUAUUGCUUAUAGGGUUU
miR-149 324 330 m8 hsa-miR-149brain UCUGGCUCCGUGUCUUCACUCC
miR-15/16/195/424/497 74 80 m8 hsa-miR-15abrain UAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brain UAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrain UAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZ UAGCAGCACAGAAAUAUUGGC
hsa-miR-424 CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497 CAGCAGCACACUGUGGUUUGU
hsa-miR-15abrain UAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brain UAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrain UAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZ UAGCAGCACAGAAAUAUUGGC
hsa-miR-424 CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497 CAGCAGCACACUGUGGUUUGU
miR-214 107 113 1A hsa-miR-214brain ACAGCAGGCACAGACAGGCAG
miR-24 323 329 1A hsa-miR-24SZ UGGCUCAGUUCAGCAGGAACAG
miR-34/449 293 299 m8 hsa-miR-34abrain UGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34c AGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449 UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449b AGGCAGUGUAUUGUUAGCUGGC
miR-34b 357 363 m8 hsa-miR-34b UAGGCAGUGUCAUUAGCUGAUUG
hsa-miR-34b UAGGCAGUGUCAUUAGCUGAUUG
miR-362 52 59 1A,m8 hsa-miR-362 AAUCCUUGGAACCUAGGUGUGAGU
miR-363 579 585 1A hsa-miR-363 AUUGCACGGUAUCCAUCUGUAA
miR-376c 532 538 m8 hsa-miR-376c AACAUAGAGGAAAUUCCACG
miR-381 551 557 1A hsa-miR-381 UAUACAAGGGCAAGCUCUCUGU
miR-493-5p 512 519 1A,m8 hsa-miR-493-5p UUGUACAUGGUAGGCUUUCAUU
miR-495 608 614 1A hsa-miR-495brain AAACAAACAUGGUGCACUUCUUU
miR-543 584 590 1A hsa-miR-543 AAACAUUCGCGGUGCACUUCU